One-line Citation Summary

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152Papers
8Topics
105Numbered refs
152With DOI/PMID
152With direct summary
152 / 152
衰弱、非奈利酮及遗传多态性在CKM管理中的角色 13地热系统与超级马拉松代谢挑战等无关主题 11CKM多病共存与认知障碍、抑郁及不良生活事件的关联 20CKM综合征分期与脑结构损伤及残余心血管风险 26SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用 32CKM综合征分期与新型生物标志物的预后评估 33CKM定义评估空白与超加工食品的代谢影响 13c8 4
[9]Extension
#1 · 2026

Explainable machine learning-driven predictive modelling of incident cognitive impairment in individuals with early-stage cardiovascular-kidney-metabolic syndrome: Insights from a longitudinal CHARLS cohort study.

Diabetes, obesity & metabolism
Duan Shoupeng 等基于4,462名早期CKM综合征患者的前瞻性队列数据,利用可解释机器学习模型发现,教育程度、总胆固醇和年龄是预测10年内新发认知损害的最重要因素。
Topic衰弱、非奈利酮及遗传多态性在CKM管理中的角色Keywords认知损害心血管-肾脏-代谢综合征机器学习XGBoost总胆固醇前瞻性队列研究教育程度空腹血糖PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1111/dom.70346 PMID: 41369001QualityOriginal summaryIdentifierNumbered
Reference
Duan Shoupeng, Wang Yijun, Yang Xiaomeng, Xu Yanan, Wang Jun. Explainable machine learning-driven predictive modelling of incident cognitive impairment in individuals with early-stage cardiovascular-kidney-metabolic syndrome: Insights from a longitudinal CHARLS cohort study. Diabetes, obesity & metabolism. 2026;28(3):1693-1709. doi:10.1111/dom.70346
[14]Excluded
#2 · 2026

Advancing brain health prevention using explainable CKM-based predictive modelling.

Diabetes, obesity & metabolism
Li J 等利用可解释的CKM预测模型,发现该模型能有效识别脑健康风险因素,为脑疾病预防提供了新工具。
Topic地热系统与超级马拉松代谢挑战等无关主题Keywords脑健康预测模型可解释性CKM模型疾病预防队列研究生物标志物PubMed疾病:CKM Title/Abstract澳大利亚medIDsDOI: 10.1111/dom.70437 PMID: 41588914QualityOriginal summaryIdentifierNumbered
Reference
Li J, Miao X, Li Z, Yang J. Advancing brain health prevention using explainable CKM-based predictive modelling. Diabetes, obesity & metabolism. 2026;28(3)(3):2497-2498. doi:10.1111/dom.70437
No ref no.Excluded
#3 · 2026

Socceromics: A Systematic Review of Omics Technologies to Optimize Performance and Health in Soccer.

International journal of molecular sciences
Owen A 等通过系统综述139项研究、涵盖19,449名足球运动员发现,基因组学、蛋白质组学、代谢组学及微生物组学可识别与耐力、损伤风险及恢复相关的生物标志物,支持个体化训练与健康管理策略。
Topic地热系统与超级马拉松代谢挑战等无关主题Keywords运动损伤组学技术系统综述单核苷酸多态性肠道微生物精准运动医学基因-环境交互PubMed疾病:CKM Title/Abstract澳大利亚medIDsDOI: 10.3390/ijms27020749 PMID: 41596414QualityOriginal summaryIdentifierNo ref no.
Reference
Owen A, Ceylan Hİ, Zmijewski P, Biz C, Sciarretta G, Rossin. Socceromics: A Systematic Review of Omics Technologies to Optimize Performance and Health in Soccer.. International journal of molecular sciences. 2026. 27(2)(2). 749.. doi:10.3390/ijms27020749
[13]Supporting
#4 · 2026

Association of Cardiovascular-Kidney-Syndrome and Brain Macrostructure and Microstructure Injury: A Prospective Cohort Study.

Diabetes, obesity & metabolism
Niu G 等在一项前瞻性队列研究中发现,心血管-肾脏-代谢综合征分期越高,脑宏观结构萎缩及白质微观结构损伤越严重,且呈进行性恶化模式。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心血管肾脏综合征脑宏观结构脑微观结构弥散张量成像白质高信号前瞻性队列研究线性混合效应模型脑体积各向异性分数CKM分期IDsDOI: 10.1111/dom.70605 PMID: 41749423QualityOriginal summaryIdentifierNumbered
Reference
Niu G, Cai X, Yang Y, Jing J, Zhang D, Wang. Association of Cardiovascular-Kidney-Syndrome and Brain Macrostructure and Microstructure Injury: A Prospective Cohort Study. Diabetes, obesity & metabolism. 2026;28(5)(5):4148-4161. doi:10.1111/dom.70605
[40]Supporting
#5 · 2026

TyG and RC combined with CVD risk in CKM syndrome: A national cohort study.

iScience
Lan H 等基于中国健康与养老追踪调查数据发现,TyG与残余胆固醇均高的个体心血管疾病风险最高(HR=1.35),且联合构建的TyG-RC指数预测价值优于其他指标。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管疾病心血管-肾脏-代谢综合征甘油三酯-葡萄糖指数残余胆固醇队列研究风险预测胰岛素抵抗脂质代谢PubMed疾病:CKM Title/AbstracttygIDsDOI: 10.1016/j.isci.2026.115060 PMID: 41816296QualityOriginal summaryIdentifierNumbered
Reference
Lan H, Jia X, Zhao Z, Chen R, Wang B, Qu C, et al. TyG and RC combined with CVD risk in CKM syndrome: A national cohort study. iScience. 2026;29(3):115060. doi:10.1016/j.isci.2026.115060
[65]Core
#6 · 2026

eCollection 2026. Current understanding of sodium-glucose transporter 2 inhibitors in cardiovascular-kidney-metabolic syndrome.

Frontiers in Pharmacology
Yang Y 等综述了SGLT-2抑制剂在心血管-肾脏-代谢综合征中的临床证据,发现其通过糖尿和尿钠排泄触发血流动力学优化、心脏效能增强及抗炎抗氧化等多效机制,形成相互关联的治疗获益网络。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords心血管-肾脏-代谢综合征SGLT-2抑制剂系统综述血糖控制血压肾脏结局心血管结局炎症与氧化应激PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fphar.2026.1800868 PMID: 42038319QualityOriginal summaryIdentifierNumbered
Reference
Yang Y, Zhou W, Yang M, Tang SCW, Liu BC. Current understanding of sodium-glucose transporter 2 inhibitors in cardiovascular-kidney-metabolic syndrome. Frontiers in Pharmacology. 2026;17:1800868. doi:10.3389/fphar.2026.1800868
[7]Supporting
#7 · 2026

eCollection 2026. Triglyceride-glucose index and its derivatives as emerging biomarkers of insulin resistance for prognostic evaluation of cardiovascular-kidney-metabolic syndrome: mechanisms and clinical applications.

Frontiers in Pharmacology
Zheng Z 等综述发现,甘油三酯-葡萄糖指数及其衍生指标作为胰岛素抵抗的新型生物标志物,在心血管-肾脏-代谢综合征的预后评估中具有显著潜力。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征胰岛素抵抗甘油三酯-葡萄糖指数系统综述生物标志物代谢紊乱预后评估PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstracttygIDsDOI: 10.3389/fphar.2026.1787130 PMID: 41878329QualityOriginal summaryIdentifierNumbered
Reference
Zheng Z, Yin X, Liu J, Zhang Y. Triglyceride-glucose index and its derivatives as emerging biomarkers of insulin resistance for prognostic evaluation of cardiovascular-kidney-metabolic syndrome: mechanisms and clinical applications. Frontiers in Pharmacology. 2026;17:1787130. doi:10.3389/fphar.2026.1787130
[12]Excluded
#8 · 2026

Current Appraisal and Gaps in Knowledge in Cardio-Kidney Metabolic Syndrome Definition.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Palazzuoli A 等探讨了心血管-肾脏-代谢综合征(CKM)的定义与评估挑战,发现其分类和管理因缺乏不同疾病阶段的心脏与肾脏结局可靠数据而存在混乱。
Topic地热系统与超级马拉松代谢挑战等无关主题Keywords慢性肾脏病心血管疾病代谢综合征系统综述氧化应激血管内皮心力衰竭肾功能障碍诊断评估实验室指纹IDsDOI: 10.3390/ijms27041657 PMID: 41751792QualityOriginal summaryIdentifierNumbered
Reference
Palazzuoli A, Mattioli AV, Fedele F. Current Appraisal and Gaps in Knowledge in Cardio-Kidney Metabolic Syndrome Definition. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2026;27(4):1657. doi:10.3390/ijms27041657
[6]Core
#9 · 2026

Melatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Hsu CN 和 Tain YL 通过综述发现,母体补充褪黑素可通过恢复氧化还原稳态、调节表观遗传及肠道微生物组,预防子代高血压、肾功能障碍及代谢紊乱。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords心血管肾脏代谢综合征褪黑素系统综述氧化应激发育编程母体补充高血压肾功能障碍代谢紊乱胎盘功能IDsDOI: 10.3390/ijms27052390 PMID: 41828607QualityOriginal summaryIdentifierNumbered
Reference
Hsu CN, Tain YL. Melatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2026;27(5):2390. doi:10.3390/ijms27052390
[4]Core
#10 · 2026

Mitochondrial Dysfunction at the Intersection of CKM Syndrome: Molecular Mechanisms and Path-to-Target Therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Kuo YJ 等在一篇综述中提出,线粒体功能障碍是心血管-肾脏-代谢综合征的核心病理枢纽,驱动从早期代谢风险向终末期器官衰竭的进展。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用KeywordsCKM综合征线粒体功能障碍SGLT-2抑制剂GLP-1受体激动剂系统综述氧化应激线粒体自噬心力衰竭慢性肾脏病PubMed疾病:CKM Title/AbstractIDsDOI: 10.3390/ijms27094120 PMID: 42123698QualityOriginal summaryIdentifierNumbered
Reference
Kuo YJ, Chen LF, Chen Y, Chen PL, Lin HY. Mitochondrial Dysfunction at the Intersection of CKM Syndrome: Molecular Mechanisms and Path-to-Target Therapies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2026;27(9):4120. doi:10.3390/ijms27094120
[33]Core
#11 · 2026

Association of Remnant Cholesterol Inflammatory Index with Stroke, Heart Disease and All-Cause Mortality Across Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: A National Cohort Study.

Nutrients
Chen H 等基于CHARLS队列研究发现,在心血管-肾脏-代谢综合征0-3期人群中,残粒胆固醇炎症指数升高与卒中、心脏病及全因死亡风险增加相关,且与全因死亡率呈J形非线性关联。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords卒中心脏病全因死亡率残粒胆固醇炎症指数高敏C反应蛋白Cox比例风险模型限制性立方样条K-means聚类队列研究心血管-肾脏-代谢综合征IDsDOI: 10.3390/nu18020205 PMID: 41599818QualityOriginal summaryIdentifierNumbered
Reference
Chen H, Wu JY, Yan H, Gao J, Li C, Xie JH. Association of Remnant Cholesterol Inflammatory Index with Stroke, Heart Disease and All-Cause Mortality Across Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: A National Cohort Study. Nutrients. 2026;18(2):205. doi:10.3390/nu18020205
[19]Supporting
#12 · 2026

Cardiovascular-Kidney-Metabolic (CKM) Syndrome Staging and Relevance to Precision Nutrition.

Nutrients
Soliman GA 在一项叙述性综述中描述了CKM综合征的分期与流行病学,发现精准营养可能有助于预防CKM进展,但肝脏在CKM定义中尚未被纳入。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心血管-肾脏-代谢综合征精准营养饮食模式叙述性综述CKM分期膳食摄入营养素代谢慢性肾脏病2型糖尿病肥胖IDsDOI: 10.3390/nu18091430 PMID: 42124030QualityOriginal summaryIdentifierNumbered
Reference
Soliman GA. Cardiovascular-Kidney-Metabolic (CKM) Syndrome Staging and Relevance to Precision Nutrition. Nutrients. 2026;18(9):1430. doi:10.3390/nu18091430
[15]Excluded
#13 · 2026

Ultra-Processed Foods and the Cardiovascular-Kidney-Metabolic Continuum: Integrating Epidemiological, Multi-Omics, and Translational Evidence.

Nutrients
Singar S 等在一项综述中整合流行病学与多组学证据发现,超加工食品摄入通过炎症、脂质代谢及肠道屏障功能障碍等通路,与肥胖、糖尿病、心血管事件及死亡率呈中低度正向关联。
Topic地热系统与超级马拉松代谢挑战等无关主题Keywords心血管-肾脏-代谢综合征超加工食品系统综述多组学代谢组学脂质组学蛋白质组学肠道微生物组肥胖慢性肾脏病IDsDOI: 10.3390/nu18071039 PMID: 41978089QualityOriginal summaryIdentifierNumbered
Reference
Singar S, Kachouei AA, Lantigua-Somoano L, Manley D, Cardinale A. Ultra-Processed Foods and the Cardiovascular-Kidney-Metabolic Continuum: Integrating Epidemiological, Multi-Omics, and Translational Evidence. Nutrients. 2026;18(7):1039. doi:10.3390/nu18071039
[58]Supporting
#14 · 2026

2026. Adherence to the EAT-Lancet diet and the risk of heart failure in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study.

Frontiers in Nutrition
Fu P 等基于120,849名心血管-肾脏-代谢综合征0-3期个体的前瞻性队列研究发现,较高依从性EAT-柳叶刀饮食与心力衰竭风险降低12%显著相关,主要得益于减少红肉和增加坚果摄入。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心力衰竭心血管-肾脏-代谢综合征EAT-柳叶刀饮食Cox回归限制性立方样条前瞻性研究饮食指数红肉摄入坚果摄入PubMed疾病:cardiovascIDsDOI: 10.3389/fnut.2026.1802388 PMID: 42211092QualityOriginal summaryIdentifierNumbered
Reference
Fu P, Zheng H, Wu K, Lan Y, Wu D, Wu W, et al. 2026. Adherence to the EAT-Lancet diet and the risk of heart failure in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study. Frontiers in Nutrition. 2026;13:1802388. doi:10.3389/fnut.2026.1802388
[41]Supporting
#15 · 2026

2026. Associations between lipid-derived indices and cardiovascular-kidney-metabolic syndrome progression among Chinese middle-aged and elderly adults: a longitudinal study.

Frontiers in Nutrition
Tang Y 等基于中国中老年人群纵向数据发现,七种脂质衍生指标(AIP、Non-HDL-C、NHHR、LCI、LAP、VAI、TyG)与心血管-肾脏-代谢综合征进展及心血管疾病风险呈正相关,其中NHHR预测价值最优。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征脂质衍生指标队列研究Cox回归限制性立方样条非高密度脂蛋白胆固醇比值血浆致动脉粥样硬化指数甘油三酯-葡萄糖比值PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fnut.2026.1742974 PMID: 41958905QualityOriginal summaryIdentifierNumbered
Reference
Tang Y, Xu W, Jiang Y, Liu C, Zhu W, Liu D, et al. 2026. Associations between lipid-derived indices and cardiovascular-kidney-metabolic syndrome progression among Chinese middle-aged and elderly adults: a longitudinal study. Frontiers in Nutrition. 2026;13:1742974. doi:10.3389/fnut.2026.1742974
[16]Core
#16 · 2026

2026. Development and validation of a prediction model for cardiovascular-kidney-metabolic syndrome progression: a multicenter study.

Frontiers in Nutrition
Tu J等基于21,026名CKM 1-2期患者构建预测模型,发现其区分度良好(AUC达0.747),且合并糖尿病与MASLD者进展风险最高(OR 2.13)。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征代谢功能障碍相关脂肪性肝病糖尿病脂质代谢指标预测模型多中心回顾性研究受试者工作特征曲线决策曲线分析比值比PubMed疾病:cardiovascIDsDOI: 10.3389/fnut.2026.1783262 PMID: 41939189QualityOriginal summaryIdentifierNumbered
Reference
Tu J, Chen F, Yan W, Xu Z, Zhan Y, Yang X. 2026. Development and validation of a prediction model for cardiovascular-kidney-metabolic syndrome progression: a multicenter study. Frontiers in Nutrition. 2026;13:1783262. doi:10.3389/fnut.2026.1783262
[42]Supporting
#17 · 2026

2026. The Triglyceride-Glucose-Chinese Visceral Adiposity Index (TyG-CVAI) outperforms other insulin resistance indices in its association with cardiovascular-kidney-metabolic syndrome severity in type 2 diabetes: a comparative study.

Frontiers in Nutrition
Yang J 等在一项纳入5,609例2型糖尿病患者的横断面研究中发现,新型TyG-CVAI指数与心血管-肾脏-代谢综合征严重程度的相关性优于其他胰岛素抵抗指标,且对晚期CKM的区分能力更强。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords2型糖尿病心血管肾脏代谢综合征甘油三酯葡萄糖指数中国内脏脂肪指数胰岛素抵抗横断面研究有序逻辑回归受试者工作特征曲线PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fnut.2026.1817071 PMID: 42180562QualityOriginal summaryIdentifierNumbered
Reference
Yang J, Deng Z, Xie B, Tian F, Leng Y, Zhou H. 2026. The Triglyceride-Glucose-Chinese Visceral Adiposity Index (TyG-CVAI) outperforms other insulin resistance indices in its association with cardiovascular-kidney-metabolic syndrome severity in type 2 diabetes: a comparative study. Frontiers in Nutrition. 2026;13:1817071. doi:10.3389/fnut.2026.1817071
[60]Core
#18 · 2026

Association of Higher Dietary Omega-3 Fatty Acid Intake With Cardiovascular-Kidney-Metabolic Syndrome Stage Severity and Mortality in US Adults: A Cross-Sectional and Prospective Cohort Analysis of NHANES 1999 to 2018.

Journal of the American Heart Association
Zhang LL 等基于27,934名美国成年人数据发现,较高膳食omega-3脂肪酸摄入与较轻的CKM综合征分期及L型阈值依赖的较低死亡率相关。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管肾脏代谢综合征Omega-3脂肪酸横断面研究队列研究限制性立方样条Cox回归全因死亡率膳食摄入量非线性关联阈值效应IDsDOI: 10.1161/JAHA.125.046079 PMID: 41532525QualityOriginal summaryIdentifierNumbered
Reference
Zhang LL, Zhu XG, Chen J, Nie P, Shi JC, Zhang Z, et al. Association of Higher Dietary Omega-3 Fatty Acid Intake With Cardiovascular-Kidney-Metabolic Syndrome Stage Severity and Mortality in US Adults: A Cross-Sectional and Prospective Cohort Analysis of NHANES 1999 to 2018. Journal of the American Heart Association. 2026;15(2):e046079. doi:10.1161/JAHA.125.046079
[35]Supporting
#19 · 2026

Effect of Mitochondria-Derived Methylmalonic Acid on Progress and Mortality Risk in US Adults With Cardiovascular-Kidney-Metabolic Syndrome.

Journal of the American Heart Association
Liu H 等基于14,581名CKM参与者的前瞻性队列研究发现,线粒体来源的甲基丙二酸与CKM分期显著相关,其高水平与全因及非心血管死亡风险增加显著相关。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心血管-肾脏-代谢综合征甲基丙二酸前瞻性队列研究Cox回归全因死亡非心血管死亡心脏代谢生物标志物比值比PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1161/JAHA.125.043066 PMID: 41532538QualityOriginal summaryIdentifierNumbered
Reference
Liu H, Wu S, Huang B, Liu Y, Zhong Z, Zhao. Effect of Mitochondria-Derived Methylmalonic Acid on Progress and Mortality Risk in US Adults With Cardiovascular-Kidney-Metabolic Syndrome. Journal of the American Heart Association. 2026;15(2):e043066. doi:10.1161/JAHA.125.043066
[78]Extension
#20 · 2026

Prognostic Impact of Cardiovascular-Kidney-Metabolic Overlap Among Patients With Acute Heart Failure: Insights From a Real-World Multinational Cohort.

Journal of the American Heart Association
Marchetti M 等在一项跨国队列研究中发现,急性心力衰竭患者合并心血管-肾脏-代谢疾病数量越多,1年内死亡风险越高。
Topic衰弱、非奈利酮及遗传多态性在CKM管理中的角色Keywords急性心力衰竭心血管肾脏代谢综合征肾功能受损心肌梗死糖尿病Cox回归全因死亡队列研究真实世界研究PubMed疾病:CKM Title/AbstractIDsDOI: 10.1161/JAHA.125.045294 PMID: 41404735QualityOriginal summaryIdentifierNumbered
Reference
Marchetti M, Antiochos P, Pitta-Gros B, Abdurashidova T. Prognostic Impact of Cardiovascular-Kidney-Metabolic Overlap Among Patients With Acute Heart Failure: Insights From a Real-World Multinational Cohort. Journal of the American Heart Association. 2026;15(1):e045294. doi:10.1161/JAHA.125.045294
[75]Core
#21 · 2026

Cardio-Kidney-Metabolic Therapy Use Among Adults With Type 1 Diabetes and Chronic Kidney Disease.

DIABETES OBESITY and METABOLISM
Caramori ML 等在一项纳入253名1型糖尿病合并慢性肾病患者的队列研究中发现,使用心-肾-代谢疗法与尿白蛋白/肌酐比值降低相关,且未增加低血糖或酮症酸中毒风险。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords1型糖尿病慢性肾脏病GLP-1受体激动剂SGLT-2抑制剂倾向评分匹配尿白蛋白肌酐比值糖化血红蛋白低血糖糖尿病酮症酸中毒队列研究IDsDOI: 10.1111/dom.70640 PMID: 41816887QualityOriginal summaryIdentifierNumbered
Reference
Caramori ML, Repetto E, Perkins C, Pandey A, Rossing P. Cardio-Kidney-Metabolic Therapy Use Among Adults With Type 1 Diabetes and Chronic Kidney Disease. DIABETES OBESITY and METABOLISM. 2026;28(5):4344-4351. doi:10.1111/dom.70640
[28]Core
#22 · 2026

Comparative Associations of Traditional and New Obesity Framework With Cardio-Kidney-Metabolic Syndrome and All-Cause Mortality: A Prospective Cohort Study.

DIABETES OBESITY and METABOLISM
Yang Y等在一项前瞻性队列研究中发现,新肥胖框架能识别出被传统标准忽视的高CKM风险个体,且同时符合两种标准的人群风险最高。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征肥胖全因死亡率体重指数人体测量指标Cox回归队列研究英国生物银行PubMed疾病:CKM Title/Abstract肾脏IDsDOI: 10.1111/dom.70883 PMID: 42169183QualityOriginal summaryIdentifierNumbered
Reference
Yang Y, Liu Y, Han S, Liu Z, Yu J, Xing B. Comparative Associations of Traditional and New Obesity Framework With Cardio-Kidney-Metabolic Syndrome and All-Cause Mortality: A Prospective Cohort Study. DIABETES OBESITY and METABOLISM. 2026. doi:10.1111/dom.70883
[10]Core
#23 · 2026

Effects of SGLT2 inhibitors across the spectrum of albuminuria in cardiovascular-kidney-metabolic conditions: A pooled analysis of randomised trials.

DIABETES OBESITY and METABOLISM
Ferreira JP 等在一项纳入26,750例患者的汇总分析中发现,SGLT2抑制剂在全部白蛋白尿范围内均能降低肾脏事件和心力衰竭死亡风险,并使白蛋白尿水平平均降低13%。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords白蛋白尿SGLT2抑制剂汇总分析尿白蛋白肌酐比肾小球滤过率肾脏事件心力衰竭随机对照试验PubMed疾病:CKM Title/AbstractckdIDsDOI: 10.1111/dom.70289 PMID: 41208574QualityOriginal summaryIdentifierNumbered
Reference
Ferreira JP, Marques P, Anker SD, Butler J, Filippatos G. Effects of SGLT2 inhibitors across the spectrum of albuminuria in cardiovascular-kidney-metabolic conditions: A pooled analysis of randomised trials. DIABETES OBESITY and METABOLISM. 2026;28(2):1105-1115. doi:10.1111/dom.70289
[5]Core
#24 · 2026

Online ahead of print. Hyperaldosteronism in the Pathophysiology and Management of Cardiovascular-Kidney-Metabolic Syndrome.

DIABETES OBESITY and METABOLISM
Zeitler E 等发现,肥胖诱导的醛固酮过量是心血管-肾脏-代谢综合征的关键病理因素,抑制醛固酮信号可改善疾病管理。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords心血管-肾脏-代谢综合征醛固酮过量盐皮质激素受体拮抗剂胰高血糖素样肽-1受体激动剂系统综述肾素-血管紧张素-醛固酮系统抑制剂肥胖心力衰竭PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1111/dom.70781 PMID: 42010373QualityOriginal summaryIdentifierNumbered
Reference
Zeitler E, Klein KR, Lingvay I, Pick A, Billings LK. Online ahead of print. Hyperaldosteronism in the Pathophysiology and Management of Cardiovascular-Kidney-Metabolic Syndrome. DIABETES OBESITY and METABOLISM. 2026. doi:10.1111/dom.70781
[8]Supporting
#25 · 2026

Proteomic Profiling Captures Residual Cardiovascular Risk Beyond the PREVENT Model in Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 2-3.

DIABETES OBESITY and METABOLISM
Han X 等基于24,017名CKM 2-3期参与者数据,构建含63种蛋白的风险评分,发现其可显著提升PREVENT模型对心血管疾病的预测能力,并捕获残余风险。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心血管疾病心血管-肾脏-代谢综合征蛋白风险评分队列研究LASSO回归生长分化因子15NT-proBNP残余风险PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1111/dom.70933 PMID: 42225325QualityOriginal summaryIdentifierNumbered
Reference
Han X, Ding J, Li J, Gao Y, Li Y. Proteomic Profiling Captures Residual Cardiovascular Risk Beyond the PREVENT Model in Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 2-3. DIABETES OBESITY and METABOLISM. 2026. doi:10.1111/dom.70933
[37]Core
#26 · 2026

Serum glycated albumin-to-albumin ratio and mortality risk in cardiovascular-kidney-metabolic syndrome: Evidence from NHANES over 15 years.

DIABETES OBESITY and METABOLISM
Li Z和Chen M基于NHANES数据库4524例CKM综合征患者15年随访发现,糖化白蛋白与白蛋白比值升高与全因及心脑血管死亡风险增加显著相关,且该比值是预测长期死亡风险的最稳健指标。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征糖化白蛋白与白蛋白比值Cox回归限制性立方样条全因死亡心脑血管死亡队列研究血清白蛋白糖化白蛋白PubMed疾病:cardiovascIDsDOI: 10.1111/dom.70387 PMID: 41403278QualityOriginal summaryIdentifierNumbered
Reference
Li Z, Chen M. Serum glycated albumin-to-albumin ratio and mortality risk in cardiovascular-kidney-metabolic syndrome: Evidence from NHANES over 15 years. DIABETES OBESITY and METABOLISM. 2026;28(3):2038-2050. doi:10.1111/dom.70387
[36]Supporting
#27 · 2026

The Evolving Role of High-Sensitivity C-Reactive Protein for Mortality Prediction Across the Spectrum of Cardiovascular-Kidney-Metabolic Syndrome.

DIABETES OBESITY and METABOLISM
Li J 等在一项纳入86,829名参与者的前瞻性研究中发现,高敏C反应蛋白与全因死亡率的关联随心血管-肾脏-代谢综合征分期进展而逐渐减弱。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心血管-肾脏-代谢综合征高敏C反应蛋白全因死亡率Cox比例风险模型CKM分期前瞻性队列研究风险比PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏IDsDOI: 10.1111/dom.70843 PMID: 42107990QualityOriginal summaryIdentifierNumbered
Reference
Li J, Chen S, Zhang X, Xia X, Yan Y. The Evolving Role of High-Sensitivity C-Reactive Protein for Mortality Prediction Across the Spectrum of Cardiovascular-Kidney-Metabolic Syndrome. DIABETES OBESITY and METABOLISM. 2026. doi:10.1111/dom.70843
[17]Core
#28 · 2026

10.1016/j.ecoenv.2025.119515. Epub 2025 Dec 4. Multimodal mechanisms of di (2-ethylhexyl) phthalate-induced cardiovascular-kidney-metabolic syndrome: Integrating epidemiology, network toxicology and experimental validation.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Wen W 等通过整合流行病学、网络毒理学和实验验证发现,DEHP暴露通过PPARG、PTGS2和MMP2通路促进CKM综合征,且肥胖显著放大该关联。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征邻苯二甲酸二乙基己酯横断面研究体重指数网络毒理学细胞毒性代谢紊乱炎症反应纤维化PubMed疾病:cardiovascIDsDOI: 10.1016/j.ecoenv.2025.119515 PMID: 41349316QualityOriginal summaryIdentifierNumbered
Reference
Wen W, Liu Z, Li L, Qiu F, Zhang H, Cao Y, et al. Multimodal mechanisms of di (2-ethylhexyl) phthalate-induced cardiovascular-kidney-metabolic syndrome: Integrating epidemiology, network toxicology and experimental validation. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2026;309:119515. doi:10.1016/j.ecoenv.2025.119515
[18]Supporting
#29 · 2026

10.1016/j.ecoenv.2026.120039. Epub 2026 Mar 20. Urinary metal mixtures and cardio-kidney-metabolic risk in adults from a legacy-contaminated area: Repeated-measures cohort evidence and computational validation.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Amujilite 等通过纵向重复测量队列发现,尿镉、铅、锰水平升高与晚期心血管-肾脏-代谢综合征风险增加相关,且累积性社会不利因素可放大该关联。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征重金属暴露广义线性混合效应模型贝叶斯核机器回归尿金属水平社会不利因素队列研究分子对接PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1016/j.ecoenv.2026.120039 PMID: 41864045QualityOriginal summaryIdentifierNumbered
Reference
Amujilite, Yin G, Chen Z, Wu J, Dong Z, Zhang S, et al. Urinary metal mixtures and cardio-kidney-metabolic risk in adults from a legacy-contaminated area: Repeated-measures cohort evidence and computational validation. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2026;314:120039. doi:10.1016/j.ecoenv.2026.120039
[76]Core
#30 · 2026

10.1177/15209156261420167. Online ahead of print. Continuous Ketone Monitoring Captures Overt Ketosis in Type 1 Diabetes Caused by Empagliflozin, Low-Carbohydrate Diet, and Exercise.

Diabetes Technology and Therapeutics
Lawton E等通过一例1型糖尿病患者使用连续酮体监测发现,在恩格列净、低碳水饮食和运动共同作用下,尽管血糖正常,仍可发生持续14小时、最高达2.9 mmol/L的酮症。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords1型糖尿病正常血糖性酮症恩格列净连续酮体监测低碳水化合物饮食病例报告酮体浓度钠-葡萄糖协同转运蛋白2抑制剂PubMed疾病:CKM Title/AbstractckdIDsDOI: 10.1177/15209156261420167 PMID: 41640091QualityOriginal summaryIdentifierNumbered
Reference
Lawton E, Perz L, Pasqua MR, Tsoukas M, Haidar. Online ahead of print. Continuous Ketone Monitoring Captures Overt Ketosis in Type 1 Diabetes Caused by Empagliflozin, Low-Carbohydrate Diet, and Exercise. Diabetes Technology and Therapeutics. 2026. doi:10.1177/15209156261420167
No ref no.Excluded
#31 · 2026

10.1177/15209156261420186. Online ahead of print. Ketone Profiles in Community-Dwelling Adults with Type 1 Diabetes Using Continuous Ketone Monitoring.

Diabetes Technology and Therapeutics
Ngan J 等通过持续酮体监测发现,社区居住的1型糖尿病成人中61%酮体持续低于0.6 mmol/L,血糖随酮体升高但无法替代诊断。
Topic地热系统与超级马拉松代谢挑战等无关主题Keywords1型糖尿病持续酮体监测酮体水平糖化血红蛋白血糖水平队列研究社区居住PubMed疾病:CKM Title/Abstract澳大利亚medIDsDOI: 10.1177/15209156261420186 PMID: 41684056QualityOriginal summaryIdentifierNo ref no.
Reference
Ngan J, Kong YW, Jones HC, Goad J, Kriketos A,. 10.1177/15209156261420186. Online ahead of print. Ketone Profiles in Community-Dwelling Adults with Type 1 Diabetes Using Continuous Ketone Monitoring.. Diabetes Technology and Therapeutics. 2026. doi:10.1177/15209156261420186
[103]Supporting
#32 · 2026

10.1177/15209156261428034. Online ahead of print. Continuous Ketone Monitoring in Diabetic Ketoacidosis: Prospective Multicenter Method-Comparison and Feasibility Study.

Diabetes Technology and Therapeutics
Haas NL 等在一项前瞻性多中心研究中发现,持续酮体监测与静脉血β-羟丁酸值高度一致,且能比标准治疗平均提前55分钟检测到糖尿病酮症酸中毒纠正。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords糖尿病酮症酸中毒持续酮体监测β-羟丁酸前瞻性研究方法比较研究Bland-Altman分析相关性分析可行性研究PubMed疾病:CKM Title/Abstract肾脏IDsDOI: 10.1177/15209156261428034 PMID: 41800718QualityOriginal summaryIdentifierNumbered
Reference
Haas NL, Korley FK, Schneider RM, Mamillapalli SL, Hepworth E. Online ahead of print. Continuous Ketone Monitoring in Diabetic Ketoacidosis: Prospective Multicenter Method-Comparison and Feasibility Study. Diabetes Technology and Therapeutics. 2026. doi:10.1177/15209156261428034
No ref no.Excluded
#33 · 2026

Preventing Diabetic Ketoacidosis with Continuous Ketone Monitoring: Insights from a Clinical Research Case.

Diabetes Technology and Therapeutics
Kong YW 等通过一项临床研究案例发现,连续酮体监测可早期预警酮症升高,促进及时干预,从而降低糖尿病酮症酸中毒风险。
Topic地热系统与超级马拉松代谢挑战等无关主题Keywords糖尿病酮症酸中毒1型糖尿病连续酮体监测自动化胰岛素输注胰岛素泵酮体糖化血红蛋白临床试验PubMed疾病:CKM Title/Abstract澳大利亚IDsDOI: 10.1177/15209156251362494 PMID: 40711834QualityOriginal summaryIdentifierNo ref no.
Reference
Kong YW, Jones HC, Ngan J, Goad J, Jenkins. Preventing Diabetic Ketoacidosis with Continuous Ketone Monitoring: Insights from a Clinical Research Case.. Diabetes Technology and Therapeutics. 2026. 28(1). 73-77.. doi:10.1177/15209156251362494
[27]Supporting
#34 · 2026

10.1016/j.diabres.2025.113051. Epub 2025 Dec 11. Kidney function decline mediates the adverse effects of arterial stiffness on all-cause and cardiovascular disease mortality in Cardiovascular-Kidney-Metabolic syndrome population: A cohort study.

DIABETES RESEARCH AND CLINICAL PRACTICE
Liu S 等基于34,004例CKM综合征患者队列发现,动脉僵硬度升高显著增加全因及心血管死亡风险,肾功能下降介导了24%-26%的死亡效应。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联KeywordsCKM综合征动脉僵硬度肾功能下降全因死亡心血管死亡Cox回归限制性立方样条中介效应分析队列研究估计脉搏波传导速度IDsDOI: 10.1016/j.diabres.2025.113051 PMID: 41386526QualityOriginal summaryIdentifierNumbered
Reference
Liu S, Man Q, Wang S, Huang Y, Wen J, Yang Y, et al. Kidney function decline mediates the adverse effects of arterial stiffness on all-cause and cardiovascular disease mortality in Cardiovascular-Kidney-Metabolic syndrome population: A cohort study. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;231:113051. doi:10.1016/j.diabres.2025.113051
[102]Supporting
#35 · 2026

10.1016/j.diabres.2025.113064. Epub 2025 Dec 21. Association between Life's Simple 7 and life's essential 8 with all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome population.

DIABETES RESEARCH AND CLINICAL PRACTICE
Yin S 等在11,487名CKM综合征人群中发现,LS7和LE8评分均与全因及心血管死亡风险呈负相关,且预测能力相当,尤其在非晚期阶段保护效应显著。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心血管疾病慢性肾病代谢综合征生命简单7项生命必需8项Cox回归全因死亡心血管死亡队列研究美国健康调查IDsDOI: 10.1016/j.diabres.2025.113064 PMID: 41435969QualityOriginal summaryIdentifierNumbered
Reference
Yin S, Yan S, Yang Z, Zhu P, Tang T, Borné Y. Association between Life's Simple 7 and life's essential 8 with all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome population. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;231:113064. doi:10.1016/j.diabres.2025.113064
[34]Core
#36 · 2026

10.1016/j.diabres.2026.113146. Epub 2026 Feb 7. Association of remnant cholesterol inflammation index with future cardiovascular disease risk in patients with cardiovascular-kidney-metabolic syndrome stages 0-3.

