衰弱、非奈利酮及遗传多态性在CKM管理中的角色 Extension | Explainable machine learning-driven predictive modelling of incident cognitive impairment in individuals with early-stage cardiovascular-kidney-metabolic syndrome: Insights from a longitudinal CHARLS cohort study. 2026 Diabetes, obesity & metabolism | Duan Shoupeng 等基于4,462名早期CKM综合征患者的前瞻性队列数据,利用可解释机器学习模型发现,教育程度、总胆固醇和年龄是预测10年内新发认知损害的最重要因素。 | 认知损害心血管-肾脏-代谢综合征机器学习XGBoost总胆固醇前瞻性队列研究教育程度空腹血糖PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1111/dom.70346;PMID: 41369001 | [9] Duan Shoupeng, Wang Yijun, Yang Xiaomeng, Xu Yanan, Wang Jun. Explainable machine learning-driven predictive modelling of incident cognitive impairment in individuals with early-stage cardiovascular-kidney-metabolic syndrome: Insights from a longitudinal CHARLS cohort study. Diabetes, obesity & metabolism. 2026;28(3):1693-1709. doi:10.1111/dom.70346 |
地热系统与超级马拉松代谢挑战等无关主题 Excluded | Advancing brain health prevention using explainable CKM-based predictive modelling. 2026 Diabetes, obesity & metabolism | Li J 等利用可解释的CKM预测模型,发现该模型能有效识别脑健康风险因素,为脑疾病预防提供了新工具。 | 脑健康预测模型可解释性CKM模型疾病预防队列研究生物标志物PubMed疾病:CKM Title/Abstract澳大利亚med | DOI: 10.1111/dom.70437;PMID: 41588914 | [14] Li J, Miao X, Li Z, Yang J. Advancing brain health prevention using explainable CKM-based predictive modelling. Diabetes, obesity & metabolism. 2026;28(3)(3):2497-2498. doi:10.1111/dom.70437 |
地热系统与超级马拉松代谢挑战等无关主题 Excluded | Socceromics: A Systematic Review of Omics Technologies to Optimize Performance and Health in Soccer. 2026 International journal of molecular sciences | Owen A 等通过系统综述139项研究、涵盖19,449名足球运动员发现,基因组学、蛋白质组学、代谢组学及微生物组学可识别与耐力、损伤风险及恢复相关的生物标志物,支持个体化训练与健康管理策略。 | 运动损伤组学技术系统综述单核苷酸多态性肠道微生物精准运动医学基因-环境交互PubMed疾病:CKM Title/Abstract澳大利亚med | DOI: 10.3390/ijms27020749;PMID: 41596414 | No ref no. Owen A, Ceylan Hİ, Zmijewski P, Biz C, Sciarretta G, Rossin. Socceromics: A Systematic Review of Omics Technologies to Optimize Performance and Health in Soccer.. International journal of molecular sciences. 2026. 27(2)(2). 749.. doi:10.3390/ijms27020749 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | Association of Cardiovascular-Kidney-Syndrome and Brain Macrostructure and Microstructure Injury: A Prospective Cohort Study. 2026 Diabetes, obesity & metabolism | Niu G 等在一项前瞻性队列研究中发现,心血管-肾脏-代谢综合征分期越高,脑宏观结构萎缩及白质微观结构损伤越严重,且呈进行性恶化模式。 | 心血管肾脏综合征脑宏观结构脑微观结构弥散张量成像白质高信号前瞻性队列研究线性混合效应模型脑体积各向异性分数CKM分期 | DOI: 10.1111/dom.70605;PMID: 41749423 | [13] Niu G, Cai X, Yang Y, Jing J, Zhang D, Wang. Association of Cardiovascular-Kidney-Syndrome and Brain Macrostructure and Microstructure Injury: A Prospective Cohort Study. Diabetes, obesity & metabolism. 2026;28(5)(5):4148-4161. doi:10.1111/dom.70605 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | TyG and RC combined with CVD risk in CKM syndrome: A national cohort study. 2026 iScience | Lan H 等基于中国健康与养老追踪调查数据发现,TyG与残余胆固醇均高的个体心血管疾病风险最高(HR=1.35),且联合构建的TyG-RC指数预测价值优于其他指标。 | 心血管疾病心血管-肾脏-代谢综合征甘油三酯-葡萄糖指数残余胆固醇队列研究风险预测胰岛素抵抗脂质代谢PubMed疾病:CKM Title/Abstracttyg | DOI: 10.1016/j.isci.2026.115060;PMID: 41816296 | [40] Lan H, Jia X, Zhao Z, Chen R, Wang B, Qu C, et al. TyG and RC combined with CVD risk in CKM syndrome: A national cohort study. iScience. 2026;29(3):115060. doi:10.1016/j.isci.2026.115060 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | eCollection 2026. Current understanding of sodium-glucose transporter 2 inhibitors in cardiovascular-kidney-metabolic syndrome. 2026 Frontiers in Pharmacology | Yang Y 等综述了SGLT-2抑制剂在心血管-肾脏-代谢综合征中的临床证据,发现其通过糖尿和尿钠排泄触发血流动力学优化、心脏效能增强及抗炎抗氧化等多效机制,形成相互关联的治疗获益网络。 | 心血管-肾脏-代谢综合征SGLT-2抑制剂系统综述血糖控制血压肾脏结局心血管结局炎症与氧化应激PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.3389/fphar.2026.1800868;PMID: 42038319 | [65] Yang Y, Zhou W, Yang M, Tang SCW, Liu BC. Current understanding of sodium-glucose transporter 2 inhibitors in cardiovascular-kidney-metabolic syndrome. Frontiers in Pharmacology. 2026;17:1800868. doi:10.3389/fphar.2026.1800868 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | eCollection 2026. Triglyceride-glucose index and its derivatives as emerging biomarkers of insulin resistance for prognostic evaluation of cardiovascular-kidney-metabolic syndrome: mechanisms and clinical applications. 2026 Frontiers in Pharmacology | Zheng Z 等综述发现,甘油三酯-葡萄糖指数及其衍生指标作为胰岛素抵抗的新型生物标志物,在心血管-肾脏-代谢综合征的预后评估中具有显著潜力。 | 心血管-肾脏-代谢综合征胰岛素抵抗甘油三酯-葡萄糖指数系统综述生物标志物代谢紊乱预后评估PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstracttyg | DOI: 10.3389/fphar.2026.1787130;PMID: 41878329 | [7] Zheng Z, Yin X, Liu J, Zhang Y. Triglyceride-glucose index and its derivatives as emerging biomarkers of insulin resistance for prognostic evaluation of cardiovascular-kidney-metabolic syndrome: mechanisms and clinical applications. Frontiers in Pharmacology. 2026;17:1787130. doi:10.3389/fphar.2026.1787130 |
地热系统与超级马拉松代谢挑战等无关主题 Excluded | Current Appraisal and Gaps in Knowledge in Cardio-Kidney Metabolic Syndrome Definition. 2026 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | Palazzuoli A 等探讨了心血管-肾脏-代谢综合征(CKM)的定义与评估挑战,发现其分类和管理因缺乏不同疾病阶段的心脏与肾脏结局可靠数据而存在混乱。 | 慢性肾脏病心血管疾病代谢综合征系统综述氧化应激血管内皮心力衰竭肾功能障碍诊断评估实验室指纹 | DOI: 10.3390/ijms27041657;PMID: 41751792 | [12] Palazzuoli A, Mattioli AV, Fedele F. Current Appraisal and Gaps in Knowledge in Cardio-Kidney Metabolic Syndrome Definition. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2026;27(4):1657. doi:10.3390/ijms27041657 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | Melatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk. 2026 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | Hsu CN 和 Tain YL 通过综述发现,母体补充褪黑素可通过恢复氧化还原稳态、调节表观遗传及肠道微生物组,预防子代高血压、肾功能障碍及代谢紊乱。 | 心血管肾脏代谢综合征褪黑素系统综述氧化应激发育编程母体补充高血压肾功能障碍代谢紊乱胎盘功能 | DOI: 10.3390/ijms27052390;PMID: 41828607 | [6] Hsu CN, Tain YL. Melatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2026;27(5):2390. doi:10.3390/ijms27052390 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | Mitochondrial Dysfunction at the Intersection of CKM Syndrome: Molecular Mechanisms and Path-to-Target Therapies. 2026 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | Kuo YJ 等在一篇综述中提出,线粒体功能障碍是心血管-肾脏-代谢综合征的核心病理枢纽,驱动从早期代谢风险向终末期器官衰竭的进展。 | CKM综合征线粒体功能障碍SGLT-2抑制剂GLP-1受体激动剂系统综述氧化应激线粒体自噬心力衰竭慢性肾脏病PubMed疾病:CKM Title/Abstract | DOI: 10.3390/ijms27094120;PMID: 42123698 | [4] Kuo YJ, Chen LF, Chen Y, Chen PL, Lin HY. Mitochondrial Dysfunction at the Intersection of CKM Syndrome: Molecular Mechanisms and Path-to-Target Therapies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2026;27(9):4120. doi:10.3390/ijms27094120 |
CKM综合征分期与新型生物标志物的预后评估 Core | Association of Remnant Cholesterol Inflammatory Index with Stroke, Heart Disease and All-Cause Mortality Across Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: A National Cohort Study. 2026 Nutrients | Chen H 等基于CHARLS队列研究发现,在心血管-肾脏-代谢综合征0-3期人群中,残粒胆固醇炎症指数升高与卒中、心脏病及全因死亡风险增加相关,且与全因死亡率呈J形非线性关联。 | 卒中心脏病全因死亡率残粒胆固醇炎症指数高敏C反应蛋白Cox比例风险模型限制性立方样条K-means聚类队列研究心血管-肾脏-代谢综合征 | DOI: 10.3390/nu18020205;PMID: 41599818 | [33] Chen H, Wu JY, Yan H, Gao J, Li C, Xie JH. Association of Remnant Cholesterol Inflammatory Index with Stroke, Heart Disease and All-Cause Mortality Across Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: A National Cohort Study. Nutrients. 2026;18(2):205. doi:10.3390/nu18020205 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | Cardiovascular-Kidney-Metabolic (CKM) Syndrome Staging and Relevance to Precision Nutrition. 2026 Nutrients | Soliman GA 在一项叙述性综述中描述了CKM综合征的分期与流行病学,发现精准营养可能有助于预防CKM进展,但肝脏在CKM定义中尚未被纳入。 | 心血管-肾脏-代谢综合征精准营养饮食模式叙述性综述CKM分期膳食摄入营养素代谢慢性肾脏病2型糖尿病肥胖 | DOI: 10.3390/nu18091430;PMID: 42124030 | [19] Soliman GA. Cardiovascular-Kidney-Metabolic (CKM) Syndrome Staging and Relevance to Precision Nutrition. Nutrients. 2026;18(9):1430. doi:10.3390/nu18091430 |
地热系统与超级马拉松代谢挑战等无关主题 Excluded | Ultra-Processed Foods and the Cardiovascular-Kidney-Metabolic Continuum: Integrating Epidemiological, Multi-Omics, and Translational Evidence. 2026 Nutrients | Singar S 等在一项综述中整合流行病学与多组学证据发现,超加工食品摄入通过炎症、脂质代谢及肠道屏障功能障碍等通路,与肥胖、糖尿病、心血管事件及死亡率呈中低度正向关联。 | 心血管-肾脏-代谢综合征超加工食品系统综述多组学代谢组学脂质组学蛋白质组学肠道微生物组肥胖慢性肾脏病 | DOI: 10.3390/nu18071039;PMID: 41978089 | [15] Singar S, Kachouei AA, Lantigua-Somoano L, Manley D, Cardinale A. Ultra-Processed Foods and the Cardiovascular-Kidney-Metabolic Continuum: Integrating Epidemiological, Multi-Omics, and Translational Evidence. Nutrients. 2026;18(7):1039. doi:10.3390/nu18071039 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 2026. Adherence to the EAT-Lancet diet and the risk of heart failure in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study. 2026 Frontiers in Nutrition | Fu P 等基于120,849名心血管-肾脏-代谢综合征0-3期个体的前瞻性队列研究发现,较高依从性EAT-柳叶刀饮食与心力衰竭风险降低12%显著相关,主要得益于减少红肉和增加坚果摄入。 | 心力衰竭心血管-肾脏-代谢综合征EAT-柳叶刀饮食Cox回归限制性立方样条前瞻性研究饮食指数红肉摄入坚果摄入PubMed疾病:cardiovasc | DOI: 10.3389/fnut.2026.1802388;PMID: 42211092 | [58] Fu P, Zheng H, Wu K, Lan Y, Wu D, Wu W, et al. 2026. Adherence to the EAT-Lancet diet and the risk of heart failure in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study. Frontiers in Nutrition. 2026;13:1802388. doi:10.3389/fnut.2026.1802388 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 2026. Associations between lipid-derived indices and cardiovascular-kidney-metabolic syndrome progression among Chinese middle-aged and elderly adults: a longitudinal study. 2026 Frontiers in Nutrition | Tang Y 等基于中国中老年人群纵向数据发现,七种脂质衍生指标(AIP、Non-HDL-C、NHHR、LCI、LAP、VAI、TyG)与心血管-肾脏-代谢综合征进展及心血管疾病风险呈正相关,其中NHHR预测价值最优。 | 心血管-肾脏-代谢综合征脂质衍生指标队列研究Cox回归限制性立方样条非高密度脂蛋白胆固醇比值血浆致动脉粥样硬化指数甘油三酯-葡萄糖比值PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.3389/fnut.2026.1742974;PMID: 41958905 | [41] Tang Y, Xu W, Jiang Y, Liu C, Zhu W, Liu D, et al. 2026. Associations between lipid-derived indices and cardiovascular-kidney-metabolic syndrome progression among Chinese middle-aged and elderly adults: a longitudinal study. Frontiers in Nutrition. 2026;13:1742974. doi:10.3389/fnut.2026.1742974 |
CKM综合征分期与新型生物标志物的预后评估 Core | 2026. Development and validation of a prediction model for cardiovascular-kidney-metabolic syndrome progression: a multicenter study. 2026 Frontiers in Nutrition | Tu J等基于21,026名CKM 1-2期患者构建预测模型,发现其区分度良好(AUC达0.747),且合并糖尿病与MASLD者进展风险最高(OR 2.13)。 | 心血管-肾脏-代谢综合征代谢功能障碍相关脂肪性肝病糖尿病脂质代谢指标预测模型多中心回顾性研究受试者工作特征曲线决策曲线分析比值比PubMed疾病:cardiovasc | DOI: 10.3389/fnut.2026.1783262;PMID: 41939189 | [16] Tu J, Chen F, Yan W, Xu Z, Zhan Y, Yang X. 2026. Development and validation of a prediction model for cardiovascular-kidney-metabolic syndrome progression: a multicenter study. Frontiers in Nutrition. 2026;13:1783262. doi:10.3389/fnut.2026.1783262 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 2026. The Triglyceride-Glucose-Chinese Visceral Adiposity Index (TyG-CVAI) outperforms other insulin resistance indices in its association with cardiovascular-kidney-metabolic syndrome severity in type 2 diabetes: a comparative study. 2026 Frontiers in Nutrition | Yang J 等在一项纳入5,609例2型糖尿病患者的横断面研究中发现,新型TyG-CVAI指数与心血管-肾脏-代谢综合征严重程度的相关性优于其他胰岛素抵抗指标,且对晚期CKM的区分能力更强。 | 2型糖尿病心血管肾脏代谢综合征甘油三酯葡萄糖指数中国内脏脂肪指数胰岛素抵抗横断面研究有序逻辑回归受试者工作特征曲线PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.3389/fnut.2026.1817071;PMID: 42180562 | [42] Yang J, Deng Z, Xie B, Tian F, Leng Y, Zhou H. 2026. The Triglyceride-Glucose-Chinese Visceral Adiposity Index (TyG-CVAI) outperforms other insulin resistance indices in its association with cardiovascular-kidney-metabolic syndrome severity in type 2 diabetes: a comparative study. Frontiers in Nutrition. 2026;13:1817071. doi:10.3389/fnut.2026.1817071 |
CKM综合征分期与新型生物标志物的预后评估 Core | Association of Higher Dietary Omega-3 Fatty Acid Intake With Cardiovascular-Kidney-Metabolic Syndrome Stage Severity and Mortality in US Adults: A Cross-Sectional and Prospective Cohort Analysis of NHANES 1999 to 2018. 2026 Journal of the American Heart Association | Zhang LL 等基于27,934名美国成年人数据发现,较高膳食omega-3脂肪酸摄入与较轻的CKM综合征分期及L型阈值依赖的较低死亡率相关。 | 心血管肾脏代谢综合征Omega-3脂肪酸横断面研究队列研究限制性立方样条Cox回归全因死亡率膳食摄入量非线性关联阈值效应 | DOI: 10.1161/JAHA.125.046079;PMID: 41532525 | [60] Zhang LL, Zhu XG, Chen J, Nie P, Shi JC, Zhang Z, et al. Association of Higher Dietary Omega-3 Fatty Acid Intake With Cardiovascular-Kidney-Metabolic Syndrome Stage Severity and Mortality in US Adults: A Cross-Sectional and Prospective Cohort Analysis of NHANES 1999 to 2018. Journal of the American Heart Association. 2026;15(2):e046079. doi:10.1161/JAHA.125.046079 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | Effect of Mitochondria-Derived Methylmalonic Acid on Progress and Mortality Risk in US Adults With Cardiovascular-Kidney-Metabolic Syndrome. 2026 Journal of the American Heart Association | Liu H 等基于14,581名CKM参与者的前瞻性队列研究发现,线粒体来源的甲基丙二酸与CKM分期显著相关,其高水平与全因及非心血管死亡风险增加显著相关。 | 心血管-肾脏-代谢综合征甲基丙二酸前瞻性队列研究Cox回归全因死亡非心血管死亡心脏代谢生物标志物比值比PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1161/JAHA.125.043066;PMID: 41532538 | [35] Liu H, Wu S, Huang B, Liu Y, Zhong Z, Zhao. Effect of Mitochondria-Derived Methylmalonic Acid on Progress and Mortality Risk in US Adults With Cardiovascular-Kidney-Metabolic Syndrome. Journal of the American Heart Association. 2026;15(2):e043066. doi:10.1161/JAHA.125.043066 |
