CKD-心血管-肾-代谢综合征0-3期患者估计葡萄糖处置率与心血管疾病风险预测之间的关系：一项全国前瞻性队列研究
Jing Tian1, Hu Chen2, Yan Luo1, Zhen Zhang1, Shiqiang Xiong1,3* and Hanxiong Liu1*
一句话总结
Tian 等基于中国健康与养老追踪调查（CHARLS）的前瞻性队列研究，纳入6,752例心血管-肾脏-代谢综合征（CKM）0-3期个体，采用多变量logistic回归和限制性立方样条分析发现，与最低eGDR水平（<7.37 mg/kg/min）相比，最高eGDR水平（≥11.16 mg/kg/min
参考文献
Jing Tian1, Hu Chen2, Yan Luo1, Zhen Zhang1, Shiqiang Xiong1,3* and Hanxiong Liu1*[J].
论文摘要
Background Insulin resistance is a crucial factor in the development of cardiovascular diseases (CVD), yet the relationship between the estimated glucose disposal rate (eGDR), an index reflecting insulin resistance, and the risk of new-onset CVD among individuals with cardiovascular-kidney-metabolic (CKM) syndrome stage 0–3 remains underexplored, and large-scale prospective cohort studies are needed to clarify this relationship. Methods All data for this study were extracted from the China Health and Retirement Longitudinal Study (CHARLS). The primary outcome was the incidence of new-onset CVD (including heart diseases (HD) and stroke) during the follow-up period (from 2013 to 2020). Multivariable logistic regression models were applied to elucidate the relationship between the eGDR and the risk of developing CVD. The restricted cubic splines (RCS), mediation analysis, and stratified analyses were also employed. Results This study included 6752 participants, of whom 1495 (22%) developed CVD. Odds ratios and 95% confidence intervals from lowest eGDR level (<7.37 mg/kg/min) to highest eGDR level (≥ 11.16 mg/kg/min) were 1.00 (reference), 0.81 (0.68, 0.96), 0.72 (0.58, 0.88), and 0.74 (0.58, 0.94) respectively, for the occurrence of CVD; 1.00 (reference), 0.81 (0.67,0.97), 0.72 (0.57,0.90), and 0.75 (0.58,0.97) respectively, for the occurrence of HD; 1.00 (reference), 0.91 (0.74,1.12), 0.80 (0.62,1.04), and 0.71 (0.52,0.97) respectively, for the occurrence of stroke after adjusting for all potential covariates. The RCS analysis discovered an approximately inverse “L” correlation between eGDR and the occurrence of CVD and HD across all individuals with CKM syndrome stages 0–3 (All P for overall < 0.001, All P for nonlinear = 0.005), while there was a negative linear correla