DIABETES RESEARCH AND CLINICAL PRACTICE
Xie N等基于7527名CKM综合征0-3期患者数据发现,残余胆固醇炎症指数升高与未来心血管疾病风险增加显著相关,且hs-CRP部分介导了残余胆固醇与CVD的关联。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管疾病心血管-肾脏-代谢综合征残余胆固醇炎症指数Cox回归限制性立方样条残余胆固醇高敏C反应蛋白队列研究PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1016/j.diabres.2026.113146 PMID: 41662975QualityOriginal summaryIdentifierNumbered
Reference
Xie N, Zeng L, Hu X, Wu Z, Lu W, Luo S, et al. Association of remnant cholesterol inflammation index with future cardiovascular disease risk in patients with cardiovascular-kidney-metabolic syndrome stages 0-3. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;233:113146. doi:10.1016/j.diabres.2026.113146
[22]Supporting
#37 · 2026

10.1016/j.diabres.2026.113223. Epub 2026 Mar 23. Cardiovascular-kidney-metabolic syndrome stages, stage transitions, and risk of cardiovascular disease and mortality: The Tehran Lipid and Glucose Study.

DIABETES RESEARCH AND CLINICAL PRACTICE
Masrouri S 等在一项纳入7770名无心血管疾病成人的研究中发现,CKM综合征2期和3期与心血管疾病及死亡风险显著升高相关,且约3年内每进展1期,风险增加1.40-2.01倍。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心血管-肾脏-代谢综合征心血管疾病冠心病心肌梗死卒中Cox回归队列研究心血管死亡率CKM分期PubMed疾病:cardiovascIDsDOI: 10.1016/j.diabres.2026.113223 PMID: 41881362QualityOriginal summaryIdentifierNumbered
Reference
Masrouri S, Ebrahimi N, Hasanpour A, Sohrabi B, Azizi F, Hadaegh. Cardiovascular-kidney-metabolic syndrome stages, stage transitions, and risk of cardiovascular disease and mortality: The Tehran Lipid and Glucose Study. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;235:113223. doi:10.1016/j.diabres.2026.113223
[69]Core
#38 · 2026

10.1016/j.diabres.2026.113233. Epub 2026 Apr 4. Cardiorenal protective effects of anti-diabetic drugs in early stage Cardiovascular-Kidney-Metabolic Syndrome: A multicenter, time-varying analysis.

DIABETES RESEARCH AND CLINICAL PRACTICE
Hao WR 等在一项纳入18,467例早期CKM综合征患者的时变分析中发现,多数抗糖尿病药物可降低心血管风险,但SGLT2抑制剂在肾脏保护和生存获益方面更具优势。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords心血管-肾脏-代谢综合征抗糖尿病药物SGLT-2抑制剂回顾性队列研究时变Cox模型终末期肾病全因死亡胰岛素PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1016/j.diabres.2026.113233 PMID: 41942012QualityOriginal summaryIdentifierNumbered
Reference
Hao WR, Liu JC, Fang YA, Hsu MH, Hsiu H, Chen CC. Cardiorenal protective effects of anti-diabetic drugs in early stage Cardiovascular-Kidney-Metabolic Syndrome: A multicenter, time-varying analysis. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;236:113233. doi:10.1016/j.diabres.2026.113233
[32]Supporting
#39 · 2026

10.1016/j.diabres.2026.113266. Epub 2026 Apr 16. Cardiovascular-kidney-metabolic syndrome stages and risk of diverse gastrointestinal diseases: a prospective cohort study and integrative proteomic analysis.

DIABETES RESEARCH AND CLINICAL PRACTICE
Xiang S 等基于354,444名英国生物银行参与者发现,心血管-肾脏-代谢综合征晚期显著增加多种胃肠道疾病风险,并识别出HGF、GDF15和PLAUR等核心蛋白介导该关联。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心血管-肾脏-代谢综合征胃肠道疾病Cox比例风险模型血浆蛋白质组学队列研究HGFGDF15PLAURPubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1016/j.diabres.2026.113266 PMID: 42000048QualityOriginal summaryIdentifierNumbered
Reference
Xiang S, Nie H, Wei Z, Li Y, Wang C, Che X, et al. Cardiovascular-kidney-metabolic syndrome stages and risk of diverse gastrointestinal diseases: a prospective cohort study and integrative proteomic analysis. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;236:113266. doi:10.1016/j.diabres.2026.113266
No ref no.Excluded
#40 · 2026

10.1016/j.diabres.2026.113273. Epub 2026 Apr 19. Comparative effectiveness of tirzepatide versus GLP-1 receptor agonists on cardiovascular-kidney-metabolic stage progression: a real-world cohort study.

DIABETES RESEARCH AND CLINICAL PRACTICE
Wu JY 等在一项纳入897,182名CKM 1-2期患者的真实世界队列研究中发现,替西帕肽相比GLP-1受体激动剂可显著降低进展至CKM 3-4期的风险(HR 0.88)。
Topic地热系统与超级马拉松代谢挑战等无关主题Keywords心血管肾脏代谢综合征替西帕肽胰高血糖素样肽-1受体激动剂倾向评分匹配Cox回归真实世界研究回顾性研究主要不良心血管事件全因死亡率PubMed疾病:cardiovascIDsDOI: 10.1016/j.diabres.2026.113273 PMID: 42009260QualityOriginal summaryIdentifierNo ref no.
Reference
Wu JY, Lee KW, Huang SC, Chang HY, Lin YM. 10.1016/j.diabres.2026.113273. Epub 2026 Apr 19. Comparative effectiveness of tirzepatide versus GLP-1 receptor agonists on cardiovascular-kidney-metabolic stage progression: a real-world cohort study.. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026. 236. 113273.. doi:10.1016/j.diabres.2026.113273
No ref no.Core
#41 · 2026

10.1016/j.diabres.2026.113288. Online ahead of print. DPP-4 inhibitors in current diabetes care: their foundational role in treating to target.

DIABETES RESEARCH AND CLINICAL PRACTICE
Avogaro A 等在综述中提出,DPP-4抑制剂可降低HbA1c约0.6-1.1%,低血糖风险低且耐受性良好,是连接“以目标为导向”与“以获益为导向”治疗策略的多功能选择。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords2型糖尿病DPP-4抑制剂系统综述糖化血红蛋白血糖控制心血管安全性低血糖风险联合用药PubMed疾病:CKM Title/AbstractckdIDsDOI: 10.1016/j.diabres.2026.113288 PMID: 42070662QualityOriginal summaryIdentifierNo ref no.
Reference
Avogaro A, Fiaccadori E, Rizzo MR. 10.1016/j.diabres.2026.113288. Online ahead of print. DPP-4 inhibitors in current diabetes care: their foundational role in treating to target.. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026. 237. 113288.. doi:10.1016/j.diabres.2026.113288
[38]Core
#42 · 2026

10.1016/j.diabres.2026.113336. Online ahead of print. Risk stratification in early-stage Cardiovascular-Kidney-Metabolic Syndrome: The Potency of visceral adiposity and insulin resistance surrogate indices.

DIABETES RESEARCH AND CLINICAL PRACTICE
He L 等综述发现,在早期心血管-肾脏-代谢综合征中,内脏脂肪和胰岛素抵抗替代指标(如腰围身高比、内脏脂肪指数)比传统测量方法具有更优的风险分层效能。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征内脏脂肪指数胰岛素抵抗腰围身高比系统综述风险分层体重指数线粒体应激PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1016/j.diabres.2026.113336 PMID: 42184891QualityOriginal summaryIdentifierNumbered
Reference
He L, Lin H, Zhang X, Ling X. Online ahead of print. Risk stratification in early-stage Cardiovascular-Kidney-Metabolic Syndrome: The Potency of visceral adiposity and insulin resistance surrogate indices. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;237:113336. doi:10.1016/j.diabres.2026.113336
[45]Supporting
#43 · 2026

The role of inflammation in longitudinal renal function decline and incident chronic kidney disease: the multi-ethnic study of atherosclerosis.

European Journal of Preventive Cardiology
Agboola OJ 等在一项纳入约4600名参与者的前瞻性队列研究中发现,较高的白细胞介素-6水平与更快的肾功能下降、蛋白尿加重及慢性肾脏病风险升高显著相关。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords慢性肾脏病炎症白细胞介素-6超敏C反应蛋白估算肾小球滤过率前瞻性队列研究Fine-Gray回归肾功能下降心血管-肾脏-代谢综合征PubMed疾病:CKM Title/AbstractIDsDOI: 10.1093/eurjpc/zwaf779 PMID: 41431747QualityOriginal summaryIdentifierNumbered
Reference
Agboola OJ, Chan JSK, Spitz JA, Chan RNC, Patel J. The role of inflammation in longitudinal renal function decline and incident chronic kidney disease: the multi-ethnic study of atherosclerosis. European Journal of Preventive Cardiology. 2026;33(5):718-728. doi:10.1093/eurjpc/zwaf779
[90]Extension
#44 · 2026

ahead of print. Frailty as a Risk-Enhancing Factor Across the Cardiovascular-Kidney-Metabolic Framework: Findings from the UK Biobank.

European Journal of Preventive Cardiology
Fang Y 等基于UK Biobank 408,163名参与者的前瞻性队列研究发现,衰弱与所有心血管-肾脏-代谢(CKM)分期中更高的心血管疾病风险显著相关,且该关联独立于传统风险因素。
TopicCKM定义评估空白与超加工食品的代谢影响Keywords衰弱心血管疾病心血管-肾脏-代谢Cox回归前瞻性队列研究Fried衰弱表型CKM分期英国生物银行PubMed疾病:CKM Title/AbstracttgsIDsDOI: 10.1093/eurjpc/zwag170 PMID: 41875371QualityOriginal summaryIdentifierNumbered
Reference
Fang Y, Huang S, Zhang H, Li M, Zhang H, Yang W, et al. ahead of print. Frailty as a Risk-Enhancing Factor Across the Cardiovascular-Kidney-Metabolic Framework: Findings from the UK Biobank. European Journal of Preventive Cardiology. 2026. doi:10.1093/eurjpc/zwag170
[88]Extension
#45 · 2026

ahead of print. Sex-Specific Associations Between Depression and Cardiovascular-Kidney-Metabolic Syndrome Progression: A National Cohort Study.

European Journal of Preventive Cardiology
Gao Q 等基于5035名中老年人群的全国队列研究发现,抑郁症状与心血管-肾脏-代谢综合征进展存在性别特异性关联,仅在女性中观察到显著风险增加。
Topic衰弱、非奈利酮及遗传多态性在CKM管理中的角色Keywords抑郁症心血管-肾脏-代谢综合征队列研究抑郁症状CKM进展性别差异流行病学调查风险预测PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1093/eurjpc/zwag135 PMID: 41802238QualityOriginal summaryIdentifierNumbered
Reference
Gao Q, Ren W, Du X, Yu Y, Ma Z, Cui Y, et al. ahead of print. Sex-Specific Associations Between Depression and Cardiovascular-Kidney-Metabolic Syndrome Progression: A National Cohort Study. European Journal of Preventive Cardiology. 2026. doi:10.1093/eurjpc/zwag135
[11]Core
#46 · 2026

10.1681/ASN.0000001016. Online ahead of print. Comparative Effectiveness of SGLT2 Inhibitor and GLP-1 Receptor Agonist on Kidney and Cardiovascular Outcomes by Kidney Failure Risk.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Hartsell SE 等在160,428名2型糖尿病退伍军人中发现,SGLT2抑制剂与GLP-1受体激动剂相比,死亡风险相似,但心血管事件风险略高;肾衰竭风险因患者基线风险水平而异。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords2型糖尿病肾衰竭SGLT-2抑制剂GLP-1受体激动剂逆概率治疗加权肾衰竭风险方程心血管事件队列研究真实世界研究全因死亡IDsDOI: 10.1681/ASN.0000001016 PMID: 41563358QualityOriginal summaryIdentifierNumbered
Reference
Hartsell SE, Wei G, Singh R, Throolin M. Online ahead of print. Comparative Effectiveness of SGLT2 Inhibitor and GLP-1 Receptor Agonist on Kidney and Cardiovascular Outcomes by Kidney Failure Risk. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2026. doi:10.1681/ASN.0000001016
[101]Core
#47 · 2026

Finerenone in CKD: Enhancing the Evidence Base in Real-World Contexts.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Mathew GG 在真实世界研究中发现,非奈利酮可有效改善慢性肾脏病患者的肾脏结局,为临床实践提供了额外证据支持。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords慢性肾病非奈利酮队列研究真实世界研究PubMed疾病:CKM Title/Abstractckdsglt型糖尿病肾脏抑制剂IDsDOI: 10.1681/ASN.0000000956 PMID: 41563387QualityOriginal summaryIdentifierNumbered
Reference
Mathew GG. Finerenone in CKD: Enhancing the Evidence Base in Real-World Contexts. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2026;37(2):423-424. doi:10.1681/ASN.0000000956
[91]Extension
#48 · 2026

Finerenone in CKD from Estimands to Clinical Interpretability under Competing Risk.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Wang A和Li Y在竞争风险框架下评估了非奈利酮在慢性肾脏病中的疗效,发现其临床获益在考虑死亡竞争风险后仍保持稳健。
TopicCKM定义评估空白与超加工食品的代谢影响Keywords慢性肾病非奈利酮系统综述竞争风险心肾综合征临床可解释性估计目标PubMed疾病:CKM Title/AbstracttgsactnIDsDOI: 10.1681/ASN.0000000925 PMID: 41563827QualityOriginal summaryIdentifierNumbered
Reference
Wang A, Li Y. Finerenone in CKD from Estimands to Clinical Interpretability under Competing Risk. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2026;37(2):425-426. doi:10.1681/ASN.0000000925
[70]Core
#49 · 2026

Online ahead of print. The Kidney in the Middle: KDIGO Guidelines Address Multiple Key Components of Cardiovascular-Kidney-Metabolic Syndrome.

KIDNEY INTERNATIONAL
Levin A 等基于KDIGO指南和争议会议报告,系统总结了慢性肾脏病在心血管-肾脏-代谢综合征中的核心作用,强调早期发现、全面风险管理和多学科协作的重要性。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords慢性肾脏病心血管疾病KDIGO指南血压管理糖尿病血脂异常系统综述心血管-肾脏-代谢综合征心力衰竭肥胖IDsDOI: 10.1016/j.kint.2026.03.031 PMID: 42191113QualityOriginal summaryIdentifierNumbered
Reference
Levin A, Bansal N, de Boer IH, Grams ME, Jadoul M, Ter Maaten. Online ahead of print. The Kidney in the Middle: KDIGO Guidelines Address Multiple Key Components of Cardiovascular-Kidney-Metabolic Syndrome. KIDNEY INTERNATIONAL. 2026. doi:10.1016/j.kint.2026.03.031
[73]Core
#50 · 2026

A urea-activated nanocarrier for site-specific SGLT2 inhibition and metabolic rescue against cardiovascular-kidney-metabolic syndrome.

Nature Communications
Ren X等开发了一种尿素激活的纳米载体,实现SGLT2抑制剂肾小管靶向递送,在CKM小鼠模型中有效改善心脏和肾脏代谢功能,优于游离药物。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords心血管-肾脏-代谢综合征SGLT-2抑制剂恩格列净纳米载体动物实验活性氧肾脏靶向能量代谢PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1038/s41467-026-71424-w PMID: 41932948QualityOriginal summaryIdentifierNumbered
Reference
Ren X, Gao D, Yun R, Liu X, Di C, Hu Z, et al. A urea-activated nanocarrier for site-specific SGLT2 inhibition and metabolic rescue against cardiovascular-kidney-metabolic syndrome. Nature Communications. 2026. doi:10.1038/s41467-026-71424-w
[2]Supporting
#51 · 2026

10.1161/CIRCULATIONAHA.125.077894. Epub 2026 Apr 1. Cardiovascular-Kidney-Metabolic Syndrome Stages, Echocardiographic Characteristics, and Heart Failure Risk: The Atherosclerosis Risk in Communities Study.

Circulation
Lassen MCH 等基于ARIC研究5,646名老年人数据发现,较高CKM综合征分期与左心室不良重构及心力衰竭风险显著增加相关,4期风险比达8.3。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心力衰竭心血管-肾脏-代谢综合征超声心动图心脏重构队列研究风险预测社区动脉粥样硬化风险研究PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏IDsDOI: 10.1161/CIRCULATIONAHA.125.077894 PMID: 41919388QualityOriginal summaryIdentifierNumbered
Reference
Lassen MCH, Ostrominski JW, Claggett BL, Ndumele CE. Cardiovascular-Kidney-Metabolic Syndrome Stages, Echocardiographic Characteristics, and Heart Failure Risk: The Atherosclerosis Risk in Communities Study. Circulation. 2026;153(17):1268-1280. doi:10.1161/CIRCULATIONAHA.125.077894
[63]Core
#52 · 2026

Advances in risk prediction and treatment strategies for CKM syndrome.

Nature Reviews Nephrology
Drexler Y 和 Fornoni A 综述了CKM综合征的风险预测与治疗策略进展,发现整合多器官指标可提升风险分层准确性,并强调了新型靶向治疗在延缓疾病进展中的潜力。
TopicCKM综合征分期与新型生物标志物的预后评估KeywordsCKM综合征风险预测治疗策略心血管疾病肾脏疾病代谢疾病综述PubMed疾病:CKM Title/Abstract肾脏代谢综合IDsDOI: 10.1038/s41581-025-01044-y PMID: 41402462QualityOriginal summaryIdentifierNumbered
Reference
Drexler Y, Fornoni A. Advances in risk prediction and treatment strategies for CKM syndrome. Nature Reviews Nephrology. 2026;22(2):95-96. doi:10.1038/s41581-025-01044-y
[3]Core
#53 · 2026

GLP-1 receptor agonists and next-generation metabolic hormone therapies in chronic kidney disease.

Nature Reviews Nephrology
Alicic RZ 等在一项纳入6,719名CKM综合征1-4期患者的前瞻性队列研究中发现,hs-CRP/HDL-C比值与长期死亡风险呈线性正相关,该比值每增加一个四分位数间距,死亡风险升高15%。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征Cox回归限制性立方样条hs-CRP/HDL-C比值全因死亡前瞻性队列研究风险预测PubMed疾病:CKM Title/Abstract肾脏代谢综合IDsDOI: 10.1038/s41581-025-01036-y PMID: 41507425QualityOriginal summaryIdentifierNumbered
Reference
Alicic RZ, Neumiller JJ, Tuttle KR. GLP-1 receptor agonists and next-generation metabolic hormone therapies in chronic kidney disease. Nature Reviews Nephrology. 2026;22(4):265-282. doi:10.1038/s41581-025-01036-y
[1]Core
#54 · 2026

print. Epidemiology of cardiovascular-kidney-metabolic syndrome.

Nature Reviews Nephrology
Mavromatis LA 和 Grams ME 综述了心血管-肾脏-代谢综合征的流行病学,发现全球患病率持续上升,多数成人已处于≥1期,且疾病负担存在人口学与地域差异。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords心血管-肾脏-代谢综合征慢性肾脏病心血管疾病胰高血糖素样肽-1受体激动剂钠-葡萄糖协同转运蛋白-2抑制剂系统综述代谢危险因素发病与死亡风险流行病学PubMed疾病:cardiovascIDsDOI: 10.1038/s41581-026-01078-w PMID: 42098477QualityOriginal summaryIdentifierNumbered
Reference
Mavromatis LA, Grams ME. print. Epidemiology of cardiovascular-kidney-metabolic syndrome. Nature Reviews Nephrology. 2026. doi:10.1038/s41581-026-01078-w
[29]Core
#55 · 2025

Association of Cardiovascular-Kidney-Metabolic Syndrome With Cognitive Decline and Dementia: The ARIC Study Insights.

Journal of the American Heart Association
Xie Peichen 等基于ARIC研究10,426名参与者发现,心血管-肾脏-代谢综合征风险等级升高与认知衰退及痴呆风险增加显著相关,风险每升一级痴呆进展风险增加6%。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征认知衰退痴呆回归分析CKM风险等级队列研究PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏代谢综合IDsDOI: 10.1161/JAHA.124.038445 PMID: 40371582QualityOriginal summaryIdentifierNumbered
Reference
Xie Peichen, Wang Yiqin, Xu Xinghao, Tan Li, Guo Xingdi, Xu Ziqi, et al. Association of Cardiovascular-Kidney-Metabolic Syndrome With Cognitive Decline and Dementia: The ARIC Study Insights. Journal of the American Heart Association. 2025;14(10):e038445. doi:10.1161/JAHA.124.038445
[20]Supporting
#56 · 2025

Associations of cardiovascular-kidney-metabolic syndrome stages with premature mortality and the role of social determinants of health.

Journal of Nutrition Health and Aging
Zhu R 等基于27,909名美国成年人数据发现,心血管-肾脏-代谢综合征3-4期与过早死亡风险显著升高相关,且不利健康社会决定因素进一步加剧该风险。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心血管-肾脏-代谢综合征过早死亡健康社会决定因素Cox比例风险模型风险比前瞻性队列研究全因死亡心血管死亡PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1016/j.jnha.2025.100504 PMID: 39952015QualityOriginal summaryIdentifierNumbered
Reference
Zhu R, Wang R, He J, Wang L, Chen H, Wang Y, et al. Associations of cardiovascular-kidney-metabolic syndrome stages with premature mortality and the role of social determinants of health. Journal of Nutrition Health and Aging. 2025;29(4):100504. doi:10.1016/j.jnha.2025.100504
[79]Extension
#57 · 2025

Cardiovascular-kidney-metabolic overlaps, clinical outcomes, and quality of life in patients with acute heart failure.

Journal of Nutrition Health and Aging
Li J等在一项纳入4,875例急性心衰患者的多中心队列中发现,合并三种心血管-肾脏-代谢疾病显著增加1年主要不良心血管事件及死亡风险,并降低生活质量。
Topic衰弱、非奈利酮及遗传多态性在CKM管理中的角色Keywords心力衰竭慢性肾脏病2型糖尿病Cox回归广义线性模型队列研究主要不良心血管事件全因死亡生活质量心血管死亡IDsDOI: 10.1016/j.jnha.2025.100613 PMID: 40555038QualityOriginal summaryIdentifierNumbered
Reference
Li J, Lei L, Zhang L, Guo Y, Yuan X. Cardiovascular-kidney-metabolic overlaps, clinical outcomes, and quality of life in patients with acute heart failure. Journal of Nutrition Health and Aging. 2025;29(8):100613. doi:10.1016/j.jnha.2025.100613
[59]Supporting
#58 · 2025

Temporal trends in the planetary health diet index and its association with cardiovascular, kidney, and metabolic diseases: A comprehensive analysis from global and individual perspectives.

Journal of Nutrition Health and Aging
Tang H 等基于185国数据及45,460名美国参与者分析发现,1990-2018年行星健康饮食指数评分全球平均为42.80,较高评分与心血管、肾脏及代谢疾病风险降低显著相关。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管疾病代谢性疾病慢性肾病行星健康饮食指数饮食评估横断面研究队列研究伤残调整生命年疾病负担CKM综合征IDsDOI: 10.1016/j.jnha.2025.100520 PMID: 39985957QualityOriginal summaryIdentifierNumbered
Reference
Tang H, Zhang X, Luo N, Huang J, Yang Q, Lin H, et al. Temporal trends in the planetary health diet index and its association with cardiovascular, kidney, and metabolic diseases: A comprehensive analysis from global and individual perspectives. Journal of Nutrition Health and Aging. 2025;29(5):100520. doi:10.1016/j.jnha.2025.100520
[104]Core
#59 · 2025

A simple score, CKM(2)S(2)-BAG, to predict cardiovascular risk with cardiovascular-kidney-metabolic health metrics.

iScience
Yang Z 等基于两个前瞻性社区队列构建并验证了CKM(2)S(2)-BAG评分,发现该评分能准确区分心血管低、中、高风险,对总CVD及其亚型预测性能稳健。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords心血管疾病心力衰竭动脉粥样硬化风险评分空腹血糖前瞻性队列研究外部验证胆固醇肾功能PubMed疾病:cardiovascIDsDOI: 10.1016/j.isci.2025.112780 PMID: 40599322QualityOriginal summaryIdentifierNumbered
Reference
Yang Z, Zhou P, Fan F, Hao Y, Zhao W, Wang Z, et al. A simple score, CKM(2)S(2)-BAG, to predict cardiovascular risk with cardiovascular-kidney-metabolic health metrics. iScience. 2025;28(7):112780. doi:10.1016/j.isci.2025.112780
No ref no.Excluded
#60 · 2025

Exploring a long distance, amagmatic, across-suture orogenic geothermal system: Sri Lanka's foreland hot springs.

iScience
Bandara D 等通过分析斯里兰卡前陆温泉的裂隙网络与地温梯度,发现流体可沿基底断裂运移达100公里,循环深度可达沉积盖层之下。
Topicc8Keywords温泉地热系统裂隙网络地温梯度循环深度横断面研究地热资源PubMed疾病:CKM Title/Abstract公里超过IDsDOI: 10.1016/j.isci.2025.112370 PMID: 40330879QualityOriginal summaryIdentifierNo ref no.
Reference
Bandara D, Smit J, Wohnlich S, Heinze T. Exploring a long distance, amagmatic, across-suture orogenic geothermal system: Sri Lanka's foreland hot springs.. iScience. 2025. 28(5). 112370.. doi:10.1016/j.isci.2025.112370
[74]Core
#61 · 2025

2025 Apr. Prognosis of non-albuminuric patients with the cardiovascular-kidney-metabolic syndrome.

Clinical Kidney Journal
Bi X 等基于中国和英国两个大型队列研究发现,正常范围内的尿白蛋白与肌酐比值升高与心血管-肾脏-代谢综合征患者进展至4期及全因死亡风险增加显著相关。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords心血管-肾脏-代谢综合征尿白蛋白肌酐比值队列研究Cox回归全因死亡率疾病进展中国肾脏数据系统英国生物银行PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1093/ckj/sfaf074 PMID: 40226369QualityOriginal summaryIdentifierNumbered
Reference
Bi X, Shen Y, Shen Y, Shen A, Zhou S, Wang W, et al. 2025 Apr. Prognosis of non-albuminuric patients with the cardiovascular-kidney-metabolic syndrome. Clinical Kidney Journal. 2025;18(4):sfaf074. doi:10.1093/ckj/sfaf074
No ref no.Supporting
#62 · 2025

2025 Jun. How do patient information documents present dialysis and conservative kidney management? A document analysis.

Clinical Kidney Journal
Sowden R 等通过定性文献分析发现,患者信息文件对透析和保守性肾脏管理的呈现存在不平衡,透析被构建为默认选择,而保守管理常被负面描述并与死亡关联。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords晚期肾病透析保守性肾脏管理患者信息文件定性文献分析批判性话语分析治疗决策预先护理计划姑息治疗PubMed疾病:CKM Title/AbstractIDsDOI: 10.1093/ckj/sfaf136 PMID: 40487369QualityOriginal summaryIdentifierNo ref no.
Reference
Sowden R, Shaw C, Robb J, Winterbottom A, Bristowe K, Bekker. 2025 Jun. How do patient information documents present dialysis and conservative kidney management? A document analysis.. Clinical Kidney Journal. 2025. 18(6). sfaf136.. doi:10.1093/ckj/sfaf136
No ref no.Excluded
#63 · 2025

eCollection 2025. Identifying potential drugs for treating Cardiovascular-kidney metabolic syndrome via reverse network pharmacology.

Frontiers in Pharmacology
Wen S 等通过反向网络药理学筛选出小檗碱(BBR)为治疗心血管-肾脏-代谢综合征(CKM)的潜在药物,并在小鼠模型中证实BBR可改善代谢紊乱、心脏舒张功能及肾损伤。
Topic地热系统与超级马拉松代谢挑战等无关主题Keywords心血管-肾脏-代谢综合征小檗碱反向网络药理学代谢参数动物实验心脏舒张功能肾损伤脂质代谢葡萄糖代谢纤维化通路IDsDOI: 10.3389/fphar.2025.1627236 PMID: 40661082QualityOriginal summaryIdentifierNo ref no.
Reference
Wen S, Fu A, Liu F, You Y,. eCollection 2025. Identifying potential drugs for treating Cardiovascular-kidney metabolic syndrome via reverse network pharmacology.. Frontiers in Pharmacology. 2025. 16. 1627236.. doi:10.3389/fphar.2025.1627236
No ref no.Excluded
#64 · 2025

Adipokines and Vascular Modulators in CKM: Emerging Biomarkers as Diagnostic and Therapeutic Targets.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Gerdanovics CA 等综述发现,脂肪因子(如RBP4、LCN2)和血管调节因子(如Klotho、MGP)在CKM综合征中失调,可作为诊断生物标志物和治疗靶点。
Topic地热系统与超级马拉松代谢挑战等无关主题Keywords心肾代谢综合征脂肪因子血管调节因子生物标志物治疗靶点系统综述视黄醇结合蛋白4Klotho基质Gla蛋白PubMed疾病:CKM Title/AbstractIDsDOI: 10.3390/ijms262211083 PMID: 41303567QualityOriginal summaryIdentifierNo ref no.
Reference
Gerdanovics CA, Suciu ȘM, Orășan OH, Para I, Turi VR, Milaciu. Adipokines and Vascular Modulators in CKM: Emerging Biomarkers as Diagnostic and Therapeutic Targets.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2025. 26(22). 11083.. doi:10.3390/ijms262211083
[100]Extension
#65 · 2025

Effects of Temperature and Salinity on Ovarian Development and Differences in Energy Metabolism Between Reproduction and Growth During Ovarian Development in the Lateolabrax maculatus.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Peng Y 等通过实验发现,低盐度(4‰)和低温(18±1°C)协同促进花鲈卵巢发育,并揭示卵巢依赖有氧代谢供能,肌肉则通过糖酵解将能量重新分配至性腺以维持繁殖与生长的平衡。
TopicCKM定义评估空白与超加工食品的代谢影响Keywords卵巢发育盐度温度能量代谢激素转录组代谢组实验研究PubMed疾病:CKM Title/AbstracttgsIDsDOI: 10.3390/ijms26178295 PMID: 40943217QualityOriginal summaryIdentifierNumbered
Reference
Peng Y, Yan L, Zhao C, Zhang B, Zhang B, Qiu. Effects of Temperature and Salinity on Ovarian Development and Differences in Energy Metabolism Between Reproduction and Growth During Ovarian Development in the Lateolabrax maculatus. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2025;26(17):8295. doi:10.3390/ijms26178295
No ref no.Excluded
#66 · 2025

Does Distance Matter? Metabolic and Muscular Challenges of a Non-Stop Ultramarathon with Sub-Analysis Depending on Running Distance.

Nutrients
John L 等在一项前瞻性观察性研究中发现,超级马拉松跑者赛后出现显著能量赤字、瘦素和胰岛素降低、饥饿素和肌肉损伤标志物升高,且230公里组变化最大。
Topicc8Keywords超级马拉松能量赤字瘦素饥饿素肌酸激酶乳酸脱氢酶前瞻性观察连续血糖监测肌肉损伤代谢紊乱IDsDOI: 10.3390/nu17233801 PMID: 41374091QualityOriginal summaryIdentifierNo ref no.
Reference
John L, Munk M, Bizjak R, Schulz SVW, Witzel J, Engler H,. Does Distance Matter? Metabolic and Muscular Challenges of a Non-Stop Ultramarathon with Sub-Analysis Depending on Running Distance.. Nutrients. 2025. 17(23). 3801.. doi:10.3390/nu17233801
[95]Extension
#67 · 2025

Influence of Genetic Polymorphisms and Biochemical Biomarkers on Response to Nutritional Iron Supplementation and Performance in a Professional Football Team: A Pilot Longitudinal Study.

Nutrients
Varillas-Delgado D等在一项针对职业足球运动员的纵向研究中发现,携带特定基因型(如ACE DD、ACTN3 CC)的运动员铁补充需求更少,且总基因型评分可有效预测补充需求及运动表现差异。
TopicCKM定义评估空白与超加工食品的代谢影响Keywords铁缺乏硫酸亚铁纵向研究铁蛋白血红蛋白基因多态性运动表现总基因型评分PubMed疾病:CKM Title/AbstracttgsIDsDOI: 10.3390/nu17081379 PMID: 40284242QualityOriginal summaryIdentifierNumbered
Reference
Varillas-Delgado D. Influence of Genetic Polymorphisms and Biochemical Biomarkers on Response to Nutritional Iron Supplementation and Performance in a Professional Football Team: A Pilot Longitudinal Study. Nutrients. 2025;17(8):1379. doi:10.3390/nu17081379
No ref no.Core
#68 · 2025

Medical Nutrition Therapy Adherence and Lifestyle in Stage 5 CKD: Challenges and Insights.

Nutrients
Palumbo P 等评估了接受保守管理的5期CKD患者对医学营养疗法的依从性,发现自我报告与生化指标存在差异,且糖尿病与较低的蛋白质摄入依从性显著相关。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords慢性肾脏病医学营养疗法饮食依从性蛋白质摄入队列研究饮食史标准化蛋白氮出现率糖尿病PubMed疾病:CKM Title/AbstractckdIDsDOI: 10.3390/nu17193091 PMID: 41097168QualityOriginal summaryIdentifierNo ref no.
Reference
Palumbo P, Alfano G, Cavani F, Giannini R, Pulizzi RA, Gabriele. Medical Nutrition Therapy Adherence and Lifestyle in Stage 5 CKD: Challenges and Insights.. Nutrients. 2025. 17(19). 3091.. doi:10.3390/nu17193091
No ref no.Supporting
#69 · 2025

2025. Altered albumin/neutrophil to lymphocyte ratio are associated with all-cause and cardiovascular mortality for advanced cardiovascular-kidney-metabolic syndrome.

Frontiers in Nutrition
Yin X 等基于3,266名晚期CKM综合征患者数据发现,白蛋白/中性粒细胞与淋巴细胞比值降低与全因及心血管死亡风险升高独立相关,呈L形关联。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心血管-肾脏-代谢综合征白蛋白中性粒细胞淋巴细胞比值全因死亡率心血管死亡率倾向评分匹配限制性立方样条Cox回归横断面研究队列研究国家健康与营养调查IDsDOI: 10.3389/fnut.2025.1595119 PMID: 40740647QualityOriginal summaryIdentifierNo ref no.
Reference
Yin X, Zou J, Yang J. 2025. Altered albumin/neutrophil to lymphocyte ratio are associated with all-cause and cardiovascular mortality for advanced cardiovascular-kidney-metabolic syndrome.. Frontiers in Nutrition. 2025. 12. 1595119.. doi:10.3389/fnut.2025.1595119
No ref no.Supporting
#70 · 2025

2025. Association between albumin to globulin ratio and all-cause and cardiovascular mortality among individuals with cardiovascular-kidney-metabolic syndrome: results from NHANES 2003 to 2018.

Frontiers in Nutrition
Wang G等基于NHANES数据库对CKM综合征患者分析发现,白蛋白与球蛋白比值升高与全因及心血管死亡风险显著降低相关,其中全因死亡呈非线性关联。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心血管-肾脏-代谢综合征白蛋白球蛋白比值全因死亡心血管死亡Cox回归队列研究剂量反应关系生物标志物PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fnut.2025.1622590 PMID: 40678773QualityOriginal summaryIdentifierNo ref no.
Reference
Wang G, Li G, Wang P, Zang M, Pu J. 2025. Association between albumin to globulin ratio and all-cause and cardiovascular mortality among individuals with cardiovascular-kidney-metabolic syndrome: results from NHANES 2003 to 2018.. Frontiers in Nutrition. 2025. 12. 1622590.. doi:10.3389/fnut.2025.1622590
[39]Core
#71 · 2025

2025. Association between body roundness index and advanced cardiovascular-kidney-metabolic syndrome.

Frontiers in Nutrition
Chen Y 等基于12,329名美国成年人数据发现,身体圆度指数升高与晚期心血管-肾脏-代谢综合征风险呈正相关,且其预测能力优于传统人体测量指标。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords晚期CKM综合征身体圆度指数横断面研究限制性立方样条受试者工作特征分析回归分析人体测量指标内脏脂肪PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fnut.2025.1623766 PMID: 40808842QualityOriginal summaryIdentifierNumbered
Reference
Chen Y, Tu H, Liang M, Shen M. 2025. Association between body roundness index and advanced cardiovascular-kidney-metabolic syndrome. Frontiers in Nutrition. 2025;12:1623766. doi:10.3389/fnut.2025.1623766
[61]Core
#72 · 2025

2025. Association between dietary index for gut microbiota and cardiovascular-kidney-metabolic syndrome: a population-based study.

Frontiers in Nutrition
Long D 等基于8,400名美国成年人数据发现,肠道微生物群膳食指数(DI-GM)评分与心血管-肾脏-代谢综合征患病率呈线性负相关,且女性中保护效应更显著。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征肠道微生物群膳食指数横断面研究限制性立方样条逻辑回归患病率膳食质量性别差异PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fnut.2025.1594481 PMID: 40808844QualityOriginal summaryIdentifierNumbered
Reference
Long D, Mao C, An H, Zhu Y, Xu Y. 2025. Association between dietary index for gut microbiota and cardiovascular-kidney-metabolic syndrome: a population-based study. Frontiers in Nutrition. 2025;12:1594481. doi:10.3389/fnut.2025.1594481
[50]Supporting
#73 · 2025

2025. Association between dietary inflammatory index score and cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES.

Frontiers in Nutrition
Yu H 等基于NHANES数据库的横断面研究发现,膳食炎症指数升高与心血管-肾脏-代谢综合征患病风险增加呈线性正相关,其中酒精摄入是关联最强的膳食因素。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征膳食炎症指数横断面研究多元逻辑回归限制性立方样条慢性肾脏病心脏代谢综合征酒精摄入PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fnut.2025.1557491 PMID: 40416382QualityOriginal summaryIdentifierNumbered
Reference
Yu H, Liu Y, Zhang T, Guan Z, Li P. 2025. Association between dietary inflammatory index score and cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES. Frontiers in Nutrition. 2025;12:1557491. doi:10.3389/fnut.2025.1557491
[48]Core
#74 · 2025

2025. Association between non-highdensity lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiovascular-kidney-metabolic syndrome: evidence from NHANES 2001-2018.