衰弱、非奈利酮及遗传多态性在CKM管理中的角色 Extension | Prognostic Impact of Cardiovascular-Kidney-Metabolic Overlap Among Patients With Acute Heart Failure: Insights From a Real-World Multinational Cohort. 2026 Journal of the American Heart Association | Marchetti M 等在一项跨国队列研究中发现,急性心力衰竭患者合并心血管-肾脏-代谢疾病数量越多,1年内死亡风险越高。 | 急性心力衰竭心血管肾脏代谢综合征肾功能受损心肌梗死糖尿病Cox回归全因死亡队列研究真实世界研究PubMed疾病:CKM Title/Abstract | DOI: 10.1161/JAHA.125.045294;PMID: 41404735 | [78] Marchetti M, Antiochos P, Pitta-Gros B, Abdurashidova T. Prognostic Impact of Cardiovascular-Kidney-Metabolic Overlap Among Patients With Acute Heart Failure: Insights From a Real-World Multinational Cohort. Journal of the American Heart Association. 2026;15(1):e045294. doi:10.1161/JAHA.125.045294 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | Cardio-Kidney-Metabolic Therapy Use Among Adults With Type 1 Diabetes and Chronic Kidney Disease. 2026 DIABETES OBESITY and METABOLISM | Caramori ML 等在一项纳入253名1型糖尿病合并慢性肾病患者的队列研究中发现,使用心-肾-代谢疗法与尿白蛋白/肌酐比值降低相关,且未增加低血糖或酮症酸中毒风险。 | 1型糖尿病慢性肾脏病GLP-1受体激动剂SGLT-2抑制剂倾向评分匹配尿白蛋白肌酐比值糖化血红蛋白低血糖糖尿病酮症酸中毒队列研究 | DOI: 10.1111/dom.70640;PMID: 41816887 | [75] Caramori ML, Repetto E, Perkins C, Pandey A, Rossing P. Cardio-Kidney-Metabolic Therapy Use Among Adults With Type 1 Diabetes and Chronic Kidney Disease. DIABETES OBESITY and METABOLISM. 2026;28(5):4344-4351. doi:10.1111/dom.70640 |
CKM综合征分期与新型生物标志物的预后评估 Core | Comparative Associations of Traditional and New Obesity Framework With Cardio-Kidney-Metabolic Syndrome and All-Cause Mortality: A Prospective Cohort Study. 2026 DIABETES OBESITY and METABOLISM | Yang Y等在一项前瞻性队列研究中发现,新肥胖框架能识别出被传统标准忽视的高CKM风险个体,且同时符合两种标准的人群风险最高。 | 心血管-肾脏-代谢综合征肥胖全因死亡率体重指数人体测量指标Cox回归队列研究英国生物银行PubMed疾病:CKM Title/Abstract肾脏 | DOI: 10.1111/dom.70883;PMID: 42169183 | [28] Yang Y, Liu Y, Han S, Liu Z, Yu J, Xing B. Comparative Associations of Traditional and New Obesity Framework With Cardio-Kidney-Metabolic Syndrome and All-Cause Mortality: A Prospective Cohort Study. DIABETES OBESITY and METABOLISM. 2026. doi:10.1111/dom.70883 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | Effects of SGLT2 inhibitors across the spectrum of albuminuria in cardiovascular-kidney-metabolic conditions: A pooled analysis of randomised trials. 2026 DIABETES OBESITY and METABOLISM | Ferreira JP 等在一项纳入26,750例患者的汇总分析中发现,SGLT2抑制剂在全部白蛋白尿范围内均能降低肾脏事件和心力衰竭死亡风险,并使白蛋白尿水平平均降低13%。 | 白蛋白尿SGLT2抑制剂汇总分析尿白蛋白肌酐比肾小球滤过率肾脏事件心力衰竭随机对照试验PubMed疾病:CKM Title/Abstractckd | DOI: 10.1111/dom.70289;PMID: 41208574 | [10] Ferreira JP, Marques P, Anker SD, Butler J, Filippatos G. Effects of SGLT2 inhibitors across the spectrum of albuminuria in cardiovascular-kidney-metabolic conditions: A pooled analysis of randomised trials. DIABETES OBESITY and METABOLISM. 2026;28(2):1105-1115. doi:10.1111/dom.70289 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | Online ahead of print. Hyperaldosteronism in the Pathophysiology and Management of Cardiovascular-Kidney-Metabolic Syndrome. 2026 DIABETES OBESITY and METABOLISM | Zeitler E 等发现,肥胖诱导的醛固酮过量是心血管-肾脏-代谢综合征的关键病理因素,抑制醛固酮信号可改善疾病管理。 | 心血管-肾脏-代谢综合征醛固酮过量盐皮质激素受体拮抗剂胰高血糖素样肽-1受体激动剂系统综述肾素-血管紧张素-醛固酮系统抑制剂肥胖心力衰竭PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1111/dom.70781;PMID: 42010373 | [5] Zeitler E, Klein KR, Lingvay I, Pick A, Billings LK. Online ahead of print. Hyperaldosteronism in the Pathophysiology and Management of Cardiovascular-Kidney-Metabolic Syndrome. DIABETES OBESITY and METABOLISM. 2026. doi:10.1111/dom.70781 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | Proteomic Profiling Captures Residual Cardiovascular Risk Beyond the PREVENT Model in Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 2-3. 2026 DIABETES OBESITY and METABOLISM | Han X 等基于24,017名CKM 2-3期参与者数据,构建含63种蛋白的风险评分,发现其可显著提升PREVENT模型对心血管疾病的预测能力,并捕获残余风险。 | 心血管疾病心血管-肾脏-代谢综合征蛋白风险评分队列研究LASSO回归生长分化因子15NT-proBNP残余风险PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1111/dom.70933;PMID: 42225325 | [8] Han X, Ding J, Li J, Gao Y, Li Y. Proteomic Profiling Captures Residual Cardiovascular Risk Beyond the PREVENT Model in Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 2-3. DIABETES OBESITY and METABOLISM. 2026. doi:10.1111/dom.70933 |
CKM综合征分期与新型生物标志物的预后评估 Core | Serum glycated albumin-to-albumin ratio and mortality risk in cardiovascular-kidney-metabolic syndrome: Evidence from NHANES over 15 years. 2026 DIABETES OBESITY and METABOLISM | Li Z和Chen M基于NHANES数据库4524例CKM综合征患者15年随访发现,糖化白蛋白与白蛋白比值升高与全因及心脑血管死亡风险增加显著相关,且该比值是预测长期死亡风险的最稳健指标。 | 心血管-肾脏-代谢综合征糖化白蛋白与白蛋白比值Cox回归限制性立方样条全因死亡心脑血管死亡队列研究血清白蛋白糖化白蛋白PubMed疾病:cardiovasc | DOI: 10.1111/dom.70387;PMID: 41403278 | [37] Li Z, Chen M. Serum glycated albumin-to-albumin ratio and mortality risk in cardiovascular-kidney-metabolic syndrome: Evidence from NHANES over 15 years. DIABETES OBESITY and METABOLISM. 2026;28(3):2038-2050. doi:10.1111/dom.70387 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | The Evolving Role of High-Sensitivity C-Reactive Protein for Mortality Prediction Across the Spectrum of Cardiovascular-Kidney-Metabolic Syndrome. 2026 DIABETES OBESITY and METABOLISM | Li J 等在一项纳入86,829名参与者的前瞻性研究中发现,高敏C反应蛋白与全因死亡率的关联随心血管-肾脏-代谢综合征分期进展而逐渐减弱。 | 心血管-肾脏-代谢综合征高敏C反应蛋白全因死亡率Cox比例风险模型CKM分期前瞻性队列研究风险比PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏 | DOI: 10.1111/dom.70843;PMID: 42107990 | [36] Li J, Chen S, Zhang X, Xia X, Yan Y. The Evolving Role of High-Sensitivity C-Reactive Protein for Mortality Prediction Across the Spectrum of Cardiovascular-Kidney-Metabolic Syndrome. DIABETES OBESITY and METABOLISM. 2026. doi:10.1111/dom.70843 |
CKM综合征分期与新型生物标志物的预后评估 Core | 10.1016/j.ecoenv.2025.119515. Epub 2025 Dec 4. Multimodal mechanisms of di (2-ethylhexyl) phthalate-induced cardiovascular-kidney-metabolic syndrome: Integrating epidemiology, network toxicology and experimental validation. 2026 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | Wen W 等通过整合流行病学、网络毒理学和实验验证发现,DEHP暴露通过PPARG、PTGS2和MMP2通路促进CKM综合征,且肥胖显著放大该关联。 | 心血管-肾脏-代谢综合征邻苯二甲酸二乙基己酯横断面研究体重指数网络毒理学细胞毒性代谢紊乱炎症反应纤维化PubMed疾病:cardiovasc | DOI: 10.1016/j.ecoenv.2025.119515;PMID: 41349316 | [17] Wen W, Liu Z, Li L, Qiu F, Zhang H, Cao Y, et al. Multimodal mechanisms of di (2-ethylhexyl) phthalate-induced cardiovascular-kidney-metabolic syndrome: Integrating epidemiology, network toxicology and experimental validation. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2026;309:119515. doi:10.1016/j.ecoenv.2025.119515 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 10.1016/j.ecoenv.2026.120039. Epub 2026 Mar 20. Urinary metal mixtures and cardio-kidney-metabolic risk in adults from a legacy-contaminated area: Repeated-measures cohort evidence and computational validation. 2026 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | Amujilite 等通过纵向重复测量队列发现,尿镉、铅、锰水平升高与晚期心血管-肾脏-代谢综合征风险增加相关,且累积性社会不利因素可放大该关联。 | 心血管-肾脏-代谢综合征重金属暴露广义线性混合效应模型贝叶斯核机器回归尿金属水平社会不利因素队列研究分子对接PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1016/j.ecoenv.2026.120039;PMID: 41864045 | [18] Amujilite, Yin G, Chen Z, Wu J, Dong Z, Zhang S, et al. Urinary metal mixtures and cardio-kidney-metabolic risk in adults from a legacy-contaminated area: Repeated-measures cohort evidence and computational validation. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2026;314:120039. doi:10.1016/j.ecoenv.2026.120039 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | 10.1177/15209156261420167. Online ahead of print. Continuous Ketone Monitoring Captures Overt Ketosis in Type 1 Diabetes Caused by Empagliflozin, Low-Carbohydrate Diet, and Exercise. 2026 Diabetes Technology and Therapeutics | Lawton E等通过一例1型糖尿病患者使用连续酮体监测发现,在恩格列净、低碳水饮食和运动共同作用下,尽管血糖正常,仍可发生持续14小时、最高达2.9 mmol/L的酮症。 | 1型糖尿病正常血糖性酮症恩格列净连续酮体监测低碳水化合物饮食病例报告酮体浓度钠-葡萄糖协同转运蛋白2抑制剂PubMed疾病:CKM Title/Abstractckd | DOI: 10.1177/15209156261420167;PMID: 41640091 | [76] Lawton E, Perz L, Pasqua MR, Tsoukas M, Haidar. Online ahead of print. Continuous Ketone Monitoring Captures Overt Ketosis in Type 1 Diabetes Caused by Empagliflozin, Low-Carbohydrate Diet, and Exercise. Diabetes Technology and Therapeutics. 2026. doi:10.1177/15209156261420167 |
地热系统与超级马拉松代谢挑战等无关主题 Excluded | 10.1177/15209156261420186. Online ahead of print. Ketone Profiles in Community-Dwelling Adults with Type 1 Diabetes Using Continuous Ketone Monitoring. 2026 Diabetes Technology and Therapeutics | Ngan J 等通过持续酮体监测发现,社区居住的1型糖尿病成人中61%酮体持续低于0.6 mmol/L,血糖随酮体升高但无法替代诊断。 | 1型糖尿病持续酮体监测酮体水平糖化血红蛋白血糖水平队列研究社区居住PubMed疾病:CKM Title/Abstract澳大利亚med | DOI: 10.1177/15209156261420186;PMID: 41684056 | No ref no. Ngan J, Kong YW, Jones HC, Goad J, Kriketos A,. 10.1177/15209156261420186. Online ahead of print. Ketone Profiles in Community-Dwelling Adults with Type 1 Diabetes Using Continuous Ketone Monitoring.. Diabetes Technology and Therapeutics. 2026. doi:10.1177/15209156261420186 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | 10.1177/15209156261428034. Online ahead of print. Continuous Ketone Monitoring in Diabetic Ketoacidosis: Prospective Multicenter Method-Comparison and Feasibility Study. 2026 Diabetes Technology and Therapeutics | Haas NL 等在一项前瞻性多中心研究中发现,持续酮体监测与静脉血β-羟丁酸值高度一致,且能比标准治疗平均提前55分钟检测到糖尿病酮症酸中毒纠正。 | 糖尿病酮症酸中毒持续酮体监测β-羟丁酸前瞻性研究方法比较研究Bland-Altman分析相关性分析可行性研究PubMed疾病:CKM Title/Abstract肾脏 | DOI: 10.1177/15209156261428034;PMID: 41800718 | [103] Haas NL, Korley FK, Schneider RM, Mamillapalli SL, Hepworth E. Online ahead of print. Continuous Ketone Monitoring in Diabetic Ketoacidosis: Prospective Multicenter Method-Comparison and Feasibility Study. Diabetes Technology and Therapeutics. 2026. doi:10.1177/15209156261428034 |
地热系统与超级马拉松代谢挑战等无关主题 Excluded | Preventing Diabetic Ketoacidosis with Continuous Ketone Monitoring: Insights from a Clinical Research Case. 2026 Diabetes Technology and Therapeutics | Kong YW 等通过一项临床研究案例发现,连续酮体监测可早期预警酮症升高,促进及时干预,从而降低糖尿病酮症酸中毒风险。 | 糖尿病酮症酸中毒1型糖尿病连续酮体监测自动化胰岛素输注胰岛素泵酮体糖化血红蛋白临床试验PubMed疾病:CKM Title/Abstract澳大利亚 | DOI: 10.1177/15209156251362494;PMID: 40711834 | No ref no. Kong YW, Jones HC, Ngan J, Goad J, Jenkins. Preventing Diabetic Ketoacidosis with Continuous Ketone Monitoring: Insights from a Clinical Research Case.. Diabetes Technology and Therapeutics. 2026. 28(1). 73-77.. doi:10.1177/15209156251362494 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | 10.1016/j.diabres.2025.113051. Epub 2025 Dec 11. Kidney function decline mediates the adverse effects of arterial stiffness on all-cause and cardiovascular disease mortality in Cardiovascular-Kidney-Metabolic syndrome population: A cohort study. 2026 DIABETES RESEARCH AND CLINICAL PRACTICE | Liu S 等基于34,004例CKM综合征患者队列发现,动脉僵硬度升高显著增加全因及心血管死亡风险,肾功能下降介导了24%-26%的死亡效应。 | CKM综合征动脉僵硬度肾功能下降全因死亡心血管死亡Cox回归限制性立方样条中介效应分析队列研究估计脉搏波传导速度 | DOI: 10.1016/j.diabres.2025.113051;PMID: 41386526 | [27] Liu S, Man Q, Wang S, Huang Y, Wen J, Yang Y, et al. Kidney function decline mediates the adverse effects of arterial stiffness on all-cause and cardiovascular disease mortality in Cardiovascular-Kidney-Metabolic syndrome population: A cohort study. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;231:113051. doi:10.1016/j.diabres.2025.113051 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | 10.1016/j.diabres.2025.113064. Epub 2025 Dec 21. Association between Life's Simple 7 and life's essential 8 with all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome population. 2026 DIABETES RESEARCH AND CLINICAL PRACTICE | Yin S 等在11,487名CKM综合征人群中发现,LS7和LE8评分均与全因及心血管死亡风险呈负相关,且预测能力相当,尤其在非晚期阶段保护效应显著。 | 心血管疾病慢性肾病代谢综合征生命简单7项生命必需8项Cox回归全因死亡心血管死亡队列研究美国健康调查 | DOI: 10.1016/j.diabres.2025.113064;PMID: 41435969 | [102] Yin S, Yan S, Yang Z, Zhu P, Tang T, Borné Y. Association between Life's Simple 7 and life's essential 8 with all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome population. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;231:113064. doi:10.1016/j.diabres.2025.113064 |