Frontiers in Nutrition
Duan Y 等基于NHANES 2001-2018年16,575名成人数据发现,非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值升高与心血管-肾脏-代谢综合征风险呈正相关,且存在非线性关联。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords慢性肾脏病心血管代谢综合征非高密度脂蛋白胆固醇限制性立方样条横断面研究体重指数高血压PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏IDsDOI: 10.3389/fnut.2025.1548851 PMID: 40093879QualityOriginal summaryIdentifierNumbered
Reference
Duan Y, Yang K, Zhang T, Guo X, Yin Q, Liu H. 2025. Association between non-highdensity lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiovascular-kidney-metabolic syndrome: evidence from NHANES 2001-2018. Frontiers in Nutrition. 2025;12:1548851. doi:10.3389/fnut.2025.1548851
[51]Core
#75 · 2025

2025. Association between oxidative balance score with cardiovascular - kidney - metabolic syndrome and all-cause mortality among US population.

Frontiers in Nutrition
Shi L 等基于12,793名美国成年人数据发现,较高的氧化平衡评分与晚期心血管-肾脏-代谢综合征风险及全因死亡率呈负相关,且存在剂量-反应关系。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征氧化平衡评分全因死亡率限制性立方样条Cox回归Logistic回归横断面研究队列研究PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fnut.2025.1564368 PMID: 40837432QualityOriginal summaryIdentifierNumbered
Reference
Shi L, Zhang D, Zhang S. 2025. Association between oxidative balance score with cardiovascular - kidney - metabolic syndrome and all-cause mortality among US population. Frontiers in Nutrition. 2025;12:1564368. doi:10.3389/fnut.2025.1564368
[54]Core
#76 · 2025

2025. Association between the composite dietary antioxidant index and cardiovascular-kidney-metabolic syndrome among U.S. adults: evidence from NHANES 2007-2018.

Frontiers in Nutrition
He Q 等基于NHANES 2007-2018年11,073名成人数据发现,复合膳食抗氧化指数升高与晚期心血管-肾脏-代谢综合征患病风险降低呈非线性负相关。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征复合膳食抗氧化指数横断面研究逻辑回归限制性立方样条维生素类胡萝卜素PubMed疾病:cardiovascIDsDOI: 10.3389/fnut.2025.1600651 PMID: 40709338QualityOriginal summaryIdentifierNumbered
Reference
He Q, Hu F, Wei W, Li J, Yu Y, Zhang H. 2025. Association between the composite dietary antioxidant index and cardiovascular-kidney-metabolic syndrome among U.S. adults: evidence from NHANES 2007-2018. Frontiers in Nutrition. 2025;12:1600651. doi:10.3389/fnut.2025.1600651
[31]Core
#77 · 2025

2025. Association between the dietary inflammatory index and depressive symptoms in adults with cardiovascular-kidney-metabolic syndrome: evidence of metabolic syndrome as a mediator.

Frontiers in Nutrition
Tian RN 等基于12,980名CKM综合征成人数据发现,膳食炎症指数与抑郁症状呈J形非线性关联,且代谢综合征介导了4.44%的效应。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords抑郁症状代谢综合征膳食炎症指数限制性立方样条逻辑回归横断面研究心血管肾脏代谢综合征中介效应PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fnut.2025.1623482 PMID: 40808838QualityOriginal summaryIdentifierNumbered
Reference
Tian RN, Zhang SX, Zhang N, Wu WJ, Guo HQ, Wang C. 2025. Association between the dietary inflammatory index and depressive symptoms in adults with cardiovascular-kidney-metabolic syndrome: evidence of metabolic syndrome as a mediator. Frontiers in Nutrition. 2025;12:1623482. doi:10.3389/fnut.2025.1623482
No ref no.Core
#78 · 2025

2025. Association between the life's essential 8 health behaviors score and all-cause mortality in cardiovascular-kidney-metabolic syndrome patients.

Frontiers in Nutrition
Tu D 等基于11,638名CKM综合征患者的前瞻性队列研究发现,生命八要素健康行为评分与全因死亡率显著相关,尤其在晚期患者中关联更强,且改善评分可避免约23%的死亡。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征全因死亡率生命八要素Cox回归限制性立方样条队列研究健康行为评分人群归因分数PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fnut.2025.1612693 PMID: 40655481QualityOriginal summaryIdentifierNo ref no.
Reference
Tu D, Zuo X, Li P, Wang J. 2025. Association between the life's essential 8 health behaviors score and all-cause mortality in cardiovascular-kidney-metabolic syndrome patients.. Frontiers in Nutrition. 2025. 12. 1612693.. doi:10.3389/fnut.2025.1612693
[56]Supporting
#79 · 2025

2025. Association between urinary heavy metals and cardiovascular-kidney-metabolic syndrome: mediating roles of TyG, WWI, and eGFR.

Frontiers in Nutrition
Liu J 等基于NHANES数据发现,尿重金属暴露与晚期心血管-肾脏-代谢综合征风险正相关,且TyG、WWI和eGFR部分中介了该关联。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征重金属暴露甘油三酯-葡萄糖指数体重调整腰围指数估算肾小球滤过率限制性立方样条加权分位数和回归横断面研究中介分析IDsDOI: 10.3389/fnut.2025.1613721 PMID: 40635894QualityOriginal summaryIdentifierNumbered
Reference
Liu J, Song Y, Luo R, Wang S, Pan P, Han L. 2025. Association between urinary heavy metals and cardiovascular-kidney-metabolic syndrome: mediating roles of TyG, WWI, and eGFR. Frontiers in Nutrition. 2025;12:1613721. doi:10.3389/fnut.2025.1613721
[46]Core
#80 · 2025

2025. Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study.

Frontiers in Nutrition
Pengfei C 等基于301,631名CKM综合征患者的前瞻性队列研究发现,升高的SII和SIRI与心血管疾病发病风险显著相关,其中SII呈U型关联,SIRI呈单调递增关联。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管疾病心血管-肾脏-代谢综合征全身免疫炎症指数全身炎症反应指数Cox回归限制性立方样条队列研究发病率PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fnut.2025.1661826 PMID: 41368184QualityOriginal summaryIdentifierNumbered
Reference
Pengfei C, Lui M, Zhang L, Chen C, Wang T, Ailin H. 2025. Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study. Frontiers in Nutrition. 2025;12:1661826. doi:10.3389/fnut.2025.1661826
No ref no.Supporting
#81 · 2025

2025. Association of cardiovascular-kidney-metabolic syndrome with depression and all-cause mortality: a population-based observational study.

Frontiers in Nutrition
Liu W等基于15,156名参与者数据发现,随着心血管-肾脏-代谢综合征分期进展,抑郁症患病率升高,晚期CKM综合征显著增加抑郁症患者的全因死亡风险。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征抑郁症全因死亡患者健康问卷-9多变量逻辑回归多变量Cox回归Kaplan-Meier生存分析横断面研究年龄标准化患病率美国成年人IDsDOI: 10.3389/fnut.2025.1620008 PMID: 41256919QualityOriginal summaryIdentifierNo ref no.
Reference
Liu W, Li Z, Ma P. 2025. Association of cardiovascular-kidney-metabolic syndrome with depression and all-cause mortality: a population-based observational study.. Frontiers in Nutrition. 2025. 12. 1620008.. doi:10.3389/fnut.2025.1620008
No ref no.Supporting
#82 · 2025

2025. Association of multiple dietary metal intake with cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES 2003-2018.

Frontiers in Nutrition
Hu S 等基于NHANES 2003-2018年15,233名成人数据发现,较高膳食铜摄入量与晚期心血管-肾脏-代谢综合征患病率降低显著相关。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征膳食金属摄入横断面研究加权逻辑回归限制性立方样条美国国家健康与营养调查亚组分析PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fnut.2025.1612458 PMID: 40761350QualityOriginal summaryIdentifierNo ref no.
Reference
Hu S, Wei B, Zhang A. 2025. Association of multiple dietary metal intake with cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES 2003-2018.. Frontiers in Nutrition. 2025. 12. 1612458.. doi:10.3389/fnut.2025.1612458
[47]Core
#83 · 2025

2025. Association of neutrophil/high-density lipoprotein cholesterol ratio with the cardiovascular-kidney-metabolic syndrome and its cardiovascular mortality.

Frontiers in Nutrition
Xu Y等基于13,165名美国成年人数据发现,中性粒细胞/高密度脂蛋白胆固醇比值升高与心血管-肾脏-代谢综合征患病率及心血管死亡风险呈正向线性关联。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征中性粒细胞/高密度脂蛋白胆固醇比值心血管死亡率Cox回归限制性立方样条横断面研究逻辑回归PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏IDsDOI: 10.3389/fnut.2025.1594041 PMID: 40535046QualityOriginal summaryIdentifierNumbered
Reference
Xu Y. 2025. Association of neutrophil/high-density lipoprotein cholesterol ratio with the cardiovascular-kidney-metabolic syndrome and its cardiovascular mortality. Frontiers in Nutrition. 2025;12:1594041. doi:10.3389/fnut.2025.1594041
No ref no.Supporting
#84 · 2025

2025. Associations between Life's Crucial 9 and severity, all-cause mortality, and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: the mediating role of phenotypic age acceleration.

Frontiers in Nutrition
Li J等基于7,647例CKM综合征患者数据发现,Life's Crucial 9评分每增加10%,进展至晚期CKM综合征风险降低37%,且与全因及心血管死亡率显著负相关,表型年龄加速在其中起中介作用。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征生命关键9项表型年龄加速全因死亡率心血管死亡率逻辑回归Cox回归限制性立方样条横断面研究中介分析IDsDOI: 10.3389/fnut.2025.1612293 PMID: 40843205QualityOriginal summaryIdentifierNo ref no.
Reference
Li J, Xu Z, Lin J, Luo S, Xu S. 2025. Associations between Life's Crucial 9 and severity, all-cause mortality, and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: the mediating role of phenotypic age acceleration.. Frontiers in Nutrition. 2025. 12. 1612293.. doi:10.3389/fnut.2025.1612293
[30]Supporting
#85 · 2025

2025. Cardiovascular-kidney-metabolic progression associated with major adverse liver outcomes: mediating roles of plasma metabolites.

Frontiers in Nutrition
Liang J 等基于英国生物银行415,713人数据发现,心血管-肾脏-代谢综合征分期进展与主要不良肝脏结局风险升高显著相关,该关联部分由酪氨酸和亚油酸/总脂肪酸比值等血浆代谢物介导。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心血管-肾脏-代谢综合征主要不良肝脏结局Cox回归血浆代谢物酪氨酸亚油酸前瞻性队列研究中介分析PubMed疾病:CKM Title/Abstract肾脏IDsDOI: 10.3389/fnut.2025.1675899 PMID: 41190151QualityOriginal summaryIdentifierNumbered
Reference
Liang J, Liang Y, Chen L, Cai M, Li S, He L. 2025. Cardiovascular-kidney-metabolic progression associated with major adverse liver outcomes: mediating roles of plasma metabolites. Frontiers in Nutrition. 2025;12:1675899. doi:10.3389/fnut.2025.1675899
[49]Supporting
#86 · 2025

2025. Machine learning with decision curve analysis evaluates nutritional metabolic biomarkers for cardiovascular-kidney-metabolic risk: an NHANES analysis.

Frontiers in Nutrition
Huang J 等基于NHANES数据,通过机器学习与决策曲线分析发现,RAR、SIRI等营养代谢生物标志物与心血管-肾脏-代谢综合征风险显著相关,其中RAR关联最强。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征胰岛素抵抗机器学习决策曲线分析限制性立方样条Cox回归RARNPAR队列研究PubMed疾病:cardiovascIDsDOI: 10.3389/fnut.2025.1597864 PMID: 40406158QualityOriginal summaryIdentifierNumbered
Reference
Huang J, Liu Z, Feng W, Huang Y, Cheng X. 2025. Machine learning with decision curve analysis evaluates nutritional metabolic biomarkers for cardiovascular-kidney-metabolic risk: an NHANES analysis. Frontiers in Nutrition. 2025;12:1597864. doi:10.3389/fnut.2025.1597864
[53]Core
#87 · 2025

2025. Non-linear associations and threshold effects of oxidative balance score and composite dietary antioxidant index on frailty risk in patients with cardiovascular-kidney-metabolic syndrome.

Frontiers in Nutrition
Wang Z等基于10,201例早期心血管-肾脏-代谢综合征患者数据发现,氧化平衡评分和复合膳食抗氧化指数与衰弱风险呈非线性负相关,并存在阈值效应。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征衰弱氧化平衡评分复合膳食抗氧化指数限制性立方样条横断面研究阈值效应逻辑回归PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fnut.2025.1673736 PMID: 41256923QualityOriginal summaryIdentifierNumbered
Reference
Wang Z, Fang L, Wang L, Zhang J. 2025. Non-linear associations and threshold effects of oxidative balance score and composite dietary antioxidant index on frailty risk in patients with cardiovascular-kidney-metabolic syndrome. Frontiers in Nutrition. 2025;12:1673736. doi:10.3389/fnut.2025.1673736
[52]Supporting
#88 · 2025

2025. The role of oxidative balance score in Cardiovascular-Kidney-Metabolic syndrome progression and mortality: insights from NHANES 1999-2020.

Frontiers in Nutrition
Xie D 等基于NHANES 1999-2020年19,433名参与者数据发现,氧化平衡评分升高与心血管-肾脏-代谢综合征进展风险降低及死亡风险下降显著相关,炎症标志物部分介导该关联。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征氧化平衡评分多项逻辑回归Cox模型全因死亡风险心血管死亡风险炎症标志物队列研究PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fnut.2025.1597693 PMID: 40667446QualityOriginal summaryIdentifierNumbered
Reference
Xie D, You F, Yang L, Li C, Liu F. 2025. The role of oxidative balance score in Cardiovascular-Kidney-Metabolic syndrome progression and mortality: insights from NHANES 1999-2020. Frontiers in Nutrition. 2025;12:1597693. doi:10.3389/fnut.2025.1597693
[89]Extension
#89 · 2025

Adverse Life Events Across the Life Course and the Risk of New-Onset Cardiovascular-Kidney-Metabolic Multimorbidity in Middle-Aged and Older Adults: Longitudinal Evidence From CHARLS.

Journal of the American Heart Association
Shi P 等基于CHARLS中6258名中老年人数据发现,儿童期和成年期不良生活事件均与新发心血管-肾脏-代谢多病共存风险升高显著相关,且暴力与剥夺型事件风险最高,心理健康部分中介该关联。
Topic衰弱、非奈利酮及遗传多态性在CKM管理中的角色Keywords心血管肾脏代谢多病共存不良生活事件队列研究多状态时间模型中介分析心理健康生命历程中国健康与养老追踪调查PubMed疾病:CKM Title/Abstract多病共存IDsDOI: 10.1161/JAHA.125.045192 PMID: 41378494QualityOriginal summaryIdentifierNumbered
Reference
Shi P, Lou C, Fang J, Song Y. Adverse Life Events Across the Life Course and the Risk of New-Onset Cardiovascular-Kidney-Metabolic Multimorbidity in Middle-Aged and Older Adults: Longitudinal Evidence From CHARLS. Journal of the American Heart Association. 2025;14(24):e045192. doi:10.1161/JAHA.125.045192
[86]Extension
#90 · 2025

Association of Atherogenic Index of Plasma With Stroke Risk in a Population With Cardiovascular-Kidney-Metabolic Syndrome Stages 0 to 3: The First Evidence From the China Health and Retirement Longitudinal Study.

Journal of the American Heart Association
Liu Z 等基于中国健康与养老追踪研究7664名CKM综合征0-3期人群发现,血浆致动脉粥样硬化指数升高与卒中风险增加呈非线性关联,阈值为1.516。
Topic衰弱、非奈利酮及遗传多态性在CKM管理中的角色Keywords卒中心血管-肾脏-代谢综合征血浆致动脉粥样硬化指数Cox回归限制性立方样条队列研究甘油三酯高密度脂蛋白胆固醇PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1161/JAHA.124.039983 PMID: 40654258QualityOriginal summaryIdentifierNumbered
Reference
Liu Z, Zhou D, Tang Y, Huo G. Association of Atherogenic Index of Plasma With Stroke Risk in a Population With Cardiovascular-Kidney-Metabolic Syndrome Stages 0 to 3: The First Evidence From the China Health and Retirement Longitudinal Study. Journal of the American Heart Association. 2025;14(14):e039983. doi:10.1161/JAHA.124.039983
No ref no.Supporting
#91 · 2025

Climate Vulnerability and Cardiovascular-Kidney-Metabolic Disease in the United States.

Journal of the American Heart Association
Vieira de Oliveira Salerno PR 等基于70,300个人口普查区数据发现,气候脆弱性指数各维度与心血管-肾脏-代谢综合征组分患病率显著相关,且关联独立于环境、社会经济及基础设施因素。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征气候脆弱性横断面研究慢性肾脏病糖尿病高血压肥胖血脂异常冠心病患病率IDsDOI: 10.1161/JAHA.124.038251 PMID: 40417800QualityOriginal summaryIdentifierNo ref no.
Reference
Vieira de Oliveira Salerno PR, Lewis PGT, Chen Z, Dazard JE, Ganatra. Climate Vulnerability and Cardiovascular-Kidney-Metabolic Disease in the United States.. Journal of the American Heart Association. 2025. 14(11). e038251.. doi:10.1161/JAHA.124.038251
No ref no.Supporting
#92 · 2025

Impact of DNA-Methylation Age Acceleration on Long-Term Mortality Among US Adults With Cardiovascular-Kidney-Metabolic Syndrome.

Journal of the American Heart Association
Wu S 等在一项纳入1889名美国成人的队列研究中发现,DNA甲基化年龄加速与心血管-肾脏-代谢综合征晚期分期及长期全因和非心血管死亡率升高显著相关。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心血管-肾脏-代谢综合征DNA甲基化年龄加速队列研究全因死亡率Cox比例风险回归GrimAge2Mort加速非心血管死亡率生物标志物中介分析健康饮食指数IDsDOI: 10.1161/JAHA.124.039751 PMID: 40118808QualityOriginal summaryIdentifierNo ref no.
Reference
Wu S, Zhu J, Lyu S, Wang J, Shao X, Zhang H,. Impact of DNA-Methylation Age Acceleration on Long-Term Mortality Among US Adults With Cardiovascular-Kidney-Metabolic Syndrome.. Journal of the American Heart Association. 2025. 14(7). e039751.. doi:10.1161/JAHA.124.039751
No ref no.Excluded
#93 · 2025

Incorporation of Metabolic Dysfunction-Associated Steatotic Liver Disease in the Health Stage of Cardiovascular-Kidney-Metabolic Syndrome Improves Predictive Ability for Coronary Artery Disease in a Japanese General Population.

Journal of the American Heart Association
Kawaharata W 等将代谢相关脂肪性肝病纳入心血管-肾脏-代谢综合征健康分期,发现改良分类能更有效分层日本普通人群的冠状动脉疾病风险。
Topic地热系统与超级马拉松代谢挑战等无关主题Keywords冠状动脉疾病代谢功能障碍相关脂肪性肝病心血管-肾脏-代谢综合征队列研究Cox比例风险分析综合判别改善指数风险比机器学习健康体检PubMed疾病:cardiovascIDsDOI: 10.1161/JAHA.125.043173 PMID: 40767277QualityOriginal summaryIdentifierNo ref no.
Reference
Kawaharata W, Tanaka M, Sato T, Akiyama Y, Hosaka I, Aida. Incorporation of Metabolic Dysfunction-Associated Steatotic Liver Disease in the Health Stage of Cardiovascular-Kidney-Metabolic Syndrome Improves Predictive Ability for Coronary Artery Disease in a Japanese General Population.. Journal of the American Heart Association. 2025. 14(16). e043173.. doi:10.1161/JAHA.125.043173
[62]Core
#94 · 2025

Overall Sleep Quality Is Associated With Advanced Stages in Patients With Cardiovascular-Kidney-Metabolic Syndrome.

Journal of the American Heart Association
Tu D 等基于12,245名美国成年人数据发现,整体睡眠质量较高的CKM综合征患者处于晚期的可能性较低,中等和高睡眠质量组晚期风险分别降低32%和45%。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征睡眠质量横断面研究逻辑回归优势比美国成年人肥胖糖尿病慢性肾脏病PubMed疾病:cardiovascIDsDOI: 10.1161/JAHA.124.038674 PMID: 40130386QualityOriginal summaryIdentifierNumbered
Reference
Tu D, Sun J, Wang P, Xu Q, Ma C. Overall Sleep Quality Is Associated With Advanced Stages in Patients With Cardiovascular-Kidney-Metabolic Syndrome. Journal of the American Heart Association. 2025;14(7):e038674. doi:10.1161/JAHA.124.038674
[26]Core
#95 · 2025

Prevalence of Cardiovascular-Kidney-Metabolic Stages in US Adolescents and Relationship to Social Determinants of Health.

Journal of the American Heart Association
Baker-Smith CM 等基于1774名美国青少年数据发现,56%处于心肾代谢综合征0期,食品安全缺乏与CKM 1-2期风险升高40%显著相关。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心肾代谢综合征动脉粥样硬化食品安全横断面研究逻辑回归家庭收入健康保险青少年PubMed疾病:CKM Title/Abstract肾脏IDsDOI: 10.1161/JAHA.124.040269 PMID: 40371589QualityOriginal summaryIdentifierNumbered
Reference
Baker-Smith CM, Gauen AM, Petito LC, Khan SS, Allen. Prevalence of Cardiovascular-Kidney-Metabolic Stages in US Adolescents and Relationship to Social Determinants of Health. Journal of the American Heart Association. 2025;14(10):e040269. doi:10.1161/JAHA.124.040269
[80]Extension
#96 · 2025

Reduced Risk of Cardiovascular Diseases After Bariatric Surgery Based on the New Predicting Risk of Cardiovascular Disease EVENTs Equations.

Journal of the American Heart Association
Wang L 等基于7804例减重手术患者数据,发现术后心血管-肾脏-代谢健康显著改善,10年及30年心血管疾病风险均下降,其中心力衰竭风险降低47%-56%。
Topic衰弱、非奈利酮及遗传多态性在CKM管理中的角色Keywords心血管疾病减重手术队列研究心力衰竭收缩压糖尿病心血管事件预测风险方程体重减轻PubMed疾病:CKM Title/Abstract多病共存IDsDOI: 10.1161/JAHA.124.038191 PMID: 40055867QualityOriginal summaryIdentifierNumbered
Reference
Wang L, Zhang X, Chen Y, Flynn CR, English WJ, Samuels JM. Reduced Risk of Cardiovascular Diseases After Bariatric Surgery Based on the New Predicting Risk of Cardiovascular Disease EVENTs Equations. Journal of the American Heart Association. 2025;14(6):e038191. doi:10.1161/JAHA.124.038191
[66]Core
#97 · 2025

The cellular and molecular mechanisms mediating the protective effects of sodium-glucose linked transporter 2 inhibitors against metabolic dysfunction-associated fatty liver disease.

DIABETES OBESITY and METABOLISM
Ao N 等综述了SGLT2抑制剂对MAFLD的保护作用,发现其通过细胞与分子机制改善脂肪肝及相关合并症(如心血管病和慢性肾病)。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords代谢功能障碍相关脂肪性肝病SGLT2抑制剂系统综述心血管疾病慢性肾脏病2型糖尿病细胞与分子机制心血管-肾脏-代谢综合征PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1111/dom.16043 PMID: 39508115QualityOriginal summaryIdentifierNumbered
Reference
Ao N, Du J, Jin S, Suo L, Yang J. The cellular and molecular mechanisms mediating the protective effects of sodium-glucose linked transporter 2 inhibitors against metabolic dysfunction-associated fatty liver disease. DIABETES OBESITY and METABOLISM. 2025;27(2):457-467. doi:10.1111/dom.16043
No ref no.Extension
#98 · 2025

eCollection 2025 Apr. Conservative Kidney Management in the Middle East and North Africa: Attitudes, Practices, and Implementation Barriers.

Kidney International Reports
Koubar SH 等通过一项涵盖336名肾脏病专家的调查发现,中东和北非地区对保守性肾脏管理认知度较高,但实施率低,主要障碍为资金和资源限制。
TopicCKM定义评估空白与超加工食品的代谢影响Keywords慢性肾病保守性肾脏管理横断面研究问卷调查实施障碍肾脏病专家中东和北非PubMed疾病:CKM Title/AbstracttgsactnIDsDOI: 10.1016/j.ekir.2025.01.011 PMID: 40303211QualityOriginal summaryIdentifierNo ref no.
Reference
Koubar SH, Hatab T, Razzak FA, Helal I, Ali A, Shebani A,. eCollection 2025 Apr. Conservative Kidney Management in the Middle East and North Africa: Attitudes, Practices, and Implementation Barriers.. Kidney International Reports. 2025. 10(4). 1076-1086.. doi:10.1016/j.ekir.2025.01.011
No ref no.Core
#99 · 2025

eCollection 2025 Aug. Kidney Disease: Improving Global Outcomes Summit Recommendations on Implementation of Diabetes Management in CKD: From Primary to Data-Driven Collaborative Care.

Kidney International Reports
Li 等通过db/db小鼠模型结合多组学分析发现,铁皮石斛通过调控NF-κB、PI3K-Akt通路及甘油磷脂、硫代谢,改善高血糖、胰岛素抵抗和肾功能障碍。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords2型糖尿病铁皮石斛动物实验多组学分析胰岛素抵抗肾功能障碍代谢物NF-κB通路PI3K-Akt通路氧化应激IDsDOI: 10.1016/j.ekir.2025.06.010 PMID: 40814615QualityOriginal summaryIdentifierNo ref no.
Reference
Li PK, Cheung M, Chow KM, Leung MKW, Lim LL, Lui. eCollection 2025 Aug. Kidney Disease: Improving Global Outcomes Summit Recommendations on Implementation of Diabetes Management in CKD: From Primary to Data-Driven Collaborative Care.. Kidney International Reports. 2025. 10(8). 2551-2565.. doi:10.1016/j.ekir.2025.06.010
No ref no.Supporting
#100 · 2025

10.1016/j.ecoenv.2025.118885. Epub 2025 Aug 16. Cadmium exposure and advanced cardiovascular-kidney-metabolic syndrome: An integrated multi-organ perspective based on epidemiology and adverse outcome pathways.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
He Y等基于NHANES 14,372名参与者数据发现,估算脉搏波传导速度升高与心血管-肾脏-代谢综合征风险呈非线性正相关,且在年轻成人中关联更强。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征估算脉搏波传导速度甘油三酯-葡萄糖指数横断面研究限制性立方样条Cox比例风险模型动脉僵硬度死亡率PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1016/j.ecoenv.2025.118885 PMID: 40819402QualityOriginal summaryIdentifierNo ref no.
Reference
He Y, Zhou X, Huang W, Wu Y, Zhang Z, Jin Y, et al. 10.1016/j.ecoenv.2025.118885. Epub 2025 Aug 16. Cadmium exposure and advanced cardiovascular-kidney-metabolic syndrome: An integrated multi-organ perspective based on epidemiology and adverse outcome pathways.. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2025. 303. 118885.. doi:10.1016/j.ecoenv.2025.118885
[57]Supporting
#101 · 2025

10.1016/j.ecoenv.2025.118915. Epub 2025 Aug 23. Effects of ambient air pollution mixtures and household fuel use on progression to advanced cardiovascular-kidney-metabolic syndrome among middle-aged and older adults.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Fan S 等基于中国健康与养老追踪调查数据发现,环境空气污染物与家庭固体燃料使用共同暴露显著增加中老年人晚期心血管-肾脏-代谢综合征风险,其中PM₁₀是主要驱动因素。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征空气污染家庭燃料队列研究加权分位数和回归贝叶斯核机器回归PM₁₀中老年人PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1016/j.ecoenv.2025.118915 PMID: 40850115QualityOriginal summaryIdentifierNumbered
Reference
Fan S, Hu H, Li Y, Deng Y, Wang S, Xian J, et al. Effects of ambient air pollution mixtures and household fuel use on progression to advanced cardiovascular-kidney-metabolic syndrome among middle-aged and older adults. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2025;303:118915. doi:10.1016/j.ecoenv.2025.118915
[64]Supporting
#102 · 2025

10.1016/j.ecoenv.2025.118993. Epub 2025 Sep 2. Environment-wide association study of cardiovascular-kidney-metabolic syndrome based on NHANES 2013-2016.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Ma J 等基于NHANES 2013-2016数据,通过暴露组学分析发现六种环境化学物与CKM综合征相关,其中金属混合暴露增加晚期CKM风险,且炎症可能起中介作用。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征环境化学物限制性立方样条加权分位数和炎症队列研究暴露组学金属多环芳烃挥发性有机物代谢物IDsDOI: 10.1016/j.ecoenv.2025.118993 PMID: 40902250QualityOriginal summaryIdentifierNumbered
Reference
Ma J, Li P, Tao L, Yang X, Luo Y, Guo X, et al. Environment-wide association study of cardiovascular-kidney-metabolic syndrome based on NHANES 2013-2016. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2025;303:118993. doi:10.1016/j.ecoenv.2025.118993
[92]Extension
#103 · 2025

Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Zhang X等通过网络毒理学和分子对接发现,塑化剂可能通过靶向CKM、SOAT2等6个核心基因诱导骨质疏松,并显示出与靶蛋白的特异性结合效应。
TopicCKM定义评估空白与超加工食品的代谢影响Keywords骨质疏松症塑化剂网络毒理学分子对接机器学习靶基因邻苯二甲酸酯系统综述PubMed疾病:CKM Title/AbstracttgsIDsDOI: 10.1016/j.ecoenv.2025.117820 PMID: 39884015QualityOriginal summaryIdentifierNumbered
Reference
Zhang X, Zhu X, Gu W, Li X, Niu T, Mao P, et al. Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2025;291:117820. doi:10.1016/j.ecoenv.2025.117820
[43]Supporting
#104 · 2025

10.1016/j.diabres.2025.112327. Epub 2025 Jun 13. Associations between insulin resistance indices and cardiovascular disease in older adults with cardiovascular-kidney-metabolic syndrome stage 0-3: The GOLD-Health cohort.

DIABETES RESEARCH AND CLINICAL PRACTICE
Wang M等基于463,545名老年CKM综合征0-3期队列发现,八种胰岛素抵抗指标均与CVD风险升高显著相关,其中TyG-WC预测效能最高。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管疾病胰岛素抵抗Cox回归限制性立方样条甘油三酯葡萄糖指数心血管-肾脏-代谢综合征队列研究老年人群PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1016/j.diabres.2025.112327 PMID: 40517908QualityOriginal summaryIdentifierNumbered
Reference
Wang M, Lin W, Liu H, Qian ZM, Chen J, Rao M, et al. Associations between insulin resistance indices and cardiovascular disease in older adults with cardiovascular-kidney-metabolic syndrome stage 0-3: The GOLD-Health cohort. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025;226:112327. doi:10.1016/j.diabres.2025.112327
No ref no.Core
#105 · 2025

10.1016/j.diabres.2025.112437. Epub 2025 Aug 25. Periodontitis, accelerated biological aging, and advanced stages in cardiovascular-kidney-metabolic syndrome in U.S. Adults: A mediation analysis.

DIABETES RESEARCH AND CLINICAL PRACTICE
Qi X 等基于3102名美国成年人数据发现,重度牙周炎与晚期心血管-肾脏-代谢综合征风险升高1.5-2.05倍相关,且生物学年龄加速介导了约20%的效应。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords牙周炎心血管-肾脏-代谢综合征生物学年龄加速Klemera-Doubal方法表型年龄横断面研究中介分析逻辑回归美国成年人口腔健康IDsDOI: 10.1016/j.diabres.2025.112437 PMID: 40865882QualityOriginal summaryIdentifierNo ref no.
Reference
Qi X, Sui J, Yang Z, Dahlen A, Zhang K, Wu B. 10.1016/j.diabres.2025.112437. Epub 2025 Aug 25. Periodontitis, accelerated biological aging, and advanced stages in cardiovascular-kidney-metabolic syndrome in U.S. Adults: A mediation analysis.. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025. 228. 112437.. doi:10.1016/j.diabres.2025.112437
[23]Supporting
#106 · 2025

10.1016/j.diabres.2025.112927. Epub 2025 Sep 28. Association of the metabolic dysfunction-associated steatotic liver disease with cardiovascular and kidney disease in patients with type 2 diabetes mellitus: a cross-sectional study.

DIABETES RESEARCH AND CLINICAL PRACTICE
Ren H 等在一项纳入2436例2型糖尿病患者的横断面研究中发现,肝纤维化与左心室肥厚及慢性肾脏病风险增加独立相关,且与心血管-肾脏-代谢综合征分期升高相关。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords2型糖尿病肝纤维化左心室肥厚慢性肾脏病NAFLD纤维化评分逻辑回归横断面研究心血管疾病代谢功能障碍相关脂肪性肝病PubMed疾病:cardiovascIDsDOI: 10.1016/j.diabres.2025.112927 PMID: 41027495QualityOriginal summaryIdentifierNumbered
Reference
Ren H, Hu M, Yan Y, Cheng M, Yang C, Yuan G, et al. Association of the metabolic dysfunction-associated steatotic liver disease with cardiovascular and kidney disease in patients with type 2 diabetes mellitus: a cross-sectional study. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025;229:112927. doi:10.1016/j.diabres.2025.112927
[55]Supporting
#107 · 2025

10.1016/j.diabres.2025.112988. Epub 2025 Nov 7. Exploring the mediating role of TyG-related indicators in the relationship between biological aging and late-stage cardiovascular-kidney-metabolic in middle-aged and older adults.

DIABETES RESEARCH AND CLINICAL PRACTICE
Li Y等基于3710名中老年人的横断面研究发现,生物衰老与晚期心血管-肾脏-代谢综合征风险正相关,且TyG相关指标在其中起部分中介作用。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征生物衰老甘油三酯-葡萄糖指数胰岛素抵抗横断面研究加权多元回归中介分析TyG-BMITyG-WHtR比值比IDsDOI: 10.1016/j.diabres.2025.112988 PMID: 41205874QualityOriginal summaryIdentifierNumbered
Reference
Li Y, Luo Z, Zhang Z, Huang N, Xiao L, Li J, et al. Exploring the mediating role of TyG-related indicators in the relationship between biological aging and late-stage cardiovascular-kidney-metabolic in middle-aged and older adults. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025;230:112988. doi:10.1016/j.diabres.2025.112988
[44]Supporting
#108 · 2025

10.1016/j.diabres.2025.112989. Epub 2025 Nov 7. Inflammation and abnormal glucose-lipid metabolism are critical for population stratification toward progressive frailty in Cardiovascular-Kidney-Metabolic syndrome.

DIABETES RESEARCH AND CLINICAL PRACTICE
Zhang C等基于5,790名CKM综合征患者7年随访数据发现,残余胆固醇炎症指数和甘油三酯-葡萄糖指数升高与衰弱进展风险独立相关,尤其在CKM早期阶段。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征衰弱残余胆固醇炎症指数甘油三酯-葡萄糖指数队列研究风险分层慢性炎症糖脂代谢紊乱PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1016/j.diabres.2025.112989 PMID: 41205877QualityOriginal summaryIdentifierNumbered
Reference
Zhang C, Chen Y, Wang T, Peng W, Ning M, Liu Y. Inflammation and abnormal glucose-lipid metabolism are critical for population stratification toward progressive frailty in Cardiovascular-Kidney-Metabolic syndrome. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025;230:112989. doi:10.1016/j.diabres.2025.112989
[84]Extension
#109 · 2025

Association between remnant cholesterol and the risk of cardiovascular-kidney-metabolic syndrome progression: insights from the China health and retirement longitudinal study.

European Journal of Preventive Cardiology
Ding X 等基于中国健康与养老追踪调查数据发现,残粒胆固醇升高与心血管-肾脏-代谢综合征进展至晚期及新发心血管疾病风险增加独立相关。
Topic衰弱、非奈利酮及遗传多态性在CKM管理中的角色Keywords心血管疾病残粒胆固醇心血管-肾脏-代谢综合征Cox回归Logistic回归队列研究风险比PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract多病共存IDsDOI: 10.1093/eurjpc/zwaf248 PMID: 40272444QualityOriginal summaryIdentifierNumbered
Reference
Ding X, Tian J, Chang X, Liu J, Wang G. Association between remnant cholesterol and the risk of cardiovascular-kidney-metabolic syndrome progression: insights from the China health and retirement longitudinal study. European Journal of Preventive Cardiology. 2025;32(13):1157-1165. doi:10.1093/eurjpc/zwaf248
No ref no.Core
#110 · 2025

Sex differences in cardiovascular-kidney-metabolic risk factors associated with degenerative valvular heart disease.

European Journal of Preventive Cardiology
Yang C等基于英国生物银行436,184名参与者发现,高血压是退行性心脏瓣膜病最大归因危险因素,且女性合并肥胖、慢性肾脏病、高血压或高甘油三酯时特定瓣膜病风险更高。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords退行性心脏瓣膜病高血压肥胖慢性肾脏病高甘油三酯血症队列研究风险比人群归因风险性别差异心血管肾脏代谢IDsDOI: 10.1093/eurjpc/zwaf050 PMID: 39937669QualityOriginal summaryIdentifierNo ref no.
Reference
Yang C, Li Z, Sui Y, Long T, Cheng S, Guo X, et al. Sex differences in cardiovascular-kidney-metabolic risk factors associated with degenerative valvular heart disease.. European Journal of Preventive Cardiology. 2025. 32(17). 1705-1715.. doi:10.1093/eurjpc/zwaf050
No ref no.Core
#111 · 2025

ahead of print. Association between the Life's Essential 8 Health Behaviors and Prognosis in Patients with Advanced Cardiovascular-Kidney-Metabolic Syndrome.

European Journal of Preventive Cardiology
Tan S 等基于10,321名参与者发现,生命八要素(LE8)评分越高,晚期心血管-肾脏-代谢综合征患者的死亡风险越低,其中健康行为评分每增加10分可显著降低全因、心血管及CKM相关死亡风险。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管肾脏代谢综合征生命八要素Cox回归限制性立方样条死亡风险健康行为队列研究全因死亡PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1093/eurjpc/zwaf443 PMID: 40674721QualityOriginal summaryIdentifierNo ref no.
Reference
Tan S, Zhou J, Li F, Zeng G, Liu. ahead of print. Association between the Life's Essential 8 Health Behaviors and Prognosis in Patients with Advanced Cardiovascular-Kidney-Metabolic Syndrome.. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf443
No ref no.Supporting
#112 · 2025

ahead of print. Association of Cardiovascular-Kidney-Metabolic Overlap with Physical Function and Prognosis in Older Patients with Heart Failure: A Post-hoc Analysis of the FRAGILE-HF and SONIC-HF.

European Journal of Preventive Cardiology
Nakade T 等通过对1,113例老年心衰患者的事后分析发现,存在2种或以上心血管-肾脏-代谢重叠状况的患者,其身体功能显著更差,且2年内死亡或再入院风险升高。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心力衰竭慢性肾脏病2型糖尿病身体功能Cox回归前瞻性研究步速复合终点事后分析老年患者IDsDOI: 10.1093/eurjpc/zwaf279 PMID: 40326534QualityOriginal summaryIdentifierNo ref no.
Reference
Nakade T, Matsue Y, Ikeda Y, Maeda D, Kagiyama N, Fujimoto. ahead of print. Association of Cardiovascular-Kidney-Metabolic Overlap with Physical Function and Prognosis in Older Patients with Heart Failure: A Post-hoc Analysis of the FRAGILE-HF and SONIC-HF.. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf279
[105]Core
#113 · 2025

ahead of print. Data-driven cluster analysis identifies distinct types of cardiovascular-kidney-metabolic syndrome.

European Journal of Preventive Cardiology
Yang M 等通过数据驱动聚类分析,在44,200名CKM综合征患者中识别出五个亚型,发现各亚型具有不同的器官特异性风险、蛋白质组学特征和遗传模式。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords心血管-肾脏-代谢综合征K均值聚类Cox回归临床生物标志物血浆蛋白质组学队列研究慢性肝病脑血管事件慢性肾脏病遗传风险模式IDsDOI: 10.1093/eurjpc/zwaf708 PMID: 41206602QualityOriginal summaryIdentifierNumbered
Reference
Yang M, Su C, Chang X, Wang G, Liu J. ahead of print. Data-driven cluster analysis identifies distinct types of cardiovascular-kidney-metabolic syndrome. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf708
No ref no.Core
#114 · 2025

ahead of print. Hepatic Steatosis in Cardiovascular-Kidney-Metabolic Syndrome: Fatty Liver Index as a Predictor of Cardiovascular Outcomes.

European Journal of Preventive Cardiology
Kim BS 等基于心血管-肾脏-代谢综合征人群研究发现,脂肪肝指数可预测心血管结局,提示肝脂肪变性是该综合征患者心血管风险的重要标志。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords心血管-肾脏-代谢综合征脂肪肝指数心血管结局肝脏脂肪变性预测因子评论文章PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractckdsgltIDsDOI: 10.1093/eurjpc/zwaf396 PMID: 40587659QualityOriginal summaryIdentifierNo ref no.
Reference
Kim BS, Kim HJ, Kim H, Lee J, Ahn SB, Shin JH, et al. ahead of print. Hepatic Steatosis in Cardiovascular-Kidney-Metabolic Syndrome: Fatty Liver Index as a Predictor of Cardiovascular Outcomes.. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf396
[87]Extension
#115 · 2025

ahead of print. MASLD in the CKM health framework: what does it add to the table?

European Journal of Preventive Cardiology
Ha KH等在一项基于CKM健康框架的评述中发现,MASLD与心血管代谢风险独立相关,为综合管理策略提供了额外证据。
Topic衰弱、非奈利酮及遗传多态性在CKM管理中的角色Keywords代谢相关脂肪肝病心血管代谢健康队列研究欧洲预防心脏病学肝脏疾病心血管疾病代谢综合征评述文章PubMed疾病:CKM Title/Abstract多病共存IDsDOI: 10.1093/eurjpc/zwaf549 PMID: 40858303QualityOriginal summaryIdentifierNumbered
Reference
Ha KH, Kim DJ, Lee H. ahead of print. MASLD in the CKM health framework: what does it add to the table?. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf549
No ref no.Excluded
#116 · 2025

ahead of print. Night shift work and its interaction with sleep duration and chronotype, and risk of cardiovascular-kidney-metabolic diseases in the UK Biobank.

European Journal of Preventive Cardiology
Tran DT 等基于96,365名英国生物样本库参与者发现,夜班工作超过20年或每月≥8次与心血管-肾脏-代谢疾病风险升高32%相关,且短睡眠(≤6小时)会进一步放大该风险。
Topicc8Keywords心血管肾脏代谢疾病夜班工作睡眠时长睡眠时型Cox回归队列研究风险比剂量反应关系PubMed疾病:CKM Title/Abstract公里IDsDOI: 10.1093/eurjpc/zwaf774 PMID: 41411331QualityOriginal summaryIdentifierNo ref no.
Reference
Tran DT, Strohmaier S, Żebrowska M, Huang T, Papantoniou K,. ahead of print. Night shift work and its interaction with sleep duration and chronotype, and risk of cardiovascular-kidney-metabolic diseases in the UK Biobank.. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf774
[85]Extension
#117 · 2025

ahead of print. Remnant Cholesterol in CHARLS: Unaddressed Dynamic Changes and Clinical Confounders in CKM Progression Analysis.

European Journal of Preventive Cardiology
Abudoureheman W 等基于CHARLS队列数据发现,残余胆固醇的动态变化及临床混杂因素在心血管-肾脏-代谢综合征进展分析中未被充分关注。
Topic衰弱、非奈利酮及遗传多态性在CKM管理中的角色Keywords残余胆固醇心血管代谢疾病队列研究动态变化临床混杂因素CHARLS数据库疾病进展分析PubMed疾病:CKM Title/Abstract多病共存charlsIDsDOI: 10.1093/eurjpc/zwaf391 PMID: 40583206QualityOriginal summaryIdentifierNumbered
Reference
Abudoureheman W, Zhang F, Sun Q. ahead of print. Remnant Cholesterol in CHARLS: Unaddressed Dynamic Changes and Clinical Confounders in CKM Progression Analysis. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf391
No ref no.Core
#118 · 2025

The New Cardiovascular-Kidney-Metabolic (CKM) Syndrome: An Opportunity for CKD Detection and Treatment in Primary Care.

AMERICAN JOURNAL OF KIDNEY DISEASES
Rumrill SM 和 Shlipak MG 在综述中阐述了新型心血管-肾脏-代谢综合征的概念,指出其有助于在初级保健中早期发现并治疗慢性肾脏病。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords心血管疾病慢性肾病代谢综合征早期检测初级保健队列研究真实世界研究PubMed疾病:CKM Title/AbstractckdsgltIDsDOI: 10.1053/j.ajkd.2024.09.016 PMID: 39706244QualityOriginal summaryIdentifierNo ref no.
Reference
Rumrill SM, Shlipak MG. The New Cardiovascular-Kidney-Metabolic (CKM) Syndrome: An Opportunity for CKD Detection and Treatment in Primary Care.. AMERICAN JOURNAL OF KIDNEY DISEASES. 2025. 85(4). 399-402.. doi:10.1053/j.ajkd.2024.09.016
[21]Supporting
#119 · 2025

Cumulative Incidence of Mortality Associated with Cardiovascular-Kidney-Metabolic (CKM) Syndrome.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Claudel SE 等在一项纳入50,678名美国成人的纵向研究中发现,CKM综合征分期越高,15年心血管死亡累积发生率呈梯度增加,4期与0期绝对风险差异达8.1个月。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords心血管疾病代谢综合征纵向研究累积发生率限制性平均生存心血管死亡CKM综合征生存分析PubMed疾病:CKM Title/Abstract肾脏IDsDOI: 10.1681/ASN.0000000637 PMID: 39932805QualityOriginal summaryIdentifierNumbered
Reference
Claudel SE, Schmidt IM, Waikar SS, Verma A. Cumulative Incidence of Mortality Associated with Cardiovascular-Kidney-Metabolic (CKM) Syndrome. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2025;36(7):1343-1351. doi:10.1681/ASN.0000000637
[24]Core
#120 · 2025

Global Burden of the Key Components of Cardiovascular-Kidney-Metabolic Syndrome.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Xie Z 等基于2021年全球疾病负担数据,分析了心血管-肾脏-代谢综合征七项关键组分的负担,发现缺血性心脏病和卒中为主要贡献因素,糖尿病和高体重指数负担呈上升趋势。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征糖尿病缺血性心脏病伤残调整寿命年全球疾病负担系统综述发病率死亡率高体重指数卒中IDsDOI: 10.1681/ASN.0000000658 PMID: 40042920QualityOriginal summaryIdentifierNumbered
Reference
Xie Z, Yu C, Cui Q, Zhao X, Zhuang J, Chen S, et al. Global Burden of the Key Components of Cardiovascular-Kidney-Metabolic Syndrome. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2025;36(8):1572-1584. doi:10.1681/ASN.0000000658
[71]Core
#121 · 2025

Preventing chronic kidney disease and maintaining kidney health: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

KIDNEY INTERNATIONAL
Ortiz A 等通过KDIGO争议会议总结发现,维护肾脏健康与预防慢性肾脏病(CKD)需结合健康生活方式及药物干预,如SGLT2抑制剂和GLP-1受体激动剂可降低高危人群CKD风险。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords慢性肾脏病2型糖尿病钠-葡萄糖协同转运蛋白2抑制剂胰高血糖素样肽-1受体激动剂系统综述心血管-肾脏-代谢风险预测肾衰竭PubMed疾病:CKM Title/AbstractckdIDsDOI: 10.1016/j.kint.2025.04.005 PMID: 40536455QualityOriginal summaryIdentifierNumbered
Reference
Ortiz A, Arreola Guerra JM, Chan JCN, Jha V, Kramer H, Nicholas. Preventing chronic kidney disease and maintaining kidney health: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. KIDNEY INTERNATIONAL. 2025;108(4):555-571. doi:10.1016/j.kint.2025.04.005
[72]Core
#122 · 2025

Restoration of branched chain amino acid catabolism improves kidney function in preclinical cardiovascular-kidney-metabolic syndrome models.

KIDNEY INTERNATIONAL
Bollinger E 等通过两种CKM动物模型发现,支链氨基酸分解代谢障碍与肾脏病变相关,使用BDK抑制剂BT2可改善肾功能,与恩格列净联用效果更佳。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords心血管-肾脏-代谢综合征支链氨基酸BDK抑制剂恩格列净蛋白质组学代谢组学线粒体功能肾功能动物实验PubMed疾病:cardiovascIDsDOI: 10.1016/j.kint.2025.04.025 PMID: 40409667QualityOriginal summaryIdentifierNumbered
Reference
Bollinger E, Williams G, Piper ME, Steen K, Neale KT, Chen X. Restoration of branched chain amino acid catabolism improves kidney function in preclinical cardiovascular-kidney-metabolic syndrome models. KIDNEY INTERNATIONAL. 2025;108(2):310-316. doi:10.1016/j.kint.2025.04.025
No ref no.Core
#123 · 2025

Risk stratification of metabolic disorder-associated kidney disease.

KIDNEY INTERNATIONAL
Xu X 等在综述中总结了代谢紊乱相关性肾脏病的传统危险因素,并介绍了CKM健康概念及CKD进展与CVD风险评估工具,指出当前风险分层工具的不足。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords代谢紊乱慢性肾脏病心血管疾病风险分层CKM分期模型CKD进展方程PREVENT方程系统综述PubMed疾病:CKM Title/AbstractckdIDsDOI: 10.1016/j.kint.2025.01.041 PMID: 40157500QualityOriginal summaryIdentifierNo ref no.
Reference
Xu X, Shao X, Hou FF. Risk stratification of metabolic disorder-associated kidney disease.. KIDNEY INTERNATIONAL. 2025. 107(6). 1002-1010.. doi:10.1016/j.kint.2025.01.041
No ref no.Excluded
#124 · 2025

Metamorphism of Venus as driver of crustal thickness and recycling.

Nature Communications
Semprich J 等通过变质相与熔融模型发现,金星玄武岩地壳厚度受热梯度控制,停滞盖层下约40公里,活动盖层下可达65公里,超过该范围会引发拆沉或熔融。
Topicc8Keywords金星地壳玄武岩变质相转变地壳厚度热梯度拆沉作用熔融条件模型研究PubMed疾病:CKM Title/Abstract公里IDsDOI: 10.1038/s41467-025-58324-1 PMID: 40133342QualityOriginal summaryIdentifierNo ref no.
Reference
Semprich J, Filiberto J, Weller M, Gorce J, Clark N. Metamorphism of Venus as driver of crustal thickness and recycling.. Nature Communications. 2025. 16(1). 2905.. doi:10.1038/s41467-025-58324-1
No ref no.Core
#125 · 2025

Observation of a rare beta decay of the charmed baryon with a Graph Neural Network. BESIII Collaboration.

Nature Communications
Collaborators: Ablikim M 等利用图神经网络技术,首次观测到粲重子的一种稀有β衰变过程。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords粒子衰变粲重子图神经网络共振态分支比质量谱角分布队列研究正负电子对撞新粒子发现IDsDOI: 10.1038/s41467-024-55042-y PMID: 39814737QualityOriginal summaryIdentifierNo ref no.
Reference
Collaborators: Ablikim M, Achasov MN, Adlarson P, Afedulidis O, Ai XC, Aliberti. Observation of a rare beta decay of the charmed baryon with a Graph Neural Network. BESIII Collaboration.. Nature Communications. 2025. 16(1). 681.. doi:10.1038/s41467-024-55042-y
[68]Core
#126 · 2024

2024 Apr. Are we ready for an adipocentric approach in people living with type 2 diabetes and chronic kidney disease?

Clinical Kidney Journal
Moreno-Pérez O 等在综述中提出,以肥胖为核心的“功能障碍性脂肪组织管理方法”可整合2型糖尿病合并慢性肾病的治疗策略,强调减重对改善心肾代谢结局至关重要。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords肥胖相关慢性病2型糖尿病慢性肾脏病减重药物功能障碍性脂肪组织系统综述减重靶器官保护血糖稳态心血管疾病IDsDOI: 10.1093/ckj/sfae039 PMID: 38572499QualityOriginal summaryIdentifierNumbered
Reference
Moreno-Pérez O, Reyes-García R, Modrego-Pardo I, López-Martínez. 2024 Apr. Are we ready for an adipocentric approach in people living with type 2 diabetes and chronic kidney disease?. Clinical Kidney Journal. 2024;17(4):sfae039. doi:10.1093/ckj/sfae039
[67]Core
#127 · 2024

eCollection 2024 Dec. GLP-1 receptor agonists in patients with chronic kidney disease and either overweight or obesity.

Clinical Kidney Journal
Abasheva D 等综述发现,GLP-1受体激动剂可改善超重或肥胖慢性肾病患者的代谢控制,并降低心血管和肾脏不良结局风险。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords慢性肾脏病超重肥胖GLP-1受体激动剂司美格鲁肽系统综述体重肾脏结局心血管结局PubMed疾病:CKM Title/AbstractIDsDOI: 10.1093/ckj/sfae296 PMID: 39583142QualityOriginal summaryIdentifierNumbered
Reference
Abasheva D, Ortiz A, Fernandez-Fernandez B. GLP-1 receptor agonists in patients with chronic kidney disease and either overweight or obesity. Clinical Kidney Journal. 2024;17(Suppl. doi:10.1093/ckj/sfae296
[93]Extension
#128 · 2024

eCollection 2024. Metabolomic analysis of Agkistrodon haly venom poisoning mouse treatment by Jidesheng snake pill based on GC-MS.

Frontiers in Pharmacology
Luo J 等通过GC-MS代谢组学分析发现,季德胜蛇药片可调节蝮蛇蛇毒中毒小鼠的长链脂肪酸和氨基酸代谢,减轻其病理损伤。
TopicCKM定义评估空白与超加工食品的代谢影响Keywords蛇咬伤季德胜蛇药片代谢组学气相色谱-质谱蝮蛇蛇毒动物实验差异代谢物氨基酸代谢脂肪酸代谢PubMed疾病:CKM Title/AbstractIDsDOI: 10.3389/fphar.2024.1419609 PMID: 39148553QualityOriginal summaryIdentifierNumbered
Reference
Luo J, Guo M, Xie K, Han TL, Ai S. Metabolomic analysis of Agkistrodon haly venom poisoning mouse treatment by Jidesheng snake pill based on GC-MS. Frontiers in Pharmacology. 2024;15:1419609. doi:10.3389/fphar.2024.1419609
No ref no.Core
#129 · 2024

Maternal Dietary Strategies for Improving Offspring Cardiovascular-Kidney-Metabolic Health: A Scoping Review.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Tain YL 和 Hsu CN 通过综述发现,母体饮食干预(如氨基酸补充、脂质调控、微量营养素及植物多酚)可改善子代心血管-肾脏-代谢健康,其机制涉及营养感应信号介导的程序化调控。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征母体饮食干预系统综述氨基酸补充微量营养素肠道微生物群植物多酚营养感应信号胎儿程序化子代健康IDsDOI: 10.3390/ijms25189788 PMID: 39337276QualityOriginal summaryIdentifierNo ref no.
Reference
Tain YL, Hsu CN. Maternal Dietary Strategies for Improving Offspring Cardiovascular-Kidney-Metabolic Health: A Scoping Review.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. 25(18). 9788.. doi:10.3390/ijms25189788
[98]Extension
#130 · 2024

The Association of Genetic Markers Involved in Muscle Performance Responding to Lactate Levels during Physical Exercise Therapy by Nordic Walking in Patients with Long COVID Syndrome: A Nonrandomized Controlled Pilot Study.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lizcano-Álvarez Á 等通过北欧健走运动疗法对长新冠患者进行基因分析发现,ACTN3和AMPD1基因多态性影响运动后乳酸水平,提示长新冠患者运动能力较差但有氧训练可改善。
TopicCKM定义评估空白与超加工食品的代谢影响Keywords长新冠北欧健走基因多态性乳酸非随机对照试验肌肉表现有氧运动物理治疗PubMed疾病:CKM Title/AbstracttgsIDsDOI: 10.3390/ijms25158305 PMID: 39125881QualityOriginal summaryIdentifierNumbered
Reference
Lizcano-Álvarez Á, Varillas-Delgado D, Cano-de-la-Cuerda R. The Association of Genetic Markers Involved in Muscle Performance Responding to Lactate Levels during Physical Exercise Therapy by Nordic Walking in Patients with Long COVID Syndrome: A Nonrandomized Controlled Pilot Study. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(15):8305. doi:10.3390/ijms25158305
No ref no.Core
#131 · 2024

The Impact of the Aryl Hydrocarbon Receptor on Antenatal Chemical Exposure-Induced Cardiovascular-Kidney-Metabolic Programming.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Tain YL 和 Hsu CN 通过综述发现,产前环境化学物暴露通过激活芳香烃受体可导致心血管-肾脏-代谢综合征编程,并探讨了潜在AHR调节剂的预防作用。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征芳香烃受体环境化学物质系统综述胎儿编程高血压糖尿病肥胖肾脏疾病非酒精性脂肪肝病IDsDOI: 10.3390/ijms25094599 PMID: 38731818QualityOriginal summaryIdentifierNo ref no.
Reference
Tain YL, Hsu CN. The Impact of the Aryl Hydrocarbon Receptor on Antenatal Chemical Exposure-Induced Cardiovascular-Kidney-Metabolic Programming.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. 25(9). 4599.. doi:10.3390/ijms25094599
No ref no.Core
#132 · 2024

The Renin-Angiotensin System and Cardiovascular-Kidney-Metabolic Syndrome: Focus on Early-Life Programming.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Tain YL 和 Hsu CN 通过综述临床前证据发现,妊娠期及哺乳期肾素-血管紧张素系统失调会通过影响胎儿编程,导致子代出现心血管-肾脏-代谢综合征特征。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords心血管-肾脏-代谢综合征肾素-血管紧张素系统早期生命编程系统综述代谢性疾病肾脏疾病心血管疾病胎儿编程重编程策略临床前证据IDsDOI: 10.3390/ijms25063298 PMID: 38542273QualityOriginal summaryIdentifierNo ref no.
Reference
Tain YL, Hsu CN. The Renin-Angiotensin System and Cardiovascular-Kidney-Metabolic Syndrome: Focus on Early-Life Programming.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. 25(6). 3298.. doi:10.3390/ijms25063298
[97]Extension
#133 · 2024

Amino Acids during Pregnancy and Offspring Cardiovascular-Kidney-Metabolic Health.

Nutrients
Tain YL 和 Hsu CN 综述发现,孕期氨基酸代谢紊乱通过胎儿编程和肠道菌群调节影响后代心血管-肾脏-代谢健康,靶向氨基酸疗法具有重编程保护潜力。
TopicCKM定义评估空白与超加工食品的代谢影响Keywords心血管-肾脏-代谢综合征氨基酸疗法系统综述胎儿编程肠道菌群氨基酸代谢后代健康发育起源PubMed疾病:CKM Title/AbstracttgsIDsDOI: 10.3390/nu16091263 PMID: 38732510QualityOriginal summaryIdentifierNumbered
Reference
Tain YL, Hsu CN. Amino Acids during Pregnancy and Offspring Cardiovascular-Kidney-Metabolic Health. Nutrients. 2024;16(9):1263. doi:10.3390/nu16091263
[99]Extension
#134 · 2024

Association of Genetic Profile with Muscle Mass Gain and Muscle Injury Prevention in Professional Football Players after Creatine Supplementation.

Nutrients
Varillas-Delgado D等对161名职业足球运动员研究发现,肌酸补充后肌肉量增加受ACE和AMPD1基因型影响,总基因型评分低于54.16者非接触性肌肉损伤风险显著升高。
TopicCKM定义评估空白与超加工食品的代谢影响Keywords肌肉损伤肌酸补充基因型评分体重指数肌肉量纵向研究职业足球运动员单核苷酸多态性PubMed疾病:CKM Title/AbstracttgsIDsDOI: 10.3390/nu16152511 PMID: 39125391QualityOriginal summaryIdentifierNumbered
Reference
Varillas-Delgado D. Association of Genetic Profile with Muscle Mass Gain and Muscle Injury Prevention in Professional Football Players after Creatine Supplementation. Nutrients. 2024;16(15):2511. doi:10.3390/nu16152511
No ref no.Core
#135 · 2024

Maternal Polyphenols and Offspring Cardiovascular-Kidney-Metabolic Health.

Nutrients
Tain YL 和 Hsu CN 通过综述研究发现,母体补充多酚可预防子代心血管-肾脏-代谢综合征,其保护作用涉及共同机制。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征多酚系统综述母体补充子代健康妊娠期哺乳期预防作用PubMed疾病:CKM Title/Abstract肾脏IDsDOI: 10.3390/nu16183168 PMID: 39339768QualityOriginal summaryIdentifierNo ref no.
Reference
Tain YL, Hsu CN. Maternal Polyphenols and Offspring Cardiovascular-Kidney-Metabolic Health.. Nutrients. 2024. 16(18). 3168.. doi:10.3390/nu16183168
No ref no.Supporting
#136 · 2024

Prevalence Rates of Abdominal Obesity, High Waist-to-Height Ratio and Excess Adiposity, and Their Associated Cardio-Kidney-Metabolic Factors: SIMETAP-AO Study.

Nutrients
Ruiz-García A 等在一项纳入6,588名成人的横断面研究中发现,腹型肥胖、高腰围身高比和体脂过多的患病率分别为39.6%、39.6%和66.7%,且与高血压、糖尿病、血脂异常等心血管-肾脏-代谢因素独立相关。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords腹型肥胖高腰围身高比体脂过多心血管-肾脏-代谢综合征横断面研究患病率高血压糖尿病高尿酸血症慢性肾脏病IDsDOI: 10.3390/nu16223948 PMID: 39599733QualityOriginal summaryIdentifierNo ref no.
Reference
Ruiz-García A, Serrano-Cumplido A, Escobar-Cervantes C,. Prevalence Rates of Abdominal Obesity, High Waist-to-Height Ratio and Excess Adiposity, and Their Associated Cardio-Kidney-Metabolic Factors: SIMETAP-AO Study.. Nutrients. 2024. 16(22). 3948.. doi:10.3390/nu16223948
No ref no.Supporting
#137 · 2024

Protective Effects of the Food Supplement Flexovital in a Model of Cardiovascular-Kidney-Metabolic Syndrome in Mice.

Nutrients
Carvalho LRRA 等通过单侧肾切除联合西方饮食诱导小鼠CKM综合征模型,发现食品补充剂Flexovital可降低体脂、血糖、血压,改善肾功能及线粒体氧化磷酸化效率。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管-肾脏-代谢综合征食品添加剂动物实验体脂质量空腹血糖动脉血压肾小球滤过率线粒体氧化磷酸化西方饮食单侧肾切除术IDsDOI: 10.3390/nu16234105 PMID: 39683499QualityOriginal summaryIdentifierNo ref no.
Reference
Carvalho LRRA, Tydén M, Shimari M, Zhuge Z, Schiffer TA. Protective Effects of the Food Supplement Flexovital in a Model of Cardiovascular-Kidney-Metabolic Syndrome in Mice.. Nutrients. 2024. 16(23). 4105.. doi:10.3390/nu16234105
[83]Extension
#138 · 2024

Social Risk Profile and Cardiovascular-Kidney-Metabolic Syndrome in US Adults.

Journal of the American Heart Association
Li J等基于18,373名美国成人数据发现,社会风险评分越低,心血管-肾脏-代谢综合征分期越高,累积社会劣势与CKM多病共存风险独立相关。
Topic衰弱、非奈利酮及遗传多态性在CKM管理中的角色Keywords心血管肾脏代谢综合征社会风险特征横断面研究多病共存比值比美国成年人健康不平等PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractcharlsIDsDOI: 10.1161/JAHA.124.034996 PMID: 39136302QualityOriginal summaryIdentifierNumbered
Reference
Li J, Lei L, Wang W, Ding W, Yu Y, Pu B, et al. Social Risk Profile and Cardiovascular-Kidney-Metabolic Syndrome in US Adults. Journal of the American Heart Association. 2024;13(16):e034996. doi:10.1161/JAHA.124.034996
[77]Core
#139 · 2024

Continuous ketone monitoring: Exciting implications for clinical practice.

DIABETES OBESITY and METABOLISM
Kong YW 等通过皮下传感器监测组织间液酮体,发现连续酮体监测(CKM)可每5分钟更新读数,建议为所有糖尿病酮症酸中毒风险人群提供该技术。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords糖尿病酮症酸中毒1型糖尿病连续酮体监测SGLT抑制剂系统综述酮体水平皮下传感器PubMed疾病:CKM Title/AbstractckdsgltIDsDOI: 10.1111/dom.15921 PMID: 39314201QualityOriginal summaryIdentifierNumbered
Reference
Kong YW, Morrison D, Lu JC, Lee MH, Jenkins AJ. Continuous ketone monitoring: Exciting implications for clinical practice. DIABETES OBESITY and METABOLISM. 2024;26. doi:10.1111/dom.15921
No ref no.Supporting
#140 · 2024

eCollection 2024 Sep. Combination of Cardiovascular, Kidney, and Metabolic Diseases in a Syndrome Named Cardiovascular-Kidney-Metabolic, With New Risk Prediction Equations.

Kidney International Reports
Massy ZA 和 Drueke TB 将心血管、肾脏与代谢疾病整合为“心血管-肾脏-代谢综合征”,并提出了新的风险预测方程。
TopicCKM综合征分期与脑结构损伤及残余心血管风险Keywords心血管疾病肾脏疾病代谢疾病心血管-肾脏-代谢综合征风险预测方程队列研究PubMed疾病:CKM Title/Abstracttyg肾脏代谢综合IDsDOI: 10.1016/j.ekir.2024.05.033 PMID: 39291205QualityOriginal summaryIdentifierNo ref no.
Reference
Massy ZA, Drueke TB. eCollection 2024 Sep. Combination of Cardiovascular, Kidney, and Metabolic Diseases in a Syndrome Named Cardiovascular-Kidney-Metabolic, With New Risk Prediction Equations.. Kidney International Reports. 2024. 9(9). 2608-2618.. doi:10.1016/j.ekir.2024.05.033
[25]Core
#141 · 2024

10.1016/j.diabres.2024.111926. Epub 2024 Nov 12. Increased prevalence of cardiovascular-kidney-metabolic syndrome during COVID-19: A propensity score-matched study.

DIABETES RESEARCH AND CLINICAL PRACTICE
Trimarco V 等通过倾向评分匹配研究发现,COVID-19大流行期间心血管-肾脏-代谢综合征患病率显著上升,近半数患者存在至少一项CKM组分。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords心血管-肾脏-代谢综合征2型糖尿病高血压倾向评分匹配队列研究真实世界研究患病率COVID-19PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractIDsDOI: 10.1016/j.diabres.2024.111926 PMID: 39536978QualityOriginal summaryIdentifierNumbered
Reference
Trimarco V, Izzo R, Pacella D, Virginia Manzi M, Trama U, Lembo. Increased prevalence of cardiovascular-kidney-metabolic syndrome during COVID-19: A propensity score-matched study. DIABETES RESEARCH AND CLINICAL PRACTICE. 2024;218:111926. doi:10.1016/j.diabres.2024.111926
No ref no.Extension
#142 · 2024

Hot Cordilleran hinterland promoted lower crust mobility and decoupling of Laramide deformation.

Nature Communications
Vlaha DR 等通过碳质拉曼光谱测温法重建北美科迪勒拉腹地热结构,发现晚白垩世高地壳地温梯度(>40 °C/km)促进了下地壳流动与壳幔解耦。
TopicCKM定义评估空白与超加工食品的代谢影响Keywords拉腊米造山运动地壳热结构地温梯度碳质拉曼光谱系统综述下地壳流动性壳幔解耦挤压变形缺失PubMed疾病:CKM Title/AbstracttgsIDsDOI: 10.1038/s41467-024-48182-8 PMID: 38704380QualityOriginal summaryIdentifierNo ref no.
Reference
Vlaha DR, Zuza AV, Chen L, Harlaux M. Hot Cordilleran hinterland promoted lower crust mobility and decoupling of Laramide deformation.. Nature Communications. 2024. 15(1). 3750.. doi:10.1038/s41467-024-48182-8
No ref no.Core
#143 · 2023

A Patient Decision Aid About Conservative Kidney Management in Advanced Kidney Disease: A Randomized Pilot Trial.

AMERICAN JOURNAL OF KIDNEY DISEASES
Wong SPY 等在一项随机先导试验中发现,针对晚期肾病患者的保守性肾脏管理决策辅助工具可行且可接受,并显著增加了患者与医生讨论该方案的比例。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords慢性肾脏病保守性肾脏管理决策辅助工具随机先导试验失访率医患沟通老年患者PubMed疾病:CKM Title/AbstractckdsgltIDsDOI: 10.1053/j.ajkd.2022.12.007 PMID: 36740038QualityOriginal summaryIdentifierNo ref no.
Reference
Wong SPY, Oestreich T, Prince DK, Curtis JR. A Patient Decision Aid About Conservative Kidney Management in Advanced Kidney Disease: A Randomized Pilot Trial.. AMERICAN JOURNAL OF KIDNEY DISEASES. 2023. 82(2). 179-188.. doi:10.1053/j.ajkd.2022.12.007
No ref no.Core
#144 · 2023

A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association.

Circulation
Ndumele CE 等通过整合主要指南与科学文献,总结了心血管-肾脏-代谢综合征在科学认知、筛查、预防及管理方面的现有证据,并指出了关键知识空白。
TopicSGLT2抑制剂及心肾代谢药物的多效性机制与临床应用Keywords心血管-肾脏-代谢综合征慢性肾脏病代谢风险因素生活方式干预心脏保护疗法系统综述健康社会决定因素生物学风险因素不良心血管结局肾脏结局IDsDOI: 10.1161/CIR.0000000000001186 PMID: 37807920QualityOriginal summaryIdentifierNo ref no.
Reference
Ndumele CE, Neeland IJ, Tuttle KR, Chow SL, Mathew RO, Khan SS, et al. A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association.. Circulation. 2023. 148(20). 1636-1664.. doi:10.1161/CIR.0000000000001186
No ref no.Supporting
#145 · 2023

Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association.

Circulation
Khan SS 等通过回顾性队列研究纳入604名终末期肾病患者,发现保守性肾脏管理组在12个月后生活质量各维度未见显著恶化,其症状负担与透析患者无显著差异。
TopicCKM多病共存与认知障碍、抑郁及不良生活事件的关联Keywords终末期肾病保守性肾脏管理透析肾移植生活质量回顾性研究观察研究EQ-5D-5L症状负担PubMed疾病:CKM Title/AbstractIDsDOI: 10.1161/CIR.0000000000001191 PMID: 37947094QualityOriginal summaryIdentifierNo ref no.
Reference
Khan SS, Coresh J, Pencina MJ, Ndumele CE, Rangaswami J, Chow SL, et al. Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association.. Circulation. 2023. 148(24). 1982-2004.. doi:10.1161/CIR.0000000000001191
No ref no.Excluded
#146 · 2022

Aberrant cyclin C nuclear release induces mitochondrial fragmentation and dysfunction in MED13L syndrome fibroblasts.

iScience
Chang KT 等在MED13L综合征患者成纤维细胞中发现,异常细胞周期蛋白C核释放导致线粒体碎片化、呼吸功能降低及氧化应激超敏,阻断其定位可部分恢复线粒体功能。
Topic地热系统与超级马拉松代谢挑战等无关主题KeywordsMED13L综合征线粒体碎片化细胞周期蛋白C线粒体功能障碍成纤维细胞病例对照研究转录组分析氧化应激PubMed疾病:CKM Title/Abstract澳大利亚IDsDOI: 10.1016/j.isci.2022.103823 PMID: 35198885QualityOriginal summaryIdentifierNo ref no.
Reference
Chang KT, Jezek J, Campbell AN, Stieg DC, Kiss ZA, Kemper K,. Aberrant cyclin C nuclear release induces mitochondrial fragmentation and dysfunction in MED13L syndrome fibroblasts.. iScience. 2022. 25(2). 103823.. doi:10.1016/j.isci.2022.103823
[94]Extension
#147 · 2022

eCollection 2022. Combined metabolomics and proteomics to reveal beneficial mechanisms of Dendrobium fimbriatum against gastric mucosal injury.

Frontiers in Pharmacology
Sun J等通过整合代谢组学与蛋白质组学,在环磷酰胺诱导的小鼠胃黏膜损伤模型中发现,流苏石斛通过调节肌酸、精氨酸与脯氨酸及嘧啶代谢通路发挥保护作用,并鉴定出Ckm、Arg1等关键靶蛋白及γ-L-谷氨酰-腐胺等潜在生物标志物。
TopicCKM定义评估空白与超加工食品的代谢影响Keywords胃黏膜损伤流苏石斛代谢组学蛋白质组学生物标志物动物实验环磷酰胺肌酸代谢PubMed疾病:CKM Title/AbstracttgsIDsDOI: 10.3389/fphar.2022.948987 PMID: 36110550QualityOriginal summaryIdentifierNumbered
Reference
Sun J, Liu PF, Liu JN, Lu C, Tong LT, Wang YQ, et al. Combined metabolomics and proteomics to reveal beneficial mechanisms of Dendrobium fimbriatum against gastric mucosal injury. Frontiers in Pharmacology. 2022;13:948987. doi:10.3389/fphar.2022.948987
No ref no.Core
#148 · 2018

2019 Apr. Quality of life with conservative care compared with assisted peritoneal dialysis and haemodialysis.

Clinical Kidney Journal
Iyasere O 等通过倾向性评分匹配84例ESKD患者发现,辅助腹膜透析比保守管理能改善部分生活质量指标,但衰弱与更差的生活质量结局相关。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords终末期肾病保守肾脏管理辅助腹膜透析血液透析倾向评分匹配生活质量衰弱抑郁评分PubMed疾病:CKM Title/Abstract肾脏IDsDOI: 10.1093/ckj/sfy059 PMID: 30976407QualityOriginal summaryIdentifierNo ref no.
Reference
Iyasere O, Brown EA, Johansson L, Davenport A, Farrington K,. 2019 Apr. Quality of life with conservative care compared with assisted peritoneal dialysis and haemodialysis.. Clinical Kidney Journal. 2018. 12(2). 262-268.. doi:10.1093/ckj/sfy059
[96]Extension
#149 · 2016

Common and rare variants associating with serum levels of creatine kinase and lactate dehydrogenase.