CKM综合征分期与新型生物标志物的预后评估 Core | 10.1016/j.diabres.2026.113146. Epub 2026 Feb 7. Association of remnant cholesterol inflammation index with future cardiovascular disease risk in patients with cardiovascular-kidney-metabolic syndrome stages 0-3. 2026 DIABETES RESEARCH AND CLINICAL PRACTICE | Xie N等基于7527名CKM综合征0-3期患者数据发现,残余胆固醇炎症指数升高与未来心血管疾病风险增加显著相关,且hs-CRP部分介导了残余胆固醇与CVD的关联。 | 心血管疾病心血管-肾脏-代谢综合征残余胆固醇炎症指数Cox回归限制性立方样条残余胆固醇高敏C反应蛋白队列研究PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1016/j.diabres.2026.113146;PMID: 41662975 | [34] Xie N, Zeng L, Hu X, Wu Z, Lu W, Luo S, et al. Association of remnant cholesterol inflammation index with future cardiovascular disease risk in patients with cardiovascular-kidney-metabolic syndrome stages 0-3. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;233:113146. doi:10.1016/j.diabres.2026.113146 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | 10.1016/j.diabres.2026.113223. Epub 2026 Mar 23. Cardiovascular-kidney-metabolic syndrome stages, stage transitions, and risk of cardiovascular disease and mortality: The Tehran Lipid and Glucose Study. 2026 DIABETES RESEARCH AND CLINICAL PRACTICE | Masrouri S 等在一项纳入7770名无心血管疾病成人的研究中发现,CKM综合征2期和3期与心血管疾病及死亡风险显著升高相关,且约3年内每进展1期,风险增加1.40-2.01倍。 | 心血管-肾脏-代谢综合征心血管疾病冠心病心肌梗死卒中Cox回归队列研究心血管死亡率CKM分期PubMed疾病:cardiovasc | DOI: 10.1016/j.diabres.2026.113223;PMID: 41881362 | [22] Masrouri S, Ebrahimi N, Hasanpour A, Sohrabi B, Azizi F, Hadaegh. Cardiovascular-kidney-metabolic syndrome stages, stage transitions, and risk of cardiovascular disease and mortality: The Tehran Lipid and Glucose Study. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;235:113223. doi:10.1016/j.diabres.2026.113223 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | 10.1016/j.diabres.2026.113233. Epub 2026 Apr 4. Cardiorenal protective effects of anti-diabetic drugs in early stage Cardiovascular-Kidney-Metabolic Syndrome: A multicenter, time-varying analysis. 2026 DIABETES RESEARCH AND CLINICAL PRACTICE | Hao WR 等在一项纳入18,467例早期CKM综合征患者的时变分析中发现,多数抗糖尿病药物可降低心血管风险,但SGLT2抑制剂在肾脏保护和生存获益方面更具优势。 | 心血管-肾脏-代谢综合征抗糖尿病药物SGLT-2抑制剂回顾性队列研究时变Cox模型终末期肾病全因死亡胰岛素PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1016/j.diabres.2026.113233;PMID: 41942012 | [69] Hao WR, Liu JC, Fang YA, Hsu MH, Hsiu H, Chen CC. Cardiorenal protective effects of anti-diabetic drugs in early stage Cardiovascular-Kidney-Metabolic Syndrome: A multicenter, time-varying analysis. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;236:113233. doi:10.1016/j.diabres.2026.113233 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | 10.1016/j.diabres.2026.113266. Epub 2026 Apr 16. Cardiovascular-kidney-metabolic syndrome stages and risk of diverse gastrointestinal diseases: a prospective cohort study and integrative proteomic analysis. 2026 DIABETES RESEARCH AND CLINICAL PRACTICE | Xiang S 等基于354,444名英国生物银行参与者发现,心血管-肾脏-代谢综合征晚期显著增加多种胃肠道疾病风险,并识别出HGF、GDF15和PLAUR等核心蛋白介导该关联。 | 心血管-肾脏-代谢综合征胃肠道疾病Cox比例风险模型血浆蛋白质组学队列研究HGFGDF15PLAURPubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1016/j.diabres.2026.113266;PMID: 42000048 | [32] Xiang S, Nie H, Wei Z, Li Y, Wang C, Che X, et al. Cardiovascular-kidney-metabolic syndrome stages and risk of diverse gastrointestinal diseases: a prospective cohort study and integrative proteomic analysis. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;236:113266. doi:10.1016/j.diabres.2026.113266 |
地热系统与超级马拉松代谢挑战等无关主题 Excluded | 10.1016/j.diabres.2026.113273. Epub 2026 Apr 19. Comparative effectiveness of tirzepatide versus GLP-1 receptor agonists on cardiovascular-kidney-metabolic stage progression: a real-world cohort study. 2026 DIABETES RESEARCH AND CLINICAL PRACTICE | Wu JY 等在一项纳入897,182名CKM 1-2期患者的真实世界队列研究中发现,替西帕肽相比GLP-1受体激动剂可显著降低进展至CKM 3-4期的风险(HR 0.88)。 | 心血管肾脏代谢综合征替西帕肽胰高血糖素样肽-1受体激动剂倾向评分匹配Cox回归真实世界研究回顾性研究主要不良心血管事件全因死亡率PubMed疾病:cardiovasc | DOI: 10.1016/j.diabres.2026.113273;PMID: 42009260 | No ref no. Wu JY, Lee KW, Huang SC, Chang HY, Lin YM. 10.1016/j.diabres.2026.113273. Epub 2026 Apr 19. Comparative effectiveness of tirzepatide versus GLP-1 receptor agonists on cardiovascular-kidney-metabolic stage progression: a real-world cohort study.. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026. 236. 113273.. doi:10.1016/j.diabres.2026.113273 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | 10.1016/j.diabres.2026.113288. Online ahead of print. DPP-4 inhibitors in current diabetes care: their foundational role in treating to target. 2026 DIABETES RESEARCH AND CLINICAL PRACTICE | Avogaro A 等在综述中提出,DPP-4抑制剂可降低HbA1c约0.6-1.1%,低血糖风险低且耐受性良好,是连接“以目标为导向”与“以获益为导向”治疗策略的多功能选择。 | 2型糖尿病DPP-4抑制剂系统综述糖化血红蛋白血糖控制心血管安全性低血糖风险联合用药PubMed疾病:CKM Title/Abstractckd | DOI: 10.1016/j.diabres.2026.113288;PMID: 42070662 | No ref no. Avogaro A, Fiaccadori E, Rizzo MR. 10.1016/j.diabres.2026.113288. Online ahead of print. DPP-4 inhibitors in current diabetes care: their foundational role in treating to target.. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026. 237. 113288.. doi:10.1016/j.diabres.2026.113288 |
CKM综合征分期与新型生物标志物的预后评估 Core | 10.1016/j.diabres.2026.113336. Online ahead of print. Risk stratification in early-stage Cardiovascular-Kidney-Metabolic Syndrome: The Potency of visceral adiposity and insulin resistance surrogate indices. 2026 DIABETES RESEARCH AND CLINICAL PRACTICE | He L 等综述发现,在早期心血管-肾脏-代谢综合征中,内脏脂肪和胰岛素抵抗替代指标(如腰围身高比、内脏脂肪指数)比传统测量方法具有更优的风险分层效能。 | 心血管-肾脏-代谢综合征内脏脂肪指数胰岛素抵抗腰围身高比系统综述风险分层体重指数线粒体应激PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1016/j.diabres.2026.113336;PMID: 42184891 | [38] He L, Lin H, Zhang X, Ling X. Online ahead of print. Risk stratification in early-stage Cardiovascular-Kidney-Metabolic Syndrome: The Potency of visceral adiposity and insulin resistance surrogate indices. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;237:113336. doi:10.1016/j.diabres.2026.113336 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | The role of inflammation in longitudinal renal function decline and incident chronic kidney disease: the multi-ethnic study of atherosclerosis. 2026 European Journal of Preventive Cardiology | Agboola OJ 等在一项纳入约4600名参与者的前瞻性队列研究中发现,较高的白细胞介素-6水平与更快的肾功能下降、蛋白尿加重及慢性肾脏病风险升高显著相关。 | 慢性肾脏病炎症白细胞介素-6超敏C反应蛋白估算肾小球滤过率前瞻性队列研究Fine-Gray回归肾功能下降心血管-肾脏-代谢综合征PubMed疾病:CKM Title/Abstract | DOI: 10.1093/eurjpc/zwaf779;PMID: 41431747 | [45] Agboola OJ, Chan JSK, Spitz JA, Chan RNC, Patel J. The role of inflammation in longitudinal renal function decline and incident chronic kidney disease: the multi-ethnic study of atherosclerosis. European Journal of Preventive Cardiology. 2026;33(5):718-728. doi:10.1093/eurjpc/zwaf779 |
CKM定义评估空白与超加工食品的代谢影响 Extension | ahead of print. Frailty as a Risk-Enhancing Factor Across the Cardiovascular-Kidney-Metabolic Framework: Findings from the UK Biobank. 2026 European Journal of Preventive Cardiology | Fang Y 等基于UK Biobank 408,163名参与者的前瞻性队列研究发现,衰弱与所有心血管-肾脏-代谢(CKM)分期中更高的心血管疾病风险显著相关,且该关联独立于传统风险因素。 | 衰弱心血管疾病心血管-肾脏-代谢Cox回归前瞻性队列研究Fried衰弱表型CKM分期英国生物银行PubMed疾病:CKM Title/Abstracttgs | DOI: 10.1093/eurjpc/zwag170;PMID: 41875371 | [90] Fang Y, Huang S, Zhang H, Li M, Zhang H, Yang W, et al. ahead of print. Frailty as a Risk-Enhancing Factor Across the Cardiovascular-Kidney-Metabolic Framework: Findings from the UK Biobank. European Journal of Preventive Cardiology. 2026. doi:10.1093/eurjpc/zwag170 |
衰弱、非奈利酮及遗传多态性在CKM管理中的角色 Extension | ahead of print. Sex-Specific Associations Between Depression and Cardiovascular-Kidney-Metabolic Syndrome Progression: A National Cohort Study. 2026 European Journal of Preventive Cardiology | Gao Q 等基于5035名中老年人群的全国队列研究发现,抑郁症状与心血管-肾脏-代谢综合征进展存在性别特异性关联,仅在女性中观察到显著风险增加。 | 抑郁症心血管-肾脏-代谢综合征队列研究抑郁症状CKM进展性别差异流行病学调查风险预测PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1093/eurjpc/zwag135;PMID: 41802238 | [88] Gao Q, Ren W, Du X, Yu Y, Ma Z, Cui Y, et al. ahead of print. Sex-Specific Associations Between Depression and Cardiovascular-Kidney-Metabolic Syndrome Progression: A National Cohort Study. European Journal of Preventive Cardiology. 2026. doi:10.1093/eurjpc/zwag135 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | 10.1681/ASN.0000001016. Online ahead of print. Comparative Effectiveness of SGLT2 Inhibitor and GLP-1 Receptor Agonist on Kidney and Cardiovascular Outcomes by Kidney Failure Risk. 2026 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | Hartsell SE 等在160,428名2型糖尿病退伍军人中发现,SGLT2抑制剂与GLP-1受体激动剂相比,死亡风险相似,但心血管事件风险略高;肾衰竭风险因患者基线风险水平而异。 | 2型糖尿病肾衰竭SGLT-2抑制剂GLP-1受体激动剂逆概率治疗加权肾衰竭风险方程心血管事件队列研究真实世界研究全因死亡 | DOI: 10.1681/ASN.0000001016;PMID: 41563358 | [11] Hartsell SE, Wei G, Singh R, Throolin M. Online ahead of print. Comparative Effectiveness of SGLT2 Inhibitor and GLP-1 Receptor Agonist on Kidney and Cardiovascular Outcomes by Kidney Failure Risk. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2026. doi:10.1681/ASN.0000001016 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | Finerenone in CKD: Enhancing the Evidence Base in Real-World Contexts. 2026 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | Mathew GG 在真实世界研究中发现,非奈利酮可有效改善慢性肾脏病患者的肾脏结局,为临床实践提供了额外证据支持。 | 慢性肾病非奈利酮队列研究真实世界研究PubMed疾病:CKM Title/Abstractckdsglt型糖尿病肾脏抑制剂 | DOI: 10.1681/ASN.0000000956;PMID: 41563387 | [101] Mathew GG. Finerenone in CKD: Enhancing the Evidence Base in Real-World Contexts. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2026;37(2):423-424. doi:10.1681/ASN.0000000956 |
CKM定义评估空白与超加工食品的代谢影响 Extension | Finerenone in CKD from Estimands to Clinical Interpretability under Competing Risk. 2026 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | Wang A和Li Y在竞争风险框架下评估了非奈利酮在慢性肾脏病中的疗效,发现其临床获益在考虑死亡竞争风险后仍保持稳健。 | 慢性肾病非奈利酮系统综述竞争风险心肾综合征临床可解释性估计目标PubMed疾病:CKM Title/Abstracttgsactn | DOI: 10.1681/ASN.0000000925;PMID: 41563827 | [91] Wang A, Li Y. Finerenone in CKD from Estimands to Clinical Interpretability under Competing Risk. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2026;37(2):425-426. doi:10.1681/ASN.0000000925 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | Online ahead of print. The Kidney in the Middle: KDIGO Guidelines Address Multiple Key Components of Cardiovascular-Kidney-Metabolic Syndrome. 2026 KIDNEY INTERNATIONAL | Levin A 等基于KDIGO指南和争议会议报告,系统总结了慢性肾脏病在心血管-肾脏-代谢综合征中的核心作用,强调早期发现、全面风险管理和多学科协作的重要性。 | 慢性肾脏病心血管疾病KDIGO指南血压管理糖尿病血脂异常系统综述心血管-肾脏-代谢综合征心力衰竭肥胖 | DOI: 10.1016/j.kint.2026.03.031;PMID: 42191113 | [70] Levin A, Bansal N, de Boer IH, Grams ME, Jadoul M, Ter Maaten. Online ahead of print. The Kidney in the Middle: KDIGO Guidelines Address Multiple Key Components of Cardiovascular-Kidney-Metabolic Syndrome. KIDNEY INTERNATIONAL. 2026. doi:10.1016/j.kint.2026.03.031 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | A urea-activated nanocarrier for site-specific SGLT2 inhibition and metabolic rescue against cardiovascular-kidney-metabolic syndrome. 2026 Nature Communications | Ren X等开发了一种尿素激活的纳米载体,实现SGLT2抑制剂肾小管靶向递送,在CKM小鼠模型中有效改善心脏和肾脏代谢功能,优于游离药物。 | 心血管-肾脏-代谢综合征SGLT-2抑制剂恩格列净纳米载体动物实验活性氧肾脏靶向能量代谢PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1038/s41467-026-71424-w;PMID: 41932948 | [73] Ren X, Gao D, Yun R, Liu X, Di C, Hu Z, et al. A urea-activated nanocarrier for site-specific SGLT2 inhibition and metabolic rescue against cardiovascular-kidney-metabolic syndrome. Nature Communications. 2026. doi:10.1038/s41467-026-71424-w |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | 10.1161/CIRCULATIONAHA.125.077894. Epub 2026 Apr 1. Cardiovascular-Kidney-Metabolic Syndrome Stages, Echocardiographic Characteristics, and Heart Failure Risk: The Atherosclerosis Risk in Communities Study. 2026 Circulation | Lassen MCH 等基于ARIC研究5,646名老年人数据发现,较高CKM综合征分期与左心室不良重构及心力衰竭风险显著增加相关,4期风险比达8.3。 | 心力衰竭心血管-肾脏-代谢综合征超声心动图心脏重构队列研究风险预测社区动脉粥样硬化风险研究PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏 | DOI: 10.1161/CIRCULATIONAHA.125.077894;PMID: 41919388 | [2] Lassen MCH, Ostrominski JW, Claggett BL, Ndumele CE. Cardiovascular-Kidney-Metabolic Syndrome Stages, Echocardiographic Characteristics, and Heart Failure Risk: The Atherosclerosis Risk in Communities Study. Circulation. 2026;153(17):1268-1280. doi:10.1161/CIRCULATIONAHA.125.077894 |
CKM综合征分期与新型生物标志物的预后评估 Core | Advances in risk prediction and treatment strategies for CKM syndrome. 2026 Nature Reviews Nephrology | Drexler Y 和 Fornoni A 综述了CKM综合征的风险预测与治疗策略进展,发现整合多器官指标可提升风险分层准确性,并强调了新型靶向治疗在延缓疾病进展中的潜力。 | CKM综合征风险预测治疗策略心血管疾病肾脏疾病代谢疾病综述PubMed疾病:CKM Title/Abstract肾脏代谢综合 | DOI: 10.1038/s41581-025-01044-y;PMID: 41402462 | [63] Drexler Y, Fornoni A. Advances in risk prediction and treatment strategies for CKM syndrome. Nature Reviews Nephrology. 2026;22(2):95-96. doi:10.1038/s41581-025-01044-y |
CKM综合征分期与新型生物标志物的预后评估 Core | GLP-1 receptor agonists and next-generation metabolic hormone therapies in chronic kidney disease. 2026 Nature Reviews Nephrology | Alicic RZ 等在一项纳入6,719名CKM综合征1-4期患者的前瞻性队列研究中发现,hs-CRP/HDL-C比值与长期死亡风险呈线性正相关,该比值每增加一个四分位数间距,死亡风险升高15%。 | 心血管-肾脏-代谢综合征Cox回归限制性立方样条hs-CRP/HDL-C比值全因死亡前瞻性队列研究风险预测PubMed疾病:CKM Title/Abstract肾脏代谢综合 | DOI: 10.1038/s41581-025-01036-y;PMID: 41507425 | [3] Alicic RZ, Neumiller JJ, Tuttle KR. GLP-1 receptor agonists and next-generation metabolic hormone therapies in chronic kidney disease. Nature Reviews Nephrology. 2026;22(4):265-282. doi:10.1038/s41581-025-01036-y |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | print. Epidemiology of cardiovascular-kidney-metabolic syndrome. 2026 Nature Reviews Nephrology | Mavromatis LA 和 Grams ME 综述了心血管-肾脏-代谢综合征的流行病学,发现全球患病率持续上升,多数成人已处于≥1期,且疾病负担存在人口学与地域差异。 | 心血管-肾脏-代谢综合征慢性肾脏病心血管疾病胰高血糖素样肽-1受体激动剂钠-葡萄糖协同转运蛋白-2抑制剂系统综述代谢危险因素发病与死亡风险流行病学PubMed疾病:cardiovasc | DOI: 10.1038/s41581-026-01078-w;PMID: 42098477 | [1] Mavromatis LA, Grams ME. print. Epidemiology of cardiovascular-kidney-metabolic syndrome. Nature Reviews Nephrology. 2026. doi:10.1038/s41581-026-01078-w |
CKM综合征分期与新型生物标志物的预后评估 Core | Association of Cardiovascular-Kidney-Metabolic Syndrome With Cognitive Decline and Dementia: The ARIC Study Insights. 2025 Journal of the American Heart Association | Xie Peichen 等基于ARIC研究10,426名参与者发现,心血管-肾脏-代谢综合征风险等级升高与认知衰退及痴呆风险增加显著相关,风险每升一级痴呆进展风险增加6%。 | 心血管-肾脏-代谢综合征认知衰退痴呆回归分析CKM风险等级队列研究PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏代谢综合 | DOI: 10.1161/JAHA.124.038445;PMID: 40371582 | [29] Xie Peichen, Wang Yiqin, Xu Xinghao, Tan Li, Guo Xingdi, Xu Ziqi, et al. Association of Cardiovascular-Kidney-Metabolic Syndrome With Cognitive Decline and Dementia: The ARIC Study Insights. Journal of the American Heart Association. 2025;14(10):e038445. doi:10.1161/JAHA.124.038445 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | Associations of cardiovascular-kidney-metabolic syndrome stages with premature mortality and the role of social determinants of health. 2025 Journal of Nutrition Health and Aging | Zhu R 等基于27,909名美国成年人数据发现,心血管-肾脏-代谢综合征3-4期与过早死亡风险显著升高相关,且不利健康社会决定因素进一步加剧该风险。 | 心血管-肾脏-代谢综合征过早死亡健康社会决定因素Cox比例风险模型风险比前瞻性队列研究全因死亡心血管死亡PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1016/j.jnha.2025.100504;PMID: 39952015 | [20] Zhu R, Wang R, He J, Wang L, Chen H, Wang Y, et al. Associations of cardiovascular-kidney-metabolic syndrome stages with premature mortality and the role of social determinants of health. Journal of Nutrition Health and Aging. 2025;29(4):100504. doi:10.1016/j.jnha.2025.100504 |
衰弱、非奈利酮及遗传多态性在CKM管理中的角色 Extension | Cardiovascular-kidney-metabolic overlaps, clinical outcomes, and quality of life in patients with acute heart failure. 2025 Journal of Nutrition Health and Aging | Li J等在一项纳入4,875例急性心衰患者的多中心队列中发现,合并三种心血管-肾脏-代谢疾病显著增加1年主要不良心血管事件及死亡风险,并降低生活质量。 | 心力衰竭慢性肾脏病2型糖尿病Cox回归广义线性模型队列研究主要不良心血管事件全因死亡生活质量心血管死亡 | DOI: 10.1016/j.jnha.2025.100613;PMID: 40555038 | [79] Li J, Lei L, Zhang L, Guo Y, Yuan X. Cardiovascular-kidney-metabolic overlaps, clinical outcomes, and quality of life in patients with acute heart failure. Journal of Nutrition Health and Aging. 2025;29(8):100613. doi:10.1016/j.jnha.2025.100613 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | Temporal trends in the planetary health diet index and its association with cardiovascular, kidney, and metabolic diseases: A comprehensive analysis from global and individual perspectives. 2025 Journal of Nutrition Health and Aging | Tang H 等基于185国数据及45,460名美国参与者分析发现,1990-2018年行星健康饮食指数评分全球平均为42.80,较高评分与心血管、肾脏及代谢疾病风险降低显著相关。 | 心血管疾病代谢性疾病慢性肾病行星健康饮食指数饮食评估横断面研究队列研究伤残调整生命年疾病负担CKM综合征 | DOI: 10.1016/j.jnha.2025.100520;PMID: 39985957 | [59] Tang H, Zhang X, Luo N, Huang J, Yang Q, Lin H, et al. Temporal trends in the planetary health diet index and its association with cardiovascular, kidney, and metabolic diseases: A comprehensive analysis from global and individual perspectives. Journal of Nutrition Health and Aging. 2025;29(5):100520. doi:10.1016/j.jnha.2025.100520 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | A simple score, CKM(2)S(2)-BAG, to predict cardiovascular risk with cardiovascular-kidney-metabolic health metrics. 2025 iScience | Yang Z 等基于两个前瞻性社区队列构建并验证了CKM(2)S(2)-BAG评分,发现该评分能准确区分心血管低、中、高风险,对总CVD及其亚型预测性能稳健。 | 心血管疾病心力衰竭动脉粥样硬化风险评分空腹血糖前瞻性队列研究外部验证胆固醇肾功能PubMed疾病:cardiovasc | DOI: 10.1016/j.isci.2025.112780;PMID: 40599322 | [104] Yang Z, Zhou P, Fan F, Hao Y, Zhao W, Wang Z, et al. A simple score, CKM(2)S(2)-BAG, to predict cardiovascular risk with cardiovascular-kidney-metabolic health metrics. iScience. 2025;28(7):112780. doi:10.1016/j.isci.2025.112780 |
c8 Excluded | Exploring a long distance, amagmatic, across-suture orogenic geothermal system: Sri Lanka's foreland hot springs. 2025 iScience | Bandara D 等通过分析斯里兰卡前陆温泉的裂隙网络与地温梯度,发现流体可沿基底断裂运移达100公里,循环深度可达沉积盖层之下。 | 温泉地热系统裂隙网络地温梯度循环深度横断面研究地热资源PubMed疾病:CKM Title/Abstract公里超过 | DOI: 10.1016/j.isci.2025.112370;PMID: 40330879 | No ref no. Bandara D, Smit J, Wohnlich S, Heinze T. Exploring a long distance, amagmatic, across-suture orogenic geothermal system: Sri Lanka's foreland hot springs.. iScience. 2025. 28(5). 112370.. doi:10.1016/j.isci.2025.112370 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | 2025 Apr. Prognosis of non-albuminuric patients with the cardiovascular-kidney-metabolic syndrome. 2025 Clinical Kidney Journal | Bi X 等基于中国和英国两个大型队列研究发现,正常范围内的尿白蛋白与肌酐比值升高与心血管-肾脏-代谢综合征患者进展至4期及全因死亡风险增加显著相关。 | 心血管-肾脏-代谢综合征尿白蛋白肌酐比值队列研究Cox回归全因死亡率疾病进展中国肾脏数据系统英国生物银行PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1093/ckj/sfaf074;PMID: 40226369 | [74] Bi X, Shen Y, Shen Y, Shen A, Zhou S, Wang W, et al. 2025 Apr. Prognosis of non-albuminuric patients with the cardiovascular-kidney-metabolic syndrome. Clinical Kidney Journal. 2025;18(4):sfaf074. doi:10.1093/ckj/sfaf074 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | 2025 Jun. How do patient information documents present dialysis and conservative kidney management? A document analysis. 2025 Clinical Kidney Journal | Sowden R 等通过定性文献分析发现,患者信息文件对透析和保守性肾脏管理的呈现存在不平衡,透析被构建为默认选择,而保守管理常被负面描述并与死亡关联。 | 晚期肾病透析保守性肾脏管理患者信息文件定性文献分析批判性话语分析治疗决策预先护理计划姑息治疗PubMed疾病:CKM Title/Abstract | DOI: 10.1093/ckj/sfaf136;PMID: 40487369 | No ref no. Sowden R, Shaw C, Robb J, Winterbottom A, Bristowe K, Bekker. 2025 Jun. How do patient information documents present dialysis and conservative kidney management? A document analysis.. Clinical Kidney Journal. 2025. 18(6). sfaf136.. doi:10.1093/ckj/sfaf136 |
地热系统与超级马拉松代谢挑战等无关主题 Excluded | eCollection 2025. Identifying potential drugs for treating Cardiovascular-kidney metabolic syndrome via reverse network pharmacology. 2025 Frontiers in Pharmacology | Wen S 等通过反向网络药理学筛选出小檗碱(BBR)为治疗心血管-肾脏-代谢综合征(CKM)的潜在药物,并在小鼠模型中证实BBR可改善代谢紊乱、心脏舒张功能及肾损伤。 | 心血管-肾脏-代谢综合征小檗碱反向网络药理学代谢参数动物实验心脏舒张功能肾损伤脂质代谢葡萄糖代谢纤维化通路 | DOI: 10.3389/fphar.2025.1627236;PMID: 40661082 | No ref no. Wen S, Fu A, Liu F, You Y,. eCollection 2025. Identifying potential drugs for treating Cardiovascular-kidney metabolic syndrome via reverse network pharmacology.. Frontiers in Pharmacology. 2025. 16. 1627236.. doi:10.3389/fphar.2025.1627236 |
地热系统与超级马拉松代谢挑战等无关主题 Excluded | Adipokines and Vascular Modulators in CKM: Emerging Biomarkers as Diagnostic and Therapeutic Targets. 2025 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | Gerdanovics CA 等综述发现,脂肪因子(如RBP4、LCN2)和血管调节因子(如Klotho、MGP)在CKM综合征中失调,可作为诊断生物标志物和治疗靶点。 | 心肾代谢综合征脂肪因子血管调节因子生物标志物治疗靶点系统综述视黄醇结合蛋白4Klotho基质Gla蛋白PubMed疾病:CKM Title/Abstract | DOI: 10.3390/ijms262211083;PMID: 41303567 | No ref no. Gerdanovics CA, Suciu ȘM, Orășan OH, Para I, Turi VR, Milaciu. Adipokines and Vascular Modulators in CKM: Emerging Biomarkers as Diagnostic and Therapeutic Targets.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2025. 26(22). 11083.. doi:10.3390/ijms262211083 |
CKM定义评估空白与超加工食品的代谢影响 Extension | Effects of Temperature and Salinity on Ovarian Development and Differences in Energy Metabolism Between Reproduction and Growth During Ovarian Development in the Lateolabrax maculatus. 2025 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | Peng Y 等通过实验发现,低盐度(4‰)和低温(18±1°C)协同促进花鲈卵巢发育,并揭示卵巢依赖有氧代谢供能,肌肉则通过糖酵解将能量重新分配至性腺以维持繁殖与生长的平衡。 | 卵巢发育盐度温度能量代谢激素转录组代谢组实验研究PubMed疾病:CKM Title/Abstracttgs | DOI: 10.3390/ijms26178295;PMID: 40943217 | [100] Peng Y, Yan L, Zhao C, Zhang B, Zhang B, Qiu. Effects of Temperature and Salinity on Ovarian Development and Differences in Energy Metabolism Between Reproduction and Growth During Ovarian Development in the Lateolabrax maculatus. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2025;26(17):8295. doi:10.3390/ijms26178295 |
c8 Excluded | Does Distance Matter? Metabolic and Muscular Challenges of a Non-Stop Ultramarathon with Sub-Analysis Depending on Running Distance. 2025 Nutrients | John L 等在一项前瞻性观察性研究中发现,超级马拉松跑者赛后出现显著能量赤字、瘦素和胰岛素降低、饥饿素和肌肉损伤标志物升高,且230公里组变化最大。 | 超级马拉松能量赤字瘦素饥饿素肌酸激酶乳酸脱氢酶前瞻性观察连续血糖监测肌肉损伤代谢紊乱 | DOI: 10.3390/nu17233801;PMID: 41374091 | No ref no. John L, Munk M, Bizjak R, Schulz SVW, Witzel J, Engler H,. Does Distance Matter? Metabolic and Muscular Challenges of a Non-Stop Ultramarathon with Sub-Analysis Depending on Running Distance.. Nutrients. 2025. 17(23). 3801.. doi:10.3390/nu17233801 |
CKM定义评估空白与超加工食品的代谢影响 Extension | Influence of Genetic Polymorphisms and Biochemical Biomarkers on Response to Nutritional Iron Supplementation and Performance in a Professional Football Team: A Pilot Longitudinal Study. 2025 Nutrients | Varillas-Delgado D等在一项针对职业足球运动员的纵向研究中发现,携带特定基因型(如ACE DD、ACTN3 CC)的运动员铁补充需求更少,且总基因型评分可有效预测补充需求及运动表现差异。 | 铁缺乏硫酸亚铁纵向研究铁蛋白血红蛋白基因多态性运动表现总基因型评分PubMed疾病:CKM Title/Abstracttgs | DOI: 10.3390/nu17081379;PMID: 40284242 | [95] Varillas-Delgado D. Influence of Genetic Polymorphisms and Biochemical Biomarkers on Response to Nutritional Iron Supplementation and Performance in a Professional Football Team: A Pilot Longitudinal Study. Nutrients. 2025;17(8):1379. doi:10.3390/nu17081379 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | Medical Nutrition Therapy Adherence and Lifestyle in Stage 5 CKD: Challenges and Insights. 2025 Nutrients | Palumbo P 等评估了接受保守管理的5期CKD患者对医学营养疗法的依从性,发现自我报告与生化指标存在差异,且糖尿病与较低的蛋白质摄入依从性显著相关。 | 慢性肾脏病医学营养疗法饮食依从性蛋白质摄入队列研究饮食史标准化蛋白氮出现率糖尿病PubMed疾病:CKM Title/Abstractckd | DOI: 10.3390/nu17193091;PMID: 41097168 | No ref no. Palumbo P, Alfano G, Cavani F, Giannini R, Pulizzi RA, Gabriele. Medical Nutrition Therapy Adherence and Lifestyle in Stage 5 CKD: Challenges and Insights.. Nutrients. 2025. 17(19). 3091.. doi:10.3390/nu17193091 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | 2025. Altered albumin/neutrophil to lymphocyte ratio are associated with all-cause and cardiovascular mortality for advanced cardiovascular-kidney-metabolic syndrome. 2025 Frontiers in Nutrition | Yin X 等基于3,266名晚期CKM综合征患者数据发现,白蛋白/中性粒细胞与淋巴细胞比值降低与全因及心血管死亡风险升高独立相关,呈L形关联。 | 心血管-肾脏-代谢综合征白蛋白中性粒细胞淋巴细胞比值全因死亡率心血管死亡率倾向评分匹配限制性立方样条Cox回归横断面研究队列研究国家健康与营养调查 | DOI: 10.3389/fnut.2025.1595119;PMID: 40740647 | No ref no. Yin X, Zou J, Yang J. 2025. Altered albumin/neutrophil to lymphocyte ratio are associated with all-cause and cardiovascular mortality for advanced cardiovascular-kidney-metabolic syndrome.. Frontiers in Nutrition. 2025. 12. 1595119.. doi:10.3389/fnut.2025.1595119 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | 2025. Association between albumin to globulin ratio and all-cause and cardiovascular mortality among individuals with cardiovascular-kidney-metabolic syndrome: results from NHANES 2003 to 2018. 2025 Frontiers in Nutrition | Wang G等基于NHANES数据库对CKM综合征患者分析发现,白蛋白与球蛋白比值升高与全因及心血管死亡风险显著降低相关,其中全因死亡呈非线性关联。 | 心血管-肾脏-代谢综合征白蛋白球蛋白比值全因死亡心血管死亡Cox回归队列研究剂量反应关系生物标志物PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.3389/fnut.2025.1622590;PMID: 40678773 | No ref no. Wang G, Li G, Wang P, Zang M, Pu J. 2025. Association between albumin to globulin ratio and all-cause and cardiovascular mortality among individuals with cardiovascular-kidney-metabolic syndrome: results from NHANES 2003 to 2018.. Frontiers in Nutrition. 2025. 12. 1622590.. doi:10.3389/fnut.2025.1622590 |
CKM综合征分期与新型生物标志物的预后评估 Core | 2025. Association between body roundness index and advanced cardiovascular-kidney-metabolic syndrome. 2025 Frontiers in Nutrition | Chen Y 等基于12,329名美国成年人数据发现,身体圆度指数升高与晚期心血管-肾脏-代谢综合征风险呈正相关,且其预测能力优于传统人体测量指标。 | 晚期CKM综合征身体圆度指数横断面研究限制性立方样条受试者工作特征分析回归分析人体测量指标内脏脂肪PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.3389/fnut.2025.1623766;PMID: 40808842 | [39] Chen Y, Tu H, Liang M, Shen M. 2025. Association between body roundness index and advanced cardiovascular-kidney-metabolic syndrome. Frontiers in Nutrition. 2025;12:1623766. doi:10.3389/fnut.2025.1623766 |
CKM综合征分期与新型生物标志物的预后评估 Core | 2025. Association between dietary index for gut microbiota and cardiovascular-kidney-metabolic syndrome: a population-based study. 2025 Frontiers in Nutrition | Long D 等基于8,400名美国成年人数据发现,肠道微生物群膳食指数(DI-GM)评分与心血管-肾脏-代谢综合征患病率呈线性负相关,且女性中保护效应更显著。 | 心血管-肾脏-代谢综合征肠道微生物群膳食指数横断面研究限制性立方样条逻辑回归患病率膳食质量性别差异PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.3389/fnut.2025.1594481;PMID: 40808844 | [61] Long D, Mao C, An H, Zhu Y, Xu Y. 2025. Association between dietary index for gut microbiota and cardiovascular-kidney-metabolic syndrome: a population-based study. Frontiers in Nutrition. 2025;12:1594481. doi:10.3389/fnut.2025.1594481 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 2025. Association between dietary inflammatory index score and cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES. 2025 Frontiers in Nutrition | Yu H 等基于NHANES数据库的横断面研究发现,膳食炎症指数升高与心血管-肾脏-代谢综合征患病风险增加呈线性正相关,其中酒精摄入是关联最强的膳食因素。 | 心血管-肾脏-代谢综合征膳食炎症指数横断面研究多元逻辑回归限制性立方样条慢性肾脏病心脏代谢综合征酒精摄入PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.3389/fnut.2025.1557491;PMID: 40416382 | [50] Yu H, Liu Y, Zhang T, Guan Z, Li P. 2025. Association between dietary inflammatory index score and cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES. Frontiers in Nutrition. 2025;12:1557491. doi:10.3389/fnut.2025.1557491 |
CKM综合征分期与新型生物标志物的预后评估 Core | 2025. Association between non-highdensity lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiovascular-kidney-metabolic syndrome: evidence from NHANES 2001-2018. 2025 Frontiers in Nutrition | Duan Y 等基于NHANES 2001-2018年16,575名成人数据发现,非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值升高与心血管-肾脏-代谢综合征风险呈正相关,且存在非线性关联。 | 慢性肾脏病心血管代谢综合征非高密度脂蛋白胆固醇限制性立方样条横断面研究体重指数高血压PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏 | DOI: 10.3389/fnut.2025.1548851;PMID: 40093879 | [48] Duan Y, Yang K, Zhang T, Guo X, Yin Q, Liu H. 2025. Association between non-highdensity lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiovascular-kidney-metabolic syndrome: evidence from NHANES 2001-2018. Frontiers in Nutrition. 2025;12:1548851. doi:10.3389/fnut.2025.1548851 |
CKM综合征分期与新型生物标志物的预后评估 Core | 2025. Association between oxidative balance score with cardiovascular - kidney - metabolic syndrome and all-cause mortality among US population. 2025 Frontiers in Nutrition | Shi L 等基于12,793名美国成年人数据发现,较高的氧化平衡评分与晚期心血管-肾脏-代谢综合征风险及全因死亡率呈负相关,且存在剂量-反应关系。 | 心血管-肾脏-代谢综合征氧化平衡评分全因死亡率限制性立方样条Cox回归Logistic回归横断面研究队列研究PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.3389/fnut.2025.1564368;PMID: 40837432 | [51] Shi L, Zhang D, Zhang S. 2025. Association between oxidative balance score with cardiovascular - kidney - metabolic syndrome and all-cause mortality among US population. Frontiers in Nutrition. 2025;12:1564368. doi:10.3389/fnut.2025.1564368 |