Nature Communications
Kristjansson RP 等通过对冰岛人群的全基因组测序和推算,发现13个与血清肌酸激酶水平相关、16个与乳酸脱氢酶水平相关的序列变异,其中多个变异位于与肌肉功能或免疫炎症相关的基因中。
TopicCKM定义评估空白与超加工食品的代谢影响Keywords肌酸激酶乳酸脱氢酶全基因组测序序列变异队列研究冰岛人群组织损伤标志物单核吞噬细胞PubMed疾病:CKM Title/AbstracttgsIDsDOI: 10.1038/ncomms10572 PMID: 26838040QualityOriginal summaryIdentifierNumbered
Reference
Kristjansson RP, Oddsson A, Helgason H, Sveinbjornsson G. Common and rare variants associating with serum levels of creatine kinase and lactate dehydrogenase. Nature Communications. 2016;7:10572. doi:10.1038/ncomms10572
No ref no.Core
#150 · 2003

Association between inflammatory mediators and muscle mass in long-term hemodialysis patients.

AMERICAN JOURNAL OF KIDNEY DISEASES
Kaizu Y 等在一项纳入188名长期血液透析患者的研究中发现,炎症介质IL-6和CRP水平与肌肉质量指标呈显著负相关。
TopicCKM综合征分期与新型生物标志物的预后评估Keywords肌肉消耗血液透析C反应蛋白白细胞介素-6多元回归分析队列研究肌肉质量炎症介质PubMed疾病:CKM Title/Abstract肾脏IDsDOI: 10.1016/s0272-6386(03 PMID: 12900811QualityOriginal summaryIdentifierNo ref no.
Reference
Kaizu Y, Ohkawa S, Odamaki M, Ikegaya N, Hibi I, Miyaji K, et al. Association between inflammatory mediators and muscle mass in long-term hemodialysis patients.. AMERICAN JOURNAL OF KIDNEY DISEASES. 2003. 42(2). 295-302.. doi:10.1016/s0272-6386(03
[81]Extension
#151 · 1998

Quantification of creatinine kinetic parameters in patients with acute renal failure.

KIDNEY INTERNATIONAL
Clark WR等通过11例急性肾衰竭患者的肌酐动力学模型分析发现,患者瘦体重显著低于正常人和终末期肾病者,提示存在严重躯体蛋白质耗竭。
Topic衰弱、非奈利酮及遗传多态性在CKM管理中的角色Keywords急性肾衰竭连续性静脉-静脉血液滤过肌酐动力学模型瘦体重肌酐生成速率营养不良队列研究蛋白质分解代谢率PubMed疾病:CKM Title/Abstract多病共存IDsDOI: 10.1046/j.1523-1755.1998.00016.x PMID: 9690223QualityOriginal summaryIdentifierNumbered
Reference
Clark WR, Mueller BA, Kraus MA, Macias WL. Quantification of creatinine kinetic parameters in patients with acute renal failure. KIDNEY INTERNATIONAL. 1998;54(2):554-60. doi:10.1046/j.1523-1755.1998.00016.x
[82]Extension
#152 · 1997

Protein catabolic rate over lean body mass ratio: a more rational approach to normalize the protein catabolic rate in dialysis patients.