CKM综合征分期与新型生物标志物的预后评估 Core | 2025. Association between the composite dietary antioxidant index and cardiovascular-kidney-metabolic syndrome among U.S. adults: evidence from NHANES 2007-2018. 2025 Frontiers in Nutrition | He Q 等基于NHANES 2007-2018年11,073名成人数据发现,复合膳食抗氧化指数升高与晚期心血管-肾脏-代谢综合征患病风险降低呈非线性负相关。 | 心血管-肾脏-代谢综合征复合膳食抗氧化指数横断面研究逻辑回归限制性立方样条维生素硒锌类胡萝卜素PubMed疾病:cardiovasc | DOI: 10.3389/fnut.2025.1600651;PMID: 40709338 | [54] He Q, Hu F, Wei W, Li J, Yu Y, Zhang H. 2025. Association between the composite dietary antioxidant index and cardiovascular-kidney-metabolic syndrome among U.S. adults: evidence from NHANES 2007-2018. Frontiers in Nutrition. 2025;12:1600651. doi:10.3389/fnut.2025.1600651 |
CKM综合征分期与新型生物标志物的预后评估 Core | 2025. Association between the dietary inflammatory index and depressive symptoms in adults with cardiovascular-kidney-metabolic syndrome: evidence of metabolic syndrome as a mediator. 2025 Frontiers in Nutrition | Tian RN 等基于12,980名CKM综合征成人数据发现,膳食炎症指数与抑郁症状呈J形非线性关联,且代谢综合征介导了4.44%的效应。 | 抑郁症状代谢综合征膳食炎症指数限制性立方样条逻辑回归横断面研究心血管肾脏代谢综合征中介效应PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.3389/fnut.2025.1623482;PMID: 40808838 | [31] Tian RN, Zhang SX, Zhang N, Wu WJ, Guo HQ, Wang C. 2025. Association between the dietary inflammatory index and depressive symptoms in adults with cardiovascular-kidney-metabolic syndrome: evidence of metabolic syndrome as a mediator. Frontiers in Nutrition. 2025;12:1623482. doi:10.3389/fnut.2025.1623482 |
CKM综合征分期与新型生物标志物的预后评估 Core | 2025. Association between the life's essential 8 health behaviors score and all-cause mortality in cardiovascular-kidney-metabolic syndrome patients. 2025 Frontiers in Nutrition | Tu D 等基于11,638名CKM综合征患者的前瞻性队列研究发现,生命八要素健康行为评分与全因死亡率显著相关,尤其在晚期患者中关联更强,且改善评分可避免约23%的死亡。 | 心血管-肾脏-代谢综合征全因死亡率生命八要素Cox回归限制性立方样条队列研究健康行为评分人群归因分数PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.3389/fnut.2025.1612693;PMID: 40655481 | No ref no. Tu D, Zuo X, Li P, Wang J. 2025. Association between the life's essential 8 health behaviors score and all-cause mortality in cardiovascular-kidney-metabolic syndrome patients.. Frontiers in Nutrition. 2025. 12. 1612693.. doi:10.3389/fnut.2025.1612693 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 2025. Association between urinary heavy metals and cardiovascular-kidney-metabolic syndrome: mediating roles of TyG, WWI, and eGFR. 2025 Frontiers in Nutrition | Liu J 等基于NHANES数据发现,尿重金属暴露与晚期心血管-肾脏-代谢综合征风险正相关,且TyG、WWI和eGFR部分中介了该关联。 | 心血管-肾脏-代谢综合征重金属暴露甘油三酯-葡萄糖指数体重调整腰围指数估算肾小球滤过率限制性立方样条加权分位数和回归横断面研究中介分析钴 | DOI: 10.3389/fnut.2025.1613721;PMID: 40635894 | [56] Liu J, Song Y, Luo R, Wang S, Pan P, Han L. 2025. Association between urinary heavy metals and cardiovascular-kidney-metabolic syndrome: mediating roles of TyG, WWI, and eGFR. Frontiers in Nutrition. 2025;12:1613721. doi:10.3389/fnut.2025.1613721 |
CKM综合征分期与新型生物标志物的预后评估 Core | 2025. Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study. 2025 Frontiers in Nutrition | Pengfei C 等基于301,631名CKM综合征患者的前瞻性队列研究发现,升高的SII和SIRI与心血管疾病发病风险显著相关,其中SII呈U型关联,SIRI呈单调递增关联。 | 心血管疾病心血管-肾脏-代谢综合征全身免疫炎症指数全身炎症反应指数Cox回归限制性立方样条队列研究发病率PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.3389/fnut.2025.1661826;PMID: 41368184 | [46] Pengfei C, Lui M, Zhang L, Chen C, Wang T, Ailin H. 2025. Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study. Frontiers in Nutrition. 2025;12:1661826. doi:10.3389/fnut.2025.1661826 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 2025. Association of cardiovascular-kidney-metabolic syndrome with depression and all-cause mortality: a population-based observational study. 2025 Frontiers in Nutrition | Liu W等基于15,156名参与者数据发现,随着心血管-肾脏-代谢综合征分期进展,抑郁症患病率升高,晚期CKM综合征显著增加抑郁症患者的全因死亡风险。 | 心血管-肾脏-代谢综合征抑郁症全因死亡患者健康问卷-9多变量逻辑回归多变量Cox回归Kaplan-Meier生存分析横断面研究年龄标准化患病率美国成年人 | DOI: 10.3389/fnut.2025.1620008;PMID: 41256919 | No ref no. Liu W, Li Z, Ma P. 2025. Association of cardiovascular-kidney-metabolic syndrome with depression and all-cause mortality: a population-based observational study.. Frontiers in Nutrition. 2025. 12. 1620008.. doi:10.3389/fnut.2025.1620008 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 2025. Association of multiple dietary metal intake with cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES 2003-2018. 2025 Frontiers in Nutrition | Hu S 等基于NHANES 2003-2018年15,233名成人数据发现,较高膳食铜摄入量与晚期心血管-肾脏-代谢综合征患病率降低显著相关。 | 心血管-肾脏-代谢综合征膳食金属摄入铜横断面研究加权逻辑回归限制性立方样条美国国家健康与营养调查亚组分析PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.3389/fnut.2025.1612458;PMID: 40761350 | No ref no. Hu S, Wei B, Zhang A. 2025. Association of multiple dietary metal intake with cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES 2003-2018.. Frontiers in Nutrition. 2025. 12. 1612458.. doi:10.3389/fnut.2025.1612458 |
CKM综合征分期与新型生物标志物的预后评估 Core | 2025. Association of neutrophil/high-density lipoprotein cholesterol ratio with the cardiovascular-kidney-metabolic syndrome and its cardiovascular mortality. 2025 Frontiers in Nutrition | Xu Y等基于13,165名美国成年人数据发现,中性粒细胞/高密度脂蛋白胆固醇比值升高与心血管-肾脏-代谢综合征患病率及心血管死亡风险呈正向线性关联。 | 心血管-肾脏-代谢综合征中性粒细胞/高密度脂蛋白胆固醇比值心血管死亡率Cox回归限制性立方样条横断面研究逻辑回归PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏 | DOI: 10.3389/fnut.2025.1594041;PMID: 40535046 | [47] Xu Y. 2025. Association of neutrophil/high-density lipoprotein cholesterol ratio with the cardiovascular-kidney-metabolic syndrome and its cardiovascular mortality. Frontiers in Nutrition. 2025;12:1594041. doi:10.3389/fnut.2025.1594041 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 2025. Associations between Life's Crucial 9 and severity, all-cause mortality, and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: the mediating role of phenotypic age acceleration. 2025 Frontiers in Nutrition | Li J等基于7,647例CKM综合征患者数据发现,Life's Crucial 9评分每增加10%,进展至晚期CKM综合征风险降低37%,且与全因及心血管死亡率显著负相关,表型年龄加速在其中起中介作用。 | 心血管-肾脏-代谢综合征生命关键9项表型年龄加速全因死亡率心血管死亡率逻辑回归Cox回归限制性立方样条横断面研究中介分析 | DOI: 10.3389/fnut.2025.1612293;PMID: 40843205 | No ref no. Li J, Xu Z, Lin J, Luo S, Xu S. 2025. Associations between Life's Crucial 9 and severity, all-cause mortality, and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: the mediating role of phenotypic age acceleration.. Frontiers in Nutrition. 2025. 12. 1612293.. doi:10.3389/fnut.2025.1612293 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | 2025. Cardiovascular-kidney-metabolic progression associated with major adverse liver outcomes: mediating roles of plasma metabolites. 2025 Frontiers in Nutrition | Liang J 等基于英国生物银行415,713人数据发现,心血管-肾脏-代谢综合征分期进展与主要不良肝脏结局风险升高显著相关,该关联部分由酪氨酸和亚油酸/总脂肪酸比值等血浆代谢物介导。 | 心血管-肾脏-代谢综合征主要不良肝脏结局Cox回归血浆代谢物酪氨酸亚油酸前瞻性队列研究中介分析PubMed疾病:CKM Title/Abstract肾脏 | DOI: 10.3389/fnut.2025.1675899;PMID: 41190151 | [30] Liang J, Liang Y, Chen L, Cai M, Li S, He L. 2025. Cardiovascular-kidney-metabolic progression associated with major adverse liver outcomes: mediating roles of plasma metabolites. Frontiers in Nutrition. 2025;12:1675899. doi:10.3389/fnut.2025.1675899 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 2025. Machine learning with decision curve analysis evaluates nutritional metabolic biomarkers for cardiovascular-kidney-metabolic risk: an NHANES analysis. 2025 Frontiers in Nutrition | Huang J 等基于NHANES数据,通过机器学习与决策曲线分析发现,RAR、SIRI等营养代谢生物标志物与心血管-肾脏-代谢综合征风险显著相关,其中RAR关联最强。 | 心血管-肾脏-代谢综合征胰岛素抵抗机器学习决策曲线分析限制性立方样条Cox回归RARNPAR队列研究PubMed疾病:cardiovasc | DOI: 10.3389/fnut.2025.1597864;PMID: 40406158 | [49] Huang J, Liu Z, Feng W, Huang Y, Cheng X. 2025. Machine learning with decision curve analysis evaluates nutritional metabolic biomarkers for cardiovascular-kidney-metabolic risk: an NHANES analysis. Frontiers in Nutrition. 2025;12:1597864. doi:10.3389/fnut.2025.1597864 |
CKM综合征分期与新型生物标志物的预后评估 Core | 2025. Non-linear associations and threshold effects of oxidative balance score and composite dietary antioxidant index on frailty risk in patients with cardiovascular-kidney-metabolic syndrome. 2025 Frontiers in Nutrition | Wang Z等基于10,201例早期心血管-肾脏-代谢综合征患者数据发现,氧化平衡评分和复合膳食抗氧化指数与衰弱风险呈非线性负相关,并存在阈值效应。 | 心血管-肾脏-代谢综合征衰弱氧化平衡评分复合膳食抗氧化指数限制性立方样条横断面研究阈值效应逻辑回归PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.3389/fnut.2025.1673736;PMID: 41256923 | [53] Wang Z, Fang L, Wang L, Zhang J. 2025. Non-linear associations and threshold effects of oxidative balance score and composite dietary antioxidant index on frailty risk in patients with cardiovascular-kidney-metabolic syndrome. Frontiers in Nutrition. 2025;12:1673736. doi:10.3389/fnut.2025.1673736 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 2025. The role of oxidative balance score in Cardiovascular-Kidney-Metabolic syndrome progression and mortality: insights from NHANES 1999-2020. 2025 Frontiers in Nutrition | Xie D 等基于NHANES 1999-2020年19,433名参与者数据发现,氧化平衡评分升高与心血管-肾脏-代谢综合征进展风险降低及死亡风险下降显著相关,炎症标志物部分介导该关联。 | 心血管-肾脏-代谢综合征氧化平衡评分多项逻辑回归Cox模型全因死亡风险心血管死亡风险炎症标志物队列研究PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.3389/fnut.2025.1597693;PMID: 40667446 | [52] Xie D, You F, Yang L, Li C, Liu F. 2025. The role of oxidative balance score in Cardiovascular-Kidney-Metabolic syndrome progression and mortality: insights from NHANES 1999-2020. Frontiers in Nutrition. 2025;12:1597693. doi:10.3389/fnut.2025.1597693 |
衰弱、非奈利酮及遗传多态性在CKM管理中的角色 Extension | Adverse Life Events Across the Life Course and the Risk of New-Onset Cardiovascular-Kidney-Metabolic Multimorbidity in Middle-Aged and Older Adults: Longitudinal Evidence From CHARLS. 2025 Journal of the American Heart Association | Shi P 等基于CHARLS中6258名中老年人数据发现,儿童期和成年期不良生活事件均与新发心血管-肾脏-代谢多病共存风险升高显著相关,且暴力与剥夺型事件风险最高,心理健康部分中介该关联。 | 心血管肾脏代谢多病共存不良生活事件队列研究多状态时间模型中介分析心理健康生命历程中国健康与养老追踪调查PubMed疾病:CKM Title/Abstract多病共存 | DOI: 10.1161/JAHA.125.045192;PMID: 41378494 | [89] Shi P, Lou C, Fang J, Song Y. Adverse Life Events Across the Life Course and the Risk of New-Onset Cardiovascular-Kidney-Metabolic Multimorbidity in Middle-Aged and Older Adults: Longitudinal Evidence From CHARLS. Journal of the American Heart Association. 2025;14(24):e045192. doi:10.1161/JAHA.125.045192 |
衰弱、非奈利酮及遗传多态性在CKM管理中的角色 Extension | Association of Atherogenic Index of Plasma With Stroke Risk in a Population With Cardiovascular-Kidney-Metabolic Syndrome Stages 0 to 3: The First Evidence From the China Health and Retirement Longitudinal Study. 2025 Journal of the American Heart Association | Liu Z 等基于中国健康与养老追踪研究7664名CKM综合征0-3期人群发现,血浆致动脉粥样硬化指数升高与卒中风险增加呈非线性关联,阈值为1.516。 | 卒中心血管-肾脏-代谢综合征血浆致动脉粥样硬化指数Cox回归限制性立方样条队列研究甘油三酯高密度脂蛋白胆固醇PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1161/JAHA.124.039983;PMID: 40654258 | [86] Liu Z, Zhou D, Tang Y, Huo G. Association of Atherogenic Index of Plasma With Stroke Risk in a Population With Cardiovascular-Kidney-Metabolic Syndrome Stages 0 to 3: The First Evidence From the China Health and Retirement Longitudinal Study. Journal of the American Heart Association. 2025;14(14):e039983. doi:10.1161/JAHA.124.039983 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | Climate Vulnerability and Cardiovascular-Kidney-Metabolic Disease in the United States. 2025 Journal of the American Heart Association | Vieira de Oliveira Salerno PR 等基于70,300个人口普查区数据发现,气候脆弱性指数各维度与心血管-肾脏-代谢综合征组分患病率显著相关,且关联独立于环境、社会经济及基础设施因素。 | 心血管-肾脏-代谢综合征气候脆弱性横断面研究慢性肾脏病糖尿病高血压肥胖血脂异常冠心病患病率 | DOI: 10.1161/JAHA.124.038251;PMID: 40417800 | No ref no. Vieira de Oliveira Salerno PR, Lewis PGT, Chen Z, Dazard JE, Ganatra. Climate Vulnerability and Cardiovascular-Kidney-Metabolic Disease in the United States.. Journal of the American Heart Association. 2025. 14(11). e038251.. doi:10.1161/JAHA.124.038251 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | Impact of DNA-Methylation Age Acceleration on Long-Term Mortality Among US Adults With Cardiovascular-Kidney-Metabolic Syndrome. 2025 Journal of the American Heart Association | Wu S 等在一项纳入1889名美国成人的队列研究中发现,DNA甲基化年龄加速与心血管-肾脏-代谢综合征晚期分期及长期全因和非心血管死亡率升高显著相关。 | 心血管-肾脏-代谢综合征DNA甲基化年龄加速队列研究全因死亡率Cox比例风险回归GrimAge2Mort加速非心血管死亡率生物标志物中介分析健康饮食指数 | DOI: 10.1161/JAHA.124.039751;PMID: 40118808 | No ref no. Wu S, Zhu J, Lyu S, Wang J, Shao X, Zhang H,. Impact of DNA-Methylation Age Acceleration on Long-Term Mortality Among US Adults With Cardiovascular-Kidney-Metabolic Syndrome.. Journal of the American Heart Association. 2025. 14(7). e039751.. doi:10.1161/JAHA.124.039751 |
地热系统与超级马拉松代谢挑战等无关主题 Excluded | Incorporation of Metabolic Dysfunction-Associated Steatotic Liver Disease in the Health Stage of Cardiovascular-Kidney-Metabolic Syndrome Improves Predictive Ability for Coronary Artery Disease in a Japanese General Population. 2025 Journal of the American Heart Association | Kawaharata W 等将代谢相关脂肪性肝病纳入心血管-肾脏-代谢综合征健康分期,发现改良分类能更有效分层日本普通人群的冠状动脉疾病风险。 | 冠状动脉疾病代谢功能障碍相关脂肪性肝病心血管-肾脏-代谢综合征队列研究Cox比例风险分析综合判别改善指数风险比机器学习健康体检PubMed疾病:cardiovasc | DOI: 10.1161/JAHA.125.043173;PMID: 40767277 | No ref no. Kawaharata W, Tanaka M, Sato T, Akiyama Y, Hosaka I, Aida. Incorporation of Metabolic Dysfunction-Associated Steatotic Liver Disease in the Health Stage of Cardiovascular-Kidney-Metabolic Syndrome Improves Predictive Ability for Coronary Artery Disease in a Japanese General Population.. Journal of the American Heart Association. 2025. 14(16). e043173.. doi:10.1161/JAHA.125.043173 |