AMERICAN JOURNAL OF KIDNEY DISEASES
Canaud B 等通过联合尿素和肌酐动力学模型,在66名透析患者中发现,将蛋白质分解代谢率标准化为瘦体重(nPCRLBM)比标准化为干体重更能准确反映蛋白质营养状况,尤其适用于身体成分异常的患者。
Topic衰弱、非奈利酮及遗传多态性在CKM管理中的角色Keywords终末期肾病蛋白质分解代谢率瘦体重尿素动力学模型肌酐动力学模型Kt/V队列研究PubMed疾病:CKM Title/Abstract多病共存charlsIDsDOI: 10.1016/s0272-6386(97 PMID: 9370183QualityOriginal summaryIdentifierNumbered
Reference
Canaud B, Leblanc M, Garred LJ, Bosc JY, Argilés A, Mion C. Protein catabolic rate over lean body mass ratio: a more rational approach to normalize the protein catabolic rate in dialysis patients. AMERICAN JOURNAL OF KIDNEY DISEASES. 1997;30(5):672-9. doi:10.1016/s0272-6386(97
No matching papers. Try another keyword or topic.
Open dense table view
Topic / rolePaperOne-line summaryKeywordsIdentifiersCitation / reference
衰弱、非奈利酮及遗传多态性在CKM管理中的角色
Extension
Explainable machine learning-driven predictive modelling of incident cognitive impairment in individuals with early-stage cardiovascular-kidney-metabolic syndrome: Insights from a longitudinal CHARLS cohort study.
2026 Diabetes, obesity & metabolism
Duan Shoupeng 等基于4,462名早期CKM综合征患者的前瞻性队列数据,利用可解释机器学习模型发现,教育程度、总胆固醇和年龄是预测10年内新发认知损害的最重要因素。认知损害心血管-肾脏-代谢综合征机器学习XGBoost总胆固醇前瞻性队列研究教育程度空腹血糖PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1111/dom.70346;PMID: 41369001[9]
Duan Shoupeng, Wang Yijun, Yang Xiaomeng, Xu Yanan, Wang Jun. Explainable machine learning-driven predictive modelling of incident cognitive impairment in individuals with early-stage cardiovascular-kidney-metabolic syndrome: Insights from a longitudinal CHARLS cohort study. Diabetes, obesity & metabolism. 2026;28(3):1693-1709. doi:10.1111/dom.70346
地热系统与超级马拉松代谢挑战等无关主题
Excluded
Advancing brain health prevention using explainable CKM-based predictive modelling.
2026 Diabetes, obesity & metabolism
Li J 等利用可解释的CKM预测模型,发现该模型能有效识别脑健康风险因素,为脑疾病预防提供了新工具。脑健康预测模型可解释性CKM模型疾病预防队列研究生物标志物PubMed疾病:CKM Title/Abstract澳大利亚medDOI: 10.1111/dom.70437;PMID: 41588914[14]
Li J, Miao X, Li Z, Yang J. Advancing brain health prevention using explainable CKM-based predictive modelling. Diabetes, obesity & metabolism. 2026;28(3)(3):2497-2498. doi:10.1111/dom.70437
地热系统与超级马拉松代谢挑战等无关主题
Excluded
Socceromics: A Systematic Review of Omics Technologies to Optimize Performance and Health in Soccer.
2026 International journal of molecular sciences
Owen A 等通过系统综述139项研究、涵盖19,449名足球运动员发现,基因组学、蛋白质组学、代谢组学及微生物组学可识别与耐力、损伤风险及恢复相关的生物标志物,支持个体化训练与健康管理策略。运动损伤组学技术系统综述单核苷酸多态性肠道微生物精准运动医学基因-环境交互PubMed疾病:CKM Title/Abstract澳大利亚medDOI: 10.3390/ijms27020749;PMID: 41596414No ref no.
Owen A, Ceylan Hİ, Zmijewski P, Biz C, Sciarretta G, Rossin. Socceromics: A Systematic Review of Omics Technologies to Optimize Performance and Health in Soccer.. International journal of molecular sciences. 2026. 27(2)(2). 749.. doi:10.3390/ijms27020749
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
Association of Cardiovascular-Kidney-Syndrome and Brain Macrostructure and Microstructure Injury: A Prospective Cohort Study.
2026 Diabetes, obesity & metabolism
Niu G 等在一项前瞻性队列研究中发现,心血管-肾脏-代谢综合征分期越高,脑宏观结构萎缩及白质微观结构损伤越严重,且呈进行性恶化模式。心血管肾脏综合征脑宏观结构脑微观结构弥散张量成像白质高信号前瞻性队列研究线性混合效应模型脑体积各向异性分数CKM分期DOI: 10.1111/dom.70605;PMID: 41749423[13]
Niu G, Cai X, Yang Y, Jing J, Zhang D, Wang. Association of Cardiovascular-Kidney-Syndrome and Brain Macrostructure and Microstructure Injury: A Prospective Cohort Study. Diabetes, obesity & metabolism. 2026;28(5)(5):4148-4161. doi:10.1111/dom.70605
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
TyG and RC combined with CVD risk in CKM syndrome: A national cohort study.
2026 iScience
Lan H 等基于中国健康与养老追踪调查数据发现,TyG与残余胆固醇均高的个体心血管疾病风险最高(HR=1.35),且联合构建的TyG-RC指数预测价值优于其他指标。心血管疾病心血管-肾脏-代谢综合征甘油三酯-葡萄糖指数残余胆固醇队列研究风险预测胰岛素抵抗脂质代谢PubMed疾病:CKM Title/AbstracttygDOI: 10.1016/j.isci.2026.115060;PMID: 41816296[40]
Lan H, Jia X, Zhao Z, Chen R, Wang B, Qu C, et al. TyG and RC combined with CVD risk in CKM syndrome: A national cohort study. iScience. 2026;29(3):115060. doi:10.1016/j.isci.2026.115060
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
eCollection 2026. Current understanding of sodium-glucose transporter 2 inhibitors in cardiovascular-kidney-metabolic syndrome.
2026 Frontiers in Pharmacology
Yang Y 等综述了SGLT-2抑制剂在心血管-肾脏-代谢综合征中的临床证据,发现其通过糖尿和尿钠排泄触发血流动力学优化、心脏效能增强及抗炎抗氧化等多效机制,形成相互关联的治疗获益网络。心血管-肾脏-代谢综合征SGLT-2抑制剂系统综述血糖控制血压肾脏结局心血管结局炎症与氧化应激PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.3389/fphar.2026.1800868;PMID: 42038319[65]
Yang Y, Zhou W, Yang M, Tang SCW, Liu BC. Current understanding of sodium-glucose transporter 2 inhibitors in cardiovascular-kidney-metabolic syndrome. Frontiers in Pharmacology. 2026;17:1800868. doi:10.3389/fphar.2026.1800868
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
eCollection 2026. Triglyceride-glucose index and its derivatives as emerging biomarkers of insulin resistance for prognostic evaluation of cardiovascular-kidney-metabolic syndrome: mechanisms and clinical applications.
2026 Frontiers in Pharmacology
Zheng Z 等综述发现,甘油三酯-葡萄糖指数及其衍生指标作为胰岛素抵抗的新型生物标志物,在心血管-肾脏-代谢综合征的预后评估中具有显著潜力。心血管-肾脏-代谢综合征胰岛素抵抗甘油三酯-葡萄糖指数系统综述生物标志物代谢紊乱预后评估PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstracttygDOI: 10.3389/fphar.2026.1787130;PMID: 41878329[7]
Zheng Z, Yin X, Liu J, Zhang Y. Triglyceride-glucose index and its derivatives as emerging biomarkers of insulin resistance for prognostic evaluation of cardiovascular-kidney-metabolic syndrome: mechanisms and clinical applications. Frontiers in Pharmacology. 2026;17:1787130. doi:10.3389/fphar.2026.1787130
地热系统与超级马拉松代谢挑战等无关主题
Excluded
Current Appraisal and Gaps in Knowledge in Cardio-Kidney Metabolic Syndrome Definition.
2026 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Palazzuoli A 等探讨了心血管-肾脏-代谢综合征(CKM)的定义与评估挑战,发现其分类和管理因缺乏不同疾病阶段的心脏与肾脏结局可靠数据而存在混乱。慢性肾脏病心血管疾病代谢综合征系统综述氧化应激血管内皮心力衰竭肾功能障碍诊断评估实验室指纹DOI: 10.3390/ijms27041657;PMID: 41751792[12]
Palazzuoli A, Mattioli AV, Fedele F. Current Appraisal and Gaps in Knowledge in Cardio-Kidney Metabolic Syndrome Definition. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2026;27(4):1657. doi:10.3390/ijms27041657
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
Melatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk.
2026 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Hsu CN 和 Tain YL 通过综述发现,母体补充褪黑素可通过恢复氧化还原稳态、调节表观遗传及肠道微生物组,预防子代高血压、肾功能障碍及代谢紊乱。心血管肾脏代谢综合征褪黑素系统综述氧化应激发育编程母体补充高血压肾功能障碍代谢紊乱胎盘功能DOI: 10.3390/ijms27052390;PMID: 41828607[6]
Hsu CN, Tain YL. Melatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2026;27(5):2390. doi:10.3390/ijms27052390
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
Mitochondrial Dysfunction at the Intersection of CKM Syndrome: Molecular Mechanisms and Path-to-Target Therapies.
2026 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Kuo YJ 等在一篇综述中提出,线粒体功能障碍是心血管-肾脏-代谢综合征的核心病理枢纽,驱动从早期代谢风险向终末期器官衰竭的进展。CKM综合征线粒体功能障碍SGLT-2抑制剂GLP-1受体激动剂系统综述氧化应激线粒体自噬心力衰竭慢性肾脏病PubMed疾病:CKM Title/AbstractDOI: 10.3390/ijms27094120;PMID: 42123698[4]
Kuo YJ, Chen LF, Chen Y, Chen PL, Lin HY. Mitochondrial Dysfunction at the Intersection of CKM Syndrome: Molecular Mechanisms and Path-to-Target Therapies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2026;27(9):4120. doi:10.3390/ijms27094120
CKM综合征分期与新型生物标志物的预后评估
Core
Association of Remnant Cholesterol Inflammatory Index with Stroke, Heart Disease and All-Cause Mortality Across Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: A National Cohort Study.
2026 Nutrients
Chen H 等基于CHARLS队列研究发现,在心血管-肾脏-代谢综合征0-3期人群中,残粒胆固醇炎症指数升高与卒中、心脏病及全因死亡风险增加相关,且与全因死亡率呈J形非线性关联。卒中心脏病全因死亡率残粒胆固醇炎症指数高敏C反应蛋白Cox比例风险模型限制性立方样条K-means聚类队列研究心血管-肾脏-代谢综合征DOI: 10.3390/nu18020205;PMID: 41599818[33]
Chen H, Wu JY, Yan H, Gao J, Li C, Xie JH. Association of Remnant Cholesterol Inflammatory Index with Stroke, Heart Disease and All-Cause Mortality Across Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: A National Cohort Study. Nutrients. 2026;18(2):205. doi:10.3390/nu18020205
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
Cardiovascular-Kidney-Metabolic (CKM) Syndrome Staging and Relevance to Precision Nutrition.
2026 Nutrients
Soliman GA 在一项叙述性综述中描述了CKM综合征的分期与流行病学,发现精准营养可能有助于预防CKM进展,但肝脏在CKM定义中尚未被纳入。心血管-肾脏-代谢综合征精准营养饮食模式叙述性综述CKM分期膳食摄入营养素代谢慢性肾脏病2型糖尿病肥胖DOI: 10.3390/nu18091430;PMID: 42124030[19]
Soliman GA. Cardiovascular-Kidney-Metabolic (CKM) Syndrome Staging and Relevance to Precision Nutrition. Nutrients. 2026;18(9):1430. doi:10.3390/nu18091430
地热系统与超级马拉松代谢挑战等无关主题
Excluded
Ultra-Processed Foods and the Cardiovascular-Kidney-Metabolic Continuum: Integrating Epidemiological, Multi-Omics, and Translational Evidence.
2026 Nutrients
Singar S 等在一项综述中整合流行病学与多组学证据发现,超加工食品摄入通过炎症、脂质代谢及肠道屏障功能障碍等通路,与肥胖、糖尿病、心血管事件及死亡率呈中低度正向关联。心血管-肾脏-代谢综合征超加工食品系统综述多组学代谢组学脂质组学蛋白质组学肠道微生物组肥胖慢性肾脏病DOI: 10.3390/nu18071039;PMID: 41978089[15]
Singar S, Kachouei AA, Lantigua-Somoano L, Manley D, Cardinale A. Ultra-Processed Foods and the Cardiovascular-Kidney-Metabolic Continuum: Integrating Epidemiological, Multi-Omics, and Translational Evidence. Nutrients. 2026;18(7):1039. doi:10.3390/nu18071039
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
2026. Adherence to the EAT-Lancet diet and the risk of heart failure in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study.
2026 Frontiers in Nutrition
Fu P 等基于120,849名心血管-肾脏-代谢综合征0-3期个体的前瞻性队列研究发现,较高依从性EAT-柳叶刀饮食与心力衰竭风险降低12%显著相关,主要得益于减少红肉和增加坚果摄入。心力衰竭心血管-肾脏-代谢综合征EAT-柳叶刀饮食Cox回归限制性立方样条前瞻性研究饮食指数红肉摄入坚果摄入PubMed疾病:cardiovascDOI: 10.3389/fnut.2026.1802388;PMID: 42211092[58]
Fu P, Zheng H, Wu K, Lan Y, Wu D, Wu W, et al. 2026. Adherence to the EAT-Lancet diet and the risk of heart failure in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study. Frontiers in Nutrition. 2026;13:1802388. doi:10.3389/fnut.2026.1802388
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
2026. Associations between lipid-derived indices and cardiovascular-kidney-metabolic syndrome progression among Chinese middle-aged and elderly adults: a longitudinal study.
2026 Frontiers in Nutrition
Tang Y 等基于中国中老年人群纵向数据发现,七种脂质衍生指标(AIP、Non-HDL-C、NHHR、LCI、LAP、VAI、TyG)与心血管-肾脏-代谢综合征进展及心血管疾病风险呈正相关,其中NHHR预测价值最优。心血管-肾脏-代谢综合征脂质衍生指标队列研究Cox回归限制性立方样条非高密度脂蛋白胆固醇比值血浆致动脉粥样硬化指数甘油三酯-葡萄糖比值PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.3389/fnut.2026.1742974;PMID: 41958905[41]
Tang Y, Xu W, Jiang Y, Liu C, Zhu W, Liu D, et al. 2026. Associations between lipid-derived indices and cardiovascular-kidney-metabolic syndrome progression among Chinese middle-aged and elderly adults: a longitudinal study. Frontiers in Nutrition. 2026;13:1742974. doi:10.3389/fnut.2026.1742974
CKM综合征分期与新型生物标志物的预后评估
Core
2026. Development and validation of a prediction model for cardiovascular-kidney-metabolic syndrome progression: a multicenter study.
2026 Frontiers in Nutrition
Tu J等基于21,026名CKM 1-2期患者构建预测模型,发现其区分度良好(AUC达0.747),且合并糖尿病与MASLD者进展风险最高(OR 2.13)。心血管-肾脏-代谢综合征代谢功能障碍相关脂肪性肝病糖尿病脂质代谢指标预测模型多中心回顾性研究受试者工作特征曲线决策曲线分析比值比PubMed疾病:cardiovascDOI: 10.3389/fnut.2026.1783262;PMID: 41939189[16]
Tu J, Chen F, Yan W, Xu Z, Zhan Y, Yang X. 2026. Development and validation of a prediction model for cardiovascular-kidney-metabolic syndrome progression: a multicenter study. Frontiers in Nutrition. 2026;13:1783262. doi:10.3389/fnut.2026.1783262
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
2026. The Triglyceride-Glucose-Chinese Visceral Adiposity Index (TyG-CVAI) outperforms other insulin resistance indices in its association with cardiovascular-kidney-metabolic syndrome severity in type 2 diabetes: a comparative study.
2026 Frontiers in Nutrition
Yang J 等在一项纳入5,609例2型糖尿病患者的横断面研究中发现,新型TyG-CVAI指数与心血管-肾脏-代谢综合征严重程度的相关性优于其他胰岛素抵抗指标,且对晚期CKM的区分能力更强。2型糖尿病心血管肾脏代谢综合征甘油三酯葡萄糖指数中国内脏脂肪指数胰岛素抵抗横断面研究有序逻辑回归受试者工作特征曲线PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.3389/fnut.2026.1817071;PMID: 42180562[42]
Yang J, Deng Z, Xie B, Tian F, Leng Y, Zhou H. 2026. The Triglyceride-Glucose-Chinese Visceral Adiposity Index (TyG-CVAI) outperforms other insulin resistance indices in its association with cardiovascular-kidney-metabolic syndrome severity in type 2 diabetes: a comparative study. Frontiers in Nutrition. 2026;13:1817071. doi:10.3389/fnut.2026.1817071
CKM综合征分期与新型生物标志物的预后评估
Core
Association of Higher Dietary Omega-3 Fatty Acid Intake With Cardiovascular-Kidney-Metabolic Syndrome Stage Severity and Mortality in US Adults: A Cross-Sectional and Prospective Cohort Analysis of NHANES 1999 to 2018.
2026 Journal of the American Heart Association
Zhang LL 等基于27,934名美国成年人数据发现,较高膳食omega-3脂肪酸摄入与较轻的CKM综合征分期及L型阈值依赖的较低死亡率相关。心血管肾脏代谢综合征Omega-3脂肪酸横断面研究队列研究限制性立方样条Cox回归全因死亡率膳食摄入量非线性关联阈值效应DOI: 10.1161/JAHA.125.046079;PMID: 41532525[60]
Zhang LL, Zhu XG, Chen J, Nie P, Shi JC, Zhang Z, et al. Association of Higher Dietary Omega-3 Fatty Acid Intake With Cardiovascular-Kidney-Metabolic Syndrome Stage Severity and Mortality in US Adults: A Cross-Sectional and Prospective Cohort Analysis of NHANES 1999 to 2018. Journal of the American Heart Association. 2026;15(2):e046079. doi:10.1161/JAHA.125.046079
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
Effect of Mitochondria-Derived Methylmalonic Acid on Progress and Mortality Risk in US Adults With Cardiovascular-Kidney-Metabolic Syndrome.
2026 Journal of the American Heart Association
Liu H 等基于14,581名CKM参与者的前瞻性队列研究发现,线粒体来源的甲基丙二酸与CKM分期显著相关,其高水平与全因及非心血管死亡风险增加显著相关。心血管-肾脏-代谢综合征甲基丙二酸前瞻性队列研究Cox回归全因死亡非心血管死亡心脏代谢生物标志物比值比PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1161/JAHA.125.043066;PMID: 41532538[35]
Liu H, Wu S, Huang B, Liu Y, Zhong Z, Zhao. Effect of Mitochondria-Derived Methylmalonic Acid on Progress and Mortality Risk in US Adults With Cardiovascular-Kidney-Metabolic Syndrome. Journal of the American Heart Association. 2026;15(2):e043066. doi:10.1161/JAHA.125.043066
衰弱、非奈利酮及遗传多态性在CKM管理中的角色
Extension
Prognostic Impact of Cardiovascular-Kidney-Metabolic Overlap Among Patients With Acute Heart Failure: Insights From a Real-World Multinational Cohort.
2026 Journal of the American Heart Association
Marchetti M 等在一项跨国队列研究中发现,急性心力衰竭患者合并心血管-肾脏-代谢疾病数量越多,1年内死亡风险越高。急性心力衰竭心血管肾脏代谢综合征肾功能受损心肌梗死糖尿病Cox回归全因死亡队列研究真实世界研究PubMed疾病:CKM Title/AbstractDOI: 10.1161/JAHA.125.045294;PMID: 41404735[78]
Marchetti M, Antiochos P, Pitta-Gros B, Abdurashidova T. Prognostic Impact of Cardiovascular-Kidney-Metabolic Overlap Among Patients With Acute Heart Failure: Insights From a Real-World Multinational Cohort. Journal of the American Heart Association. 2026;15(1):e045294. doi:10.1161/JAHA.125.045294
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
Cardio-Kidney-Metabolic Therapy Use Among Adults With Type 1 Diabetes and Chronic Kidney Disease.
2026 DIABETES OBESITY and METABOLISM
Caramori ML 等在一项纳入253名1型糖尿病合并慢性肾病患者的队列研究中发现,使用心-肾-代谢疗法与尿白蛋白/肌酐比值降低相关,且未增加低血糖或酮症酸中毒风险。1型糖尿病慢性肾脏病GLP-1受体激动剂SGLT-2抑制剂倾向评分匹配尿白蛋白肌酐比值糖化血红蛋白低血糖糖尿病酮症酸中毒队列研究DOI: 10.1111/dom.70640;PMID: 41816887[75]
Caramori ML, Repetto E, Perkins C, Pandey A, Rossing P. Cardio-Kidney-Metabolic Therapy Use Among Adults With Type 1 Diabetes and Chronic Kidney Disease. DIABETES OBESITY and METABOLISM. 2026;28(5):4344-4351. doi:10.1111/dom.70640
CKM综合征分期与新型生物标志物的预后评估
Core
Comparative Associations of Traditional and New Obesity Framework With Cardio-Kidney-Metabolic Syndrome and All-Cause Mortality: A Prospective Cohort Study.
2026 DIABETES OBESITY and METABOLISM
Yang Y等在一项前瞻性队列研究中发现,新肥胖框架能识别出被传统标准忽视的高CKM风险个体,且同时符合两种标准的人群风险最高。心血管-肾脏-代谢综合征肥胖全因死亡率体重指数人体测量指标Cox回归队列研究英国生物银行PubMed疾病:CKM Title/Abstract肾脏DOI: 10.1111/dom.70883;PMID: 42169183[28]
Yang Y, Liu Y, Han S, Liu Z, Yu J, Xing B. Comparative Associations of Traditional and New Obesity Framework With Cardio-Kidney-Metabolic Syndrome and All-Cause Mortality: A Prospective Cohort Study. DIABETES OBESITY and METABOLISM. 2026. doi:10.1111/dom.70883
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
Effects of SGLT2 inhibitors across the spectrum of albuminuria in cardiovascular-kidney-metabolic conditions: A pooled analysis of randomised trials.
2026 DIABETES OBESITY and METABOLISM
Ferreira JP 等在一项纳入26,750例患者的汇总分析中发现,SGLT2抑制剂在全部白蛋白尿范围内均能降低肾脏事件和心力衰竭死亡风险,并使白蛋白尿水平平均降低13%。白蛋白尿SGLT2抑制剂汇总分析尿白蛋白肌酐比肾小球滤过率肾脏事件心力衰竭随机对照试验PubMed疾病:CKM Title/AbstractckdDOI: 10.1111/dom.70289;PMID: 41208574[10]
Ferreira JP, Marques P, Anker SD, Butler J, Filippatos G. Effects of SGLT2 inhibitors across the spectrum of albuminuria in cardiovascular-kidney-metabolic conditions: A pooled analysis of randomised trials. DIABETES OBESITY and METABOLISM. 2026;28(2):1105-1115. doi:10.1111/dom.70289
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
Online ahead of print. Hyperaldosteronism in the Pathophysiology and Management of Cardiovascular-Kidney-Metabolic Syndrome.
2026 DIABETES OBESITY and METABOLISM
Zeitler E 等发现,肥胖诱导的醛固酮过量是心血管-肾脏-代谢综合征的关键病理因素,抑制醛固酮信号可改善疾病管理。心血管-肾脏-代谢综合征醛固酮过量盐皮质激素受体拮抗剂胰高血糖素样肽-1受体激动剂系统综述肾素-血管紧张素-醛固酮系统抑制剂肥胖心力衰竭PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1111/dom.70781;PMID: 42010373[5]
Zeitler E, Klein KR, Lingvay I, Pick A, Billings LK. Online ahead of print. Hyperaldosteronism in the Pathophysiology and Management of Cardiovascular-Kidney-Metabolic Syndrome. DIABETES OBESITY and METABOLISM. 2026. doi:10.1111/dom.70781
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
Proteomic Profiling Captures Residual Cardiovascular Risk Beyond the PREVENT Model in Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 2-3.
2026 DIABETES OBESITY and METABOLISM
Han X 等基于24,017名CKM 2-3期参与者数据,构建含63种蛋白的风险评分,发现其可显著提升PREVENT模型对心血管疾病的预测能力,并捕获残余风险。心血管疾病心血管-肾脏-代谢综合征蛋白风险评分队列研究LASSO回归生长分化因子15NT-proBNP残余风险PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1111/dom.70933;PMID: 42225325[8]
Han X, Ding J, Li J, Gao Y, Li Y. Proteomic Profiling Captures Residual Cardiovascular Risk Beyond the PREVENT Model in Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 2-3. DIABETES OBESITY and METABOLISM. 2026. doi:10.1111/dom.70933
CKM综合征分期与新型生物标志物的预后评估
Core
Serum glycated albumin-to-albumin ratio and mortality risk in cardiovascular-kidney-metabolic syndrome: Evidence from NHANES over 15 years.
2026 DIABETES OBESITY and METABOLISM
Li Z和Chen M基于NHANES数据库4524例CKM综合征患者15年随访发现,糖化白蛋白与白蛋白比值升高与全因及心脑血管死亡风险增加显著相关,且该比值是预测长期死亡风险的最稳健指标。心血管-肾脏-代谢综合征糖化白蛋白与白蛋白比值Cox回归限制性立方样条全因死亡心脑血管死亡队列研究血清白蛋白糖化白蛋白PubMed疾病:cardiovascDOI: 10.1111/dom.70387;PMID: 41403278[37]
Li Z, Chen M. Serum glycated albumin-to-albumin ratio and mortality risk in cardiovascular-kidney-metabolic syndrome: Evidence from NHANES over 15 years. DIABETES OBESITY and METABOLISM. 2026;28(3):2038-2050. doi:10.1111/dom.70387
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
The Evolving Role of High-Sensitivity C-Reactive Protein for Mortality Prediction Across the Spectrum of Cardiovascular-Kidney-Metabolic Syndrome.
2026 DIABETES OBESITY and METABOLISM
Li J 等在一项纳入86,829名参与者的前瞻性研究中发现,高敏C反应蛋白与全因死亡率的关联随心血管-肾脏-代谢综合征分期进展而逐渐减弱。心血管-肾脏-代谢综合征高敏C反应蛋白全因死亡率Cox比例风险模型CKM分期前瞻性队列研究风险比PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏DOI: 10.1111/dom.70843;PMID: 42107990[36]
Li J, Chen S, Zhang X, Xia X, Yan Y. The Evolving Role of High-Sensitivity C-Reactive Protein for Mortality Prediction Across the Spectrum of Cardiovascular-Kidney-Metabolic Syndrome. DIABETES OBESITY and METABOLISM. 2026. doi:10.1111/dom.70843
CKM综合征分期与新型生物标志物的预后评估
Core
10.1016/j.ecoenv.2025.119515. Epub 2025 Dec 4. Multimodal mechanisms of di (2-ethylhexyl) phthalate-induced cardiovascular-kidney-metabolic syndrome: Integrating epidemiology, network toxicology and experimental validation.
2026 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Wen W 等通过整合流行病学、网络毒理学和实验验证发现,DEHP暴露通过PPARG、PTGS2和MMP2通路促进CKM综合征,且肥胖显著放大该关联。心血管-肾脏-代谢综合征邻苯二甲酸二乙基己酯横断面研究体重指数网络毒理学细胞毒性代谢紊乱炎症反应纤维化PubMed疾病:cardiovascDOI: 10.1016/j.ecoenv.2025.119515;PMID: 41349316[17]
Wen W, Liu Z, Li L, Qiu F, Zhang H, Cao Y, et al. Multimodal mechanisms of di (2-ethylhexyl) phthalate-induced cardiovascular-kidney-metabolic syndrome: Integrating epidemiology, network toxicology and experimental validation. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2026;309:119515. doi:10.1016/j.ecoenv.2025.119515
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
10.1016/j.ecoenv.2026.120039. Epub 2026 Mar 20. Urinary metal mixtures and cardio-kidney-metabolic risk in adults from a legacy-contaminated area: Repeated-measures cohort evidence and computational validation.
2026 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Amujilite 等通过纵向重复测量队列发现,尿镉、铅、锰水平升高与晚期心血管-肾脏-代谢综合征风险增加相关,且累积性社会不利因素可放大该关联。心血管-肾脏-代谢综合征重金属暴露广义线性混合效应模型贝叶斯核机器回归尿金属水平社会不利因素队列研究分子对接PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1016/j.ecoenv.2026.120039;PMID: 41864045[18]
Amujilite, Yin G, Chen Z, Wu J, Dong Z, Zhang S, et al. Urinary metal mixtures and cardio-kidney-metabolic risk in adults from a legacy-contaminated area: Repeated-measures cohort evidence and computational validation. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2026;314:120039. doi:10.1016/j.ecoenv.2026.120039
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
10.1177/15209156261420167. Online ahead of print. Continuous Ketone Monitoring Captures Overt Ketosis in Type 1 Diabetes Caused by Empagliflozin, Low-Carbohydrate Diet, and Exercise.
2026 Diabetes Technology and Therapeutics
Lawton E等通过一例1型糖尿病患者使用连续酮体监测发现,在恩格列净、低碳水饮食和运动共同作用下,尽管血糖正常,仍可发生持续14小时、最高达2.9 mmol/L的酮症。1型糖尿病正常血糖性酮症恩格列净连续酮体监测低碳水化合物饮食病例报告酮体浓度钠-葡萄糖协同转运蛋白2抑制剂PubMed疾病:CKM Title/AbstractckdDOI: 10.1177/15209156261420167;PMID: 41640091[76]
Lawton E, Perz L, Pasqua MR, Tsoukas M, Haidar. Online ahead of print. Continuous Ketone Monitoring Captures Overt Ketosis in Type 1 Diabetes Caused by Empagliflozin, Low-Carbohydrate Diet, and Exercise. Diabetes Technology and Therapeutics. 2026. doi:10.1177/15209156261420167
地热系统与超级马拉松代谢挑战等无关主题
Excluded
10.1177/15209156261420186. Online ahead of print. Ketone Profiles in Community-Dwelling Adults with Type 1 Diabetes Using Continuous Ketone Monitoring.
2026 Diabetes Technology and Therapeutics
Ngan J 等通过持续酮体监测发现,社区居住的1型糖尿病成人中61%酮体持续低于0.6 mmol/L,血糖随酮体升高但无法替代诊断。1型糖尿病持续酮体监测酮体水平糖化血红蛋白血糖水平队列研究社区居住PubMed疾病:CKM Title/Abstract澳大利亚medDOI: 10.1177/15209156261420186;PMID: 41684056No ref no.
Ngan J, Kong YW, Jones HC, Goad J, Kriketos A,. 10.1177/15209156261420186. Online ahead of print. Ketone Profiles in Community-Dwelling Adults with Type 1 Diabetes Using Continuous Ketone Monitoring.. Diabetes Technology and Therapeutics. 2026. doi:10.1177/15209156261420186
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
10.1177/15209156261428034. Online ahead of print. Continuous Ketone Monitoring in Diabetic Ketoacidosis: Prospective Multicenter Method-Comparison and Feasibility Study.
2026 Diabetes Technology and Therapeutics
Haas NL 等在一项前瞻性多中心研究中发现,持续酮体监测与静脉血β-羟丁酸值高度一致,且能比标准治疗平均提前55分钟检测到糖尿病酮症酸中毒纠正。糖尿病酮症酸中毒持续酮体监测β-羟丁酸前瞻性研究方法比较研究Bland-Altman分析相关性分析可行性研究PubMed疾病:CKM Title/Abstract肾脏DOI: 10.1177/15209156261428034;PMID: 41800718[103]
Haas NL, Korley FK, Schneider RM, Mamillapalli SL, Hepworth E. Online ahead of print. Continuous Ketone Monitoring in Diabetic Ketoacidosis: Prospective Multicenter Method-Comparison and Feasibility Study. Diabetes Technology and Therapeutics. 2026. doi:10.1177/15209156261428034
地热系统与超级马拉松代谢挑战等无关主题
Excluded
Preventing Diabetic Ketoacidosis with Continuous Ketone Monitoring: Insights from a Clinical Research Case.
2026 Diabetes Technology and Therapeutics
Kong YW 等通过一项临床研究案例发现,连续酮体监测可早期预警酮症升高,促进及时干预,从而降低糖尿病酮症酸中毒风险。糖尿病酮症酸中毒1型糖尿病连续酮体监测自动化胰岛素输注胰岛素泵酮体糖化血红蛋白临床试验PubMed疾病:CKM Title/Abstract澳大利亚DOI: 10.1177/15209156251362494;PMID: 40711834No ref no.
Kong YW, Jones HC, Ngan J, Goad J, Jenkins. Preventing Diabetic Ketoacidosis with Continuous Ketone Monitoring: Insights from a Clinical Research Case.. Diabetes Technology and Therapeutics. 2026. 28(1). 73-77.. doi:10.1177/15209156251362494
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
10.1016/j.diabres.2025.113051. Epub 2025 Dec 11. Kidney function decline mediates the adverse effects of arterial stiffness on all-cause and cardiovascular disease mortality in Cardiovascular-Kidney-Metabolic syndrome population: A cohort study.
2026 DIABETES RESEARCH AND CLINICAL PRACTICE
Liu S 等基于34,004例CKM综合征患者队列发现,动脉僵硬度升高显著增加全因及心血管死亡风险,肾功能下降介导了24%-26%的死亡效应。CKM综合征动脉僵硬度肾功能下降全因死亡心血管死亡Cox回归限制性立方样条中介效应分析队列研究估计脉搏波传导速度DOI: 10.1016/j.diabres.2025.113051;PMID: 41386526[27]
Liu S, Man Q, Wang S, Huang Y, Wen J, Yang Y, et al. Kidney function decline mediates the adverse effects of arterial stiffness on all-cause and cardiovascular disease mortality in Cardiovascular-Kidney-Metabolic syndrome population: A cohort study. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;231:113051. doi:10.1016/j.diabres.2025.113051
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
10.1016/j.diabres.2025.113064. Epub 2025 Dec 21. Association between Life's Simple 7 and life's essential 8 with all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome population.
2026 DIABETES RESEARCH AND CLINICAL PRACTICE
Yin S 等在11,487名CKM综合征人群中发现,LS7和LE8评分均与全因及心血管死亡风险呈负相关,且预测能力相当,尤其在非晚期阶段保护效应显著。心血管疾病慢性肾病代谢综合征生命简单7项生命必需8项Cox回归全因死亡心血管死亡队列研究美国健康调查DOI: 10.1016/j.diabres.2025.113064;PMID: 41435969[102]
Yin S, Yan S, Yang Z, Zhu P, Tang T, Borné Y. Association between Life's Simple 7 and life's essential 8 with all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome population. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;231:113064. doi:10.1016/j.diabres.2025.113064
CKM综合征分期与新型生物标志物的预后评估
Core
10.1016/j.diabres.2026.113146. Epub 2026 Feb 7. Association of remnant cholesterol inflammation index with future cardiovascular disease risk in patients with cardiovascular-kidney-metabolic syndrome stages 0-3.
2026 DIABETES RESEARCH AND CLINICAL PRACTICE
Xie N等基于7527名CKM综合征0-3期患者数据发现,残余胆固醇炎症指数升高与未来心血管疾病风险增加显著相关,且hs-CRP部分介导了残余胆固醇与CVD的关联。心血管疾病心血管-肾脏-代谢综合征残余胆固醇炎症指数Cox回归限制性立方样条残余胆固醇高敏C反应蛋白队列研究PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1016/j.diabres.2026.113146;PMID: 41662975[34]
Xie N, Zeng L, Hu X, Wu Z, Lu W, Luo S, et al. Association of remnant cholesterol inflammation index with future cardiovascular disease risk in patients with cardiovascular-kidney-metabolic syndrome stages 0-3. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;233:113146. doi:10.1016/j.diabres.2026.113146
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
10.1016/j.diabres.2026.113223. Epub 2026 Mar 23. Cardiovascular-kidney-metabolic syndrome stages, stage transitions, and risk of cardiovascular disease and mortality: The Tehran Lipid and Glucose Study.
2026 DIABETES RESEARCH AND CLINICAL PRACTICE
Masrouri S 等在一项纳入7770名无心血管疾病成人的研究中发现,CKM综合征2期和3期与心血管疾病及死亡风险显著升高相关,且约3年内每进展1期,风险增加1.40-2.01倍。心血管-肾脏-代谢综合征心血管疾病冠心病心肌梗死卒中Cox回归队列研究心血管死亡率CKM分期PubMed疾病:cardiovascDOI: 10.1016/j.diabres.2026.113223;PMID: 41881362[22]
Masrouri S, Ebrahimi N, Hasanpour A, Sohrabi B, Azizi F, Hadaegh. Cardiovascular-kidney-metabolic syndrome stages, stage transitions, and risk of cardiovascular disease and mortality: The Tehran Lipid and Glucose Study. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;235:113223. doi:10.1016/j.diabres.2026.113223
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
10.1016/j.diabres.2026.113233. Epub 2026 Apr 4. Cardiorenal protective effects of anti-diabetic drugs in early stage Cardiovascular-Kidney-Metabolic Syndrome: A multicenter, time-varying analysis.
2026 DIABETES RESEARCH AND CLINICAL PRACTICE
Hao WR 等在一项纳入18,467例早期CKM综合征患者的时变分析中发现,多数抗糖尿病药物可降低心血管风险,但SGLT2抑制剂在肾脏保护和生存获益方面更具优势。心血管-肾脏-代谢综合征抗糖尿病药物SGLT-2抑制剂回顾性队列研究时变Cox模型终末期肾病全因死亡胰岛素PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1016/j.diabres.2026.113233;PMID: 41942012[69]
Hao WR, Liu JC, Fang YA, Hsu MH, Hsiu H, Chen CC. Cardiorenal protective effects of anti-diabetic drugs in early stage Cardiovascular-Kidney-Metabolic Syndrome: A multicenter, time-varying analysis. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;236:113233. doi:10.1016/j.diabres.2026.113233
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
10.1016/j.diabres.2026.113266. Epub 2026 Apr 16. Cardiovascular-kidney-metabolic syndrome stages and risk of diverse gastrointestinal diseases: a prospective cohort study and integrative proteomic analysis.
2026 DIABETES RESEARCH AND CLINICAL PRACTICE
Xiang S 等基于354,444名英国生物银行参与者发现,心血管-肾脏-代谢综合征晚期显著增加多种胃肠道疾病风险,并识别出HGF、GDF15和PLAUR等核心蛋白介导该关联。心血管-肾脏-代谢综合征胃肠道疾病Cox比例风险模型血浆蛋白质组学队列研究HGFGDF15PLAURPubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1016/j.diabres.2026.113266;PMID: 42000048[32]
Xiang S, Nie H, Wei Z, Li Y, Wang C, Che X, et al. Cardiovascular-kidney-metabolic syndrome stages and risk of diverse gastrointestinal diseases: a prospective cohort study and integrative proteomic analysis. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;236:113266. doi:10.1016/j.diabres.2026.113266
地热系统与超级马拉松代谢挑战等无关主题
Excluded
10.1016/j.diabres.2026.113273. Epub 2026 Apr 19. Comparative effectiveness of tirzepatide versus GLP-1 receptor agonists on cardiovascular-kidney-metabolic stage progression: a real-world cohort study.
2026 DIABETES RESEARCH AND CLINICAL PRACTICE
Wu JY 等在一项纳入897,182名CKM 1-2期患者的真实世界队列研究中发现,替西帕肽相比GLP-1受体激动剂可显著降低进展至CKM 3-4期的风险(HR 0.88)。心血管肾脏代谢综合征替西帕肽胰高血糖素样肽-1受体激动剂倾向评分匹配Cox回归真实世界研究回顾性研究主要不良心血管事件全因死亡率PubMed疾病:cardiovascDOI: 10.1016/j.diabres.2026.113273;PMID: 42009260No ref no.
Wu JY, Lee KW, Huang SC, Chang HY, Lin YM. 10.1016/j.diabres.2026.113273. Epub 2026 Apr 19. Comparative effectiveness of tirzepatide versus GLP-1 receptor agonists on cardiovascular-kidney-metabolic stage progression: a real-world cohort study.. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026. 236. 113273.. doi:10.1016/j.diabres.2026.113273
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
10.1016/j.diabres.2026.113288. Online ahead of print. DPP-4 inhibitors in current diabetes care: their foundational role in treating to target.
2026 DIABETES RESEARCH AND CLINICAL PRACTICE
Avogaro A 等在综述中提出,DPP-4抑制剂可降低HbA1c约0.6-1.1%,低血糖风险低且耐受性良好,是连接“以目标为导向”与“以获益为导向”治疗策略的多功能选择。2型糖尿病DPP-4抑制剂系统综述糖化血红蛋白血糖控制心血管安全性低血糖风险联合用药PubMed疾病:CKM Title/AbstractckdDOI: 10.1016/j.diabres.2026.113288;PMID: 42070662No ref no.
Avogaro A, Fiaccadori E, Rizzo MR. 10.1016/j.diabres.2026.113288. Online ahead of print. DPP-4 inhibitors in current diabetes care: their foundational role in treating to target.. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026. 237. 113288.. doi:10.1016/j.diabres.2026.113288
CKM综合征分期与新型生物标志物的预后评估
Core
10.1016/j.diabres.2026.113336. Online ahead of print. Risk stratification in early-stage Cardiovascular-Kidney-Metabolic Syndrome: The Potency of visceral adiposity and insulin resistance surrogate indices.
2026 DIABETES RESEARCH AND CLINICAL PRACTICE
He L 等综述发现,在早期心血管-肾脏-代谢综合征中,内脏脂肪和胰岛素抵抗替代指标(如腰围身高比、内脏脂肪指数)比传统测量方法具有更优的风险分层效能。心血管-肾脏-代谢综合征内脏脂肪指数胰岛素抵抗腰围身高比系统综述风险分层体重指数线粒体应激PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1016/j.diabres.2026.113336;PMID: 42184891[38]
He L, Lin H, Zhang X, Ling X. Online ahead of print. Risk stratification in early-stage Cardiovascular-Kidney-Metabolic Syndrome: The Potency of visceral adiposity and insulin resistance surrogate indices. DIABETES RESEARCH AND CLINICAL PRACTICE. 2026;237:113336. doi:10.1016/j.diabres.2026.113336
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
The role of inflammation in longitudinal renal function decline and incident chronic kidney disease: the multi-ethnic study of atherosclerosis.
2026 European Journal of Preventive Cardiology
Agboola OJ 等在一项纳入约4600名参与者的前瞻性队列研究中发现,较高的白细胞介素-6水平与更快的肾功能下降、蛋白尿加重及慢性肾脏病风险升高显著相关。慢性肾脏病炎症白细胞介素-6超敏C反应蛋白估算肾小球滤过率前瞻性队列研究Fine-Gray回归肾功能下降心血管-肾脏-代谢综合征PubMed疾病:CKM Title/AbstractDOI: 10.1093/eurjpc/zwaf779;PMID: 41431747[45]
Agboola OJ, Chan JSK, Spitz JA, Chan RNC, Patel J. The role of inflammation in longitudinal renal function decline and incident chronic kidney disease: the multi-ethnic study of atherosclerosis. European Journal of Preventive Cardiology. 2026;33(5):718-728. doi:10.1093/eurjpc/zwaf779
CKM定义评估空白与超加工食品的代谢影响
Extension
ahead of print. Frailty as a Risk-Enhancing Factor Across the Cardiovascular-Kidney-Metabolic Framework: Findings from the UK Biobank.
2026 European Journal of Preventive Cardiology
Fang Y 等基于UK Biobank 408,163名参与者的前瞻性队列研究发现,衰弱与所有心血管-肾脏-代谢(CKM)分期中更高的心血管疾病风险显著相关,且该关联独立于传统风险因素。衰弱心血管疾病心血管-肾脏-代谢Cox回归前瞻性队列研究Fried衰弱表型CKM分期英国生物银行PubMed疾病:CKM Title/AbstracttgsDOI: 10.1093/eurjpc/zwag170;PMID: 41875371[90]
Fang Y, Huang S, Zhang H, Li M, Zhang H, Yang W, et al. ahead of print. Frailty as a Risk-Enhancing Factor Across the Cardiovascular-Kidney-Metabolic Framework: Findings from the UK Biobank. European Journal of Preventive Cardiology. 2026. doi:10.1093/eurjpc/zwag170
衰弱、非奈利酮及遗传多态性在CKM管理中的角色
Extension
ahead of print. Sex-Specific Associations Between Depression and Cardiovascular-Kidney-Metabolic Syndrome Progression: A National Cohort Study.
2026 European Journal of Preventive Cardiology
Gao Q 等基于5035名中老年人群的全国队列研究发现,抑郁症状与心血管-肾脏-代谢综合征进展存在性别特异性关联,仅在女性中观察到显著风险增加。抑郁症心血管-肾脏-代谢综合征队列研究抑郁症状CKM进展性别差异流行病学调查风险预测PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1093/eurjpc/zwag135;PMID: 41802238[88]
Gao Q, Ren W, Du X, Yu Y, Ma Z, Cui Y, et al. ahead of print. Sex-Specific Associations Between Depression and Cardiovascular-Kidney-Metabolic Syndrome Progression: A National Cohort Study. European Journal of Preventive Cardiology. 2026. doi:10.1093/eurjpc/zwag135
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
10.1681/ASN.0000001016. Online ahead of print. Comparative Effectiveness of SGLT2 Inhibitor and GLP-1 Receptor Agonist on Kidney and Cardiovascular Outcomes by Kidney Failure Risk.
2026 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Hartsell SE 等在160,428名2型糖尿病退伍军人中发现,SGLT2抑制剂与GLP-1受体激动剂相比,死亡风险相似,但心血管事件风险略高;肾衰竭风险因患者基线风险水平而异。2型糖尿病肾衰竭SGLT-2抑制剂GLP-1受体激动剂逆概率治疗加权肾衰竭风险方程心血管事件队列研究真实世界研究全因死亡DOI: 10.1681/ASN.0000001016;PMID: 41563358[11]
Hartsell SE, Wei G, Singh R, Throolin M. Online ahead of print. Comparative Effectiveness of SGLT2 Inhibitor and GLP-1 Receptor Agonist on Kidney and Cardiovascular Outcomes by Kidney Failure Risk. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2026. doi:10.1681/ASN.0000001016
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
Finerenone in CKD: Enhancing the Evidence Base in Real-World Contexts.
2026 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Mathew GG 在真实世界研究中发现,非奈利酮可有效改善慢性肾脏病患者的肾脏结局,为临床实践提供了额外证据支持。慢性肾病非奈利酮队列研究真实世界研究PubMed疾病:CKM Title/Abstractckdsglt型糖尿病肾脏抑制剂DOI: 10.1681/ASN.0000000956;PMID: 41563387[101]
Mathew GG. Finerenone in CKD: Enhancing the Evidence Base in Real-World Contexts. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2026;37(2):423-424. doi:10.1681/ASN.0000000956
CKM定义评估空白与超加工食品的代谢影响
Extension
Finerenone in CKD from Estimands to Clinical Interpretability under Competing Risk.
2026 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Wang A和Li Y在竞争风险框架下评估了非奈利酮在慢性肾脏病中的疗效,发现其临床获益在考虑死亡竞争风险后仍保持稳健。慢性肾病非奈利酮系统综述竞争风险心肾综合征临床可解释性估计目标PubMed疾病:CKM Title/AbstracttgsactnDOI: 10.1681/ASN.0000000925;PMID: 41563827[91]
Wang A, Li Y. Finerenone in CKD from Estimands to Clinical Interpretability under Competing Risk. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2026;37(2):425-426. doi:10.1681/ASN.0000000925