CKM综合征分期与新型生物标志物的预后评估 Core | Overall Sleep Quality Is Associated With Advanced Stages in Patients With Cardiovascular-Kidney-Metabolic Syndrome. 2025 Journal of the American Heart Association | Tu D 等基于12,245名美国成年人数据发现,整体睡眠质量较高的CKM综合征患者处于晚期的可能性较低,中等和高睡眠质量组晚期风险分别降低32%和45%。 | 心血管-肾脏-代谢综合征睡眠质量横断面研究逻辑回归优势比美国成年人肥胖糖尿病慢性肾脏病PubMed疾病:cardiovasc | DOI: 10.1161/JAHA.124.038674;PMID: 40130386 | [62] Tu D, Sun J, Wang P, Xu Q, Ma C. Overall Sleep Quality Is Associated With Advanced Stages in Patients With Cardiovascular-Kidney-Metabolic Syndrome. Journal of the American Heart Association. 2025;14(7):e038674. doi:10.1161/JAHA.124.038674 |
CKM综合征分期与新型生物标志物的预后评估 Core | Prevalence of Cardiovascular-Kidney-Metabolic Stages in US Adolescents and Relationship to Social Determinants of Health. 2025 Journal of the American Heart Association | Baker-Smith CM 等基于1774名美国青少年数据发现,56%处于心肾代谢综合征0期,食品安全缺乏与CKM 1-2期风险升高40%显著相关。 | 心肾代谢综合征动脉粥样硬化食品安全横断面研究逻辑回归家庭收入健康保险青少年PubMed疾病:CKM Title/Abstract肾脏 | DOI: 10.1161/JAHA.124.040269;PMID: 40371589 | [26] Baker-Smith CM, Gauen AM, Petito LC, Khan SS, Allen. Prevalence of Cardiovascular-Kidney-Metabolic Stages in US Adolescents and Relationship to Social Determinants of Health. Journal of the American Heart Association. 2025;14(10):e040269. doi:10.1161/JAHA.124.040269 |
衰弱、非奈利酮及遗传多态性在CKM管理中的角色 Extension | Reduced Risk of Cardiovascular Diseases After Bariatric Surgery Based on the New Predicting Risk of Cardiovascular Disease EVENTs Equations. 2025 Journal of the American Heart Association | Wang L 等基于7804例减重手术患者数据,发现术后心血管-肾脏-代谢健康显著改善,10年及30年心血管疾病风险均下降,其中心力衰竭风险降低47%-56%。 | 心血管疾病减重手术队列研究心力衰竭收缩压糖尿病心血管事件预测风险方程体重减轻PubMed疾病:CKM Title/Abstract多病共存 | DOI: 10.1161/JAHA.124.038191;PMID: 40055867 | [80] Wang L, Zhang X, Chen Y, Flynn CR, English WJ, Samuels JM. Reduced Risk of Cardiovascular Diseases After Bariatric Surgery Based on the New Predicting Risk of Cardiovascular Disease EVENTs Equations. Journal of the American Heart Association. 2025;14(6):e038191. doi:10.1161/JAHA.124.038191 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | The cellular and molecular mechanisms mediating the protective effects of sodium-glucose linked transporter 2 inhibitors against metabolic dysfunction-associated fatty liver disease. 2025 DIABETES OBESITY and METABOLISM | Ao N 等综述了SGLT2抑制剂对MAFLD的保护作用,发现其通过细胞与分子机制改善脂肪肝及相关合并症(如心血管病和慢性肾病)。 | 代谢功能障碍相关脂肪性肝病SGLT2抑制剂系统综述心血管疾病慢性肾脏病2型糖尿病细胞与分子机制心血管-肾脏-代谢综合征PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1111/dom.16043;PMID: 39508115 | [66] Ao N, Du J, Jin S, Suo L, Yang J. The cellular and molecular mechanisms mediating the protective effects of sodium-glucose linked transporter 2 inhibitors against metabolic dysfunction-associated fatty liver disease. DIABETES OBESITY and METABOLISM. 2025;27(2):457-467. doi:10.1111/dom.16043 |
CKM定义评估空白与超加工食品的代谢影响 Extension | eCollection 2025 Apr. Conservative Kidney Management in the Middle East and North Africa: Attitudes, Practices, and Implementation Barriers. 2025 Kidney International Reports | Koubar SH 等通过一项涵盖336名肾脏病专家的调查发现,中东和北非地区对保守性肾脏管理认知度较高,但实施率低,主要障碍为资金和资源限制。 | 慢性肾病保守性肾脏管理横断面研究问卷调查实施障碍肾脏病专家中东和北非PubMed疾病:CKM Title/Abstracttgsactn | DOI: 10.1016/j.ekir.2025.01.011;PMID: 40303211 | No ref no. Koubar SH, Hatab T, Razzak FA, Helal I, Ali A, Shebani A,. eCollection 2025 Apr. Conservative Kidney Management in the Middle East and North Africa: Attitudes, Practices, and Implementation Barriers.. Kidney International Reports. 2025. 10(4). 1076-1086.. doi:10.1016/j.ekir.2025.01.011 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | eCollection 2025 Aug. Kidney Disease: Improving Global Outcomes Summit Recommendations on Implementation of Diabetes Management in CKD: From Primary to Data-Driven Collaborative Care. 2025 Kidney International Reports | Li 等通过db/db小鼠模型结合多组学分析发现,铁皮石斛通过调控NF-κB、PI3K-Akt通路及甘油磷脂、硫代谢,改善高血糖、胰岛素抵抗和肾功能障碍。 | 2型糖尿病铁皮石斛动物实验多组学分析胰岛素抵抗肾功能障碍代谢物NF-κB通路PI3K-Akt通路氧化应激 | DOI: 10.1016/j.ekir.2025.06.010;PMID: 40814615 | No ref no. Li PK, Cheung M, Chow KM, Leung MKW, Lim LL, Lui. eCollection 2025 Aug. Kidney Disease: Improving Global Outcomes Summit Recommendations on Implementation of Diabetes Management in CKD: From Primary to Data-Driven Collaborative Care.. Kidney International Reports. 2025. 10(8). 2551-2565.. doi:10.1016/j.ekir.2025.06.010 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 10.1016/j.ecoenv.2025.118885. Epub 2025 Aug 16. Cadmium exposure and advanced cardiovascular-kidney-metabolic syndrome: An integrated multi-organ perspective based on epidemiology and adverse outcome pathways. 2025 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | He Y等基于NHANES 14,372名参与者数据发现,估算脉搏波传导速度升高与心血管-肾脏-代谢综合征风险呈非线性正相关,且在年轻成人中关联更强。 | 心血管-肾脏-代谢综合征估算脉搏波传导速度甘油三酯-葡萄糖指数横断面研究限制性立方样条Cox比例风险模型动脉僵硬度死亡率PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1016/j.ecoenv.2025.118885;PMID: 40819402 | No ref no. He Y, Zhou X, Huang W, Wu Y, Zhang Z, Jin Y, et al. 10.1016/j.ecoenv.2025.118885. Epub 2025 Aug 16. Cadmium exposure and advanced cardiovascular-kidney-metabolic syndrome: An integrated multi-organ perspective based on epidemiology and adverse outcome pathways.. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2025. 303. 118885.. doi:10.1016/j.ecoenv.2025.118885 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 10.1016/j.ecoenv.2025.118915. Epub 2025 Aug 23. Effects of ambient air pollution mixtures and household fuel use on progression to advanced cardiovascular-kidney-metabolic syndrome among middle-aged and older adults. 2025 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | Fan S 等基于中国健康与养老追踪调查数据发现,环境空气污染物与家庭固体燃料使用共同暴露显著增加中老年人晚期心血管-肾脏-代谢综合征风险,其中PM₁₀是主要驱动因素。 | 心血管-肾脏-代谢综合征空气污染家庭燃料队列研究加权分位数和回归贝叶斯核机器回归PM₁₀中老年人PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1016/j.ecoenv.2025.118915;PMID: 40850115 | [57] Fan S, Hu H, Li Y, Deng Y, Wang S, Xian J, et al. Effects of ambient air pollution mixtures and household fuel use on progression to advanced cardiovascular-kidney-metabolic syndrome among middle-aged and older adults. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2025;303:118915. doi:10.1016/j.ecoenv.2025.118915 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 10.1016/j.ecoenv.2025.118993. Epub 2025 Sep 2. Environment-wide association study of cardiovascular-kidney-metabolic syndrome based on NHANES 2013-2016. 2025 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | Ma J 等基于NHANES 2013-2016数据,通过暴露组学分析发现六种环境化学物与CKM综合征相关,其中金属混合暴露增加晚期CKM风险,且炎症可能起中介作用。 | 心血管-肾脏-代谢综合征环境化学物限制性立方样条加权分位数和炎症队列研究暴露组学金属多环芳烃挥发性有机物代谢物 | DOI: 10.1016/j.ecoenv.2025.118993;PMID: 40902250 | [64] Ma J, Li P, Tao L, Yang X, Luo Y, Guo X, et al. Environment-wide association study of cardiovascular-kidney-metabolic syndrome based on NHANES 2013-2016. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2025;303:118993. doi:10.1016/j.ecoenv.2025.118993 |
CKM定义评估空白与超加工食品的代谢影响 Extension | Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking. 2025 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | Zhang X等通过网络毒理学和分子对接发现,塑化剂可能通过靶向CKM、SOAT2等6个核心基因诱导骨质疏松,并显示出与靶蛋白的特异性结合效应。 | 骨质疏松症塑化剂网络毒理学分子对接机器学习靶基因邻苯二甲酸酯系统综述PubMed疾病:CKM Title/Abstracttgs | DOI: 10.1016/j.ecoenv.2025.117820;PMID: 39884015 | [92] Zhang X, Zhu X, Gu W, Li X, Niu T, Mao P, et al. Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2025;291:117820. doi:10.1016/j.ecoenv.2025.117820 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 10.1016/j.diabres.2025.112327. Epub 2025 Jun 13. Associations between insulin resistance indices and cardiovascular disease in older adults with cardiovascular-kidney-metabolic syndrome stage 0-3: The GOLD-Health cohort. 2025 DIABETES RESEARCH AND CLINICAL PRACTICE | Wang M等基于463,545名老年CKM综合征0-3期队列发现,八种胰岛素抵抗指标均与CVD风险升高显著相关,其中TyG-WC预测效能最高。 | 心血管疾病胰岛素抵抗Cox回归限制性立方样条甘油三酯葡萄糖指数心血管-肾脏-代谢综合征队列研究老年人群PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1016/j.diabres.2025.112327;PMID: 40517908 | [43] Wang M, Lin W, Liu H, Qian ZM, Chen J, Rao M, et al. Associations between insulin resistance indices and cardiovascular disease in older adults with cardiovascular-kidney-metabolic syndrome stage 0-3: The GOLD-Health cohort. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025;226:112327. doi:10.1016/j.diabres.2025.112327 |
CKM综合征分期与新型生物标志物的预后评估 Core | 10.1016/j.diabres.2025.112437. Epub 2025 Aug 25. Periodontitis, accelerated biological aging, and advanced stages in cardiovascular-kidney-metabolic syndrome in U.S. Adults: A mediation analysis. 2025 DIABETES RESEARCH AND CLINICAL PRACTICE | Qi X 等基于3102名美国成年人数据发现,重度牙周炎与晚期心血管-肾脏-代谢综合征风险升高1.5-2.05倍相关,且生物学年龄加速介导了约20%的效应。 | 牙周炎心血管-肾脏-代谢综合征生物学年龄加速Klemera-Doubal方法表型年龄横断面研究中介分析逻辑回归美国成年人口腔健康 | DOI: 10.1016/j.diabres.2025.112437;PMID: 40865882 | No ref no. Qi X, Sui J, Yang Z, Dahlen A, Zhang K, Wu B. 10.1016/j.diabres.2025.112437. Epub 2025 Aug 25. Periodontitis, accelerated biological aging, and advanced stages in cardiovascular-kidney-metabolic syndrome in U.S. Adults: A mediation analysis.. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025. 228. 112437.. doi:10.1016/j.diabres.2025.112437 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | 10.1016/j.diabres.2025.112927. Epub 2025 Sep 28. Association of the metabolic dysfunction-associated steatotic liver disease with cardiovascular and kidney disease in patients with type 2 diabetes mellitus: a cross-sectional study. 2025 DIABETES RESEARCH AND CLINICAL PRACTICE | Ren H 等在一项纳入2436例2型糖尿病患者的横断面研究中发现,肝纤维化与左心室肥厚及慢性肾脏病风险增加独立相关,且与心血管-肾脏-代谢综合征分期升高相关。 | 2型糖尿病肝纤维化左心室肥厚慢性肾脏病NAFLD纤维化评分逻辑回归横断面研究心血管疾病代谢功能障碍相关脂肪性肝病PubMed疾病:cardiovasc | DOI: 10.1016/j.diabres.2025.112927;PMID: 41027495 | [23] Ren H, Hu M, Yan Y, Cheng M, Yang C, Yuan G, et al. Association of the metabolic dysfunction-associated steatotic liver disease with cardiovascular and kidney disease in patients with type 2 diabetes mellitus: a cross-sectional study. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025;229:112927. doi:10.1016/j.diabres.2025.112927 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 10.1016/j.diabres.2025.112988. Epub 2025 Nov 7. Exploring the mediating role of TyG-related indicators in the relationship between biological aging and late-stage cardiovascular-kidney-metabolic in middle-aged and older adults. 2025 DIABETES RESEARCH AND CLINICAL PRACTICE | Li Y等基于3710名中老年人的横断面研究发现,生物衰老与晚期心血管-肾脏-代谢综合征风险正相关,且TyG相关指标在其中起部分中介作用。 | 心血管-肾脏-代谢综合征生物衰老甘油三酯-葡萄糖指数胰岛素抵抗横断面研究加权多元回归中介分析TyG-BMITyG-WHtR比值比 | DOI: 10.1016/j.diabres.2025.112988;PMID: 41205874 | [55] Li Y, Luo Z, Zhang Z, Huang N, Xiao L, Li J, et al. Exploring the mediating role of TyG-related indicators in the relationship between biological aging and late-stage cardiovascular-kidney-metabolic in middle-aged and older adults. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025;230:112988. doi:10.1016/j.diabres.2025.112988 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | 10.1016/j.diabres.2025.112989. Epub 2025 Nov 7. Inflammation and abnormal glucose-lipid metabolism are critical for population stratification toward progressive frailty in Cardiovascular-Kidney-Metabolic syndrome. 2025 DIABETES RESEARCH AND CLINICAL PRACTICE | Zhang C等基于5,790名CKM综合征患者7年随访数据发现,残余胆固醇炎症指数和甘油三酯-葡萄糖指数升高与衰弱进展风险独立相关,尤其在CKM早期阶段。 | 心血管-肾脏-代谢综合征衰弱残余胆固醇炎症指数甘油三酯-葡萄糖指数队列研究风险分层慢性炎症糖脂代谢紊乱PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1016/j.diabres.2025.112989;PMID: 41205877 | [44] Zhang C, Chen Y, Wang T, Peng W, Ning M, Liu Y. Inflammation and abnormal glucose-lipid metabolism are critical for population stratification toward progressive frailty in Cardiovascular-Kidney-Metabolic syndrome. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025;230:112989. doi:10.1016/j.diabres.2025.112989 |
衰弱、非奈利酮及遗传多态性在CKM管理中的角色 Extension | Association between remnant cholesterol and the risk of cardiovascular-kidney-metabolic syndrome progression: insights from the China health and retirement longitudinal study. 2025 European Journal of Preventive Cardiology | Ding X 等基于中国健康与养老追踪调查数据发现,残粒胆固醇升高与心血管-肾脏-代谢综合征进展至晚期及新发心血管疾病风险增加独立相关。 | 心血管疾病残粒胆固醇心血管-肾脏-代谢综合征Cox回归Logistic回归队列研究风险比PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract多病共存 | DOI: 10.1093/eurjpc/zwaf248;PMID: 40272444 | [84] Ding X, Tian J, Chang X, Liu J, Wang G. Association between remnant cholesterol and the risk of cardiovascular-kidney-metabolic syndrome progression: insights from the China health and retirement longitudinal study. European Journal of Preventive Cardiology. 2025;32(13):1157-1165. doi:10.1093/eurjpc/zwaf248 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | Sex differences in cardiovascular-kidney-metabolic risk factors associated with degenerative valvular heart disease. 2025 European Journal of Preventive Cardiology | Yang C等基于英国生物银行436,184名参与者发现,高血压是退行性心脏瓣膜病最大归因危险因素,且女性合并肥胖、慢性肾脏病、高血压或高甘油三酯时特定瓣膜病风险更高。 | 退行性心脏瓣膜病高血压肥胖慢性肾脏病高甘油三酯血症队列研究风险比人群归因风险性别差异心血管肾脏代谢 | DOI: 10.1093/eurjpc/zwaf050;PMID: 39937669 | No ref no. Yang C, Li Z, Sui Y, Long T, Cheng S, Guo X, et al. Sex differences in cardiovascular-kidney-metabolic risk factors associated with degenerative valvular heart disease.. European Journal of Preventive Cardiology. 2025. 32(17). 1705-1715.. doi:10.1093/eurjpc/zwaf050 |
CKM综合征分期与新型生物标志物的预后评估 Core | ahead of print. Association between the Life's Essential 8 Health Behaviors and Prognosis in Patients with Advanced Cardiovascular-Kidney-Metabolic Syndrome. 2025 European Journal of Preventive Cardiology | Tan S 等基于10,321名参与者发现,生命八要素(LE8)评分越高,晚期心血管-肾脏-代谢综合征患者的死亡风险越低,其中健康行为评分每增加10分可显著降低全因、心血管及CKM相关死亡风险。 | 心血管肾脏代谢综合征生命八要素Cox回归限制性立方样条死亡风险健康行为队列研究全因死亡PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1093/eurjpc/zwaf443;PMID: 40674721 | No ref no. Tan S, Zhou J, Li F, Zeng G, Liu. ahead of print. Association between the Life's Essential 8 Health Behaviors and Prognosis in Patients with Advanced Cardiovascular-Kidney-Metabolic Syndrome.. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf443 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | ahead of print. Association of Cardiovascular-Kidney-Metabolic Overlap with Physical Function and Prognosis in Older Patients with Heart Failure: A Post-hoc Analysis of the FRAGILE-HF and SONIC-HF. 2025 European Journal of Preventive Cardiology | Nakade T 等通过对1,113例老年心衰患者的事后分析发现,存在2种或以上心血管-肾脏-代谢重叠状况的患者,其身体功能显著更差,且2年内死亡或再入院风险升高。 | 心力衰竭慢性肾脏病2型糖尿病身体功能Cox回归前瞻性研究步速复合终点事后分析老年患者 | DOI: 10.1093/eurjpc/zwaf279;PMID: 40326534 | No ref no. Nakade T, Matsue Y, Ikeda Y, Maeda D, Kagiyama N, Fujimoto. ahead of print. Association of Cardiovascular-Kidney-Metabolic Overlap with Physical Function and Prognosis in Older Patients with Heart Failure: A Post-hoc Analysis of the FRAGILE-HF and SONIC-HF.. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf279 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | ahead of print. Data-driven cluster analysis identifies distinct types of cardiovascular-kidney-metabolic syndrome. 2025 European Journal of Preventive Cardiology | Yang M 等通过数据驱动聚类分析,在44,200名CKM综合征患者中识别出五个亚型,发现各亚型具有不同的器官特异性风险、蛋白质组学特征和遗传模式。 | 心血管-肾脏-代谢综合征K均值聚类Cox回归临床生物标志物血浆蛋白质组学队列研究慢性肝病脑血管事件慢性肾脏病遗传风险模式 | DOI: 10.1093/eurjpc/zwaf708;PMID: 41206602 | [105] Yang M, Su C, Chang X, Wang G, Liu J. ahead of print. Data-driven cluster analysis identifies distinct types of cardiovascular-kidney-metabolic syndrome. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf708 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | ahead of print. Hepatic Steatosis in Cardiovascular-Kidney-Metabolic Syndrome: Fatty Liver Index as a Predictor of Cardiovascular Outcomes. 2025 European Journal of Preventive Cardiology | Kim BS 等基于心血管-肾脏-代谢综合征人群研究发现,脂肪肝指数可预测心血管结局,提示肝脂肪变性是该综合征患者心血管风险的重要标志。 | 心血管-肾脏-代谢综合征脂肪肝指数心血管结局肝脏脂肪变性预测因子评论文章PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstractckdsglt | DOI: 10.1093/eurjpc/zwaf396;PMID: 40587659 | No ref no. Kim BS, Kim HJ, Kim H, Lee J, Ahn SB, Shin JH, et al. ahead of print. Hepatic Steatosis in Cardiovascular-Kidney-Metabolic Syndrome: Fatty Liver Index as a Predictor of Cardiovascular Outcomes.. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf396 |
衰弱、非奈利酮及遗传多态性在CKM管理中的角色 Extension | ahead of print. MASLD in the CKM health framework: what does it add to the table? 2025 European Journal of Preventive Cardiology | Ha KH等在一项基于CKM健康框架的评述中发现,MASLD与心血管代谢风险独立相关,为综合管理策略提供了额外证据。 | 代谢相关脂肪肝病心血管代谢健康队列研究欧洲预防心脏病学肝脏疾病心血管疾病代谢综合征评述文章PubMed疾病:CKM Title/Abstract多病共存 | DOI: 10.1093/eurjpc/zwaf549;PMID: 40858303 | [87] Ha KH, Kim DJ, Lee H. ahead of print. MASLD in the CKM health framework: what does it add to the table?. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf549 |
c8 Excluded | ahead of print. Night shift work and its interaction with sleep duration and chronotype, and risk of cardiovascular-kidney-metabolic diseases in the UK Biobank. 2025 European Journal of Preventive Cardiology | Tran DT 等基于96,365名英国生物样本库参与者发现,夜班工作超过20年或每月≥8次与心血管-肾脏-代谢疾病风险升高32%相关,且短睡眠(≤6小时)会进一步放大该风险。 | 心血管肾脏代谢疾病夜班工作睡眠时长睡眠时型Cox回归队列研究风险比剂量反应关系PubMed疾病:CKM Title/Abstract公里 | DOI: 10.1093/eurjpc/zwaf774;PMID: 41411331 | No ref no. Tran DT, Strohmaier S, Żebrowska M, Huang T, Papantoniou K,. ahead of print. Night shift work and its interaction with sleep duration and chronotype, and risk of cardiovascular-kidney-metabolic diseases in the UK Biobank.. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf774 |
衰弱、非奈利酮及遗传多态性在CKM管理中的角色 Extension | ahead of print. Remnant Cholesterol in CHARLS: Unaddressed Dynamic Changes and Clinical Confounders in CKM Progression Analysis. 2025 European Journal of Preventive Cardiology | Abudoureheman W 等基于CHARLS队列数据发现,残余胆固醇的动态变化及临床混杂因素在心血管-肾脏-代谢综合征进展分析中未被充分关注。 | 残余胆固醇心血管代谢疾病队列研究动态变化临床混杂因素CHARLS数据库疾病进展分析PubMed疾病:CKM Title/Abstract多病共存charls | DOI: 10.1093/eurjpc/zwaf391;PMID: 40583206 | [85] Abudoureheman W, Zhang F, Sun Q. ahead of print. Remnant Cholesterol in CHARLS: Unaddressed Dynamic Changes and Clinical Confounders in CKM Progression Analysis. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf391 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | The New Cardiovascular-Kidney-Metabolic (CKM) Syndrome: An Opportunity for CKD Detection and Treatment in Primary Care. 2025 AMERICAN JOURNAL OF KIDNEY DISEASES | Rumrill SM 和 Shlipak MG 在综述中阐述了新型心血管-肾脏-代谢综合征的概念,指出其有助于在初级保健中早期发现并治疗慢性肾脏病。 | 心血管疾病慢性肾病代谢综合征早期检测初级保健队列研究真实世界研究PubMed疾病:CKM Title/Abstractckdsglt | DOI: 10.1053/j.ajkd.2024.09.016;PMID: 39706244 | No ref no. Rumrill SM, Shlipak MG. The New Cardiovascular-Kidney-Metabolic (CKM) Syndrome: An Opportunity for CKD Detection and Treatment in Primary Care.. AMERICAN JOURNAL OF KIDNEY DISEASES. 2025. 85(4). 399-402.. doi:10.1053/j.ajkd.2024.09.016 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | Cumulative Incidence of Mortality Associated with Cardiovascular-Kidney-Metabolic (CKM) Syndrome. 2025 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | Claudel SE 等在一项纳入50,678名美国成人的纵向研究中发现,CKM综合征分期越高,15年心血管死亡累积发生率呈梯度增加,4期与0期绝对风险差异达8.1个月。 | 心血管疾病代谢综合征纵向研究累积发生率限制性平均生存心血管死亡CKM综合征生存分析PubMed疾病:CKM Title/Abstract肾脏 | DOI: 10.1681/ASN.0000000637;PMID: 39932805 | [21] Claudel SE, Schmidt IM, Waikar SS, Verma A. Cumulative Incidence of Mortality Associated with Cardiovascular-Kidney-Metabolic (CKM) Syndrome. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2025;36(7):1343-1351. doi:10.1681/ASN.0000000637 |
CKM综合征分期与新型生物标志物的预后评估 Core | Global Burden of the Key Components of Cardiovascular-Kidney-Metabolic Syndrome. 2025 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | Xie Z 等基于2021年全球疾病负担数据,分析了心血管-肾脏-代谢综合征七项关键组分的负担,发现缺血性心脏病和卒中为主要贡献因素,糖尿病和高体重指数负担呈上升趋势。 | 心血管-肾脏-代谢综合征糖尿病缺血性心脏病伤残调整寿命年全球疾病负担系统综述发病率死亡率高体重指数卒中 | DOI: 10.1681/ASN.0000000658;PMID: 40042920 | [24] Xie Z, Yu C, Cui Q, Zhao X, Zhuang J, Chen S, et al. Global Burden of the Key Components of Cardiovascular-Kidney-Metabolic Syndrome. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2025;36(8):1572-1584. doi:10.1681/ASN.0000000658 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | Preventing chronic kidney disease and maintaining kidney health: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. 2025 KIDNEY INTERNATIONAL | Ortiz A 等通过KDIGO争议会议总结发现,维护肾脏健康与预防慢性肾脏病(CKD)需结合健康生活方式及药物干预,如SGLT2抑制剂和GLP-1受体激动剂可降低高危人群CKD风险。 | 慢性肾脏病2型糖尿病钠-葡萄糖协同转运蛋白2抑制剂胰高血糖素样肽-1受体激动剂系统综述心血管-肾脏-代谢风险预测肾衰竭PubMed疾病:CKM Title/Abstractckd | DOI: 10.1016/j.kint.2025.04.005;PMID: 40536455 | [71] Ortiz A, Arreola Guerra JM, Chan JCN, Jha V, Kramer H, Nicholas. Preventing chronic kidney disease and maintaining kidney health: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. KIDNEY INTERNATIONAL. 2025;108(4):555-571. doi:10.1016/j.kint.2025.04.005 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | Restoration of branched chain amino acid catabolism improves kidney function in preclinical cardiovascular-kidney-metabolic syndrome models. 2025 KIDNEY INTERNATIONAL | Bollinger E 等通过两种CKM动物模型发现,支链氨基酸分解代谢障碍与肾脏病变相关,使用BDK抑制剂BT2可改善肾功能,与恩格列净联用效果更佳。 | 心血管-肾脏-代谢综合征支链氨基酸BDK抑制剂恩格列净蛋白质组学代谢组学线粒体功能肾功能动物实验PubMed疾病:cardiovasc | DOI: 10.1016/j.kint.2025.04.025;PMID: 40409667 | [72] Bollinger E, Williams G, Piper ME, Steen K, Neale KT, Chen X. Restoration of branched chain amino acid catabolism improves kidney function in preclinical cardiovascular-kidney-metabolic syndrome models. KIDNEY INTERNATIONAL. 2025;108(2):310-316. doi:10.1016/j.kint.2025.04.025 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | Risk stratification of metabolic disorder-associated kidney disease. 2025 KIDNEY INTERNATIONAL | Xu X 等在综述中总结了代谢紊乱相关性肾脏病的传统危险因素,并介绍了CKM健康概念及CKD进展与CVD风险评估工具,指出当前风险分层工具的不足。 | 代谢紊乱慢性肾脏病心血管疾病风险分层CKM分期模型CKD进展方程PREVENT方程系统综述PubMed疾病:CKM Title/Abstractckd | DOI: 10.1016/j.kint.2025.01.041;PMID: 40157500 | No ref no. Xu X, Shao X, Hou FF. Risk stratification of metabolic disorder-associated kidney disease.. KIDNEY INTERNATIONAL. 2025. 107(6). 1002-1010.. doi:10.1016/j.kint.2025.01.041 |
c8 Excluded | Metamorphism of Venus as driver of crustal thickness and recycling. 2025 Nature Communications | Semprich J 等通过变质相与熔融模型发现,金星玄武岩地壳厚度受热梯度控制,停滞盖层下约40公里,活动盖层下可达65公里,超过该范围会引发拆沉或熔融。 | 金星地壳玄武岩变质相转变地壳厚度热梯度拆沉作用熔融条件模型研究PubMed疾病:CKM Title/Abstract公里 | DOI: 10.1038/s41467-025-58324-1;PMID: 40133342 | No ref no. Semprich J, Filiberto J, Weller M, Gorce J, Clark N. Metamorphism of Venus as driver of crustal thickness and recycling.. Nature Communications. 2025. 16(1). 2905.. doi:10.1038/s41467-025-58324-1 |
CKM综合征分期与新型生物标志物的预后评估 Core | Observation of a rare beta decay of the charmed baryon with a Graph Neural Network. BESIII Collaboration. 2025 Nature Communications | Collaborators: Ablikim M 等利用图神经网络技术,首次观测到粲重子的一种稀有β衰变过程。 | 粒子衰变粲重子图神经网络共振态分支比质量谱角分布队列研究正负电子对撞新粒子发现 | DOI: 10.1038/s41467-024-55042-y;PMID: 39814737 | No ref no. Collaborators: Ablikim M, Achasov MN, Adlarson P, Afedulidis O, Ai XC, Aliberti. Observation of a rare beta decay of the charmed baryon with a Graph Neural Network. BESIII Collaboration.. Nature Communications. 2025. 16(1). 681.. doi:10.1038/s41467-024-55042-y |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | 2024 Apr. Are we ready for an adipocentric approach in people living with type 2 diabetes and chronic kidney disease? 2024 Clinical Kidney Journal | Moreno-Pérez O 等在综述中提出,以肥胖为核心的“功能障碍性脂肪组织管理方法”可整合2型糖尿病合并慢性肾病的治疗策略,强调减重对改善心肾代谢结局至关重要。 | 肥胖相关慢性病2型糖尿病慢性肾脏病减重药物功能障碍性脂肪组织系统综述减重靶器官保护血糖稳态心血管疾病 | DOI: 10.1093/ckj/sfae039;PMID: 38572499 | [68] Moreno-Pérez O, Reyes-García R, Modrego-Pardo I, López-Martínez. 2024 Apr. Are we ready for an adipocentric approach in people living with type 2 diabetes and chronic kidney disease?. Clinical Kidney Journal. 2024;17(4):sfae039. doi:10.1093/ckj/sfae039 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | eCollection 2024 Dec. GLP-1 receptor agonists in patients with chronic kidney disease and either overweight or obesity. 2024 Clinical Kidney Journal | Abasheva D 等综述发现,GLP-1受体激动剂可改善超重或肥胖慢性肾病患者的代谢控制,并降低心血管和肾脏不良结局风险。 | 慢性肾脏病超重肥胖GLP-1受体激动剂司美格鲁肽系统综述体重肾脏结局心血管结局PubMed疾病:CKM Title/Abstract | DOI: 10.1093/ckj/sfae296;PMID: 39583142 | [67] Abasheva D, Ortiz A, Fernandez-Fernandez B. GLP-1 receptor agonists in patients with chronic kidney disease and either overweight or obesity. Clinical Kidney Journal. 2024;17(Suppl. doi:10.1093/ckj/sfae296 |
CKM定义评估空白与超加工食品的代谢影响 Extension | eCollection 2024. Metabolomic analysis of Agkistrodon haly venom poisoning mouse treatment by Jidesheng snake pill based on GC-MS. 2024 Frontiers in Pharmacology | Luo J 等通过GC-MS代谢组学分析发现,季德胜蛇药片可调节蝮蛇蛇毒中毒小鼠的长链脂肪酸和氨基酸代谢,减轻其病理损伤。 | 蛇咬伤季德胜蛇药片代谢组学气相色谱-质谱蝮蛇蛇毒动物实验差异代谢物氨基酸代谢脂肪酸代谢PubMed疾病:CKM Title/Abstract | DOI: 10.3389/fphar.2024.1419609;PMID: 39148553 | [93] Luo J, Guo M, Xie K, Han TL, Ai S. Metabolomic analysis of Agkistrodon haly venom poisoning mouse treatment by Jidesheng snake pill based on GC-MS. Frontiers in Pharmacology. 2024;15:1419609. doi:10.3389/fphar.2024.1419609 |
CKM综合征分期与新型生物标志物的预后评估 Core | Maternal Dietary Strategies for Improving Offspring Cardiovascular-Kidney-Metabolic Health: A Scoping Review. 2024 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | Tain YL 和 Hsu CN 通过综述发现,母体饮食干预(如氨基酸补充、脂质调控、微量营养素及植物多酚)可改善子代心血管-肾脏-代谢健康,其机制涉及营养感应信号介导的程序化调控。 | 心血管-肾脏-代谢综合征母体饮食干预系统综述氨基酸补充微量营养素肠道微生物群植物多酚营养感应信号胎儿程序化子代健康 | DOI: 10.3390/ijms25189788;PMID: 39337276 | No ref no. Tain YL, Hsu CN. Maternal Dietary Strategies for Improving Offspring Cardiovascular-Kidney-Metabolic Health: A Scoping Review.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. 25(18). 9788.. doi:10.3390/ijms25189788 |
CKM定义评估空白与超加工食品的代谢影响 Extension | The Association of Genetic Markers Involved in Muscle Performance Responding to Lactate Levels during Physical Exercise Therapy by Nordic Walking in Patients with Long COVID Syndrome: A Nonrandomized Controlled Pilot Study. 2024 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | Lizcano-Álvarez Á 等通过北欧健走运动疗法对长新冠患者进行基因分析发现,ACTN3和AMPD1基因多态性影响运动后乳酸水平,提示长新冠患者运动能力较差但有氧训练可改善。 | 长新冠北欧健走基因多态性乳酸非随机对照试验肌肉表现有氧运动物理治疗PubMed疾病:CKM Title/Abstracttgs | DOI: 10.3390/ijms25158305;PMID: 39125881 | [98] Lizcano-Álvarez Á, Varillas-Delgado D, Cano-de-la-Cuerda R. The Association of Genetic Markers Involved in Muscle Performance Responding to Lactate Levels during Physical Exercise Therapy by Nordic Walking in Patients with Long COVID Syndrome: A Nonrandomized Controlled Pilot Study. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(15):8305. doi:10.3390/ijms25158305 |