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
Online ahead of print. The Kidney in the Middle: KDIGO Guidelines Address Multiple Key Components of Cardiovascular-Kidney-Metabolic Syndrome.
2026 KIDNEY INTERNATIONAL
Levin A 等基于KDIGO指南和争议会议报告,系统总结了慢性肾脏病在心血管-肾脏-代谢综合征中的核心作用,强调早期发现、全面风险管理和多学科协作的重要性。慢性肾脏病心血管疾病KDIGO指南血压管理糖尿病血脂异常系统综述心血管-肾脏-代谢综合征心力衰竭肥胖DOI: 10.1016/j.kint.2026.03.031;PMID: 42191113[70]
Levin A, Bansal N, de Boer IH, Grams ME, Jadoul M, Ter Maaten. Online ahead of print. The Kidney in the Middle: KDIGO Guidelines Address Multiple Key Components of Cardiovascular-Kidney-Metabolic Syndrome. KIDNEY INTERNATIONAL. 2026. doi:10.1016/j.kint.2026.03.031
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
A urea-activated nanocarrier for site-specific SGLT2 inhibition and metabolic rescue against cardiovascular-kidney-metabolic syndrome.
2026 Nature Communications
Ren X等开发了一种尿素激活的纳米载体,实现SGLT2抑制剂肾小管靶向递送,在CKM小鼠模型中有效改善心脏和肾脏代谢功能,优于游离药物。心血管-肾脏-代谢综合征SGLT-2抑制剂恩格列净纳米载体动物实验活性氧肾脏靶向能量代谢PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1038/s41467-026-71424-w;PMID: 41932948[73]
Ren X, Gao D, Yun R, Liu X, Di C, Hu Z, et al. A urea-activated nanocarrier for site-specific SGLT2 inhibition and metabolic rescue against cardiovascular-kidney-metabolic syndrome. Nature Communications. 2026. doi:10.1038/s41467-026-71424-w
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
10.1161/CIRCULATIONAHA.125.077894. Epub 2026 Apr 1. Cardiovascular-Kidney-Metabolic Syndrome Stages, Echocardiographic Characteristics, and Heart Failure Risk: The Atherosclerosis Risk in Communities Study.
2026 Circulation
Lassen MCH 等基于ARIC研究5,646名老年人数据发现,较高CKM综合征分期与左心室不良重构及心力衰竭风险显著增加相关,4期风险比达8.3。心力衰竭心血管-肾脏-代谢综合征超声心动图心脏重构队列研究风险预测社区动脉粥样硬化风险研究PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏DOI: 10.1161/CIRCULATIONAHA.125.077894;PMID: 41919388[2]
Lassen MCH, Ostrominski JW, Claggett BL, Ndumele CE. Cardiovascular-Kidney-Metabolic Syndrome Stages, Echocardiographic Characteristics, and Heart Failure Risk: The Atherosclerosis Risk in Communities Study. Circulation. 2026;153(17):1268-1280. doi:10.1161/CIRCULATIONAHA.125.077894
CKM综合征分期与新型生物标志物的预后评估
Core
Advances in risk prediction and treatment strategies for CKM syndrome.
2026 Nature Reviews Nephrology
Drexler Y 和 Fornoni A 综述了CKM综合征的风险预测与治疗策略进展,发现整合多器官指标可提升风险分层准确性,并强调了新型靶向治疗在延缓疾病进展中的潜力。CKM综合征风险预测治疗策略心血管疾病肾脏疾病代谢疾病综述PubMed疾病:CKM Title/Abstract肾脏代谢综合DOI: 10.1038/s41581-025-01044-y;PMID: 41402462[63]
Drexler Y, Fornoni A. Advances in risk prediction and treatment strategies for CKM syndrome. Nature Reviews Nephrology. 2026;22(2):95-96. doi:10.1038/s41581-025-01044-y
CKM综合征分期与新型生物标志物的预后评估
Core
GLP-1 receptor agonists and next-generation metabolic hormone therapies in chronic kidney disease.
2026 Nature Reviews Nephrology
Alicic RZ 等在一项纳入6,719名CKM综合征1-4期患者的前瞻性队列研究中发现,hs-CRP/HDL-C比值与长期死亡风险呈线性正相关,该比值每增加一个四分位数间距,死亡风险升高15%。心血管-肾脏-代谢综合征Cox回归限制性立方样条hs-CRP/HDL-C比值全因死亡前瞻性队列研究风险预测PubMed疾病:CKM Title/Abstract肾脏代谢综合DOI: 10.1038/s41581-025-01036-y;PMID: 41507425[3]
Alicic RZ, Neumiller JJ, Tuttle KR. GLP-1 receptor agonists and next-generation metabolic hormone therapies in chronic kidney disease. Nature Reviews Nephrology. 2026;22(4):265-282. doi:10.1038/s41581-025-01036-y
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
print. Epidemiology of cardiovascular-kidney-metabolic syndrome.
2026 Nature Reviews Nephrology
Mavromatis LA 和 Grams ME 综述了心血管-肾脏-代谢综合征的流行病学,发现全球患病率持续上升,多数成人已处于≥1期,且疾病负担存在人口学与地域差异。心血管-肾脏-代谢综合征慢性肾脏病心血管疾病胰高血糖素样肽-1受体激动剂钠-葡萄糖协同转运蛋白-2抑制剂系统综述代谢危险因素发病与死亡风险流行病学PubMed疾病:cardiovascDOI: 10.1038/s41581-026-01078-w;PMID: 42098477[1]
Mavromatis LA, Grams ME. print. Epidemiology of cardiovascular-kidney-metabolic syndrome. Nature Reviews Nephrology. 2026. doi:10.1038/s41581-026-01078-w
CKM综合征分期与新型生物标志物的预后评估
Core
Association of Cardiovascular-Kidney-Metabolic Syndrome With Cognitive Decline and Dementia: The ARIC Study Insights.
2025 Journal of the American Heart Association
Xie Peichen 等基于ARIC研究10,426名参与者发现,心血管-肾脏-代谢综合征风险等级升高与认知衰退及痴呆风险增加显著相关,风险每升一级痴呆进展风险增加6%。心血管-肾脏-代谢综合征认知衰退痴呆回归分析CKM风险等级队列研究PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏代谢综合DOI: 10.1161/JAHA.124.038445;PMID: 40371582[29]
Xie Peichen, Wang Yiqin, Xu Xinghao, Tan Li, Guo Xingdi, Xu Ziqi, et al. Association of Cardiovascular-Kidney-Metabolic Syndrome With Cognitive Decline and Dementia: The ARIC Study Insights. Journal of the American Heart Association. 2025;14(10):e038445. doi:10.1161/JAHA.124.038445
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
Associations of cardiovascular-kidney-metabolic syndrome stages with premature mortality and the role of social determinants of health.
2025 Journal of Nutrition Health and Aging
Zhu R 等基于27,909名美国成年人数据发现,心血管-肾脏-代谢综合征3-4期与过早死亡风险显著升高相关,且不利健康社会决定因素进一步加剧该风险。心血管-肾脏-代谢综合征过早死亡健康社会决定因素Cox比例风险模型风险比前瞻性队列研究全因死亡心血管死亡PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1016/j.jnha.2025.100504;PMID: 39952015[20]
Zhu R, Wang R, He J, Wang L, Chen H, Wang Y, et al. Associations of cardiovascular-kidney-metabolic syndrome stages with premature mortality and the role of social determinants of health. Journal of Nutrition Health and Aging. 2025;29(4):100504. doi:10.1016/j.jnha.2025.100504
衰弱、非奈利酮及遗传多态性在CKM管理中的角色
Extension
Cardiovascular-kidney-metabolic overlaps, clinical outcomes, and quality of life in patients with acute heart failure.
2025 Journal of Nutrition Health and Aging
Li J等在一项纳入4,875例急性心衰患者的多中心队列中发现,合并三种心血管-肾脏-代谢疾病显著增加1年主要不良心血管事件及死亡风险,并降低生活质量。心力衰竭慢性肾脏病2型糖尿病Cox回归广义线性模型队列研究主要不良心血管事件全因死亡生活质量心血管死亡DOI: 10.1016/j.jnha.2025.100613;PMID: 40555038[79]
Li J, Lei L, Zhang L, Guo Y, Yuan X. Cardiovascular-kidney-metabolic overlaps, clinical outcomes, and quality of life in patients with acute heart failure. Journal of Nutrition Health and Aging. 2025;29(8):100613. doi:10.1016/j.jnha.2025.100613
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
Temporal trends in the planetary health diet index and its association with cardiovascular, kidney, and metabolic diseases: A comprehensive analysis from global and individual perspectives.
2025 Journal of Nutrition Health and Aging
Tang H 等基于185国数据及45,460名美国参与者分析发现,1990-2018年行星健康饮食指数评分全球平均为42.80,较高评分与心血管、肾脏及代谢疾病风险降低显著相关。心血管疾病代谢性疾病慢性肾病行星健康饮食指数饮食评估横断面研究队列研究伤残调整生命年疾病负担CKM综合征DOI: 10.1016/j.jnha.2025.100520;PMID: 39985957[59]
Tang H, Zhang X, Luo N, Huang J, Yang Q, Lin H, et al. Temporal trends in the planetary health diet index and its association with cardiovascular, kidney, and metabolic diseases: A comprehensive analysis from global and individual perspectives. Journal of Nutrition Health and Aging. 2025;29(5):100520. doi:10.1016/j.jnha.2025.100520
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
A simple score, CKM(2)S(2)-BAG, to predict cardiovascular risk with cardiovascular-kidney-metabolic health metrics.
2025 iScience
Yang Z 等基于两个前瞻性社区队列构建并验证了CKM(2)S(2)-BAG评分,发现该评分能准确区分心血管低、中、高风险,对总CVD及其亚型预测性能稳健。心血管疾病心力衰竭动脉粥样硬化风险评分空腹血糖前瞻性队列研究外部验证胆固醇肾功能PubMed疾病:cardiovascDOI: 10.1016/j.isci.2025.112780;PMID: 40599322[104]
Yang Z, Zhou P, Fan F, Hao Y, Zhao W, Wang Z, et al. A simple score, CKM(2)S(2)-BAG, to predict cardiovascular risk with cardiovascular-kidney-metabolic health metrics. iScience. 2025;28(7):112780. doi:10.1016/j.isci.2025.112780
c8
Excluded
Exploring a long distance, amagmatic, across-suture orogenic geothermal system: Sri Lanka's foreland hot springs.
2025 iScience
Bandara D 等通过分析斯里兰卡前陆温泉的裂隙网络与地温梯度,发现流体可沿基底断裂运移达100公里,循环深度可达沉积盖层之下。温泉地热系统裂隙网络地温梯度循环深度横断面研究地热资源PubMed疾病:CKM Title/Abstract公里超过DOI: 10.1016/j.isci.2025.112370;PMID: 40330879No ref no.
Bandara D, Smit J, Wohnlich S, Heinze T. Exploring a long distance, amagmatic, across-suture orogenic geothermal system: Sri Lanka's foreland hot springs.. iScience. 2025. 28(5). 112370.. doi:10.1016/j.isci.2025.112370
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
2025 Apr. Prognosis of non-albuminuric patients with the cardiovascular-kidney-metabolic syndrome.
2025 Clinical Kidney Journal
Bi X 等基于中国和英国两个大型队列研究发现,正常范围内的尿白蛋白与肌酐比值升高与心血管-肾脏-代谢综合征患者进展至4期及全因死亡风险增加显著相关。心血管-肾脏-代谢综合征尿白蛋白肌酐比值队列研究Cox回归全因死亡率疾病进展中国肾脏数据系统英国生物银行PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1093/ckj/sfaf074;PMID: 40226369[74]
Bi X, Shen Y, Shen Y, Shen A, Zhou S, Wang W, et al. 2025 Apr. Prognosis of non-albuminuric patients with the cardiovascular-kidney-metabolic syndrome. Clinical Kidney Journal. 2025;18(4):sfaf074. doi:10.1093/ckj/sfaf074
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
2025 Jun. How do patient information documents present dialysis and conservative kidney management? A document analysis.
2025 Clinical Kidney Journal
Sowden R 等通过定性文献分析发现,患者信息文件对透析和保守性肾脏管理的呈现存在不平衡,透析被构建为默认选择,而保守管理常被负面描述并与死亡关联。晚期肾病透析保守性肾脏管理患者信息文件定性文献分析批判性话语分析治疗决策预先护理计划姑息治疗PubMed疾病:CKM Title/AbstractDOI: 10.1093/ckj/sfaf136;PMID: 40487369No ref no.
Sowden R, Shaw C, Robb J, Winterbottom A, Bristowe K, Bekker. 2025 Jun. How do patient information documents present dialysis and conservative kidney management? A document analysis.. Clinical Kidney Journal. 2025. 18(6). sfaf136.. doi:10.1093/ckj/sfaf136
地热系统与超级马拉松代谢挑战等无关主题
Excluded
eCollection 2025. Identifying potential drugs for treating Cardiovascular-kidney metabolic syndrome via reverse network pharmacology.
2025 Frontiers in Pharmacology
Wen S 等通过反向网络药理学筛选出小檗碱(BBR)为治疗心血管-肾脏-代谢综合征(CKM)的潜在药物,并在小鼠模型中证实BBR可改善代谢紊乱、心脏舒张功能及肾损伤。心血管-肾脏-代谢综合征小檗碱反向网络药理学代谢参数动物实验心脏舒张功能肾损伤脂质代谢葡萄糖代谢纤维化通路DOI: 10.3389/fphar.2025.1627236;PMID: 40661082No ref no.
Wen S, Fu A, Liu F, You Y,. eCollection 2025. Identifying potential drugs for treating Cardiovascular-kidney metabolic syndrome via reverse network pharmacology.. Frontiers in Pharmacology. 2025. 16. 1627236.. doi:10.3389/fphar.2025.1627236
地热系统与超级马拉松代谢挑战等无关主题
Excluded
Adipokines and Vascular Modulators in CKM: Emerging Biomarkers as Diagnostic and Therapeutic Targets.
2025 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Gerdanovics CA 等综述发现,脂肪因子(如RBP4、LCN2)和血管调节因子(如Klotho、MGP)在CKM综合征中失调,可作为诊断生物标志物和治疗靶点。心肾代谢综合征脂肪因子血管调节因子生物标志物治疗靶点系统综述视黄醇结合蛋白4Klotho基质Gla蛋白PubMed疾病:CKM Title/AbstractDOI: 10.3390/ijms262211083;PMID: 41303567No ref no.
Gerdanovics CA, Suciu ȘM, Orășan OH, Para I, Turi VR, Milaciu. Adipokines and Vascular Modulators in CKM: Emerging Biomarkers as Diagnostic and Therapeutic Targets.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2025. 26(22). 11083.. doi:10.3390/ijms262211083
CKM定义评估空白与超加工食品的代谢影响
Extension
Effects of Temperature and Salinity on Ovarian Development and Differences in Energy Metabolism Between Reproduction and Growth During Ovarian Development in the Lateolabrax maculatus.
2025 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Peng Y 等通过实验发现,低盐度(4‰)和低温(18±1°C)协同促进花鲈卵巢发育,并揭示卵巢依赖有氧代谢供能,肌肉则通过糖酵解将能量重新分配至性腺以维持繁殖与生长的平衡。卵巢发育盐度温度能量代谢激素转录组代谢组实验研究PubMed疾病:CKM Title/AbstracttgsDOI: 10.3390/ijms26178295;PMID: 40943217[100]
Peng Y, Yan L, Zhao C, Zhang B, Zhang B, Qiu. Effects of Temperature and Salinity on Ovarian Development and Differences in Energy Metabolism Between Reproduction and Growth During Ovarian Development in the Lateolabrax maculatus. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2025;26(17):8295. doi:10.3390/ijms26178295
c8
Excluded
Does Distance Matter? Metabolic and Muscular Challenges of a Non-Stop Ultramarathon with Sub-Analysis Depending on Running Distance.
2025 Nutrients
John L 等在一项前瞻性观察性研究中发现,超级马拉松跑者赛后出现显著能量赤字、瘦素和胰岛素降低、饥饿素和肌肉损伤标志物升高,且230公里组变化最大。超级马拉松能量赤字瘦素饥饿素肌酸激酶乳酸脱氢酶前瞻性观察连续血糖监测肌肉损伤代谢紊乱DOI: 10.3390/nu17233801;PMID: 41374091No ref no.
John L, Munk M, Bizjak R, Schulz SVW, Witzel J, Engler H,. Does Distance Matter? Metabolic and Muscular Challenges of a Non-Stop Ultramarathon with Sub-Analysis Depending on Running Distance.. Nutrients. 2025. 17(23). 3801.. doi:10.3390/nu17233801
CKM定义评估空白与超加工食品的代谢影响
Extension
Influence of Genetic Polymorphisms and Biochemical Biomarkers on Response to Nutritional Iron Supplementation and Performance in a Professional Football Team: A Pilot Longitudinal Study.
2025 Nutrients
Varillas-Delgado D等在一项针对职业足球运动员的纵向研究中发现,携带特定基因型(如ACE DD、ACTN3 CC)的运动员铁补充需求更少,且总基因型评分可有效预测补充需求及运动表现差异。铁缺乏硫酸亚铁纵向研究铁蛋白血红蛋白基因多态性运动表现总基因型评分PubMed疾病:CKM Title/AbstracttgsDOI: 10.3390/nu17081379;PMID: 40284242[95]
Varillas-Delgado D. Influence of Genetic Polymorphisms and Biochemical Biomarkers on Response to Nutritional Iron Supplementation and Performance in a Professional Football Team: A Pilot Longitudinal Study. Nutrients. 2025;17(8):1379. doi:10.3390/nu17081379
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
Medical Nutrition Therapy Adherence and Lifestyle in Stage 5 CKD: Challenges and Insights.
2025 Nutrients
Palumbo P 等评估了接受保守管理的5期CKD患者对医学营养疗法的依从性,发现自我报告与生化指标存在差异,且糖尿病与较低的蛋白质摄入依从性显著相关。慢性肾脏病医学营养疗法饮食依从性蛋白质摄入队列研究饮食史标准化蛋白氮出现率糖尿病PubMed疾病:CKM Title/AbstractckdDOI: 10.3390/nu17193091;PMID: 41097168No ref no.
Palumbo P, Alfano G, Cavani F, Giannini R, Pulizzi RA, Gabriele. Medical Nutrition Therapy Adherence and Lifestyle in Stage 5 CKD: Challenges and Insights.. Nutrients. 2025. 17(19). 3091.. doi:10.3390/nu17193091
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
2025. Altered albumin/neutrophil to lymphocyte ratio are associated with all-cause and cardiovascular mortality for advanced cardiovascular-kidney-metabolic syndrome.
2025 Frontiers in Nutrition
Yin X 等基于3,266名晚期CKM综合征患者数据发现,白蛋白/中性粒细胞与淋巴细胞比值降低与全因及心血管死亡风险升高独立相关,呈L形关联。心血管-肾脏-代谢综合征白蛋白中性粒细胞淋巴细胞比值全因死亡率心血管死亡率倾向评分匹配限制性立方样条Cox回归横断面研究队列研究国家健康与营养调查DOI: 10.3389/fnut.2025.1595119;PMID: 40740647No ref no.
Yin X, Zou J, Yang J. 2025. Altered albumin/neutrophil to lymphocyte ratio are associated with all-cause and cardiovascular mortality for advanced cardiovascular-kidney-metabolic syndrome.. Frontiers in Nutrition. 2025. 12. 1595119.. doi:10.3389/fnut.2025.1595119
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
2025. Association between albumin to globulin ratio and all-cause and cardiovascular mortality among individuals with cardiovascular-kidney-metabolic syndrome: results from NHANES 2003 to 2018.
2025 Frontiers in Nutrition
Wang G等基于NHANES数据库对CKM综合征患者分析发现,白蛋白与球蛋白比值升高与全因及心血管死亡风险显著降低相关,其中全因死亡呈非线性关联。心血管-肾脏-代谢综合征白蛋白球蛋白比值全因死亡心血管死亡Cox回归队列研究剂量反应关系生物标志物PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.3389/fnut.2025.1622590;PMID: 40678773No ref no.
Wang G, Li G, Wang P, Zang M, Pu J. 2025. Association between albumin to globulin ratio and all-cause and cardiovascular mortality among individuals with cardiovascular-kidney-metabolic syndrome: results from NHANES 2003 to 2018.. Frontiers in Nutrition. 2025. 12. 1622590.. doi:10.3389/fnut.2025.1622590
CKM综合征分期与新型生物标志物的预后评估
Core
2025. Association between body roundness index and advanced cardiovascular-kidney-metabolic syndrome.
2025 Frontiers in Nutrition
Chen Y 等基于12,329名美国成年人数据发现,身体圆度指数升高与晚期心血管-肾脏-代谢综合征风险呈正相关,且其预测能力优于传统人体测量指标。晚期CKM综合征身体圆度指数横断面研究限制性立方样条受试者工作特征分析回归分析人体测量指标内脏脂肪PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.3389/fnut.2025.1623766;PMID: 40808842[39]
Chen Y, Tu H, Liang M, Shen M. 2025. Association between body roundness index and advanced cardiovascular-kidney-metabolic syndrome. Frontiers in Nutrition. 2025;12:1623766. doi:10.3389/fnut.2025.1623766
CKM综合征分期与新型生物标志物的预后评估
Core
2025. Association between dietary index for gut microbiota and cardiovascular-kidney-metabolic syndrome: a population-based study.
2025 Frontiers in Nutrition
Long D 等基于8,400名美国成年人数据发现,肠道微生物群膳食指数(DI-GM)评分与心血管-肾脏-代谢综合征患病率呈线性负相关,且女性中保护效应更显著。心血管-肾脏-代谢综合征肠道微生物群膳食指数横断面研究限制性立方样条逻辑回归患病率膳食质量性别差异PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.3389/fnut.2025.1594481;PMID: 40808844[61]
Long D, Mao C, An H, Zhu Y, Xu Y. 2025. Association between dietary index for gut microbiota and cardiovascular-kidney-metabolic syndrome: a population-based study. Frontiers in Nutrition. 2025;12:1594481. doi:10.3389/fnut.2025.1594481
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
2025. Association between dietary inflammatory index score and cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES.
2025 Frontiers in Nutrition
Yu H 等基于NHANES数据库的横断面研究发现,膳食炎症指数升高与心血管-肾脏-代谢综合征患病风险增加呈线性正相关,其中酒精摄入是关联最强的膳食因素。心血管-肾脏-代谢综合征膳食炎症指数横断面研究多元逻辑回归限制性立方样条慢性肾脏病心脏代谢综合征酒精摄入PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.3389/fnut.2025.1557491;PMID: 40416382[50]
Yu H, Liu Y, Zhang T, Guan Z, Li P. 2025. Association between dietary inflammatory index score and cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES. Frontiers in Nutrition. 2025;12:1557491. doi:10.3389/fnut.2025.1557491
CKM综合征分期与新型生物标志物的预后评估
Core
2025. Association between non-highdensity lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiovascular-kidney-metabolic syndrome: evidence from NHANES 2001-2018.
2025 Frontiers in Nutrition
Duan Y 等基于NHANES 2001-2018年16,575名成人数据发现,非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值升高与心血管-肾脏-代谢综合征风险呈正相关,且存在非线性关联。慢性肾脏病心血管代谢综合征非高密度脂蛋白胆固醇限制性立方样条横断面研究体重指数高血压PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏DOI: 10.3389/fnut.2025.1548851;PMID: 40093879[48]
Duan Y, Yang K, Zhang T, Guo X, Yin Q, Liu H. 2025. Association between non-highdensity lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiovascular-kidney-metabolic syndrome: evidence from NHANES 2001-2018. Frontiers in Nutrition. 2025;12:1548851. doi:10.3389/fnut.2025.1548851
CKM综合征分期与新型生物标志物的预后评估
Core
2025. Association between oxidative balance score with cardiovascular - kidney - metabolic syndrome and all-cause mortality among US population.
2025 Frontiers in Nutrition
Shi L 等基于12,793名美国成年人数据发现,较高的氧化平衡评分与晚期心血管-肾脏-代谢综合征风险及全因死亡率呈负相关,且存在剂量-反应关系。心血管-肾脏-代谢综合征氧化平衡评分全因死亡率限制性立方样条Cox回归Logistic回归横断面研究队列研究PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.3389/fnut.2025.1564368;PMID: 40837432[51]
Shi L, Zhang D, Zhang S. 2025. Association between oxidative balance score with cardiovascular - kidney - metabolic syndrome and all-cause mortality among US population. Frontiers in Nutrition. 2025;12:1564368. doi:10.3389/fnut.2025.1564368
CKM综合征分期与新型生物标志物的预后评估
Core
2025. Association between the composite dietary antioxidant index and cardiovascular-kidney-metabolic syndrome among U.S. adults: evidence from NHANES 2007-2018.
2025 Frontiers in Nutrition
He Q 等基于NHANES 2007-2018年11,073名成人数据发现,复合膳食抗氧化指数升高与晚期心血管-肾脏-代谢综合征患病风险降低呈非线性负相关。心血管-肾脏-代谢综合征复合膳食抗氧化指数横断面研究逻辑回归限制性立方样条维生素类胡萝卜素PubMed疾病:cardiovascDOI: 10.3389/fnut.2025.1600651;PMID: 40709338[54]
He Q, Hu F, Wei W, Li J, Yu Y, Zhang H. 2025. Association between the composite dietary antioxidant index and cardiovascular-kidney-metabolic syndrome among U.S. adults: evidence from NHANES 2007-2018. Frontiers in Nutrition. 2025;12:1600651. doi:10.3389/fnut.2025.1600651
CKM综合征分期与新型生物标志物的预后评估
Core
2025. Association between the dietary inflammatory index and depressive symptoms in adults with cardiovascular-kidney-metabolic syndrome: evidence of metabolic syndrome as a mediator.
2025 Frontiers in Nutrition
Tian RN 等基于12,980名CKM综合征成人数据发现,膳食炎症指数与抑郁症状呈J形非线性关联,且代谢综合征介导了4.44%的效应。抑郁症状代谢综合征膳食炎症指数限制性立方样条逻辑回归横断面研究心血管肾脏代谢综合征中介效应PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.3389/fnut.2025.1623482;PMID: 40808838[31]
Tian RN, Zhang SX, Zhang N, Wu WJ, Guo HQ, Wang C. 2025. Association between the dietary inflammatory index and depressive symptoms in adults with cardiovascular-kidney-metabolic syndrome: evidence of metabolic syndrome as a mediator. Frontiers in Nutrition. 2025;12:1623482. doi:10.3389/fnut.2025.1623482
CKM综合征分期与新型生物标志物的预后评估
Core
2025. Association between the life's essential 8 health behaviors score and all-cause mortality in cardiovascular-kidney-metabolic syndrome patients.
2025 Frontiers in Nutrition
Tu D 等基于11,638名CKM综合征患者的前瞻性队列研究发现,生命八要素健康行为评分与全因死亡率显著相关,尤其在晚期患者中关联更强,且改善评分可避免约23%的死亡。心血管-肾脏-代谢综合征全因死亡率生命八要素Cox回归限制性立方样条队列研究健康行为评分人群归因分数PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.3389/fnut.2025.1612693;PMID: 40655481No ref no.
Tu D, Zuo X, Li P, Wang J. 2025. Association between the life's essential 8 health behaviors score and all-cause mortality in cardiovascular-kidney-metabolic syndrome patients.. Frontiers in Nutrition. 2025. 12. 1612693.. doi:10.3389/fnut.2025.1612693
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
2025. Association between urinary heavy metals and cardiovascular-kidney-metabolic syndrome: mediating roles of TyG, WWI, and eGFR.
2025 Frontiers in Nutrition
Liu J 等基于NHANES数据发现,尿重金属暴露与晚期心血管-肾脏-代谢综合征风险正相关,且TyG、WWI和eGFR部分中介了该关联。心血管-肾脏-代谢综合征重金属暴露甘油三酯-葡萄糖指数体重调整腰围指数估算肾小球滤过率限制性立方样条加权分位数和回归横断面研究中介分析DOI: 10.3389/fnut.2025.1613721;PMID: 40635894[56]
Liu J, Song Y, Luo R, Wang S, Pan P, Han L. 2025. Association between urinary heavy metals and cardiovascular-kidney-metabolic syndrome: mediating roles of TyG, WWI, and eGFR. Frontiers in Nutrition. 2025;12:1613721. doi:10.3389/fnut.2025.1613721
CKM综合征分期与新型生物标志物的预后评估
Core
2025. Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study.
2025 Frontiers in Nutrition
Pengfei C 等基于301,631名CKM综合征患者的前瞻性队列研究发现,升高的SII和SIRI与心血管疾病发病风险显著相关,其中SII呈U型关联,SIRI呈单调递增关联。心血管疾病心血管-肾脏-代谢综合征全身免疫炎症指数全身炎症反应指数Cox回归限制性立方样条队列研究发病率PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.3389/fnut.2025.1661826;PMID: 41368184[46]
Pengfei C, Lui M, Zhang L, Chen C, Wang T, Ailin H. 2025. Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study. Frontiers in Nutrition. 2025;12:1661826. doi:10.3389/fnut.2025.1661826
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
2025. Association of cardiovascular-kidney-metabolic syndrome with depression and all-cause mortality: a population-based observational study.
2025 Frontiers in Nutrition
Liu W等基于15,156名参与者数据发现,随着心血管-肾脏-代谢综合征分期进展,抑郁症患病率升高,晚期CKM综合征显著增加抑郁症患者的全因死亡风险。心血管-肾脏-代谢综合征抑郁症全因死亡患者健康问卷-9多变量逻辑回归多变量Cox回归Kaplan-Meier生存分析横断面研究年龄标准化患病率美国成年人DOI: 10.3389/fnut.2025.1620008;PMID: 41256919No ref no.
Liu W, Li Z, Ma P. 2025. Association of cardiovascular-kidney-metabolic syndrome with depression and all-cause mortality: a population-based observational study.. Frontiers in Nutrition. 2025. 12. 1620008.. doi:10.3389/fnut.2025.1620008
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
2025. Association of multiple dietary metal intake with cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES 2003-2018.
2025 Frontiers in Nutrition
Hu S 等基于NHANES 2003-2018年15,233名成人数据发现,较高膳食铜摄入量与晚期心血管-肾脏-代谢综合征患病率降低显著相关。心血管-肾脏-代谢综合征膳食金属摄入横断面研究加权逻辑回归限制性立方样条美国国家健康与营养调查亚组分析PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.3389/fnut.2025.1612458;PMID: 40761350No ref no.
Hu S, Wei B, Zhang A. 2025. Association of multiple dietary metal intake with cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES 2003-2018.. Frontiers in Nutrition. 2025. 12. 1612458.. doi:10.3389/fnut.2025.1612458
CKM综合征分期与新型生物标志物的预后评估
Core
2025. Association of neutrophil/high-density lipoprotein cholesterol ratio with the cardiovascular-kidney-metabolic syndrome and its cardiovascular mortality.
2025 Frontiers in Nutrition
Xu Y等基于13,165名美国成年人数据发现,中性粒细胞/高密度脂蛋白胆固醇比值升高与心血管-肾脏-代谢综合征患病率及心血管死亡风险呈正向线性关联。心血管-肾脏-代谢综合征中性粒细胞/高密度脂蛋白胆固醇比值心血管死亡率Cox回归限制性立方样条横断面研究逻辑回归PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract肾脏DOI: 10.3389/fnut.2025.1594041;PMID: 40535046[47]
Xu Y. 2025. Association of neutrophil/high-density lipoprotein cholesterol ratio with the cardiovascular-kidney-metabolic syndrome and its cardiovascular mortality. Frontiers in Nutrition. 2025;12:1594041. doi:10.3389/fnut.2025.1594041
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
2025. Associations between Life's Crucial 9 and severity, all-cause mortality, and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: the mediating role of phenotypic age acceleration.
2025 Frontiers in Nutrition
Li J等基于7,647例CKM综合征患者数据发现,Life's Crucial 9评分每增加10%,进展至晚期CKM综合征风险降低37%,且与全因及心血管死亡率显著负相关,表型年龄加速在其中起中介作用。心血管-肾脏-代谢综合征生命关键9项表型年龄加速全因死亡率心血管死亡率逻辑回归Cox回归限制性立方样条横断面研究中介分析DOI: 10.3389/fnut.2025.1612293;PMID: 40843205No ref no.
Li J, Xu Z, Lin J, Luo S, Xu S. 2025. Associations between Life's Crucial 9 and severity, all-cause mortality, and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: the mediating role of phenotypic age acceleration.. Frontiers in Nutrition. 2025. 12. 1612293.. doi:10.3389/fnut.2025.1612293
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
2025. Cardiovascular-kidney-metabolic progression associated with major adverse liver outcomes: mediating roles of plasma metabolites.
2025 Frontiers in Nutrition
Liang J 等基于英国生物银行415,713人数据发现,心血管-肾脏-代谢综合征分期进展与主要不良肝脏结局风险升高显著相关,该关联部分由酪氨酸和亚油酸/总脂肪酸比值等血浆代谢物介导。心血管-肾脏-代谢综合征主要不良肝脏结局Cox回归血浆代谢物酪氨酸亚油酸前瞻性队列研究中介分析PubMed疾病:CKM Title/Abstract肾脏DOI: 10.3389/fnut.2025.1675899;PMID: 41190151[30]
Liang J, Liang Y, Chen L, Cai M, Li S, He L. 2025. Cardiovascular-kidney-metabolic progression associated with major adverse liver outcomes: mediating roles of plasma metabolites. Frontiers in Nutrition. 2025;12:1675899. doi:10.3389/fnut.2025.1675899
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
2025. Machine learning with decision curve analysis evaluates nutritional metabolic biomarkers for cardiovascular-kidney-metabolic risk: an NHANES analysis.
2025 Frontiers in Nutrition
Huang J 等基于NHANES数据,通过机器学习与决策曲线分析发现,RAR、SIRI等营养代谢生物标志物与心血管-肾脏-代谢综合征风险显著相关,其中RAR关联最强。心血管-肾脏-代谢综合征胰岛素抵抗机器学习决策曲线分析限制性立方样条Cox回归RARNPAR队列研究PubMed疾病:cardiovascDOI: 10.3389/fnut.2025.1597864;PMID: 40406158[49]
Huang J, Liu Z, Feng W, Huang Y, Cheng X. 2025. Machine learning with decision curve analysis evaluates nutritional metabolic biomarkers for cardiovascular-kidney-metabolic risk: an NHANES analysis. Frontiers in Nutrition. 2025;12:1597864. doi:10.3389/fnut.2025.1597864
CKM综合征分期与新型生物标志物的预后评估
Core
2025. Non-linear associations and threshold effects of oxidative balance score and composite dietary antioxidant index on frailty risk in patients with cardiovascular-kidney-metabolic syndrome.
2025 Frontiers in Nutrition
Wang Z等基于10,201例早期心血管-肾脏-代谢综合征患者数据发现,氧化平衡评分和复合膳食抗氧化指数与衰弱风险呈非线性负相关,并存在阈值效应。心血管-肾脏-代谢综合征衰弱氧化平衡评分复合膳食抗氧化指数限制性立方样条横断面研究阈值效应逻辑回归PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.3389/fnut.2025.1673736;PMID: 41256923[53]
Wang Z, Fang L, Wang L, Zhang J. 2025. Non-linear associations and threshold effects of oxidative balance score and composite dietary antioxidant index on frailty risk in patients with cardiovascular-kidney-metabolic syndrome. Frontiers in Nutrition. 2025;12:1673736. doi:10.3389/fnut.2025.1673736
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
2025. The role of oxidative balance score in Cardiovascular-Kidney-Metabolic syndrome progression and mortality: insights from NHANES 1999-2020.
2025 Frontiers in Nutrition
Xie D 等基于NHANES 1999-2020年19,433名参与者数据发现,氧化平衡评分升高与心血管-肾脏-代谢综合征进展风险降低及死亡风险下降显著相关,炎症标志物部分介导该关联。心血管-肾脏-代谢综合征氧化平衡评分多项逻辑回归Cox模型全因死亡风险心血管死亡风险炎症标志物队列研究PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.3389/fnut.2025.1597693;PMID: 40667446[52]
Xie D, You F, Yang L, Li C, Liu F. 2025. The role of oxidative balance score in Cardiovascular-Kidney-Metabolic syndrome progression and mortality: insights from NHANES 1999-2020. Frontiers in Nutrition. 2025;12:1597693. doi:10.3389/fnut.2025.1597693
衰弱、非奈利酮及遗传多态性在CKM管理中的角色
Extension
Adverse Life Events Across the Life Course and the Risk of New-Onset Cardiovascular-Kidney-Metabolic Multimorbidity in Middle-Aged and Older Adults: Longitudinal Evidence From CHARLS.
2025 Journal of the American Heart Association
Shi P 等基于CHARLS中6258名中老年人数据发现,儿童期和成年期不良生活事件均与新发心血管-肾脏-代谢多病共存风险升高显著相关,且暴力与剥夺型事件风险最高,心理健康部分中介该关联。心血管肾脏代谢多病共存不良生活事件队列研究多状态时间模型中介分析心理健康生命历程中国健康与养老追踪调查PubMed疾病:CKM Title/Abstract多病共存DOI: 10.1161/JAHA.125.045192;PMID: 41378494[89]
Shi P, Lou C, Fang J, Song Y. Adverse Life Events Across the Life Course and the Risk of New-Onset Cardiovascular-Kidney-Metabolic Multimorbidity in Middle-Aged and Older Adults: Longitudinal Evidence From CHARLS. Journal of the American Heart Association. 2025;14(24):e045192. doi:10.1161/JAHA.125.045192
衰弱、非奈利酮及遗传多态性在CKM管理中的角色
Extension
Association of Atherogenic Index of Plasma With Stroke Risk in a Population With Cardiovascular-Kidney-Metabolic Syndrome Stages 0 to 3: The First Evidence From the China Health and Retirement Longitudinal Study.
2025 Journal of the American Heart Association
Liu Z 等基于中国健康与养老追踪研究7664名CKM综合征0-3期人群发现,血浆致动脉粥样硬化指数升高与卒中风险增加呈非线性关联,阈值为1.516。卒中心血管-肾脏-代谢综合征血浆致动脉粥样硬化指数Cox回归限制性立方样条队列研究甘油三酯高密度脂蛋白胆固醇PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1161/JAHA.124.039983;PMID: 40654258[86]
Liu Z, Zhou D, Tang Y, Huo G. Association of Atherogenic Index of Plasma With Stroke Risk in a Population With Cardiovascular-Kidney-Metabolic Syndrome Stages 0 to 3: The First Evidence From the China Health and Retirement Longitudinal Study. Journal of the American Heart Association. 2025;14(14):e039983. doi:10.1161/JAHA.124.039983
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
Climate Vulnerability and Cardiovascular-Kidney-Metabolic Disease in the United States.
2025 Journal of the American Heart Association
Vieira de Oliveira Salerno PR 等基于70,300个人口普查区数据发现,气候脆弱性指数各维度与心血管-肾脏-代谢综合征组分患病率显著相关,且关联独立于环境、社会经济及基础设施因素。心血管-肾脏-代谢综合征气候脆弱性横断面研究慢性肾脏病糖尿病高血压肥胖血脂异常冠心病患病率DOI: 10.1161/JAHA.124.038251;PMID: 40417800No ref no.
Vieira de Oliveira Salerno PR, Lewis PGT, Chen Z, Dazard JE, Ganatra. Climate Vulnerability and Cardiovascular-Kidney-Metabolic Disease in the United States.. Journal of the American Heart Association. 2025. 14(11). e038251.. doi:10.1161/JAHA.124.038251
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
Impact of DNA-Methylation Age Acceleration on Long-Term Mortality Among US Adults With Cardiovascular-Kidney-Metabolic Syndrome.
2025 Journal of the American Heart Association
Wu S 等在一项纳入1889名美国成人的队列研究中发现,DNA甲基化年龄加速与心血管-肾脏-代谢综合征晚期分期及长期全因和非心血管死亡率升高显著相关。心血管-肾脏-代谢综合征DNA甲基化年龄加速队列研究全因死亡率Cox比例风险回归GrimAge2Mort加速非心血管死亡率生物标志物中介分析健康饮食指数DOI: 10.1161/JAHA.124.039751;PMID: 40118808No ref no.
Wu S, Zhu J, Lyu S, Wang J, Shao X, Zhang H,. Impact of DNA-Methylation Age Acceleration on Long-Term Mortality Among US Adults With Cardiovascular-Kidney-Metabolic Syndrome.. Journal of the American Heart Association. 2025. 14(7). e039751.. doi:10.1161/JAHA.124.039751
地热系统与超级马拉松代谢挑战等无关主题
Excluded
Incorporation of Metabolic Dysfunction-Associated Steatotic Liver Disease in the Health Stage of Cardiovascular-Kidney-Metabolic Syndrome Improves Predictive Ability for Coronary Artery Disease in a Japanese General Population.
2025 Journal of the American Heart Association
Kawaharata W 等将代谢相关脂肪性肝病纳入心血管-肾脏-代谢综合征健康分期,发现改良分类能更有效分层日本普通人群的冠状动脉疾病风险。冠状动脉疾病代谢功能障碍相关脂肪性肝病心血管-肾脏-代谢综合征队列研究Cox比例风险分析综合判别改善指数风险比机器学习健康体检PubMed疾病:cardiovascDOI: 10.1161/JAHA.125.043173;PMID: 40767277No ref no.
Kawaharata W, Tanaka M, Sato T, Akiyama Y, Hosaka I, Aida. Incorporation of Metabolic Dysfunction-Associated Steatotic Liver Disease in the Health Stage of Cardiovascular-Kidney-Metabolic Syndrome Improves Predictive Ability for Coronary Artery Disease in a Japanese General Population.. Journal of the American Heart Association. 2025. 14(16). e043173.. doi:10.1161/JAHA.125.043173
CKM综合征分期与新型生物标志物的预后评估
Core
Overall Sleep Quality Is Associated With Advanced Stages in Patients With Cardiovascular-Kidney-Metabolic Syndrome.
2025 Journal of the American Heart Association
Tu D 等基于12,245名美国成年人数据发现,整体睡眠质量较高的CKM综合征患者处于晚期的可能性较低,中等和高睡眠质量组晚期风险分别降低32%和45%。心血管-肾脏-代谢综合征睡眠质量横断面研究逻辑回归优势比美国成年人肥胖糖尿病慢性肾脏病PubMed疾病:cardiovascDOI: 10.1161/JAHA.124.038674;PMID: 40130386[62]
Tu D, Sun J, Wang P, Xu Q, Ma C. Overall Sleep Quality Is Associated With Advanced Stages in Patients With Cardiovascular-Kidney-Metabolic Syndrome. Journal of the American Heart Association. 2025;14(7):e038674. doi:10.1161/JAHA.124.038674
CKM综合征分期与新型生物标志物的预后评估
Core
Prevalence of Cardiovascular-Kidney-Metabolic Stages in US Adolescents and Relationship to Social Determinants of Health.
2025 Journal of the American Heart Association
Baker-Smith CM 等基于1774名美国青少年数据发现,56%处于心肾代谢综合征0期,食品安全缺乏与CKM 1-2期风险升高40%显著相关。心肾代谢综合征动脉粥样硬化食品安全横断面研究逻辑回归家庭收入健康保险青少年PubMed疾病:CKM Title/Abstract肾脏DOI: 10.1161/JAHA.124.040269;PMID: 40371589[26]
Baker-Smith CM, Gauen AM, Petito LC, Khan SS, Allen. Prevalence of Cardiovascular-Kidney-Metabolic Stages in US Adolescents and Relationship to Social Determinants of Health. Journal of the American Heart Association. 2025;14(10):e040269. doi:10.1161/JAHA.124.040269
衰弱、非奈利酮及遗传多态性在CKM管理中的角色
Extension
Reduced Risk of Cardiovascular Diseases After Bariatric Surgery Based on the New Predicting Risk of Cardiovascular Disease EVENTs Equations.
2025 Journal of the American Heart Association
Wang L 等基于7804例减重手术患者数据,发现术后心血管-肾脏-代谢健康显著改善,10年及30年心血管疾病风险均下降,其中心力衰竭风险降低47%-56%。心血管疾病减重手术队列研究心力衰竭收缩压糖尿病心血管事件预测风险方程体重减轻PubMed疾病:CKM Title/Abstract多病共存DOI: 10.1161/JAHA.124.038191;PMID: 40055867[80]
Wang L, Zhang X, Chen Y, Flynn CR, English WJ, Samuels JM. Reduced Risk of Cardiovascular Diseases After Bariatric Surgery Based on the New Predicting Risk of Cardiovascular Disease EVENTs Equations. Journal of the American Heart Association. 2025;14(6):e038191. doi:10.1161/JAHA.124.038191
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
The cellular and molecular mechanisms mediating the protective effects of sodium-glucose linked transporter 2 inhibitors against metabolic dysfunction-associated fatty liver disease.
2025 DIABETES OBESITY and METABOLISM
Ao N 等综述了SGLT2抑制剂对MAFLD的保护作用,发现其通过细胞与分子机制改善脂肪肝及相关合并症(如心血管病和慢性肾病)。代谢功能障碍相关脂肪性肝病SGLT2抑制剂系统综述心血管疾病慢性肾脏病2型糖尿病细胞与分子机制心血管-肾脏-代谢综合征PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1111/dom.16043;PMID: 39508115[66]
Ao N, Du J, Jin S, Suo L, Yang J. The cellular and molecular mechanisms mediating the protective effects of sodium-glucose linked transporter 2 inhibitors against metabolic dysfunction-associated fatty liver disease. DIABETES OBESITY and METABOLISM. 2025;27(2):457-467. doi:10.1111/dom.16043
CKM定义评估空白与超加工食品的代谢影响
Extension
eCollection 2025 Apr. Conservative Kidney Management in the Middle East and North Africa: Attitudes, Practices, and Implementation Barriers.
2025 Kidney International Reports
Koubar SH 等通过一项涵盖336名肾脏病专家的调查发现,中东和北非地区对保守性肾脏管理认知度较高,但实施率低,主要障碍为资金和资源限制。慢性肾病保守性肾脏管理横断面研究问卷调查实施障碍肾脏病专家中东和北非PubMed疾病:CKM Title/AbstracttgsactnDOI: 10.1016/j.ekir.2025.01.011;PMID: 40303211No ref no.
Koubar SH, Hatab T, Razzak FA, Helal I, Ali A, Shebani A,. eCollection 2025 Apr. Conservative Kidney Management in the Middle East and North Africa: Attitudes, Practices, and Implementation Barriers.. Kidney International Reports. 2025. 10(4). 1076-1086.. doi:10.1016/j.ekir.2025.01.011
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
eCollection 2025 Aug. Kidney Disease: Improving Global Outcomes Summit Recommendations on Implementation of Diabetes Management in CKD: From Primary to Data-Driven Collaborative Care.
2025 Kidney International Reports
Li 等通过db/db小鼠模型结合多组学分析发现,铁皮石斛通过调控NF-κB、PI3K-Akt通路及甘油磷脂、硫代谢,改善高血糖、胰岛素抵抗和肾功能障碍。2型糖尿病铁皮石斛动物实验多组学分析胰岛素抵抗肾功能障碍代谢物NF-κB通路PI3K-Akt通路氧化应激DOI: 10.1016/j.ekir.2025.06.010;PMID: 40814615No ref no.
Li PK, Cheung M, Chow KM, Leung MKW, Lim LL, Lui. eCollection 2025 Aug. Kidney Disease: Improving Global Outcomes Summit Recommendations on Implementation of Diabetes Management in CKD: From Primary to Data-Driven Collaborative Care.. Kidney International Reports. 2025. 10(8). 2551-2565.. doi:10.1016/j.ekir.2025.06.010
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