CKM综合征分期与新型生物标志物的预后评估 Core | The Impact of the Aryl Hydrocarbon Receptor on Antenatal Chemical Exposure-Induced Cardiovascular-Kidney-Metabolic Programming. 2024 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | Tain YL 和 Hsu CN 通过综述发现,产前环境化学物暴露通过激活芳香烃受体可导致心血管-肾脏-代谢综合征编程,并探讨了潜在AHR调节剂的预防作用。 | 心血管-肾脏-代谢综合征芳香烃受体环境化学物质系统综述胎儿编程高血压糖尿病肥胖肾脏疾病非酒精性脂肪肝病 | DOI: 10.3390/ijms25094599;PMID: 38731818 | No ref no. Tain YL, Hsu CN. The Impact of the Aryl Hydrocarbon Receptor on Antenatal Chemical Exposure-Induced Cardiovascular-Kidney-Metabolic Programming.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. 25(9). 4599.. doi:10.3390/ijms25094599 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | The Renin-Angiotensin System and Cardiovascular-Kidney-Metabolic Syndrome: Focus on Early-Life Programming. 2024 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | Tain YL 和 Hsu CN 通过综述临床前证据发现,妊娠期及哺乳期肾素-血管紧张素系统失调会通过影响胎儿编程,导致子代出现心血管-肾脏-代谢综合征特征。 | 心血管-肾脏-代谢综合征肾素-血管紧张素系统早期生命编程系统综述代谢性疾病肾脏疾病心血管疾病胎儿编程重编程策略临床前证据 | DOI: 10.3390/ijms25063298;PMID: 38542273 | No ref no. Tain YL, Hsu CN. The Renin-Angiotensin System and Cardiovascular-Kidney-Metabolic Syndrome: Focus on Early-Life Programming.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. 25(6). 3298.. doi:10.3390/ijms25063298 |
CKM定义评估空白与超加工食品的代谢影响 Extension | Amino Acids during Pregnancy and Offspring Cardiovascular-Kidney-Metabolic Health. 2024 Nutrients | Tain YL 和 Hsu CN 综述发现,孕期氨基酸代谢紊乱通过胎儿编程和肠道菌群调节影响后代心血管-肾脏-代谢健康,靶向氨基酸疗法具有重编程保护潜力。 | 心血管-肾脏-代谢综合征氨基酸疗法系统综述胎儿编程肠道菌群氨基酸代谢后代健康发育起源PubMed疾病:CKM Title/Abstracttgs | DOI: 10.3390/nu16091263;PMID: 38732510 | [97] Tain YL, Hsu CN. Amino Acids during Pregnancy and Offspring Cardiovascular-Kidney-Metabolic Health. Nutrients. 2024;16(9):1263. doi:10.3390/nu16091263 |
CKM定义评估空白与超加工食品的代谢影响 Extension | Association of Genetic Profile with Muscle Mass Gain and Muscle Injury Prevention in Professional Football Players after Creatine Supplementation. 2024 Nutrients | Varillas-Delgado D等对161名职业足球运动员研究发现,肌酸补充后肌肉量增加受ACE和AMPD1基因型影响,总基因型评分低于54.16者非接触性肌肉损伤风险显著升高。 | 肌肉损伤肌酸补充基因型评分体重指数肌肉量纵向研究职业足球运动员单核苷酸多态性PubMed疾病:CKM Title/Abstracttgs | DOI: 10.3390/nu16152511;PMID: 39125391 | [99] Varillas-Delgado D. Association of Genetic Profile with Muscle Mass Gain and Muscle Injury Prevention in Professional Football Players after Creatine Supplementation. Nutrients. 2024;16(15):2511. doi:10.3390/nu16152511 |
CKM综合征分期与新型生物标志物的预后评估 Core | Maternal Polyphenols and Offspring Cardiovascular-Kidney-Metabolic Health. 2024 Nutrients | Tain YL 和 Hsu CN 通过综述研究发现,母体补充多酚可预防子代心血管-肾脏-代谢综合征,其保护作用涉及共同机制。 | 心血管-肾脏-代谢综合征多酚系统综述母体补充子代健康妊娠期哺乳期预防作用PubMed疾病:CKM Title/Abstract肾脏 | DOI: 10.3390/nu16183168;PMID: 39339768 | No ref no. Tain YL, Hsu CN. Maternal Polyphenols and Offspring Cardiovascular-Kidney-Metabolic Health.. Nutrients. 2024. 16(18). 3168.. doi:10.3390/nu16183168 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | Prevalence Rates of Abdominal Obesity, High Waist-to-Height Ratio and Excess Adiposity, and Their Associated Cardio-Kidney-Metabolic Factors: SIMETAP-AO Study. 2024 Nutrients | Ruiz-García A 等在一项纳入6,588名成人的横断面研究中发现,腹型肥胖、高腰围身高比和体脂过多的患病率分别为39.6%、39.6%和66.7%,且与高血压、糖尿病、血脂异常等心血管-肾脏-代谢因素独立相关。 | 腹型肥胖高腰围身高比体脂过多心血管-肾脏-代谢综合征横断面研究患病率高血压糖尿病高尿酸血症慢性肾脏病 | DOI: 10.3390/nu16223948;PMID: 39599733 | No ref no. Ruiz-García A, Serrano-Cumplido A, Escobar-Cervantes C,. Prevalence Rates of Abdominal Obesity, High Waist-to-Height Ratio and Excess Adiposity, and Their Associated Cardio-Kidney-Metabolic Factors: SIMETAP-AO Study.. Nutrients. 2024. 16(22). 3948.. doi:10.3390/nu16223948 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | Protective Effects of the Food Supplement Flexovital in a Model of Cardiovascular-Kidney-Metabolic Syndrome in Mice. 2024 Nutrients | Carvalho LRRA 等通过单侧肾切除联合西方饮食诱导小鼠CKM综合征模型,发现食品补充剂Flexovital可降低体脂、血糖、血压,改善肾功能及线粒体氧化磷酸化效率。 | 心血管-肾脏-代谢综合征食品添加剂动物实验体脂质量空腹血糖动脉血压肾小球滤过率线粒体氧化磷酸化西方饮食单侧肾切除术 | DOI: 10.3390/nu16234105;PMID: 39683499 | No ref no. Carvalho LRRA, Tydén M, Shimari M, Zhuge Z, Schiffer TA. Protective Effects of the Food Supplement Flexovital in a Model of Cardiovascular-Kidney-Metabolic Syndrome in Mice.. Nutrients. 2024. 16(23). 4105.. doi:10.3390/nu16234105 |
衰弱、非奈利酮及遗传多态性在CKM管理中的角色 Extension | Social Risk Profile and Cardiovascular-Kidney-Metabolic Syndrome in US Adults. 2024 Journal of the American Heart Association | Li J等基于18,373名美国成人数据发现,社会风险评分越低,心血管-肾脏-代谢综合征分期越高,累积社会劣势与CKM多病共存风险独立相关。 | 心血管肾脏代谢综合征社会风险特征横断面研究多病共存比值比美国成年人健康不平等PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstractcharls | DOI: 10.1161/JAHA.124.034996;PMID: 39136302 | [83] Li J, Lei L, Wang W, Ding W, Yu Y, Pu B, et al. Social Risk Profile and Cardiovascular-Kidney-Metabolic Syndrome in US Adults. Journal of the American Heart Association. 2024;13(16):e034996. doi:10.1161/JAHA.124.034996 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | Continuous ketone monitoring: Exciting implications for clinical practice. 2024 DIABETES OBESITY and METABOLISM | Kong YW 等通过皮下传感器监测组织间液酮体,发现连续酮体监测(CKM)可每5分钟更新读数,建议为所有糖尿病酮症酸中毒风险人群提供该技术。 | 糖尿病酮症酸中毒1型糖尿病连续酮体监测SGLT抑制剂系统综述酮体水平皮下传感器PubMed疾病:CKM Title/Abstractckdsglt | DOI: 10.1111/dom.15921;PMID: 39314201 | [77] Kong YW, Morrison D, Lu JC, Lee MH, Jenkins AJ. Continuous ketone monitoring: Exciting implications for clinical practice. DIABETES OBESITY and METABOLISM. 2024;26. doi:10.1111/dom.15921 |
CKM综合征分期与脑结构损伤及残余心血管风险 Supporting | eCollection 2024 Sep. Combination of Cardiovascular, Kidney, and Metabolic Diseases in a Syndrome Named Cardiovascular-Kidney-Metabolic, With New Risk Prediction Equations. 2024 Kidney International Reports | Massy ZA 和 Drueke TB 将心血管、肾脏与代谢疾病整合为“心血管-肾脏-代谢综合征”,并提出了新的风险预测方程。 | 心血管疾病肾脏疾病代谢疾病心血管-肾脏-代谢综合征风险预测方程队列研究PubMed疾病:CKM Title/Abstracttyg肾脏代谢综合 | DOI: 10.1016/j.ekir.2024.05.033;PMID: 39291205 | No ref no. Massy ZA, Drueke TB. eCollection 2024 Sep. Combination of Cardiovascular, Kidney, and Metabolic Diseases in a Syndrome Named Cardiovascular-Kidney-Metabolic, With New Risk Prediction Equations.. Kidney International Reports. 2024. 9(9). 2608-2618.. doi:10.1016/j.ekir.2024.05.033 |
CKM综合征分期与新型生物标志物的预后评估 Core | 10.1016/j.diabres.2024.111926. Epub 2024 Nov 12. Increased prevalence of cardiovascular-kidney-metabolic syndrome during COVID-19: A propensity score-matched study. 2024 DIABETES RESEARCH AND CLINICAL PRACTICE | Trimarco V 等通过倾向评分匹配研究发现,COVID-19大流行期间心血管-肾脏-代谢综合征患病率显著上升,近半数患者存在至少一项CKM组分。 | 心血管-肾脏-代谢综合征2型糖尿病高血压倾向评分匹配队列研究真实世界研究患病率COVID-19PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract | DOI: 10.1016/j.diabres.2024.111926;PMID: 39536978 | [25] Trimarco V, Izzo R, Pacella D, Virginia Manzi M, Trama U, Lembo. Increased prevalence of cardiovascular-kidney-metabolic syndrome during COVID-19: A propensity score-matched study. DIABETES RESEARCH AND CLINICAL PRACTICE. 2024;218:111926. doi:10.1016/j.diabres.2024.111926 |
CKM定义评估空白与超加工食品的代谢影响 Extension | Hot Cordilleran hinterland promoted lower crust mobility and decoupling of Laramide deformation. 2024 Nature Communications | Vlaha DR 等通过碳质拉曼光谱测温法重建北美科迪勒拉腹地热结构,发现晚白垩世高地壳地温梯度(>40 °C/km)促进了下地壳流动与壳幔解耦。 | 拉腊米造山运动地壳热结构地温梯度碳质拉曼光谱系统综述下地壳流动性壳幔解耦挤压变形缺失PubMed疾病:CKM Title/Abstracttgs | DOI: 10.1038/s41467-024-48182-8;PMID: 38704380 | No ref no. Vlaha DR, Zuza AV, Chen L, Harlaux M. Hot Cordilleran hinterland promoted lower crust mobility and decoupling of Laramide deformation.. Nature Communications. 2024. 15(1). 3750.. doi:10.1038/s41467-024-48182-8 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | A Patient Decision Aid About Conservative Kidney Management in Advanced Kidney Disease: A Randomized Pilot Trial. 2023 AMERICAN JOURNAL OF KIDNEY DISEASES | Wong SPY 等在一项随机先导试验中发现,针对晚期肾病患者的保守性肾脏管理决策辅助工具可行且可接受,并显著增加了患者与医生讨论该方案的比例。 | 慢性肾脏病保守性肾脏管理决策辅助工具随机先导试验失访率医患沟通老年患者PubMed疾病:CKM Title/Abstractckdsglt | DOI: 10.1053/j.ajkd.2022.12.007;PMID: 36740038 | No ref no. Wong SPY, Oestreich T, Prince DK, Curtis JR. A Patient Decision Aid About Conservative Kidney Management in Advanced Kidney Disease: A Randomized Pilot Trial.. AMERICAN JOURNAL OF KIDNEY DISEASES. 2023. 82(2). 179-188.. doi:10.1053/j.ajkd.2022.12.007 |
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 Core | A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association. 2023 Circulation | Ndumele CE 等通过整合主要指南与科学文献,总结了心血管-肾脏-代谢综合征在科学认知、筛查、预防及管理方面的现有证据,并指出了关键知识空白。 | 心血管-肾脏-代谢综合征慢性肾脏病代谢风险因素生活方式干预心脏保护疗法系统综述健康社会决定因素生物学风险因素不良心血管结局肾脏结局 | DOI: 10.1161/CIR.0000000000001186;PMID: 37807920 | No ref no. Ndumele CE, Neeland IJ, Tuttle KR, Chow SL, Mathew RO, Khan SS, et al. A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association.. Circulation. 2023. 148(20). 1636-1664.. doi:10.1161/CIR.0000000000001186 |
CKM多病共存与认知障碍、抑郁及不良生活事件的关联 Supporting | Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association. 2023 Circulation | Khan SS 等通过回顾性队列研究纳入604名终末期肾病患者,发现保守性肾脏管理组在12个月后生活质量各维度未见显著恶化,其症状负担与透析患者无显著差异。 | 终末期肾病保守性肾脏管理透析肾移植生活质量回顾性研究观察研究EQ-5D-5L症状负担PubMed疾病:CKM Title/Abstract | DOI: 10.1161/CIR.0000000000001191;PMID: 37947094 | No ref no. Khan SS, Coresh J, Pencina MJ, Ndumele CE, Rangaswami J, Chow SL, et al. Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association.. Circulation. 2023. 148(24). 1982-2004.. doi:10.1161/CIR.0000000000001191 |
地热系统与超级马拉松代谢挑战等无关主题 Excluded | Aberrant cyclin C nuclear release induces mitochondrial fragmentation and dysfunction in MED13L syndrome fibroblasts. 2022 iScience | Chang KT 等在MED13L综合征患者成纤维细胞中发现,异常细胞周期蛋白C核释放导致线粒体碎片化、呼吸功能降低及氧化应激超敏,阻断其定位可部分恢复线粒体功能。 | MED13L综合征线粒体碎片化细胞周期蛋白C线粒体功能障碍成纤维细胞病例对照研究转录组分析氧化应激PubMed疾病:CKM Title/Abstract澳大利亚 | DOI: 10.1016/j.isci.2022.103823;PMID: 35198885 | No ref no. Chang KT, Jezek J, Campbell AN, Stieg DC, Kiss ZA, Kemper K,. Aberrant cyclin C nuclear release induces mitochondrial fragmentation and dysfunction in MED13L syndrome fibroblasts.. iScience. 2022. 25(2). 103823.. doi:10.1016/j.isci.2022.103823 |
CKM定义评估空白与超加工食品的代谢影响 Extension | eCollection 2022. Combined metabolomics and proteomics to reveal beneficial mechanisms of Dendrobium fimbriatum against gastric mucosal injury. 2022 Frontiers in Pharmacology | Sun J等通过整合代谢组学与蛋白质组学,在环磷酰胺诱导的小鼠胃黏膜损伤模型中发现,流苏石斛通过调节肌酸、精氨酸与脯氨酸及嘧啶代谢通路发挥保护作用,并鉴定出Ckm、Arg1等关键靶蛋白及γ-L-谷氨酰-腐胺等潜在生物标志物。 | 胃黏膜损伤流苏石斛代谢组学蛋白质组学生物标志物动物实验环磷酰胺肌酸代谢PubMed疾病:CKM Title/Abstracttgs | DOI: 10.3389/fphar.2022.948987;PMID: 36110550 | [94] Sun J, Liu PF, Liu JN, Lu C, Tong LT, Wang YQ, et al. Combined metabolomics and proteomics to reveal beneficial mechanisms of Dendrobium fimbriatum against gastric mucosal injury. Frontiers in Pharmacology. 2022;13:948987. doi:10.3389/fphar.2022.948987 |
CKM综合征分期与新型生物标志物的预后评估 Core | 2019 Apr. Quality of life with conservative care compared with assisted peritoneal dialysis and haemodialysis. 2018 Clinical Kidney Journal | Iyasere O 等通过倾向性评分匹配84例ESKD患者发现,辅助腹膜透析比保守管理能改善部分生活质量指标,但衰弱与更差的生活质量结局相关。 | 终末期肾病保守肾脏管理辅助腹膜透析血液透析倾向评分匹配生活质量衰弱抑郁评分PubMed疾病:CKM Title/Abstract肾脏 | DOI: 10.1093/ckj/sfy059;PMID: 30976407 | No ref no. Iyasere O, Brown EA, Johansson L, Davenport A, Farrington K,. 2019 Apr. Quality of life with conservative care compared with assisted peritoneal dialysis and haemodialysis.. Clinical Kidney Journal. 2018. 12(2). 262-268.. doi:10.1093/ckj/sfy059 |
CKM定义评估空白与超加工食品的代谢影响 Extension | Common and rare variants associating with serum levels of creatine kinase and lactate dehydrogenase. 2016 Nature Communications | Kristjansson RP 等通过对冰岛人群的全基因组测序和推算,发现13个与血清肌酸激酶水平相关、16个与乳酸脱氢酶水平相关的序列变异,其中多个变异位于与肌肉功能或免疫炎症相关的基因中。 | 肌酸激酶乳酸脱氢酶全基因组测序序列变异队列研究冰岛人群组织损伤标志物单核吞噬细胞PubMed疾病:CKM Title/Abstracttgs | DOI: 10.1038/ncomms10572;PMID: 26838040 | [96] Kristjansson RP, Oddsson A, Helgason H, Sveinbjornsson G. Common and rare variants associating with serum levels of creatine kinase and lactate dehydrogenase. Nature Communications. 2016;7:10572. doi:10.1038/ncomms10572 |
CKM综合征分期与新型生物标志物的预后评估 Core | Association between inflammatory mediators and muscle mass in long-term hemodialysis patients. 2003 AMERICAN JOURNAL OF KIDNEY DISEASES | Kaizu Y 等在一项纳入188名长期血液透析患者的研究中发现,炎症介质IL-6和CRP水平与肌肉质量指标呈显著负相关。 | 肌肉消耗血液透析C反应蛋白白细胞介素-6多元回归分析队列研究肌肉质量炎症介质PubMed疾病:CKM Title/Abstract肾脏 | DOI: 10.1016/s0272-6386(03;PMID: 12900811 | No ref no. Kaizu Y, Ohkawa S, Odamaki M, Ikegaya N, Hibi I, Miyaji K, et al. Association between inflammatory mediators and muscle mass in long-term hemodialysis patients.. AMERICAN JOURNAL OF KIDNEY DISEASES. 2003. 42(2). 295-302.. doi:10.1016/s0272-6386(03 |
衰弱、非奈利酮及遗传多态性在CKM管理中的角色 Extension | Quantification of creatinine kinetic parameters in patients with acute renal failure. 1998 KIDNEY INTERNATIONAL | Clark WR等通过11例急性肾衰竭患者的肌酐动力学模型分析发现,患者瘦体重显著低于正常人和终末期肾病者,提示存在严重躯体蛋白质耗竭。 | 急性肾衰竭连续性静脉-静脉血液滤过肌酐动力学模型瘦体重肌酐生成速率营养不良队列研究蛋白质分解代谢率PubMed疾病:CKM Title/Abstract多病共存 | DOI: 10.1046/j.1523-1755.1998.00016.x;PMID: 9690223 | [81] Clark WR, Mueller BA, Kraus MA, Macias WL. Quantification of creatinine kinetic parameters in patients with acute renal failure. KIDNEY INTERNATIONAL. 1998;54(2):554-60. doi:10.1046/j.1523-1755.1998.00016.x |
衰弱、非奈利酮及遗传多态性在CKM管理中的角色 Extension | Protein catabolic rate over lean body mass ratio: a more rational approach to normalize the protein catabolic rate in dialysis patients. 1997 AMERICAN JOURNAL OF KIDNEY DISEASES | Canaud B 等通过联合尿素和肌酐动力学模型,在66名透析患者中发现,将蛋白质分解代谢率标准化为瘦体重(nPCRLBM)比标准化为干体重更能准确反映蛋白质营养状况,尤其适用于身体成分异常的患者。 | 终末期肾病蛋白质分解代谢率瘦体重尿素动力学模型肌酐动力学模型Kt/V队列研究PubMed疾病:CKM Title/Abstract多病共存charls | DOI: 10.1016/s0272-6386(97;PMID: 9370183 | [82] Canaud B, Leblanc M, Garred LJ, Bosc JY, Argilés A, Mion C. Protein catabolic rate over lean body mass ratio: a more rational approach to normalize the protein catabolic rate in dialysis patients. AMERICAN JOURNAL OF KIDNEY DISEASES. 1997;30(5):672-9. doi:10.1016/s0272-6386(97 |