10.1016/j.ecoenv.2025.118885. Epub 2025 Aug 16. Cadmium exposure and advanced cardiovascular-kidney-metabolic syndrome: An integrated multi-organ perspective based on epidemiology and adverse outcome pathways.
2025 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
He Y等基于NHANES 14,372名参与者数据发现,估算脉搏波传导速度升高与心血管-肾脏-代谢综合征风险呈非线性正相关,且在年轻成人中关联更强。心血管-肾脏-代谢综合征估算脉搏波传导速度甘油三酯-葡萄糖指数横断面研究限制性立方样条Cox比例风险模型动脉僵硬度死亡率PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1016/j.ecoenv.2025.118885;PMID: 40819402No ref no.
He Y, Zhou X, Huang W, Wu Y, Zhang Z, Jin Y, et al. 10.1016/j.ecoenv.2025.118885. Epub 2025 Aug 16. Cadmium exposure and advanced cardiovascular-kidney-metabolic syndrome: An integrated multi-organ perspective based on epidemiology and adverse outcome pathways.. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2025. 303. 118885.. doi:10.1016/j.ecoenv.2025.118885
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
10.1016/j.ecoenv.2025.118915. Epub 2025 Aug 23. Effects of ambient air pollution mixtures and household fuel use on progression to advanced cardiovascular-kidney-metabolic syndrome among middle-aged and older adults.
2025 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Fan S 等基于中国健康与养老追踪调查数据发现,环境空气污染物与家庭固体燃料使用共同暴露显著增加中老年人晚期心血管-肾脏-代谢综合征风险,其中PM₁₀是主要驱动因素。心血管-肾脏-代谢综合征空气污染家庭燃料队列研究加权分位数和回归贝叶斯核机器回归PM₁₀中老年人PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1016/j.ecoenv.2025.118915;PMID: 40850115[57]
Fan S, Hu H, Li Y, Deng Y, Wang S, Xian J, et al. Effects of ambient air pollution mixtures and household fuel use on progression to advanced cardiovascular-kidney-metabolic syndrome among middle-aged and older adults. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2025;303:118915. doi:10.1016/j.ecoenv.2025.118915
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
10.1016/j.ecoenv.2025.118993. Epub 2025 Sep 2. Environment-wide association study of cardiovascular-kidney-metabolic syndrome based on NHANES 2013-2016.
2025 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Ma J 等基于NHANES 2013-2016数据,通过暴露组学分析发现六种环境化学物与CKM综合征相关,其中金属混合暴露增加晚期CKM风险,且炎症可能起中介作用。心血管-肾脏-代谢综合征环境化学物限制性立方样条加权分位数和炎症队列研究暴露组学金属多环芳烃挥发性有机物代谢物DOI: 10.1016/j.ecoenv.2025.118993;PMID: 40902250[64]
Ma J, Li P, Tao L, Yang X, Luo Y, Guo X, et al. Environment-wide association study of cardiovascular-kidney-metabolic syndrome based on NHANES 2013-2016. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2025;303:118993. doi:10.1016/j.ecoenv.2025.118993
CKM定义评估空白与超加工食品的代谢影响
Extension
Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking.
2025 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Zhang X等通过网络毒理学和分子对接发现,塑化剂可能通过靶向CKM、SOAT2等6个核心基因诱导骨质疏松,并显示出与靶蛋白的特异性结合效应。骨质疏松症塑化剂网络毒理学分子对接机器学习靶基因邻苯二甲酸酯系统综述PubMed疾病:CKM Title/AbstracttgsDOI: 10.1016/j.ecoenv.2025.117820;PMID: 39884015[92]
Zhang X, Zhu X, Gu W, Li X, Niu T, Mao P, et al. Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2025;291:117820. doi:10.1016/j.ecoenv.2025.117820
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
10.1016/j.diabres.2025.112327. Epub 2025 Jun 13. Associations between insulin resistance indices and cardiovascular disease in older adults with cardiovascular-kidney-metabolic syndrome stage 0-3: The GOLD-Health cohort.
2025 DIABETES RESEARCH AND CLINICAL PRACTICE
Wang M等基于463,545名老年CKM综合征0-3期队列发现,八种胰岛素抵抗指标均与CVD风险升高显著相关,其中TyG-WC预测效能最高。心血管疾病胰岛素抵抗Cox回归限制性立方样条甘油三酯葡萄糖指数心血管-肾脏-代谢综合征队列研究老年人群PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1016/j.diabres.2025.112327;PMID: 40517908[43]
Wang M, Lin W, Liu H, Qian ZM, Chen J, Rao M, et al. Associations between insulin resistance indices and cardiovascular disease in older adults with cardiovascular-kidney-metabolic syndrome stage 0-3: The GOLD-Health cohort. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025;226:112327. doi:10.1016/j.diabres.2025.112327
CKM综合征分期与新型生物标志物的预后评估
Core
10.1016/j.diabres.2025.112437. Epub 2025 Aug 25. Periodontitis, accelerated biological aging, and advanced stages in cardiovascular-kidney-metabolic syndrome in U.S. Adults: A mediation analysis.
2025 DIABETES RESEARCH AND CLINICAL PRACTICE
Qi X 等基于3102名美国成年人数据发现,重度牙周炎与晚期心血管-肾脏-代谢综合征风险升高1.5-2.05倍相关,且生物学年龄加速介导了约20%的效应。牙周炎心血管-肾脏-代谢综合征生物学年龄加速Klemera-Doubal方法表型年龄横断面研究中介分析逻辑回归美国成年人口腔健康DOI: 10.1016/j.diabres.2025.112437;PMID: 40865882No ref no.
Qi X, Sui J, Yang Z, Dahlen A, Zhang K, Wu B. 10.1016/j.diabres.2025.112437. Epub 2025 Aug 25. Periodontitis, accelerated biological aging, and advanced stages in cardiovascular-kidney-metabolic syndrome in U.S. Adults: A mediation analysis.. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025. 228. 112437.. doi:10.1016/j.diabres.2025.112437
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
10.1016/j.diabres.2025.112927. Epub 2025 Sep 28. Association of the metabolic dysfunction-associated steatotic liver disease with cardiovascular and kidney disease in patients with type 2 diabetes mellitus: a cross-sectional study.
2025 DIABETES RESEARCH AND CLINICAL PRACTICE
Ren H 等在一项纳入2436例2型糖尿病患者的横断面研究中发现,肝纤维化与左心室肥厚及慢性肾脏病风险增加独立相关,且与心血管-肾脏-代谢综合征分期升高相关。2型糖尿病肝纤维化左心室肥厚慢性肾脏病NAFLD纤维化评分逻辑回归横断面研究心血管疾病代谢功能障碍相关脂肪性肝病PubMed疾病:cardiovascDOI: 10.1016/j.diabres.2025.112927;PMID: 41027495[23]
Ren H, Hu M, Yan Y, Cheng M, Yang C, Yuan G, et al. Association of the metabolic dysfunction-associated steatotic liver disease with cardiovascular and kidney disease in patients with type 2 diabetes mellitus: a cross-sectional study. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025;229:112927. doi:10.1016/j.diabres.2025.112927
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
10.1016/j.diabres.2025.112988. Epub 2025 Nov 7. Exploring the mediating role of TyG-related indicators in the relationship between biological aging and late-stage cardiovascular-kidney-metabolic in middle-aged and older adults.
2025 DIABETES RESEARCH AND CLINICAL PRACTICE
Li Y等基于3710名中老年人的横断面研究发现,生物衰老与晚期心血管-肾脏-代谢综合征风险正相关,且TyG相关指标在其中起部分中介作用。心血管-肾脏-代谢综合征生物衰老甘油三酯-葡萄糖指数胰岛素抵抗横断面研究加权多元回归中介分析TyG-BMITyG-WHtR比值比DOI: 10.1016/j.diabres.2025.112988;PMID: 41205874[55]
Li Y, Luo Z, Zhang Z, Huang N, Xiao L, Li J, et al. Exploring the mediating role of TyG-related indicators in the relationship between biological aging and late-stage cardiovascular-kidney-metabolic in middle-aged and older adults. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025;230:112988. doi:10.1016/j.diabres.2025.112988
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
10.1016/j.diabres.2025.112989. Epub 2025 Nov 7. Inflammation and abnormal glucose-lipid metabolism are critical for population stratification toward progressive frailty in Cardiovascular-Kidney-Metabolic syndrome.
2025 DIABETES RESEARCH AND CLINICAL PRACTICE
Zhang C等基于5,790名CKM综合征患者7年随访数据发现,残余胆固醇炎症指数和甘油三酯-葡萄糖指数升高与衰弱进展风险独立相关,尤其在CKM早期阶段。心血管-肾脏-代谢综合征衰弱残余胆固醇炎症指数甘油三酯-葡萄糖指数队列研究风险分层慢性炎症糖脂代谢紊乱PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1016/j.diabres.2025.112989;PMID: 41205877[44]
Zhang C, Chen Y, Wang T, Peng W, Ning M, Liu Y. Inflammation and abnormal glucose-lipid metabolism are critical for population stratification toward progressive frailty in Cardiovascular-Kidney-Metabolic syndrome. DIABETES RESEARCH AND CLINICAL PRACTICE. 2025;230:112989. doi:10.1016/j.diabres.2025.112989
衰弱、非奈利酮及遗传多态性在CKM管理中的角色
Extension
Association between remnant cholesterol and the risk of cardiovascular-kidney-metabolic syndrome progression: insights from the China health and retirement longitudinal study.
2025 European Journal of Preventive Cardiology
Ding X 等基于中国健康与养老追踪调查数据发现,残粒胆固醇升高与心血管-肾脏-代谢综合征进展至晚期及新发心血管疾病风险增加独立相关。心血管疾病残粒胆固醇心血管-肾脏-代谢综合征Cox回归Logistic回归队列研究风险比PubMed疾病:cardiovascPubMed疾病:CKM Title/Abstract多病共存DOI: 10.1093/eurjpc/zwaf248;PMID: 40272444[84]
Ding X, Tian J, Chang X, Liu J, Wang G. Association between remnant cholesterol and the risk of cardiovascular-kidney-metabolic syndrome progression: insights from the China health and retirement longitudinal study. European Journal of Preventive Cardiology. 2025;32(13):1157-1165. doi:10.1093/eurjpc/zwaf248
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
Sex differences in cardiovascular-kidney-metabolic risk factors associated with degenerative valvular heart disease.
2025 European Journal of Preventive Cardiology
Yang C等基于英国生物银行436,184名参与者发现,高血压是退行性心脏瓣膜病最大归因危险因素,且女性合并肥胖、慢性肾脏病、高血压或高甘油三酯时特定瓣膜病风险更高。退行性心脏瓣膜病高血压肥胖慢性肾脏病高甘油三酯血症队列研究风险比人群归因风险性别差异心血管肾脏代谢DOI: 10.1093/eurjpc/zwaf050;PMID: 39937669No ref no.
Yang C, Li Z, Sui Y, Long T, Cheng S, Guo X, et al. Sex differences in cardiovascular-kidney-metabolic risk factors associated with degenerative valvular heart disease.. European Journal of Preventive Cardiology. 2025. 32(17). 1705-1715.. doi:10.1093/eurjpc/zwaf050
CKM综合征分期与新型生物标志物的预后评估
Core
ahead of print. Association between the Life's Essential 8 Health Behaviors and Prognosis in Patients with Advanced Cardiovascular-Kidney-Metabolic Syndrome.
2025 European Journal of Preventive Cardiology
Tan S 等基于10,321名参与者发现,生命八要素(LE8)评分越高,晚期心血管-肾脏-代谢综合征患者的死亡风险越低,其中健康行为评分每增加10分可显著降低全因、心血管及CKM相关死亡风险。心血管肾脏代谢综合征生命八要素Cox回归限制性立方样条死亡风险健康行为队列研究全因死亡PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1093/eurjpc/zwaf443;PMID: 40674721No ref no.
Tan S, Zhou J, Li F, Zeng G, Liu. ahead of print. Association between the Life's Essential 8 Health Behaviors and Prognosis in Patients with Advanced Cardiovascular-Kidney-Metabolic Syndrome.. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf443
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
ahead of print. Association of Cardiovascular-Kidney-Metabolic Overlap with Physical Function and Prognosis in Older Patients with Heart Failure: A Post-hoc Analysis of the FRAGILE-HF and SONIC-HF.
2025 European Journal of Preventive Cardiology
Nakade T 等通过对1,113例老年心衰患者的事后分析发现,存在2种或以上心血管-肾脏-代谢重叠状况的患者,其身体功能显著更差,且2年内死亡或再入院风险升高。心力衰竭慢性肾脏病2型糖尿病身体功能Cox回归前瞻性研究步速复合终点事后分析老年患者DOI: 10.1093/eurjpc/zwaf279;PMID: 40326534No ref no.
Nakade T, Matsue Y, Ikeda Y, Maeda D, Kagiyama N, Fujimoto. ahead of print. Association of Cardiovascular-Kidney-Metabolic Overlap with Physical Function and Prognosis in Older Patients with Heart Failure: A Post-hoc Analysis of the FRAGILE-HF and SONIC-HF.. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf279
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
ahead of print. Data-driven cluster analysis identifies distinct types of cardiovascular-kidney-metabolic syndrome.
2025 European Journal of Preventive Cardiology
Yang M 等通过数据驱动聚类分析,在44,200名CKM综合征患者中识别出五个亚型,发现各亚型具有不同的器官特异性风险、蛋白质组学特征和遗传模式。心血管-肾脏-代谢综合征K均值聚类Cox回归临床生物标志物血浆蛋白质组学队列研究慢性肝病脑血管事件慢性肾脏病遗传风险模式DOI: 10.1093/eurjpc/zwaf708;PMID: 41206602[105]
Yang M, Su C, Chang X, Wang G, Liu J. ahead of print. Data-driven cluster analysis identifies distinct types of cardiovascular-kidney-metabolic syndrome. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf708
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
ahead of print. Hepatic Steatosis in Cardiovascular-Kidney-Metabolic Syndrome: Fatty Liver Index as a Predictor of Cardiovascular Outcomes.
2025 European Journal of Preventive Cardiology
Kim BS 等基于心血管-肾脏-代谢综合征人群研究发现,脂肪肝指数可预测心血管结局,提示肝脂肪变性是该综合征患者心血管风险的重要标志。心血管-肾脏-代谢综合征脂肪肝指数心血管结局肝脏脂肪变性预测因子评论文章PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractckdsgltDOI: 10.1093/eurjpc/zwaf396;PMID: 40587659No ref no.
Kim BS, Kim HJ, Kim H, Lee J, Ahn SB, Shin JH, et al. ahead of print. Hepatic Steatosis in Cardiovascular-Kidney-Metabolic Syndrome: Fatty Liver Index as a Predictor of Cardiovascular Outcomes.. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf396
衰弱、非奈利酮及遗传多态性在CKM管理中的角色
Extension
ahead of print. MASLD in the CKM health framework: what does it add to the table?
2025 European Journal of Preventive Cardiology
Ha KH等在一项基于CKM健康框架的评述中发现,MASLD与心血管代谢风险独立相关,为综合管理策略提供了额外证据。代谢相关脂肪肝病心血管代谢健康队列研究欧洲预防心脏病学肝脏疾病心血管疾病代谢综合征评述文章PubMed疾病:CKM Title/Abstract多病共存DOI: 10.1093/eurjpc/zwaf549;PMID: 40858303[87]
Ha KH, Kim DJ, Lee H. ahead of print. MASLD in the CKM health framework: what does it add to the table?. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf549
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Excluded
ahead of print. Night shift work and its interaction with sleep duration and chronotype, and risk of cardiovascular-kidney-metabolic diseases in the UK Biobank.
2025 European Journal of Preventive Cardiology
Tran DT 等基于96,365名英国生物样本库参与者发现,夜班工作超过20年或每月≥8次与心血管-肾脏-代谢疾病风险升高32%相关,且短睡眠(≤6小时)会进一步放大该风险。心血管肾脏代谢疾病夜班工作睡眠时长睡眠时型Cox回归队列研究风险比剂量反应关系PubMed疾病:CKM Title/Abstract公里DOI: 10.1093/eurjpc/zwaf774;PMID: 41411331No ref no.
Tran DT, Strohmaier S, Żebrowska M, Huang T, Papantoniou K,. ahead of print. Night shift work and its interaction with sleep duration and chronotype, and risk of cardiovascular-kidney-metabolic diseases in the UK Biobank.. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf774
衰弱、非奈利酮及遗传多态性在CKM管理中的角色
Extension
ahead of print. Remnant Cholesterol in CHARLS: Unaddressed Dynamic Changes and Clinical Confounders in CKM Progression Analysis.
2025 European Journal of Preventive Cardiology
Abudoureheman W 等基于CHARLS队列数据发现,残余胆固醇的动态变化及临床混杂因素在心血管-肾脏-代谢综合征进展分析中未被充分关注。残余胆固醇心血管代谢疾病队列研究动态变化临床混杂因素CHARLS数据库疾病进展分析PubMed疾病:CKM Title/Abstract多病共存charlsDOI: 10.1093/eurjpc/zwaf391;PMID: 40583206[85]
Abudoureheman W, Zhang F, Sun Q. ahead of print. Remnant Cholesterol in CHARLS: Unaddressed Dynamic Changes and Clinical Confounders in CKM Progression Analysis. European Journal of Preventive Cardiology. 2025. doi:10.1093/eurjpc/zwaf391
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
The New Cardiovascular-Kidney-Metabolic (CKM) Syndrome: An Opportunity for CKD Detection and Treatment in Primary Care.
2025 AMERICAN JOURNAL OF KIDNEY DISEASES
Rumrill SM 和 Shlipak MG 在综述中阐述了新型心血管-肾脏-代谢综合征的概念,指出其有助于在初级保健中早期发现并治疗慢性肾脏病。心血管疾病慢性肾病代谢综合征早期检测初级保健队列研究真实世界研究PubMed疾病:CKM Title/AbstractckdsgltDOI: 10.1053/j.ajkd.2024.09.016;PMID: 39706244No ref no.
Rumrill SM, Shlipak MG. The New Cardiovascular-Kidney-Metabolic (CKM) Syndrome: An Opportunity for CKD Detection and Treatment in Primary Care.. AMERICAN JOURNAL OF KIDNEY DISEASES. 2025. 85(4). 399-402.. doi:10.1053/j.ajkd.2024.09.016
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
Cumulative Incidence of Mortality Associated with Cardiovascular-Kidney-Metabolic (CKM) Syndrome.
2025 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Claudel SE 等在一项纳入50,678名美国成人的纵向研究中发现,CKM综合征分期越高,15年心血管死亡累积发生率呈梯度增加,4期与0期绝对风险差异达8.1个月。心血管疾病代谢综合征纵向研究累积发生率限制性平均生存心血管死亡CKM综合征生存分析PubMed疾病:CKM Title/Abstract肾脏DOI: 10.1681/ASN.0000000637;PMID: 39932805[21]
Claudel SE, Schmidt IM, Waikar SS, Verma A. Cumulative Incidence of Mortality Associated with Cardiovascular-Kidney-Metabolic (CKM) Syndrome. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2025;36(7):1343-1351. doi:10.1681/ASN.0000000637
CKM综合征分期与新型生物标志物的预后评估
Core
Global Burden of the Key Components of Cardiovascular-Kidney-Metabolic Syndrome.
2025 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Xie Z 等基于2021年全球疾病负担数据,分析了心血管-肾脏-代谢综合征七项关键组分的负担,发现缺血性心脏病和卒中为主要贡献因素,糖尿病和高体重指数负担呈上升趋势。心血管-肾脏-代谢综合征糖尿病缺血性心脏病伤残调整寿命年全球疾病负担系统综述发病率死亡率高体重指数卒中DOI: 10.1681/ASN.0000000658;PMID: 40042920[24]
Xie Z, Yu C, Cui Q, Zhao X, Zhuang J, Chen S, et al. Global Burden of the Key Components of Cardiovascular-Kidney-Metabolic Syndrome. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2025;36(8):1572-1584. doi:10.1681/ASN.0000000658
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
Preventing chronic kidney disease and maintaining kidney health: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
2025 KIDNEY INTERNATIONAL
Ortiz A 等通过KDIGO争议会议总结发现,维护肾脏健康与预防慢性肾脏病(CKD)需结合健康生活方式及药物干预,如SGLT2抑制剂和GLP-1受体激动剂可降低高危人群CKD风险。慢性肾脏病2型糖尿病钠-葡萄糖协同转运蛋白2抑制剂胰高血糖素样肽-1受体激动剂系统综述心血管-肾脏-代谢风险预测肾衰竭PubMed疾病:CKM Title/AbstractckdDOI: 10.1016/j.kint.2025.04.005;PMID: 40536455[71]
Ortiz A, Arreola Guerra JM, Chan JCN, Jha V, Kramer H, Nicholas. Preventing chronic kidney disease and maintaining kidney health: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. KIDNEY INTERNATIONAL. 2025;108(4):555-571. doi:10.1016/j.kint.2025.04.005
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
Restoration of branched chain amino acid catabolism improves kidney function in preclinical cardiovascular-kidney-metabolic syndrome models.
2025 KIDNEY INTERNATIONAL
Bollinger E 等通过两种CKM动物模型发现,支链氨基酸分解代谢障碍与肾脏病变相关,使用BDK抑制剂BT2可改善肾功能,与恩格列净联用效果更佳。心血管-肾脏-代谢综合征支链氨基酸BDK抑制剂恩格列净蛋白质组学代谢组学线粒体功能肾功能动物实验PubMed疾病:cardiovascDOI: 10.1016/j.kint.2025.04.025;PMID: 40409667[72]
Bollinger E, Williams G, Piper ME, Steen K, Neale KT, Chen X. Restoration of branched chain amino acid catabolism improves kidney function in preclinical cardiovascular-kidney-metabolic syndrome models. KIDNEY INTERNATIONAL. 2025;108(2):310-316. doi:10.1016/j.kint.2025.04.025
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
Risk stratification of metabolic disorder-associated kidney disease.
2025 KIDNEY INTERNATIONAL
Xu X 等在综述中总结了代谢紊乱相关性肾脏病的传统危险因素,并介绍了CKM健康概念及CKD进展与CVD风险评估工具,指出当前风险分层工具的不足。代谢紊乱慢性肾脏病心血管疾病风险分层CKM分期模型CKD进展方程PREVENT方程系统综述PubMed疾病:CKM Title/AbstractckdDOI: 10.1016/j.kint.2025.01.041;PMID: 40157500No ref no.
Xu X, Shao X, Hou FF. Risk stratification of metabolic disorder-associated kidney disease.. KIDNEY INTERNATIONAL. 2025. 107(6). 1002-1010.. doi:10.1016/j.kint.2025.01.041
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Excluded
Metamorphism of Venus as driver of crustal thickness and recycling.
2025 Nature Communications
Semprich J 等通过变质相与熔融模型发现,金星玄武岩地壳厚度受热梯度控制,停滞盖层下约40公里,活动盖层下可达65公里,超过该范围会引发拆沉或熔融。金星地壳玄武岩变质相转变地壳厚度热梯度拆沉作用熔融条件模型研究PubMed疾病:CKM Title/Abstract公里DOI: 10.1038/s41467-025-58324-1;PMID: 40133342No ref no.
Semprich J, Filiberto J, Weller M, Gorce J, Clark N. Metamorphism of Venus as driver of crustal thickness and recycling.. Nature Communications. 2025. 16(1). 2905.. doi:10.1038/s41467-025-58324-1
CKM综合征分期与新型生物标志物的预后评估
Core
Observation of a rare beta decay of the charmed baryon with a Graph Neural Network. BESIII Collaboration.
2025 Nature Communications
Collaborators: Ablikim M 等利用图神经网络技术,首次观测到粲重子的一种稀有β衰变过程。粒子衰变粲重子图神经网络共振态分支比质量谱角分布队列研究正负电子对撞新粒子发现DOI: 10.1038/s41467-024-55042-y;PMID: 39814737No ref no.
Collaborators: Ablikim M, Achasov MN, Adlarson P, Afedulidis O, Ai XC, Aliberti. Observation of a rare beta decay of the charmed baryon with a Graph Neural Network. BESIII Collaboration.. Nature Communications. 2025. 16(1). 681.. doi:10.1038/s41467-024-55042-y
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
2024 Apr. Are we ready for an adipocentric approach in people living with type 2 diabetes and chronic kidney disease?
2024 Clinical Kidney Journal
Moreno-Pérez O 等在综述中提出,以肥胖为核心的“功能障碍性脂肪组织管理方法”可整合2型糖尿病合并慢性肾病的治疗策略,强调减重对改善心肾代谢结局至关重要。肥胖相关慢性病2型糖尿病慢性肾脏病减重药物功能障碍性脂肪组织系统综述减重靶器官保护血糖稳态心血管疾病DOI: 10.1093/ckj/sfae039;PMID: 38572499[68]
Moreno-Pérez O, Reyes-García R, Modrego-Pardo I, López-Martínez. 2024 Apr. Are we ready for an adipocentric approach in people living with type 2 diabetes and chronic kidney disease?. Clinical Kidney Journal. 2024;17(4):sfae039. doi:10.1093/ckj/sfae039
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
eCollection 2024 Dec. GLP-1 receptor agonists in patients with chronic kidney disease and either overweight or obesity.
2024 Clinical Kidney Journal
Abasheva D 等综述发现,GLP-1受体激动剂可改善超重或肥胖慢性肾病患者的代谢控制,并降低心血管和肾脏不良结局风险。慢性肾脏病超重肥胖GLP-1受体激动剂司美格鲁肽系统综述体重肾脏结局心血管结局PubMed疾病:CKM Title/AbstractDOI: 10.1093/ckj/sfae296;PMID: 39583142[67]
Abasheva D, Ortiz A, Fernandez-Fernandez B. GLP-1 receptor agonists in patients with chronic kidney disease and either overweight or obesity. Clinical Kidney Journal. 2024;17(Suppl. doi:10.1093/ckj/sfae296
CKM定义评估空白与超加工食品的代谢影响
Extension
eCollection 2024. Metabolomic analysis of Agkistrodon haly venom poisoning mouse treatment by Jidesheng snake pill based on GC-MS.
2024 Frontiers in Pharmacology
Luo J 等通过GC-MS代谢组学分析发现,季德胜蛇药片可调节蝮蛇蛇毒中毒小鼠的长链脂肪酸和氨基酸代谢,减轻其病理损伤。蛇咬伤季德胜蛇药片代谢组学气相色谱-质谱蝮蛇蛇毒动物实验差异代谢物氨基酸代谢脂肪酸代谢PubMed疾病:CKM Title/AbstractDOI: 10.3389/fphar.2024.1419609;PMID: 39148553[93]
Luo J, Guo M, Xie K, Han TL, Ai S. Metabolomic analysis of Agkistrodon haly venom poisoning mouse treatment by Jidesheng snake pill based on GC-MS. Frontiers in Pharmacology. 2024;15:1419609. doi:10.3389/fphar.2024.1419609
CKM综合征分期与新型生物标志物的预后评估
Core
Maternal Dietary Strategies for Improving Offspring Cardiovascular-Kidney-Metabolic Health: A Scoping Review.
2024 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Tain YL 和 Hsu CN 通过综述发现,母体饮食干预(如氨基酸补充、脂质调控、微量营养素及植物多酚)可改善子代心血管-肾脏-代谢健康,其机制涉及营养感应信号介导的程序化调控。心血管-肾脏-代谢综合征母体饮食干预系统综述氨基酸补充微量营养素肠道微生物群植物多酚营养感应信号胎儿程序化子代健康DOI: 10.3390/ijms25189788;PMID: 39337276No ref no.
Tain YL, Hsu CN. Maternal Dietary Strategies for Improving Offspring Cardiovascular-Kidney-Metabolic Health: A Scoping Review.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. 25(18). 9788.. doi:10.3390/ijms25189788
CKM定义评估空白与超加工食品的代谢影响
Extension
The Association of Genetic Markers Involved in Muscle Performance Responding to Lactate Levels during Physical Exercise Therapy by Nordic Walking in Patients with Long COVID Syndrome: A Nonrandomized Controlled Pilot Study.
2024 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lizcano-Álvarez Á 等通过北欧健走运动疗法对长新冠患者进行基因分析发现,ACTN3和AMPD1基因多态性影响运动后乳酸水平,提示长新冠患者运动能力较差但有氧训练可改善。长新冠北欧健走基因多态性乳酸非随机对照试验肌肉表现有氧运动物理治疗PubMed疾病:CKM Title/AbstracttgsDOI: 10.3390/ijms25158305;PMID: 39125881[98]
Lizcano-Álvarez Á, Varillas-Delgado D, Cano-de-la-Cuerda R. The Association of Genetic Markers Involved in Muscle Performance Responding to Lactate Levels during Physical Exercise Therapy by Nordic Walking in Patients with Long COVID Syndrome: A Nonrandomized Controlled Pilot Study. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(15):8305. doi:10.3390/ijms25158305
CKM综合征分期与新型生物标志物的预后评估
Core
The Impact of the Aryl Hydrocarbon Receptor on Antenatal Chemical Exposure-Induced Cardiovascular-Kidney-Metabolic Programming.
2024 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Tain YL 和 Hsu CN 通过综述发现,产前环境化学物暴露通过激活芳香烃受体可导致心血管-肾脏-代谢综合征编程,并探讨了潜在AHR调节剂的预防作用。心血管-肾脏-代谢综合征芳香烃受体环境化学物质系统综述胎儿编程高血压糖尿病肥胖肾脏疾病非酒精性脂肪肝病DOI: 10.3390/ijms25094599;PMID: 38731818No ref no.
Tain YL, Hsu CN. The Impact of the Aryl Hydrocarbon Receptor on Antenatal Chemical Exposure-Induced Cardiovascular-Kidney-Metabolic Programming.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. 25(9). 4599.. doi:10.3390/ijms25094599
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
The Renin-Angiotensin System and Cardiovascular-Kidney-Metabolic Syndrome: Focus on Early-Life Programming.
2024 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Tain YL 和 Hsu CN 通过综述临床前证据发现,妊娠期及哺乳期肾素-血管紧张素系统失调会通过影响胎儿编程,导致子代出现心血管-肾脏-代谢综合征特征。心血管-肾脏-代谢综合征肾素-血管紧张素系统早期生命编程系统综述代谢性疾病肾脏疾病心血管疾病胎儿编程重编程策略临床前证据DOI: 10.3390/ijms25063298;PMID: 38542273No ref no.
Tain YL, Hsu CN. The Renin-Angiotensin System and Cardiovascular-Kidney-Metabolic Syndrome: Focus on Early-Life Programming.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. 25(6). 3298.. doi:10.3390/ijms25063298
CKM定义评估空白与超加工食品的代谢影响
Extension
Amino Acids during Pregnancy and Offspring Cardiovascular-Kidney-Metabolic Health.
2024 Nutrients
Tain YL 和 Hsu CN 综述发现,孕期氨基酸代谢紊乱通过胎儿编程和肠道菌群调节影响后代心血管-肾脏-代谢健康,靶向氨基酸疗法具有重编程保护潜力。心血管-肾脏-代谢综合征氨基酸疗法系统综述胎儿编程肠道菌群氨基酸代谢后代健康发育起源PubMed疾病:CKM Title/AbstracttgsDOI: 10.3390/nu16091263;PMID: 38732510[97]
Tain YL, Hsu CN. Amino Acids during Pregnancy and Offspring Cardiovascular-Kidney-Metabolic Health. Nutrients. 2024;16(9):1263. doi:10.3390/nu16091263
CKM定义评估空白与超加工食品的代谢影响
Extension
Association of Genetic Profile with Muscle Mass Gain and Muscle Injury Prevention in Professional Football Players after Creatine Supplementation.
2024 Nutrients
Varillas-Delgado D等对161名职业足球运动员研究发现,肌酸补充后肌肉量增加受ACE和AMPD1基因型影响,总基因型评分低于54.16者非接触性肌肉损伤风险显著升高。肌肉损伤肌酸补充基因型评分体重指数肌肉量纵向研究职业足球运动员单核苷酸多态性PubMed疾病:CKM Title/AbstracttgsDOI: 10.3390/nu16152511;PMID: 39125391[99]
Varillas-Delgado D. Association of Genetic Profile with Muscle Mass Gain and Muscle Injury Prevention in Professional Football Players after Creatine Supplementation. Nutrients. 2024;16(15):2511. doi:10.3390/nu16152511
CKM综合征分期与新型生物标志物的预后评估
Core
Maternal Polyphenols and Offspring Cardiovascular-Kidney-Metabolic Health.
2024 Nutrients
Tain YL 和 Hsu CN 通过综述研究发现,母体补充多酚可预防子代心血管-肾脏-代谢综合征,其保护作用涉及共同机制。心血管-肾脏-代谢综合征多酚系统综述母体补充子代健康妊娠期哺乳期预防作用PubMed疾病:CKM Title/Abstract肾脏DOI: 10.3390/nu16183168;PMID: 39339768No ref no.
Tain YL, Hsu CN. Maternal Polyphenols and Offspring Cardiovascular-Kidney-Metabolic Health.. Nutrients. 2024. 16(18). 3168.. doi:10.3390/nu16183168
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
Prevalence Rates of Abdominal Obesity, High Waist-to-Height Ratio and Excess Adiposity, and Their Associated Cardio-Kidney-Metabolic Factors: SIMETAP-AO Study.
2024 Nutrients
Ruiz-García A 等在一项纳入6,588名成人的横断面研究中发现,腹型肥胖、高腰围身高比和体脂过多的患病率分别为39.6%、39.6%和66.7%,且与高血压、糖尿病、血脂异常等心血管-肾脏-代谢因素独立相关。腹型肥胖高腰围身高比体脂过多心血管-肾脏-代谢综合征横断面研究患病率高血压糖尿病高尿酸血症慢性肾脏病DOI: 10.3390/nu16223948;PMID: 39599733No ref no.
Ruiz-García A, Serrano-Cumplido A, Escobar-Cervantes C,. Prevalence Rates of Abdominal Obesity, High Waist-to-Height Ratio and Excess Adiposity, and Their Associated Cardio-Kidney-Metabolic Factors: SIMETAP-AO Study.. Nutrients. 2024. 16(22). 3948.. doi:10.3390/nu16223948
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
Protective Effects of the Food Supplement Flexovital in a Model of Cardiovascular-Kidney-Metabolic Syndrome in Mice.
2024 Nutrients
Carvalho LRRA 等通过单侧肾切除联合西方饮食诱导小鼠CKM综合征模型,发现食品补充剂Flexovital可降低体脂、血糖、血压,改善肾功能及线粒体氧化磷酸化效率。心血管-肾脏-代谢综合征食品添加剂动物实验体脂质量空腹血糖动脉血压肾小球滤过率线粒体氧化磷酸化西方饮食单侧肾切除术DOI: 10.3390/nu16234105;PMID: 39683499No ref no.
Carvalho LRRA, Tydén M, Shimari M, Zhuge Z, Schiffer TA. Protective Effects of the Food Supplement Flexovital in a Model of Cardiovascular-Kidney-Metabolic Syndrome in Mice.. Nutrients. 2024. 16(23). 4105.. doi:10.3390/nu16234105
衰弱、非奈利酮及遗传多态性在CKM管理中的角色
Extension
Social Risk Profile and Cardiovascular-Kidney-Metabolic Syndrome in US Adults.
2024 Journal of the American Heart Association
Li J等基于18,373名美国成人数据发现,社会风险评分越低,心血管-肾脏-代谢综合征分期越高,累积社会劣势与CKM多病共存风险独立相关。心血管肾脏代谢综合征社会风险特征横断面研究多病共存比值比美国成年人健康不平等PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractcharlsDOI: 10.1161/JAHA.124.034996;PMID: 39136302[83]
Li J, Lei L, Wang W, Ding W, Yu Y, Pu B, et al. Social Risk Profile and Cardiovascular-Kidney-Metabolic Syndrome in US Adults. Journal of the American Heart Association. 2024;13(16):e034996. doi:10.1161/JAHA.124.034996
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
Continuous ketone monitoring: Exciting implications for clinical practice.
2024 DIABETES OBESITY and METABOLISM
Kong YW 等通过皮下传感器监测组织间液酮体,发现连续酮体监测(CKM)可每5分钟更新读数,建议为所有糖尿病酮症酸中毒风险人群提供该技术。糖尿病酮症酸中毒1型糖尿病连续酮体监测SGLT抑制剂系统综述酮体水平皮下传感器PubMed疾病:CKM Title/AbstractckdsgltDOI: 10.1111/dom.15921;PMID: 39314201[77]
Kong YW, Morrison D, Lu JC, Lee MH, Jenkins AJ. Continuous ketone monitoring: Exciting implications for clinical practice. DIABETES OBESITY and METABOLISM. 2024;26. doi:10.1111/dom.15921
CKM综合征分期与脑结构损伤及残余心血管风险
Supporting
eCollection 2024 Sep. Combination of Cardiovascular, Kidney, and Metabolic Diseases in a Syndrome Named Cardiovascular-Kidney-Metabolic, With New Risk Prediction Equations.
2024 Kidney International Reports
Massy ZA 和 Drueke TB 将心血管、肾脏与代谢疾病整合为“心血管-肾脏-代谢综合征”,并提出了新的风险预测方程。心血管疾病肾脏疾病代谢疾病心血管-肾脏-代谢综合征风险预测方程队列研究PubMed疾病:CKM Title/Abstracttyg肾脏代谢综合DOI: 10.1016/j.ekir.2024.05.033;PMID: 39291205No ref no.
Massy ZA, Drueke TB. eCollection 2024 Sep. Combination of Cardiovascular, Kidney, and Metabolic Diseases in a Syndrome Named Cardiovascular-Kidney-Metabolic, With New Risk Prediction Equations.. Kidney International Reports. 2024. 9(9). 2608-2618.. doi:10.1016/j.ekir.2024.05.033
CKM综合征分期与新型生物标志物的预后评估
Core
10.1016/j.diabres.2024.111926. Epub 2024 Nov 12. Increased prevalence of cardiovascular-kidney-metabolic syndrome during COVID-19: A propensity score-matched study.
2024 DIABETES RESEARCH AND CLINICAL PRACTICE
Trimarco V 等通过倾向评分匹配研究发现,COVID-19大流行期间心血管-肾脏-代谢综合征患病率显著上升,近半数患者存在至少一项CKM组分。心血管-肾脏-代谢综合征2型糖尿病高血压倾向评分匹配队列研究真实世界研究患病率COVID-19PubMed疾病:cardiovascPubMed疾病:CKM Title/AbstractDOI: 10.1016/j.diabres.2024.111926;PMID: 39536978[25]
Trimarco V, Izzo R, Pacella D, Virginia Manzi M, Trama U, Lembo. Increased prevalence of cardiovascular-kidney-metabolic syndrome during COVID-19: A propensity score-matched study. DIABETES RESEARCH AND CLINICAL PRACTICE. 2024;218:111926. doi:10.1016/j.diabres.2024.111926
CKM定义评估空白与超加工食品的代谢影响
Extension
Hot Cordilleran hinterland promoted lower crust mobility and decoupling of Laramide deformation.
2024 Nature Communications
Vlaha DR 等通过碳质拉曼光谱测温法重建北美科迪勒拉腹地热结构,发现晚白垩世高地壳地温梯度(>40 °C/km)促进了下地壳流动与壳幔解耦。拉腊米造山运动地壳热结构地温梯度碳质拉曼光谱系统综述下地壳流动性壳幔解耦挤压变形缺失PubMed疾病:CKM Title/AbstracttgsDOI: 10.1038/s41467-024-48182-8;PMID: 38704380No ref no.
Vlaha DR, Zuza AV, Chen L, Harlaux M. Hot Cordilleran hinterland promoted lower crust mobility and decoupling of Laramide deformation.. Nature Communications. 2024. 15(1). 3750.. doi:10.1038/s41467-024-48182-8
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
A Patient Decision Aid About Conservative Kidney Management in Advanced Kidney Disease: A Randomized Pilot Trial.
2023 AMERICAN JOURNAL OF KIDNEY DISEASES
Wong SPY 等在一项随机先导试验中发现,针对晚期肾病患者的保守性肾脏管理决策辅助工具可行且可接受,并显著增加了患者与医生讨论该方案的比例。慢性肾脏病保守性肾脏管理决策辅助工具随机先导试验失访率医患沟通老年患者PubMed疾病:CKM Title/AbstractckdsgltDOI: 10.1053/j.ajkd.2022.12.007;PMID: 36740038No ref no.
Wong SPY, Oestreich T, Prince DK, Curtis JR. A Patient Decision Aid About Conservative Kidney Management in Advanced Kidney Disease: A Randomized Pilot Trial.. AMERICAN JOURNAL OF KIDNEY DISEASES. 2023. 82(2). 179-188.. doi:10.1053/j.ajkd.2022.12.007
SGLT2抑制剂及心肾代谢药物的多效性机制与临床应用
Core
A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association.
2023 Circulation
Ndumele CE 等通过整合主要指南与科学文献,总结了心血管-肾脏-代谢综合征在科学认知、筛查、预防及管理方面的现有证据,并指出了关键知识空白。心血管-肾脏-代谢综合征慢性肾脏病代谢风险因素生活方式干预心脏保护疗法系统综述健康社会决定因素生物学风险因素不良心血管结局肾脏结局DOI: 10.1161/CIR.0000000000001186;PMID: 37807920No ref no.
Ndumele CE, Neeland IJ, Tuttle KR, Chow SL, Mathew RO, Khan SS, et al. A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association.. Circulation. 2023. 148(20). 1636-1664.. doi:10.1161/CIR.0000000000001186
CKM多病共存与认知障碍、抑郁及不良生活事件的关联
Supporting
Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association.
2023 Circulation
Khan SS 等通过回顾性队列研究纳入604名终末期肾病患者,发现保守性肾脏管理组在12个月后生活质量各维度未见显著恶化,其症状负担与透析患者无显著差异。终末期肾病保守性肾脏管理透析肾移植生活质量回顾性研究观察研究EQ-5D-5L症状负担PubMed疾病:CKM Title/AbstractDOI: 10.1161/CIR.0000000000001191;PMID: 37947094No ref no.
Khan SS, Coresh J, Pencina MJ, Ndumele CE, Rangaswami J, Chow SL, et al. Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association.. Circulation. 2023. 148(24). 1982-2004.. doi:10.1161/CIR.0000000000001191
地热系统与超级马拉松代谢挑战等无关主题
Excluded
Aberrant cyclin C nuclear release induces mitochondrial fragmentation and dysfunction in MED13L syndrome fibroblasts.
2022 iScience
Chang KT 等在MED13L综合征患者成纤维细胞中发现,异常细胞周期蛋白C核释放导致线粒体碎片化、呼吸功能降低及氧化应激超敏,阻断其定位可部分恢复线粒体功能。MED13L综合征线粒体碎片化细胞周期蛋白C线粒体功能障碍成纤维细胞病例对照研究转录组分析氧化应激PubMed疾病:CKM Title/Abstract澳大利亚DOI: 10.1016/j.isci.2022.103823;PMID: 35198885No ref no.
Chang KT, Jezek J, Campbell AN, Stieg DC, Kiss ZA, Kemper K,. Aberrant cyclin C nuclear release induces mitochondrial fragmentation and dysfunction in MED13L syndrome fibroblasts.. iScience. 2022. 25(2). 103823.. doi:10.1016/j.isci.2022.103823
CKM定义评估空白与超加工食品的代谢影响
Extension
eCollection 2022. Combined metabolomics and proteomics to reveal beneficial mechanisms of Dendrobium fimbriatum against gastric mucosal injury.
2022 Frontiers in Pharmacology
Sun J等通过整合代谢组学与蛋白质组学,在环磷酰胺诱导的小鼠胃黏膜损伤模型中发现,流苏石斛通过调节肌酸、精氨酸与脯氨酸及嘧啶代谢通路发挥保护作用,并鉴定出Ckm、Arg1等关键靶蛋白及γ-L-谷氨酰-腐胺等潜在生物标志物。胃黏膜损伤流苏石斛代谢组学蛋白质组学生物标志物动物实验环磷酰胺肌酸代谢PubMed疾病:CKM Title/AbstracttgsDOI: 10.3389/fphar.2022.948987;PMID: 36110550[94]
Sun J, Liu PF, Liu JN, Lu C, Tong LT, Wang YQ, et al. Combined metabolomics and proteomics to reveal beneficial mechanisms of Dendrobium fimbriatum against gastric mucosal injury. Frontiers in Pharmacology. 2022;13:948987. doi:10.3389/fphar.2022.948987
CKM综合征分期与新型生物标志物的预后评估
Core
2019 Apr. Quality of life with conservative care compared with assisted peritoneal dialysis and haemodialysis.
2018 Clinical Kidney Journal
Iyasere O 等通过倾向性评分匹配84例ESKD患者发现,辅助腹膜透析比保守管理能改善部分生活质量指标,但衰弱与更差的生活质量结局相关。终末期肾病保守肾脏管理辅助腹膜透析血液透析倾向评分匹配生活质量衰弱抑郁评分PubMed疾病:CKM Title/Abstract肾脏DOI: 10.1093/ckj/sfy059;PMID: 30976407No ref no.
Iyasere O, Brown EA, Johansson L, Davenport A, Farrington K,. 2019 Apr. Quality of life with conservative care compared with assisted peritoneal dialysis and haemodialysis.. Clinical Kidney Journal. 2018. 12(2). 262-268.. doi:10.1093/ckj/sfy059
CKM定义评估空白与超加工食品的代谢影响
Extension
Common and rare variants associating with serum levels of creatine kinase and lactate dehydrogenase.
2016 Nature Communications
Kristjansson RP 等通过对冰岛人群的全基因组测序和推算,发现13个与血清肌酸激酶水平相关、16个与乳酸脱氢酶水平相关的序列变异,其中多个变异位于与肌肉功能或免疫炎症相关的基因中。肌酸激酶乳酸脱氢酶全基因组测序序列变异队列研究冰岛人群组织损伤标志物单核吞噬细胞PubMed疾病:CKM Title/AbstracttgsDOI: 10.1038/ncomms10572;PMID: 26838040[96]
Kristjansson RP, Oddsson A, Helgason H, Sveinbjornsson G. Common and rare variants associating with serum levels of creatine kinase and lactate dehydrogenase. Nature Communications. 2016;7:10572. doi:10.1038/ncomms10572
CKM综合征分期与新型生物标志物的预后评估
Core
Association between inflammatory mediators and muscle mass in long-term hemodialysis patients.
2003 AMERICAN JOURNAL OF KIDNEY DISEASES
Kaizu Y 等在一项纳入188名长期血液透析患者的研究中发现,炎症介质IL-6和CRP水平与肌肉质量指标呈显著负相关。肌肉消耗血液透析C反应蛋白白细胞介素-6多元回归分析队列研究肌肉质量炎症介质PubMed疾病:CKM Title/Abstract肾脏DOI: 10.1016/s0272-6386(03;PMID: 12900811No ref no.
Kaizu Y, Ohkawa S, Odamaki M, Ikegaya N, Hibi I, Miyaji K, et al. Association between inflammatory mediators and muscle mass in long-term hemodialysis patients.. AMERICAN JOURNAL OF KIDNEY DISEASES. 2003. 42(2). 295-302.. doi:10.1016/s0272-6386(03
衰弱、非奈利酮及遗传多态性在CKM管理中的角色
Extension
Quantification of creatinine kinetic parameters in patients with acute renal failure.
1998 KIDNEY INTERNATIONAL
Clark WR等通过11例急性肾衰竭患者的肌酐动力学模型分析发现,患者瘦体重显著低于正常人和终末期肾病者,提示存在严重躯体蛋白质耗竭。急性肾衰竭连续性静脉-静脉血液滤过肌酐动力学模型瘦体重肌酐生成速率营养不良队列研究蛋白质分解代谢率PubMed疾病:CKM Title/Abstract多病共存DOI: 10.1046/j.1523-1755.1998.00016.x;PMID: 9690223[81]
Clark WR, Mueller BA, Kraus MA, Macias WL. Quantification of creatinine kinetic parameters in patients with acute renal failure. KIDNEY INTERNATIONAL. 1998;54(2):554-60. doi:10.1046/j.1523-1755.1998.00016.x
衰弱、非奈利酮及遗传多态性在CKM管理中的角色
Extension
Protein catabolic rate over lean body mass ratio: a more rational approach to normalize the protein catabolic rate in dialysis patients.
1997 AMERICAN JOURNAL OF KIDNEY DISEASES
Canaud B 等通过联合尿素和肌酐动力学模型,在66名透析患者中发现,将蛋白质分解代谢率标准化为瘦体重(nPCRLBM)比标准化为干体重更能准确反映蛋白质营养状况,尤其适用于身体成分异常的患者。终末期肾病蛋白质分解代谢率瘦体重尿素动力学模型肌酐动力学模型Kt/V队列研究PubMed疾病:CKM Title/Abstract多病共存charlsDOI: 10.1016/s0272-6386(97;PMID: 9370183[82]
Canaud B, Leblanc M, Garred LJ, Bosc JY, Argilés A, Mion C. Protein catabolic rate over lean body mass ratio: a more rational approach to normalize the protein catabolic rate in dialysis patients. AMERICAN JOURNAL OF KIDNEY DISEASES. 1997;30(5):672-9. doi:10.1016/s0272-6386(97